• Korean Journal of Clinical Laboratory Science
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• v.55 no.2
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• pp.105-112
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• 2023

Leucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson's disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whether LRRK2 expression correlates with the pathogenesis of lung squamous cell carcinoma (LUSC). This study analyzes the prognostic significance of LRRK2 in LUSC using the Kaplan-Meier plotter tool. High expression of LRRK2 is known to be associated with a bad prognosis in patients with LUSC. Patients with high LRRK2 expression, tumor mutational burden, high neoantigen load, and even gender correlation reportedly have the worse survival rates. In the gene expression profiling interactive analysis (GEPIA) database, the severity of pathogenesis in LUSC with high LRRK2 expression positively corresponds to a high expression of anti-inflammatory cytokines but not inflammatory cytokines. Similarly, the increased expression of interleukin (IL)10-related genes was shown to be significantly linked in LRRK2-high LUSC patients having a poor prognosis. Moreover, the tumor immune estimation resource (TIMER) database suggests that macrophages are one of the cellular sources of IL10 in LRRK2-high LUSC patients. Collectively, our results demonstrate that the postulated LRRK2-IL10 axis is a potential therapeutic target and prognostic biomarker for LUSC.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.56.1-56.1
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• 2020

한국의 고문헌 중에는 다양한 고천문 기록들이 한문 형태로 존재하며, 이를 학술적으로 활용하기 위해서는 전문 번역가 투입에 따른 많은 비용과 시간이 요구된다. 이에 인공신경망 기계학습에 의한 인공지능 번역기를 개발하여 비록 초벌 번역 수준일지라도 문장 형태의 한문을 한글로 자동번역해 주는 학술 도구를 소개하고자 한다. 이 자동번역기는 한국천문연구원이 한국정보화진흥원이 주관하는 2019년도 Information and Communication Technology 기반 공공서비스 촉진사업에 한국고전번역원과 공동 참여하여 개발 완료한 것이다. 이 연구는 고천문 도메인에 특화된 인공지능 기계학습용 데이터인 천문 고전 코퍼스를 구축하여 이를 기반으로 천문 고전 특화 자동번역 모델을 개발하고 번역 서비스하는 것을 목적으로 한다. 이를 위해 구축되는 시스템은 크게 세 가지이다. 첫째, 로그인이 필요 없이 누구나 웹 접속을 통해 사용이 가능한 클라우드 기반의 고문헌 자동번역 대국민서비스 시스템이다. 둘째, 참여 기관별로 구축된 코퍼스와 도메인 특화된 번역 모델의 생성 및 관리할 수 있는 클라우드 기반의 대기관 서비스 플랫폼 구축이다. 셋째, 개발된 자동번역 Applied Programmable Interface를 활용한 한국천문연구원 내 자체 서비스가 가능한 AITHA 시스템이다. 연구 결과로서 먼저 구축된 천문 고전 코퍼스 60,760건에 대한 샘플링 검수 결과는 품질 순도 99.9% 이상이다. 아울러 도출된 천문 고전 특화 번역 모델 총 20개 중 대표 모델에 대한 성능 평가 결과는 기계 번역 텍스트 품질 평가 알고리즘인 Bilingual Evaluation Understudy 평가에서 40.02점이며, 전문가에 의한 휴먼 평가에서 5.0 만점 중 4.05점이다. 이는 당초 연구 목표로 삼았던 초벌 번역 수준에 충분하며, 현재 개발된 시스템들은 자체 시험 운영 중이다. 이 연구는 특수 고문헌에 해당되는 고천문 기록들의 번역 장벽을 낮춰 관련 연구자들의 학술적 접근 및 다양한 연구에 도움을 줄 수 있다는 점에서 의의가 있다. 또한 고천문 분야가 인공지능 자동번역 확산 플랫폼 시범의 첫 케이스로써 추후 타 학문 분야 참여 시 시너지 효과도 기대해 볼 수 있다. 고문헌 자동번역기는 점차 더 많은 학습 데이터와 학습량이 쌓일수록 더 좋은 학술 도구로 진화할 것이다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.4A
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• pp.753-759
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• 2006

