• Title/Summary/Keyword: 최적 설계변수

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A Study on Formulation Optimization for Improving Skin Absorption of Glabridin-Containing Nanoemulsion Using Response Surface Methodology (반응표면분석법을 활용한 Glabridin 함유 나노에멀젼의 피부흡수 향상을 위한 제형 최적화 연구)

  • Se-Yeon Kim;Won Hyung Kim;Kyung-Sup Yoon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.3
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    • pp.231-245
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    • 2023
  • In the cosmetics industry, it is important to develop new materials for functional cosmetics such as whitening, wrinkles, anti-oxidation, and anti-aging, as well as technology to increase absorption when applied to the skin. Therefore, in this study, we tried to optimize the nanoemulsion formulation by utilizing response surface methodology (RSM), an experimental design method. A nanoemulsion was prepared by a high-pressure emulsification method using Glabridin as an active ingredient, and finally, the optimized skin absorption rate of the nanoemulsion was evaluated. Nanoemulsions were prepared by varying the surfactant content, cholesterol content, oil content, polyol content, high-pressure homogenization pressure, and cycling number of high-pressure homogenization as RSM factors. Among them, surfactant content, oil content, high-pressure homogenization pressure, and cycling number of high-pressure homogenization, which are factors that have the greatest influence on particle size, were used as independent variables, and particle size and skin absorption rate of nanoemulsion were used as response variables. A total of 29 experiments were conducted at random, including 5 repetitions of the center point, and the particle size and skin absorption of the prepared nanoemulsion were measured. Based on the results, the formulation with the minimum particle size and maximum skin absorption was optimized, and the surfactant content of 5.0 wt%, oil content of 2.0 wt%, high-pressure homogenization pressure of 1,000 bar, and the cycling number of high-pressure homogenization of 4 pass were derived as the optimal conditions. As the physical properties of the nanoemulsion prepared under optimal conditions, the particle size was 111.6 ± 0.2 nm, the PDI was 0.247 ± 0.014, and the zeta potential was -56.7 ± 1.2 mV. The skin absorption rate of the nanoemulsion was compared with emulsion as a control. As a result of the nanoemulsion and general emulsion skin absorption test, the cumulative absorption of the nanoemulsion was 79.53 ± 0.23%, and the cumulative absorption of the emulsion as a control was 66.54 ± 1.45% after 24 h, which was 13% higher than the emulsion.

A Feasibility Study on the Use of Liner and Cover Materials Using Sewage Sludge (하수슬러지의 차수재 및 복토재로의 이용타당성에 관한 연구)

  • 유남재;김영길;박병수;정하익
    • Journal of the Korean Geotechnical Society
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    • v.15 no.2
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    • pp.43-71
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    • 1999
  • This research is an experimental work of developing a construction material using municipal wastewater sludge as liner and cover materials for waste disposal landfill. Weathered granite soil and flyash, produced as a by-product in the power plant, were used as the primary additives to improve geotechnical engineering properties of sludge. For secondary additives, bentonite and cement were mixed with sludge to decrease the permeability and to increase the shear strength, respectively. Various laboratory test required to evaluate the design criteria for liner and cover materials, were carried out by changing the mixing ratio of sludge with the additives. Basic soil properties such as specific gravity, grain size distribution, liquid and plastic limits were measured to analyze their effects on permeability, compaction, compressibility and shear strength properties of mixtures. Laboratory compaction tests were conducted to find the maximum dry densities and the optimum moisture contents of mixtures, and their effectiveness of compaction in field was consequently evaluated. Permeability tests of variable heads with compacted samples, and the stress-controlled consolidation tests with measuring permeabilities of samples during consolidation process were performed to obtain permeability, and to find the compressibility as well as consolidational coefficients of mixtures, respectively. To evaluate the long term stability of sludges, creep tests were also conducted in parallel with permeability tests of variable heads. On the other hand, for the compacted sludge decomposed for a month, permeability tests were carried out to investigate the effect of decomposition of organic matters in sludges on its permeability. Direct shear tests were performed to evaluate the shear strength parameters of mixed sludge with weathered granite, flyash and bentonite. For the mixture of sludge with cement, unconfined compression tests were carried out to find their strength with varying mixing ratio and curing time. On the other hand, CBR tests for compacted specimen were also conducted to evaluate the trafficability of mixtures. Various test results with mixtures were assessed to evaluate whether their properties meet the requirements as liner and cover materials in waste disposal landfill.

