• Title/Summary/Keyword: 초임계유체

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Volatile Compounds and Antiproliferative Effects of Dendropanax morbifera on HepG2 Cells (황칠나무의 휘발성 화합물 분석 및 HepG2 세포의 증식 억제 효과)

  • Yang, Seun-Ah;Garcia, Coralia V.;Lee, Ji-Won
    • Journal of Life Science
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    • v.27 no.5
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    • pp.561-566
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    • 2017
  • Dendropanax morbifera Lev. is known in Korea for its golden sap and medicinal properties. The many biological activities of the leaf and stem extracts suggest that this tree could be a valuable source of medicinal compounds for the treatment of various ailments such as dermatitis, migraines, dysmenorrhea, muscle pain, and infectious diseases. However, there is little information on the composition and biological activity of the volatile fraction of D. morbifera. Therefore, in this study, the volatile compounds in leaves, stems, and sap of D. morbifera were isolated using solvent and supercritical fluid extraction (SFE), and analyzed by gas chromatography/mass spectrometry to reveal their chemical composition and identify potential compounds of interest. Fifteen compounds were identified in the leaf extracts, whereas 29 and 3 compounds were identified in the stem and sap extracts, respectively. The volatile profiles obtained using solvent and SFE differed. Esters and aromatic hydrocarbons predominated in the solvent extract of leaves and SFE extract of stems, whereas the solvent extract of stems and SFE extract of leaves contained terpenoids. Limonene, ${\alpha}$-pinene, and ${\beta}$-myrcene were identified in the volatile extract of sap, with limonene representing 96.30% of the total peak area. In addition, the antiproliferative effects of the solvent extracts of leaves and stems were evaluated, revealing that these solvent extracts were particularly effective in decreasing the proliferation of HepG2 cells.

Extraction of Brown Rice Oil Including Essential Fatty Acid Using Supercritical Fluid Process (초임계유체 공정에 의한 유효지방산이 풍부한 현미유의 추출)

  • Kim, H.J.;Shin, M.O.;Hong, I.K.;Park, K.A.
    • Applied Chemistry for Engineering
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    • v.8 no.5
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    • pp.860-865
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    • 1997
  • Brown rice oil contains palmitic acid, linolenic acid, linoleic acid, oleic acid, stearic acid, tocopherol, squalene, etc. The oil including essential fatty acids was extracted from the domestic brown rice bran using supercritical carbon dioxide(SCC) process, and the extracts were analyzed with GC-MSD. The extraction amount of brown rice oil was dependent upon the operating pressure and temperature, and the fatty acid composition of oil was varied with the reduced density(${\rho}_{\gamma}$) of the SCC. About 70~80% of brown rice oil was extracted in 4 hours. Especially, squalene which was not found in solvent extract phase was identified in supercritical fluid extraction phase only.

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Trend on the Recycling Technologies for Recycling of Insoluble/infusible Plastic Wastes using Supercritical Fluids by the Patent and Paper Analysis (특허와 논문으로 본 초임계유체 이용 불융/불용 폐플라스틱 자원순환기술 동향)

  • Hong, Soon-Man;Koo, Chong Min;Cho, Young-Ju;Cho, Bong-Gyoo
    • Resources Recycling
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    • v.23 no.3
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    • pp.71-77
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    • 2014
  • It is believed to have the international competitiveness of the domestic petrochemical in conjunction with the production of high value-added new product and variety of application by supercritical fluid process and the reaction of infusible/insoluble plastic wastes recycling. In this article, the patents and papers for the recycling of organic residues from the plastic wastes using supercritical fluids were collected and analyzed. The open patents of USA (US), European Union (EP), Japan (JP), and Korea (KR) and SCI journals from 1993 to 2012 were investigated. The patents and journals were collected using key-words and filtered by the definition of the technology. The patents and journals were analyzed by the years, countries, companies, and technologies and the technical trends were discussed in this paper.

Study of a Supercritical Fluid Process for the Preparation of Hydroxypropyl-β-cyclodextrin Inclusion Complexes (Hydroxypropyl-β-cyclodextrin 포접복합체 제조를 위한 초임계유체 공정 연구)

  • Lee, Sang-Yun;Kim, Jeong-Kyu;Kim, Woo-Sik;Ryu, Jong-Hoon;Lim, Gio-Bin
    • Korean Chemical Engineering Research
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    • v.43 no.1
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    • pp.110-117
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    • 2005
  • In this work, solid-state inclusion complex powders of itraconazole and $2-hydroxypropyl-{\beta}-cyclodextrin(HP-{\beta}-CD)$ were produced by a supercritical anti-solvent (SAS) process. In order to evaluate the degree of complexation, the thermal behavior of the microparticulate complexes was investigated using differential scanning calorimetry. The experimental results obtained for the solubility and dissolution rate of the microparticulate inclusion complexes in a buffer solution of pH 1.2 showed that the complexation of itraconazole with $HP-{\beta}-CD$ results in a significant increase in the solubility and dissolution rate of itraconazole. The particle size of the SAS-produced inclusion complexes was dramatically reduced ($<0.1-0.5{\mu}m$) compared with untreated itraconazole ($30-50{\mu}m$) and $HP-{\beta}-CD$ ($50-100{\mu}m$). The solubility of itraconazole was increased with the increase of pressure at a constant temperature to ca. $758.6{\mu}g/mL$ in an aqueous medium of pH 1.2. The dissolution rate of itraconazole was observed to be significantly improved and about 90% of itraconazole was found to be dissolved within 5-10 min.