To predict service life of concrete structures exposed to chloride attack, surface chloride concentration, diffusion coefficient of chloride ion, and chloride corrosion threshold value in concrete, are used as important factors. Of these, as the diffusion coefficient of chloride ion for concrete is strongly influenced by concrete quality and environmental conditions of structures and may significantly change the service life of structures, it is considered as the most important factor for service life prediction. The qualitative factors affecting the penetration and diffusion of chloride ion into concrete are water-cement (W/C) ratio, age, curing conditions, chloride ion concentration of given environment, wet and dry conditions, etc. In this paper the influence of W/C ratio and curing conditions on the diffusion characteristics of chloride ion in concrete was investigated through the chloride ion diffusion test. In the test, the voltages passing through the diffusion cell were measured by accelerated test method using potential difference, and then with the consideration of IR drop ratio the diffusion coefficient of chloride ion for concrete with different W/C ratios were estimated by Andrade's model. Furthermore, under different curing conditions formulas for the estimation of the diffusion coefficient of chloride ion have been proposed by the regression analysis considering the effect of W/C ratio and age.

• The Korean Journal of Archival Studies
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• no.77
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• pp.37-74
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• 2023

As the Yoon Seok-yeol administration enters its second year in office, it is beginning to vigorously promote policies related to the "digital platform government," which is the 11th of the 120 national tasks. Accordingly, the Digital Platform Government Committee established and reported the 'Digital Platform Government Realization Plan' to the President in April 2023, and the 「Act on Provision and Use of Public Data」 and 「Data An amendment to the Act on the Vitalization of Infrastructure Administration" was submitted to the National Assembly in June 2023. In addition, the 「Regulations on the Promotion of Administrative Efficiency and Collaboration」, which is a Presidential Decree, was revised to 「Regulations on Operation and Innovation of Administrative Affairs」, including the name change, to effectively promote innovation in administrative work, and was completed on June 27, 2023. Therefore, this study aims to examine the trends of public institutions related to the digital platform government as a government task, and discuss whether the recent trends will affect the management of institutional records. Indications to respond to the government's digital platform, which is leading the way, it was emphasized that the operation of the current Medical Records Act is strange.

• 한국체육학회지인문사회과학편
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• v.57 no.2
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• pp.611-624
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• 2018

The purpose of the present study was to investigate the exercise program preference of breast cancer survivors. The qualitative data on group exercise participation experiences of ten participants was acquired through in-depth interviews, and participant observation, using the thematic analysis. As a result, 4 themes indicated the preference of breast cancer survivors: (1) Supervised Exercise, (2) Group Exercise, (3) Specialized exercise program for breast cancer survivors, and (4) Enjoyment factor. First, the participating breast cancer survivors showed a preference towards supervised exercise by responding that a exercise specialist is needed along with a personalized exercise program. Second, breast cancer survivors preferred to participate in group exercise programs. Participants preferred to exercise with other breast cancer survivors and mentioned that group exercises cause a synergy effect that promotes exercise participation. Third, the participant's responses showed anticipation of and preference for a specialized exercise program for breast cancer survivors. Lastly, an important factor influencing the preference of breast cancer survivors was the enjoyment factor. Participants preferred enjoyable exercises and the most prevalent enjoyment factors included the element of music and self-felt enjoyment.

• Korean Journal of Culture and Social Issue
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• v.18 no.1
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• pp.111-125
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• 2012

The total fertility rate of our nation has been in the world's lowest level with constant falling since it reached an all-time low in 1983. The increase in economic participation of women, difficulties to balance work and family life, and traditional gender role and family norms in our society have been blamed for causing low birth rates. In addition, the current economic recession and increased polarization of wealth make it more difficult for working families to balance work and family life, resulting in lowering fertility rates. The Korean government has recently prepared the second five-year basic plan(2011-2015) to deal with low fertility and population ageing. The basic plan aims at providing support for working families in balancing work and family life and helping people ease the burden of marriage, childbirth, and raising their children. The work-family balance policies based on gender equality will do much to increase fertility rates in the future. In this context, this study examined current status and problems of balancing work and family life in our society, the Korean government and corporate policies for work-family balance, and the effects of policies on childbirth. Suggestions for future directions are presented.

• Smart Media Journal
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• v.12 no.8
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• pp.45-59
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• 2023

Users who want to experience the metaverse for tourism are exposed to strategic planning in space for the purpose of cultural content. In addition, users learn integrated cultural content in the process of proceeding according to the virtual environment. and Along with the meaning of time and space, users will experience space-telling. It is important to induce interest from the beginning of the experience to continue the experience. However, obstacles arise in this process. This is because developers should promote connections with new information to users who do not have sufficient prior knowledge and only have keywords of interest. Therefore, efficient design methods to enhance interest should be studied in advance. But so far, there has been no research on how to systematically design prior organizers to induce interest in virtual space. This study is an interest-inducing design method that occurs in the process of developing the meaning of virtual space and storytelling of cultural content, and can be seen as a basic study using conceptual guidance-based prior organizer education and learning techniques. First, virtual space elements and human behavior theories were considered. Subsequently, five representative examples of previous organizers currently used were explored, and redesigned and proposed based on a conceptual map for information access and delivery purposes. Through this research process, it was possible to confirm that spatial attributes and cognitive interest elements were effectively transmitted to meaningful learning leading to storytelling learning and elements of service design design method through conceptual guidance.