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Development of Vacuum Puffing Machine for Non-deep Fried Yukwa and Its Puffing Characteristics by Process Variables (비유탕 유과 제조를 위한 진공팽화기의 개발 및 공정변수에 따른 유과의 팽화특성)

  • Yu, Je-Hyeok;Ryu, Gi-Hyung
    • Food Engineering Progress
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    • v.14 no.3
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    • pp.193-201
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    • 2010
  • The aim of this study was to analyse the quality of Yukwa puffed by using a vacuum puffing machine and compare to deep-fried Yukwa. The effect of vacuum puffing condition including heating temperature(100-${160^{\circ}C}$), preheating time(0-8 min) and vacuum puffing time(5-20 min) on physical and microstructure characteristics of the Yukwa was investigated. Vacuum puffed Yukwa at ${100^{\circ}C}$ heating temperature, 6 min preheating time and 10 min puffing time had highest value in volumetric expansion ratio(10.04) and lowest value in bulk density(0.15 g/$cm^{3}$). The breaking strength showed the lowest value of 140 g/$cm^{3}$ in vacuum puffing Yukwa at ${100^{\circ}C}$ heating temperature, 6 min preheating time and 15 min puffing time. The Yukwa puffed with the vacuum puffing machine at ${100^{\circ}C}$ heating temperature, 6 min preheating time and 15 min puffing time had the higher value of bulk density and the lower value of volumetric expansion ratio than those of deep-fried Yukwa. Increasing preheating time and vacuum puffing time caused an increase in white and an decrease in yellowness. The vacuum-puffed Yukwa exhibited smaller and uniform cell structure, while deep-fried Yukwa exhibited apparently in larger pores inside and smaller pores near the surface layer. The optimum condition of vacuum puffing machine for the production of vacuum-puffing Yukwa was ${120^{\circ}C}$ heating temperature, 4 min preheating time and 5 min puffing time.

Evaluation of Image Qualities for a Digital X-ray Imaging System Based on Gd$_2$O$_2$S(Tb) Scintillator and Photosensor Array by Using a Monte Carlo Imaging Simulation Code (몬테카를로 영상모의실험 코드를 이용한 Gd$_2$O$_2$S(Tb) 섬광체 및 광센서 어레이 기반 디지털 X-선 영상시스템의 화질평가)

  • Jung, Man-Hee;Jung, In-Bum;Park, Ju-Hee;Oh, Ji-Eun;Cho, Hyo-Sung;Han, Bong-Soo;Kim, Sin;Lee, Bong-Soo;Kim, Ho-Kyung
    • Journal of Biomedical Engineering Research
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    • v.25 no.4
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    • pp.253-259
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    • 2004
  • in this study, we developed a Monte Carlo imaging simulation code written by the visual C$\^$++/ programing language for design optimization of a digital X-ray imaging system. As a digital X-ray imaging system, we considered a Gd$_2$O$_2$S(Tb) scintillator and a photosensor array, and included a 2D parallel grid to simulate general test renditions. The interactions between X-ray beams and the system structure, the behavior of lights generated in the scintillator, and their collection in the photosensor array were simulated by using the Monte Carlo method. The scintillator thickness and the photosensor array pitch were assumed to 66$\mu\textrm{m}$ and 48$\mu\textrm{m}$, respertively, and the pixel format was set to 256 x 256. Using the code, we obtained X-ray images under various simulation conditions, and evaluated their image qualities through the calculations of SNR (signal-to-noise ratio), MTF (modulation transfer function), NPS (noise power spectrum), DQE (detective quantum efficiency). The image simulation code developed in this study can be applied effectively for a variety of digital X-ray imaging systems for their design optimization on various design parameters.