A Study on the Possibility of Produced by Supercritical Fluid Extraction from Lycii Fructus Seed for Cosmetic Ingredients (구기자 종자 초임계유체 추출물의 화장품소재로서의 가능성 평가)

  • Kim, Bo-Ae
    • Journal of the Korean Applied Science and Technology
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    • v.34 no.3
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    • pp.623-630
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    • 2017
  • The purpose of this study was to investigate the possibility of applying cosmetic material about extracted from Lycii Fructus seed supercritical fluid. This study was conducted to evaluate the anti-melanogenesis effect and antimicrobial activity about the extracts from Lycii Fructus seed. These researches studied for emulsion physical stability of pH, viscosity, particle size from emulsion containing Lycii Fructus seed extract. As a result, the supercritical fluid extract from Lycii Fructus seed significantly inhibited melanin synthesis by 81.86 % at the concentration $750{\mu}g/mL$. Antimicrobial effects of extract was determined against Staphylococcus aureus, Candida albicans, Escherichia coli. except by Staphylococcus epidermidis. The physical stability of viscosity and pH on the emulsion containing Lycii Fructus seed extract were stable for 28 days. Emulsion containing Lycii Fructus seed extract did not change particles at observation into optical microscope. These results suggest that extracts from Lycii Fructus seed may have value as the potential cosmetic formulation.

Preparation of Micro- and Submicron-Particles of a Poorly Water-Soluble Antifungal Drug Using Supercritical Fluid Process (초임계유체공정을 이용한 난용성 항진균제의 미세입자 제조)

  • Kim, Seok-Yun;Lee, Jung-Min;Won, Byoung- Hyun;Jung, In-Il;Ryu, Jong-Hoon;Lim, Gio-Bin
    • Clean Technology
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    • v.16 no.2
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    • pp.80-87
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    • 2010
  • In this study, micro- and submicron particles of itraconazole, a poorly water-soluble antifungal drug, were prepared for improving its aqueous solubility using an ultrasound-assisted supercritical fluid technique, called SAS-EM. The SAS-EM process used in our experiments was different from the conventional SAS-EM in that the ultrasound was applied directly to the spray nozzle. The effect of the ultrasonic power, temperature, and solvent on the formation of itraconazole particles were investigated. Smaller particles were obtained through our SAS-EM process compared with the ASES process, and the mean particle size decreased as the ultrasonic power increased. Our experimental results confirmed that the ultrasound-assisted supercritical fluid process is an efficient method for producing ultrafine particles.

Extraction of Resveratrol Containing Grade Seed Oil with Supercritical Carbon Dioxide (초임계 이산와탄소를 이용한 Resveratrol 함유 포도씨유 추출)

  • Woo Moon Jae;Seo Jang-Won;Byun Sang Yo
    • KSBB Journal
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    • v.20 no.5 s.94
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    • pp.383-386
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    • 2005
  • Grape seed oil made by press or organic solvent extraction does not contain resveratrol, a bioactive compound. Supercritical carbon dioxide could extract oil containing resveratrol from grape seed. The extraction efficiency was mainly dependent on the water content in grape seed. More resveratrol was contained in the oil extracted with un-dried grape seed. No resveratrol was extracted with dried grape seed. Time course changes of grape seed oil extraction also resulted that resveratrol could be extracted by supercritical carbon dioxide with the positive influence of water.

Solubility Measurement and its Correlation of Disperse Dye in Supercritical HFC-134a (초임계 HFC-134a에 대한 분산염료의 용해도 측정과 모델링)

  • Park, Min-Woo;Bae, Hyo-Kwang
    • Korean Chemical Engineering Research
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    • v.40 no.6
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    • pp.715-718
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    • 2002
  • The supercritical dyeing process has been gaining the increasing importance because of environment reason. For further development of this process, it is needed to measure the solubility in supercritical fluids in the extensive ranges of temperature and pressure. In this study, using the semi-flow type apparatus consisted of supercritical fluid equilibrium cell, the solubility of disperse dye(C.I. disperse red 60) in supercritical HFC-134a has been measured at the temperatures of 383.2 K and 413.2 K, and in the pressure range of 50 bar to 160 bar. The solubility data are, with good agreement, correlated by an expanded liquid model which considers the supercritical fluid as compressed liquid.