• Title/Summary/Keyword: 최소 유의확률 방법

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Categorizing tumor size as a prognostic factor for risk of relapse of hepatocellular carcinoma (간세포암종의 재발 위험과 관련된 한 예후인자로서의 종양의 크기의 범주화)

  • 김선우;박철근
    • The Korean Journal of Applied Statistics
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    • v.15 no.1
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    • pp.1-8
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    • 2002
  • Categorizing prognostic factors is very useful for a disease diagnosis, determination of treatment and study eligibility criteria. Methods often used to categorize factors are to select a cutpoint by biological theory, by graphical examination, by the minimum p-value approach. The last method involves multiple testing, and several methods for adjusting p-values have been developed. This study determines the cutpoint of tumor size to separate patients of high risk of relapse after hepatic resection of hepatocellular carcinoma.

비중심 카이제곱분포의 동결성검정

  • 황형태;오희정
    • Communications for Statistical Applications and Methods
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    • v.5 no.1
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    • pp.217-223
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    • 1998
  • 공통의 자유도를 갖는 $textsc{k}$개의 비중심 카이제곱분포들의 동질성을 검정하기 위하여 우선 적당한 형태의 검정방법을 제시하였다. 통상적인 방법대로, 제시된 검정방법이 주어진 유의수준을 만족시키도록 하기 위해서는, 귀무가설하에서 제 1종의 오류의 확률을 최대화하는 모수의 최소 우호적 위치(Least favorable configuration)가 유도되었으며, 이에 따라서 주어진 유의수준을 충족하는 기각치를 도표화하였다.

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Study on the size of experiments in mixed models (혼합모형에서 실험의 크기에 관한 연구)

  • 이연수;임용빈;김재주
    • The Korean Journal of Applied Statistics
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    • v.12 no.2
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    • pp.593-603
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    • 1999
  • 표본의 크기의 제1종오류의 확률 $\alpha$, 실용적으로 차이가 있다고 판독되어서 검출하고자하는 요인효과의 오차에 대한 상대적인 크기, 그 값에서의 제2종오류의 확률 $\beta$에 따라서 결정된다. 이 논문에서, 우리는 고정요인과 랜덤요인이 포함된 실험계획에서 표본의 크기를 결정하는 방법을 간단한 MATLAB 프로그램을 사용하여 고려한다. 분할법과 지분요인배치법의 예제를 들어 유의수준 $\alpha$와 최소 표준과 검출효과 $\Delta^*$에서 검정력이 적어도 $1-\beta$를 갖도록 표본의 크기를 결정한다

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Methods of Estimating Growing Degree Days to Predict Growth Duration in Maize (옥수수의 생육기간 예측을 위한 Growing Degree Days의 계산방법)

  • Jong, Seung-Keun;Lee, Suk-Soon;Park, Keun-Yong
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.31 no.2
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    • pp.186-194
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    • 1986
  • In an attempt to find better ways to relate growth with temperature and to estimate maturity differences in corn (Zea mays L.), various formulas of computing Growing Degree Days (GDD) were evaluated. Utilizing data from 17 plantings of a single cross, Suweon 19, over a 3 year period, 24 different methods of computing GDD were compared for their ability to reduce variations over different plantings. The best equation was to compute GDD with a base temperature of 10$^{\circ}C$ and an optimum of 30$^{\circ}C$. The excess temperature above 30$^{\circ}C$ was subtracted to account for high temperature stress. GDDs required for emergence and silking of Suweon 19 were 64${\pm}$12$^{\circ}$ and 794${\pm}$19$^{\circ}$, respectively. Based on these GDD values, emergence and silking dates could be estimated with a variation less than 3 days. The observed and estimated number of days from planting to emergence and silking were not significantly different.

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The Study on Factors Affecting Educational Need to Convergence Major of Dental Hygiene Students at K University (K대학교 치위생학과 학생의 융합전공 교육 요구도에 영향을 미치는 요인에 관한 연구)

  • Ma I Choi;Min-Sun Lee
    • Journal of Korean Dental Hygiene Science
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    • v.7 no.1
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    • pp.29-37
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    • 2024
  • Background: This study investigatedthe factors influencing the degree of education in the Department of Dental Hygiene at K University on the degree of education required for a convergence major related to the medical device industry. Methods: For 5 days from December 5, 2023, 257 students of the Department of Dental Hygiene at a university in Wonju Citywere surveyed, and an online survey was conducted. General characteristics, school satisfaction, satisfaction with majors, perceptions of multi-majors in universities, and the degree of demand for a convergence major related to the medical device industry were examined. Since normality was not satisfied, non-parametric analysis was performed. To confirm the differences in convergence major related to medical device industry education needs according to general characteristics, the Mann-Whitney U test and Kruskal-Wallis test were performed. Post-hoc analysis was performed, and the median, minimum, and maximum values were presented. Multiple regression analysis was performed to confirm the effect on the demand for a convergence major related to the medical device industry, and the statistical significance probability was set at 0.05. Results: As a result of examining the factors affecting the demand for a convergence major related to the medical device industry, it was found that the more experience one has in completing a double major in college (p<0.05) and the higher the degree of satisfaction with the major (p<0.05), the statistically significant need for an interdisciplinary major was higher(p<0.05).