Development of Rainfall-runoff Analysis Algorithm on Road Surface (도로 표면 강우 유출 해석 알고리즘 개발)

  • Jo, Jun Beom;Kim, Jung Soo;Kwak, Chang Jae
    • Ecology and Resilient Infrastructure
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    • v.8 no.4
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    • pp.223-232
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    • 2021
  • In general, stormwater flows to the road surface, especially in urban areas, and it is discharged through the drainage grate inlets on roads. The appropriate evaluation of the road drainage capacity is essential not only in the design of roads and inlets but also in the design of sewer systems. However, the method of road surface flow analysis that reflects the topographical and hydraulic conditions might not be fully developed. Therefore, the enhanced method of road surface flow analysis should be presented by investigating the existing analysis method such as the flow analysis module (uniform; varied) and the flow travel time (critical; fixed). In this study, the algorithm based on varied and uniform flow analysis was developed to analyze the flow pattern of road surface. The numerical analysis applied the uniform and varied flow analysis module and travel time as parameters were conducted to estimate the characteristics of rainfall-runoff in various road conditions using the developed algorithm. The width of the road (two-lane (6 m)) and the slope of the road (longitudinal slope of road 1 - 10%, transverse slope of road 2%, and transverse slope of gutter 2 - 10%) was considered. In addition, the flow of the road surface is collected from the gutter along the road slope and drained through the gutter in the downstream part, and the width of the gutter was selected to be 0.5 m. The simulation results were revealed that the runoff characteristics were affected by the road slope conditions, and it was found that the varied flow analysis module adequately reflected the gutter flow which is changed along the downstream caused by collecting of road surface flow at the gutter. The varied flow analysis module simulated 11.80% longer flow travel time on average (max. 23.66%) and 4.73% larger total road surface discharge on average (max. 9.50%) than the uniform flow analysis module. In order to accurately estimate the amount of runoff from the road, it was appropriate to perform flow analysis by applying the critical duration and the varied flow analysis module. The developed algorithm was expected to be able to be used in the design of road drainage because it was accurately simulated the runoff characteristics on the road surface.

Study on Pre-treatment of Tropical Crop Oil for Bio-diesel Production (열대작물 오일로부터 바이오디젤 생산을 위한 전처리 공정 연구)

