• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.4
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• pp.51-63
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• 2023

The purpose of this study is to develop and implement a secondary teacher training program based on the TPACK model to strengthen the capacity of teachers of youth entrepreneurship education in the context of the increasing importance of entrepreneurship as a future competency, and to provide theoretical and practical implications based on it. To this end, a teacher training program was developed through the process of analysis, design, development, implementation, and evaluation based on the ADDIE model, and 22 secondary school teachers in Gangwon Province were trained and the effectiveness and validity were analyzed. First, the results of the paired sample t-test of TPACK in entrepreneurship education conducted before and after the program showed statistically significant improvements in all sub-competencies. Second, the satisfaction survey of the training program showed that the overall satisfaction was high with M=4.83. Third, the validity of the program was reviewed by three experts, and it was found to be highly valid with a validity of M=5.0, usefulness of M=4.7, and universality of M=5.0. Based on the results, it is suggested that in order to expand entrepreneurship education, opportunities for teachers' holistic capacity building such as TPACK should be expanded, teachers' understanding and practice of backward design should be promoted, and access to various resources that can be utilized in entrepreneurship education should be improved.

• Journal of Life Science
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• v.34 no.7
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• pp.520-530
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• 2024

Tumor suppressor genes (TSGs) play a crucial role in maintaining cellular homeostasis. When the function of these genes is lost, it can lead to cellular plasticity that drives the development of various cancers, including small-cell lung cancer (SCLC), which is known for its aggressive nature. SCLC is primarily driven by numerous loss-of-function mutations in TSGs, often involving genes that encode epigenetic regulators. These mutations pose a significant therapeutic challenge as they are not directly targetable. However, understanding the molecular changes resulting from these mutations might provide insights for developing tumor intervention strategies. We propose that despite the heterogeneous genomic landscape of SCLC, the effects of mutations in patient tumors converge on a few critical pathways that drive malignancy. Specifically, alterations in epigenetic regulators lead to transcriptional dysregulation, pushing mutant cells toward a highly plastic state that makes them immune evasive and highly metastatic. This review will highlight studies showing how an imbalance of epigenetic regulators with opposing functions leads to the loss of immune recognition markers, effectively hiding tumor cells from the immune system. Additionally, we will discuss the role of epigenetic regulators in maintaining neuroendocrine features and how aberrant transcriptional control promotes epithelial-to-mesenchymal transition during tumor development. Although these pathways seem distinct, we emphasize that they often share common molecular drivers and mediators. Understanding the connection among frequently altered epigenetic regulators will provide valuable insights into the molecular mechanisms underlying SCLC development, potentially revealing preventive and therapeutic vulnerabilities for SCLC and other cancers with similar mutations.

• Journal of the Korea Society for Simulation
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• v.33 no.2
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• pp.1-11
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• 2024

A cyber-physical system is a technology that connects the physical systems of a manufacturing environment with a cyber space to enable simulation. One of the major challenges in this technology is the seamless communication between these two environments. In complex manufacturing processes, it is crucial to adapt to various protocols of manufacturing equipment and ensure the transmission and reception of a large volume of data without delays or errors. In this study, we propose a method for constructing agent models for real-time simulation-capable cyberphysical systems. To achieve this, we design data collection units as independent agent models and effectively integrate them with existing simulation tools to develop the overall system architecture. To validate the proposed structure and ensure reliability, we conducted empirical testing by integrating various equipment from a real-world smart microfactory system to assess the data collection capabilities. The experiments involved testing data delay and data gaps related to data collection cycles. As a result, the proposed approach demonstrates flexibility by enabling the application of various internal data collection methods and accommodating different data formats and communication protocols for various equipment with relatively low communication delays. Consequently, it is expected that this approach will promote innovation in the manufacturing industry, enhance production line efficiency, and contribute to cost savings in maintenance.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.29 no.2
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• pp.116-138
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• 2024