A Study on the Efficiency and Determinants of Static and Dynamic in Korean property casualty insurance Company (국내 손해보험회사의 효율성 및 결정요인에 대한 Static and Dynamic 분석)

  • Kim, Tae-Hyuk;Park, Chun-Gwang;Kim, Byeong-Chul
    • The Korean Journal of Financial Management
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    • v.25 no.4
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    • pp.183-212
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    • 2008
  • The purpose of this paper is to analyze the efficiency change and determinants of the korean non-life insurance companies. we use DEA (Data Envelopment Analysis) model to measure company efficiency change and use GLS, Tobit model, FIixed effect model, Random effect model, GMM to measure efficiency determinants. we utilize ten non-life insurance companies in korea and the panel data for five from 2001 to 2005. The empirical results show the following findings. First, technical efficiency shows that approximately 15.5% of inefficiency exists on the non-life insurance companies and it reveals that the cause for technical inefficiency is due to scale inefficiency. Second, Dea Window results show that the stable dissimilarity by standard deviation, LDP of CCR. Third, the results of efficiency determinants show that increase efficiency is depend on the premium income and real estates.

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Social Networks and hypertension in Some rural residents Aged 60-64 (일부 60~64세 농촌 인구에서 사회조직망과 고혈압)

  • Lee, Choong-Won;Cho, Hee-Young;Lee, Mi-Young;Kim, Gui-Yeon;Park, Jong-Won;Kang, Mi-Jung;Suh, Suk-Kwon
    • Journal of agricultural medicine and community health
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    • v.23 no.2
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    • pp.229-242
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    • 1998
  • Face-to-face interviews were carried out to investigate the relationship between social networks and hypertension in 958 rural residents(males=440, females=518) aged 60-64 of a community-dwelling sample of Dalsung County from April to September in 1996. Eight elements of social network were measured : marital status, regular religious attendance, membership in groups, number of friends, relatives, siblings, children, grandchildren. Hypertensives were defined as meeting at least one of following criteria : hypertension history, systolic blood pressure more than 160 mmHg, diastolic blood pressure more than 95 mmHg. In univariate logistic regression for males, having 1-4 friends vs. none showed odds ratio 0.43 (95% Confidence interval CI 0.19-0.96) and having 2-3, 4 and more than 5 children had reduced prevalence of hypertension with odds ratios 0.21 (95% CI 0.06-0.72), 0.14 (95% CI 0.04-0.49), 0.24 (95% CI 0.07-0.82), respectively when compared with persons without children. In females, there was no elements of social network statistically significant. Having 5-9 grandchildren vs. none showed a marginally significant odds ratio 0.42. In multivariate logistic regression models for males with adjustment for age, education, body mass index, smoking and drinking, number of friends and children showed increased odds ratios and number of close relatives gained a statistically significant odds ratios (0.44-0.50). In females, the adjustment yielded little changes of odds ratios except number of grandchildren which gained a statistically significance. These results suggest that only a certain elements of social network may be associated with reduced risk of hypertension and they may be different between genders in rural resident aged 60-64.

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Development of Quantification Methods for the Myocardial Blood Flow Using Ensemble Independent Component Analysis for Dynamic $H_2^{15}O$ PET (동적 $H_2^{15}O$ PET에서 앙상블 독립성분분석법을 이용한 심근 혈류 정량화 방법 개발)

  • Lee, Byeong-Il;Lee, Jae-Sung;Lee, Dong-Soo;Kang, Won-Jun;Lee, Jong-Jin;Kim, Soo-Jin;Choi, Seung-Jin;Chung, June-Key;Lee, Myung-Chul
    • The Korean Journal of Nuclear Medicine
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    • v.38 no.6
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    • pp.486-491
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    • 2004
  • Purpose: factor analysis and independent component analysis (ICA) has been used for handling dynamic image sequences. Theoretical advantages of a newly suggested ICA method, ensemble ICA, leaded us to consider applying this method to the analysis of dynamic myocardial $H_2^{15}O$ PET data. In this study, we quantified patients' blood flow using the ensemble ICA method. Materials and Methods: Twenty subjects underwent $H_2^{15}O$ PET scans using ECAT EXACT 47 scanner and myocardial perfusion SPECT using Vertex scanner. After transmission scanning, dynamic emission scans were initiated simultaneously with the injection of $555{\sim}740$ MBq $H_2^{15}O$. Hidden independent components can be extracted from the observed mixed data (PET image) by means of ICA algorithms. Ensemble learning is a variational Bayesian method that provides an analytical approximation to the parameter posterior using a tractable distribution. Variational approximation forms a lower bound on the ensemble likelihood and the maximization of the lower bound is achieved through minimizing the Kullback-Leibler divergence between the true posterior and the variational posterior. In this study, posterior pdf was approximated by a rectified Gaussian distribution to incorporate non-negativity constraint, which is suitable to dynamic images in nuclear medicine. Blood flow was measured in 9 regions - apex, four areas in mid wall, and four areas in base wall. Myocardial perfusion SPECT score and angiography results were compared with the regional blood flow. Results: Major cardiac components were separated successfully by the ensemble ICA method and blood flow could be estimated in 15 among 20 patients. Mean myocardial blood flow was $1.2{\pm}0.40$ ml/min/g in rest, $1.85{\pm}1.12$ ml/min/g in stress state. Blood flow values obtained by an operator in two different occasion were highly correlated (r=0.99). In myocardium component image, the image contrast between left ventricle and myocardium was 1:2.7 in average. Perfusion reserve was significantly different between the regions with and without stenosis detected by the coronary angiography (P<0.01). In 66 segment with stenosis confirmed by angiography, the segments with reversible perfusion decrease in perfusion SPECT showed lower perfusion reserve values in $H_2^{15}O$ PET. Conclusions: Myocardial blood flow could be estimated using an ICA method with ensemble learning. We suggest that the ensemble ICA incorporating non-negative constraint is a feasible method to handle dynamic image sequence obtained by the nuclear medicine techniques.