  • Kim, Deogkeun;Park, Jiyeon;Lee, Joonpyo;Park, Soonchul;Lee, Jinsuk
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.06a
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    • pp.249.2-249.2
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    • 2010
  • 최근의 고유가와 환경오염에 대한 대응 수단으로 수송용 바이오연료의 보급에 대한 관심이 세계적으로 높아지고 있다. 이 중 바이오디젤은 동식물성 기름으로부터 메탄올과의 전이에스테르화 반응에 의해 생산되는 경유대체 연료로서 환경 친화성과 지속가능성이 인정됨에 따라 그 생산량이 급격히 증가하고 있다. 바이오디젤의 생산량이 증가함에 따라 대두유, 유채유, 팜유 등의 원료유 가격 상승 및 수급 불안정 문제가 대두되고 있으며 식량자원과의 충돌 문제도 발생되고 있다. 이를 해결하기 위한 방안으로 유리지방산 함량이 높은 저가유지 자원(폐식용유, 폐돈지, 폐우지, soapstock, trapped grease)을 이용한 공정 개발 연구가 활발히 진행되고 있다. 본 연구에서는 비활용되고 있는 해외 열대작물 열매씨앗에서 착유한 식물성 오일의 바이오디젤 원료유로서의 사용 가능성을 검토하였다. 열대작물 오일의 물성 분석 결과 고형물, 수분, 인, 유리지방산 함량이 대두원유보다 매우 높게 나타났다. 오일 중의 인지질은 바이오디젤 제조 반응후 에스테르와 글리세린의 층분리를 방해하여 공정 효율을 감소시키고 유리지방산은 염기촉매와 결합하여 지방산염을 생성해 생산수율을 감소시키는 문제를 일으킨다. 고형물과 수분은 여과와 감압증발에 의해 쉽게 제거가 가능하였다. 15~20%의 유리지방산 함유 열대작물 오일의 전처리를 위해 균질계 산촉매와 비균질 고체 산촉매를 이용해 에스테르화 반응 효율을 조사한 결과 황산이 가장 높은 효율을 보였다. 반응표면분석법(Response Surface Method, RSM)을 적용해 메탄올과 촉매량의 2변수 에스테르화반응 최적화를 수행한 결과 메탄올 26%, 촉매 0.98%로 최적 조건이 도출되었으며 초기 산가 33mgKOH/g에서 0.98mgKOH/g으로 감소됨을 확인하였다. 전처리 정제한 오일의 물성분석 결과 고형물 0.1%, 수분 0.10%, 산가 1.0mgKOH/g, 인함량 20ppm 이하로 바람직한 원료유가 생산됨을 알 수 있었다. 제조된 원료유를 이용해 전이에스테르화 반응 최적화 실험을 RSM에 근거하여 진행한 결과 KOH 0.8%, 메탄올:오일 몰비 6.2:1, 반응온도 $60^{\circ}C$, 교반속도 200rpm, 반응시간 30분으로 나타났으며 증류 정제전 97.3%, 증류후 100.0%의 바이오디젤을 생산 할 수 있었다. 열대작물 오일의 전처리 공정은 메탄올을 과잉양으로 사용함으로 효과적인 알콜 회수 공정이 중요하다. 전처리 후 층분리를 통해 회수되는 메탄올 중의 수분함량은 2%~7%로서 이를 전처리 반응에 재사용하기 위해서는 0.3%이하의 수분함량으로 정제가 필요하다. 본 연구에서는 고가의 증류탑 형태가 아닌 단증류방식으로 2단계 내지 3단계로 0.3% 수분의 메탄올 회수 조건을 도출하였으며 파일롯 공정 설계를 진행하고 있다. 이로서 본 연구의 열대작물 오일은 저가로 충분한 물량의 확보가 가능하다면 바이오디젤 원료 자원으로서 큰 활용가치가 있는 것으로 판단된다.

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Improvement of Frozen Yeast Dough Stability for Doughnuts by Response Surface Methodology (반응표면 방법에 의한 도우넛용 냉동 yeast dough의 안정성 향상)

  • Lee, Young-Chun;Kang, Yun-Young;Lee, Kyung-Hae
    • Korean Journal of Food Science and Technology
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    • v.23 no.4
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    • pp.510-516
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    • 1991
  • To improve the stability of frozen yeast raised dough for doughnuts, amounts of sugar, sodium steroyl lactylate(SSL) and $KBrO_{3}$ to be added to the premix were optimized, using the fractional factorial design with 3 variables and 3 levels, by a RSM computer program. The optimum sugar, SSL and$KBrO_{3}$ levels to be added to the premix were 2%, 0.3% and 25 ppm for a desired doughnut volume, and 2%, 0.4% and 10 ppm for a desired doughnut texture, and 2%, 0.4% and 20 ppm, respectively, for an overall optimum quality of doughnuts. The frozen stored yeast raised dough prepared without floor time resulted in better doughnut volume and texture than that with floor time. The yeast raised dough prepared with the formula for overall optimum quality, was formed to ‘plain ring’ type doughnuts and stored at $-18^{\circ}C$ for 5 weeks. Volume and texture of fried doughnuts were comparable to those of control for 2 weeks of storage, and then deteriorated noticeablly from 3 weeks of storage.