This study presents a new tool and protocol to assess the impact of 'Marine Invasive and Harmful Species' (MIHS) on marine environments and socio-economic aspects. It addresses shortcomings in the Marine Ecosystems Conservation and Management Act in South Korea by proposing an impact assessment framework divided into marine environmental and socio-economic groups. Six distinct evaluation categories are included in each group, and a semi-quantitative five-step scale is utilized to provide a flexible approach, addressing a variety of issues from ecological disturbances to effects on health and property. The assessment tool is applied through a systematic five-stage process based on the Delphi method. This approach posters collaboration among a diverse sets of experts and stakeholders, enabling a comprehensive evaluation that incorporates various perspectives. The study also examines strategies to effectively manage uncertainties and improve the consistency of the outcomes. The application of this assessment protocol is expected to be crucial in quantifying the ecological damage caused by MIHS and in identifying management and prevention priorities. The ultimate aim of this evaluation process is to aid decision-makers in developing strategies to preserve the marine ecosystem and mitigate socio-economic impacts.

• Journal of Life Science
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• v.34 no.2
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• pp.128-137
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• 2024

This review discusses the pivotal role of vascular endothelial growth factors (VEGF) in angiogenesis and lymphangiogenesis, vital processes influencing vascular permeability, endothelial cell recruitment, and the maintenance of tumor-associated blood and lymphatic vessels. VEGF exerts its effects through tyrosine-kinase receptors, VEGFR-1, VEGFR-2, and VEGFR-3. This VEGF-VEGFR system is central not only to cancer but also to diseases arising from abnormal blood vessel and lymphatic vessel formation. In the context of cancer, VEGF and its receptors are essential for the development of tumor-associated vessels, making them attractive targets for therapeutic intervention. Various approaches, such as anti-VEGF antibodies, receptor antagonists, and VEGF receptor function inhibitors, are being explored to interfere with tumor growth. However, the clinical efficacy of anti-angiogenic agents remains uncertain and necessitates further refinement. The article also highlights the physiological role of VEGFs, emphasizing their involvement in endothelial cell functions, survival, and vascular permeability. The identification of five distinct VEGFs in humans (VEGF-A, VEGF-B, VEGF-C, VEGF-D, and PLGF) is discussed, along with the classification of VEGFRs as typical receptor tyrosine kinases with distinct signaling systems. The family includes VEGFR-1 and VEGFR-2, crucial in tumor biology and angiogenesis, and VEGFR-3, specifically involved in lymphangiogenesis. Overall, this review has provided a comprehensive overview of VEGF and VEGFR, detailing their roles in various diseases, including cancer. This is expected to further facilitate the utilization of VEGF and VEGFR as therapeutic targets.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.282-288
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• 2023

Due to the COVID-19 pandemic, the immuneenhancing health functional food market that protects our bodies from pathogens such as viruses continues to grow. In this study, we aimed to prove the Cheonggukjang, a high-nutrient food with high protein, fat, and dietary fiber content, as an immuneenhancing nutraceutical. Cheonggukjang water extract (CWE) increased the production of nitric oxide, reactive oxygen species, and cytokines such interleukin (IL)-6, IL-1β, and tumor necrosis factor-α without affecting viability in RAW 264.7 cells. Furthermore, CWE significantly upregulated the expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells. CWE enhanced the phosphorylation of I kappa B kinase α/β and I kappa B (IκB)α, as well as the degradation of IκBα. CWE also induced increased phosphorylation of nuclear factor-kappa B p65 and facilitated the redistribution of p65 from the cytoplasm to the nucleus in RAW 264.7 cells. These findings suggest that CWE has potential as a health functional food material that can enhance the innate immune response.

• Journal of The Korean Association For Science Education
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• v.44 no.1
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• pp.77-86
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• 2024

This study analyzed students' discourse and learning to investigate the impact of using Google Docs in science classes. The researcher, who is also a science teacher, conducted classes for 49 second-year middle school students. The classes included one using Google Docs and another using traditional paper worksheets covering identical content. Students' discourse collected from each class was compared and analyzed using Epistemic Network Analysis (ENA). The findings indicated that in the class using Google Docs, the proportion of discourse related to task was higher compared to the traditional class. More specifically, discourse regarding taking and uploading photos was prominent. However, such discourse did not lead to peer learning as intended by the teacher. An analysis based on achievement levels revealed that the class utilizing Google Docs had a relatively higher proportion of discourse from lower-achieving students. Additionally, differences were observed in the types of utterances and connection structures between the higher and lower-achieving students. The higher-achieving students took a leading role in providing suggestions and explanations, while the lower-achieving students played a role in transcribing them, with this tendency being more pronounced in the class using Google Docs. Lastly, students' changes in perception regarding the cause of static electricity were visualized using ENA. Based on the research findings, this study proposes strategies to enhance collaborative learning using Google Docs, including the use of open-ended problems to allow diverse opinions and outputs, and exploring the potential use of ENA to assess the learning effects of conceptual learning.