• Journal of the Korean Institute of Gas
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• v.27 no.3
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• pp.59-71
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• 2023

Carbon capture, and storage (CCS) is important for the reduction of greenhouse gases and achieving carbon neutrality. CCS focuses on storing captured CO₂ permanently in underground reservoirs. CO₂-enhanced oil recovery (CO₂-EOR) is one form of CCS, where CO₂ is injected into the underground to enhance oil recovery. CO₂-EOR not only aids in the extraction of residual oil but also contributes to carbon neutrality by storing CO₂ underground continuously. CO₂-EOR can be classified into miscible and immiscible methods, with the CO₂-water alternating gas (CO₂-WAG) technique being a representative approach within the miscible method. In CO₂-WAG, water and CO₂ are alternately injected into the reservoir, enabling oil production and CO₂ storage. The WAG method allows for controlling the breakthrough of injection fluids, providing advantages in oil recovery. It also induces hysteresis in relative permeability during the injection and production process, expanding the amount of trapped CO₂. In this study, the effects of enhancing oil recovery and storing CO₂ underground during CO₂-EOR were presented. Additionally, cases of CO₂-EOR application in relation to CCS were introduced.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.827-831
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• 2023

This study sought to verify and examine the factors that influence social capital on social economy awareness. To summarize the results of the study, the results are as follows. As a result of analyzing the impact of social capital on social economy awareness, norms (t=3.228, p<.01) and participation (t=3.057, p<.01) had a significant impact on social economy awareness. In other words, the better the norms are observed and the higher the participation, the more influence it has on social economy awareness. Based on these results, the following implications were drawn. First, 'norms' refer to rules or standards that community members must adhere to within society, and these norms play a role in regulating the behavior of individuals and promoting social cooperation. Through this, it is believed that a strong normative system can have a significant impact on the way people participate or cooperate in social economy activities. Second, 'participation' is an indicator of how actively an individual or group participates in social activities. People with high levels of participation through social capital will have a high level of understanding of social economy awareness and will be able to act effectively. These results show that in previous studies, the better the norms were observed and the more trust and networks were strengthened, the higher the awareness of social economy. In contrast, in this study, norms and trust were found to have an effect, but the network did not, showing a difference from the results of previous studies, so repeated research is expected to be necessary in the future. Considering the results above, strengthening and developing the elements of social capital such as norms and participation can have a positive impact on overall socioeconomic awareness and development.

• Korean Journal of Culture and Social Issue
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• v.10 no.spc
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• pp.87-115
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• 2004

This paper examines the influence of interpersonal relationship on delinquent behavior among adolescents. The role that parent-child relationship, teacher-student relationship, and relationship with friends play on delinquent behavior is reviewed. Review of empirical studies reveal the following results. First, adolescents who perceive their parents as being hostile and rejecting are more likely to engage in delinquent behavior. Second, those adolescents with parents, who have low expectations and who are less likely pressure them to succeed academically, are more likely to engage in delinquent behavior. Third, adolescents who feel that they have been abandoned by their parents are more likely to engage in delinquent behavior. Fourth, those adolescents with low social support from parents and teachers and high social support from their friends are more likely to engage in delinquent behavior. Fifth, those students who feel hostility from their teachers, have negative relationship with teachers, and experience greater punishment are more likely to engage in delinquent behavior. The results indicate that punishment can have adverse effect on some adolescents, further damaging the teacher-student relationship. Punishment can further reinforce the existing negative cycle that can increase the likelihood of adolescents engaging in delinquent behavior. The results indicate that a lack of support from parents and teacher leads to low academic and self-regulatory efficacy, which leads to low academic performance, which can results in punishments that could further damage their relationship with their parents and teachers and bring them closer to their friends. Adolescents caught up in this negative cycle are more likely to engage in delinquent behavior. These results indicate the need to reform the relational, social, and cultural environment of adolescents who are engaged in delinquent behavior.