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A Study on the Charateristics of Antiwashout Underwater Concrete with Mineral Admixture (광물질 혼화재료를 첨가한 수중불분리성 콘크리트의 특성에 관한 연구)

  • Baek Dong-Il;Kim Myung-Sik;Jang Hee-Suk
    • Journal of the Korea Concrete Institute
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    • v.16 no.6 s.84
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    • pp.777-783
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    • 2004
  • In this study, for improving of concrete properties, those are used ground granulated blast slag(GGBS) and fly ash(FA). There are some advantage to add the GGBS and FA in plain concrete. The objective of this study is to find the characteristics of fresh and hardened antiwashout underwater concrete which is followed by blended ratio of GGBS and FA. Experimental parameters were chosen that W/C was 50%, S/a was 40% and as the blended ratio of GGBS was set at 0, 10, 20, 30, 40, 50, 60% and FA was set at 0, 10, 15, 20, 25, 30, 35% in order to prove the properties of antiwashout underwater concrete can be changed by blended ratio of GGBS md FA. It was measured pH, suspension and slump flow of fresh antiwashout underwater concrete and compressive strength of hardened antiwashout underwater concrete in age of 7 days, 28 days and 56 days. The experimental results of fresh concrete show that pH, suspension and slump flow were all satisfied with KSCE (Korea Society of Civil Engineering) standard value and mix design standard value. To synthetically consider, the optimum blended ratio is about 30% of GGBS and FA.

Design and Safety Control in Construction Stage of Prestressed Concrete Box Girder Bridge with Corrugated Steel Web (파형강판 PSC 박스거더 교량의 설계 및 시공중 안전관리)

  • Kim, Kwang-Soo
    • Journal of the Korean Society of Safety
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    • v.23 no.2
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    • pp.87-97
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    • 2008
  • The Ilsun Bridge is the world's longest box girder bridge(801m) with corrugated steel webs and has the widest width($21.2{\sim}30.9m$: tri-cellular cross section) among these kinds of composite girder bridges. It has fourteen spans(50m, 10 at 60m, 50m, 2 at 50.5m) where twelve spans are erected by the incremental launching method and two spans by full staging method. Special topics related to the structural safety of prestressed concrete box girder bridge with corrugated steel web in construction stage and service were reviewed. Investigations focus on the span-to-depth ratio, shear stress of corrugated steel webs and optimization of tile length of steel launching nose. The span-to-depth ratio of Ilsun bridge has been found to be well-planned while the corrugated steel web has been designed highly conservative and it has been observed that the conventional nose-deck interaction equation do not fit well with corrugated steel web bridges. As a result, detailed construction stage analysis was performed to check the stress levels and the safety of preceding design conditions. Finally, from the design review of Ilsun bridge, this study suggests optimal design issues which should be of interest in designing a prestressed concrete box girder bridge with corrugated steel webs.

A study on the hybrid communication system to remove the communication shadow area for controller system of navigational aids (전파 음영지역 해소를 위한 항로표지관리용 하이브리드 통신 시스템에 관한 연구)

  • Jeon, Joong Sung
    • Journal of Advanced Marine Engineering and Technology
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    • v.37 no.4
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    • pp.409-417
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    • 2013
  • Mu-communication board supported by multi-communication is designed with Atxmega 128A1 which is a low power energy consuming of 8-bit microcontroller. ATxmega128A1 microcontroller consists of 8 UART(Universal asynchronous receiver/transmitter) ports which can be setting appropriate user interface having command line interpreter(CLI) program with each port, 2 kbytes EEPROM, 128 kbytes flash memory, 8 kbytes SRAM. 8 URAT ports are used for the multi communication modem, GPS module, etc. and EEPROM is used for saving a configuration for program running, and flash memory of 128 kbytes is used for storing a Firm Ware, and 8 kbytes SRAM is used for stack, storing memory of global variables while program running. If we uses the hybrid communication of path optimization of VHF, TRS and CDMA to remote control AtoN(aid to navigation), it is able to remove the communication shadow area. Even though there is a shadow area for individual communication method, we can select an optimum communication method. The compatibility of data has been enhanced as using of same data frame per communication devices. For the test, 8640 of data has been collected from the each buoy during 30 days in every 5 minutes and the receiving rate of the data has shown more than 99.4 %.