• Journal of The Korean Association For Science Education
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• v.27 no.9
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• pp.832-847
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• 2007

The purpose of the study was to analyze and interpret parent-child dyadic discourses in depth with emphases on the ZPD system in a museum, an informal learning setting. Second graders and their parents from Seoul and its environs were voluntarily participated in the study. Data were collected from the museum documents, the photos of exhibits, and the video recordings of dyadic discourses at and between exhibits. The documents and the photos were analyzed to investigate what the topics, medium and goals of the exhibits were. The video recordings were all transcribed and analyzed to understand what and how they talked to each other through the lens of the ZPD system; situation definition, intersubjectivity, and semiotic mediation, The results of the study consisted of two parts. First, it showed that parent-child dyadic discourses were categorized in four: (1) within the actual developmental level; (2) in the zone of proximal development; (3) toward the potential developmental level; and (4) out of developmental level. The most common categories were the dyadic discourses within the actual developmental level and in the zone of proxima I development. Second, the representative cases in each categories were described and interpreted to understand the nature of parent-child dyadic discourses. It can be concluded that we gained some important understandings of an intrinsic attribute of parent-child discourses in a museum, an informal learning setting. Based on the results of the study, it can be suggested that museums make efforts to cultivate the affordance of exhibit environment to promote visitor's learning.

• Journal of Life Science
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• v.34 no.6
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• pp.418-425
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• 2024

Solid tumors are heterogeneous populations of multiple cell types. While the majority of the cells that comprise cancer are unable to divide, cancer stem cells have self-renewal and differentiation properties. Normal stem cell pathways that control self-renewal are overactivated in cancer stem cells, making cancer stem cells important for cancer cell expansion and progression. Dick first proposed the definition of cancer stem cells in acute myeloid leukemia, according to which cancer stem cells can be classified based on the expression of cell surface markers. Cancer stem cells maintain their potential in the tumor microenvironment. Multiple cell types in the tumor microenvironment maintain quiescent cancer stem cells and serve as regulators of cancer growth. Since current cancer treatments target proliferative cells, quiescent state cancer stem cells that are resistant to treatment increase the risk of recurrence or metastasis. Various signals of the tumor microenvironment induce changes to become a tumor-supportive environment by remodeling the vasculature and extracellular matrix. To effectively treat cancer, cancer stem cells and the tumor microenvironment must be targeted. Therefore, it is important to understand how the tumor microenvironment induces reprogramming of the immune response to promote cancer growth, immune resistance, and metastasis. In this review, we discuss the cellular and molecular mechanisms that can enhance immunosuppression in the tumor microenvironment.

• The Korean Journal of Coaching Psychology
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• v.7 no.3
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• pp.127-152
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• 2023

Employees' innovative behavior is crucial for organizations to maintain competitiveness and foster growth. Empowering leadership coaching styles, which delegate authority and responsibility to organizational members while respecting their autonomy, create opportunities for members to solve problems and present innovative ideas. Drawing on signal theory, this study aims to clarify the process through which political skill influences employees' work innovative behavior, mediated by empowering leadership. Additionally, we examine whether the leader's implicit followership prototype moderates the relationship between employees' political skills and empowering leadership. Survey data were collected in two rounds with a two-week lag from 180 employees in a manufacturing company in South Korea. The results revealed that political skill was related to empowering leadership and subsequent work innovative behavior. Furthermore, the leaders' implicit followership prototype strengthened the relationship between political skill and empowering leadership. This study provides meaningful theoretical and practical insights into empowering coaching styles.