Risk Assessment of Arsenic by Human Exposure of Contaminated Soil, Groundwater and Rice Grain (오염된 토양, 지하수 및 쌀의 인체노출에 따른 비소의 위해성 평가)

  • Lee Jin-Soo;Chon Hyo-Taek
    • Economic and Environmental Geology
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    • v.38 no.5 s.174
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    • pp.535-545
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    • 2005
  • Environmental survey from some abandoned metal mine areas was undertaken on to assess the risk of adverse health effects on human exposure to arsenic influenced by past Au-Ag mining activities. Elevated levels of As were found in tailings from the studied mine areas. This high concentration may have a impact on soils and waters around the tailing piles. In order to perform the human risk assessment, chemical analysis data of soils, rice grains and waters fur As have been used. The HQ values fer As via the rice grain and groundwater consumption were significantly higher compared with other exposure pathways in all metal mine areas. However, there were minimal soil and water dermal contact risks. The resulting Hl values of As from the Dongil, Okdong and Hwacheon mine areas were higher than 5.0, and their toxic risk due to drinking water and rice grain was strong in these mine areas. The cancer risk of being exposed to As by the rice grain route from the Dongil, Okdong and Hwacheon mine areas was $5.2\times10^{-4},\;6.0\times10^{-4}\;and\;8.1\times10^{-4}$, respectively. The As cancer risk via the exposure pathway of drinking water from these mine areas exceeded the acceptable risk of 1 in 10,000 fer regulatory purposes. Thus, the daily intakes of groundwater and rice grain by the local residents from the Dongil, Okdong and Hwacheon mine areas can pose a potential health threat if exposed by long-term arsenic exposure.

Helicobacter pylori reinfection rate by a 13C-urea breath test and endoscopic biopsy tests in Korean children (한국 소아에서 Helicobacter pylori 박멸 후 13C-요소 호기 검사와 내시경적 생검을 이용한 재감염률 연구)

  • Shim, Jeong Ok;Seo, Jeong Kee
    • Clinical and Experimental Pediatrics
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    • v.49 no.3
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    • pp.268-272
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    • 2006
  • Purpose : The reinfection rate of H. pylori reported before $^{13}C$-urea breath test($^{13}C$-UBT) era was higher than that of the post $^{13}C$-UBT era. Children are usually reluctant to receive invasive endoscopic evaluation for the reinfection of H. pylori, particularly when they are asymptomatic. The aim of the study is to discover the reinfection rate by different diagnostic tests, and to find out what causes the difference. Methods : Children confirmed to be eradicated from H. pylori were included in the study. Reinfection was evaluated by endoscopic biopsy based tests(n=34, mean age $11.5{\pm}3.7$ years) and/or a $^{13}C$-UBT(n=38, mean age $10.0{\pm}3.6$ years) at the time of 18 months after eradication. At first visit, H. pylori infection had been diagnosed by positive results from a rapid urease test, Giemsa stain and Warthin-Starry stain and/or a positive culture. Eradication was defined as negative results from all above tests 1-3 months after eradication therapy. Results : Reinfection rate by endoscopic biopsy based tests was 35.3 percent(12/34). All patients had abdominal symptoms(P=0.000). Reinfection rate was 13.2 percent(5/38) by a $^{13}C$-UBT. Reinfection rate was higher in children with abdominal symptoms(P=0.008). There was no evidence that reinfection rate depended on the sex(P=0.694), age(P=0.827), diseases(peptic ulcers vs gastritis, P=0.730) and eradication regimen(P=0.087). Conclusion : Helocibacter pylori reinfection rate in Korean children was 13.2 percent per 18 months by a non-invasive test or $^{13}C$-UBT. Accurate determinations of the reinfection rate in children is affected by the compliance of the diagnostic tests. Non-invasive tests should be considered to investigate the reinfection rate in children.