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http://dx.doi.org/10.7464/ksct.2010.16.2.080

Preparation of Micro- and Submicron-Particles of a Poorly Water-Soluble Antifungal Drug Using Supercritical Fluid Process  

Kim, Seok-Yun (Department of Chemical and Biochemical Engineering, The University of Suwon)
Lee, Jung-Min (Department of Chemical and Biochemical Engineering, The University of Suwon)
Won, Byoung- Hyun (Department of Chemical and Biochemical Engineering, The University of Suwon)
Jung, In-Il (Department of Chemical and Biomolecular Engineering, Yonsei University)
Ryu, Jong-Hoon (Department of Chemical and Biochemical Engineering, The University of Suwon)
Lim, Gio-Bin (Department of Chemical and Biochemical Engineering, The University of Suwon)
Publication Information
Clean Technology / v.16, no.2, 2010 , pp. 80-87 More about this Journal
Abstract
In this study, micro- and submicron particles of itraconazole, a poorly water-soluble antifungal drug, were prepared for improving its aqueous solubility using an ultrasound-assisted supercritical fluid technique, called SAS-EM. The SAS-EM process used in our experiments was different from the conventional SAS-EM in that the ultrasound was applied directly to the spray nozzle. The effect of the ultrasonic power, temperature, and solvent on the formation of itraconazole particles were investigated. Smaller particles were obtained through our SAS-EM process compared with the ASES process, and the mean particle size decreased as the ultrasonic power increased. Our experimental results confirmed that the ultrasound-assisted supercritical fluid process is an efficient method for producing ultrafine particles.
Keywords
Supercritical fluid; Ultrasound; Itraconazole; Ultrafine particles;
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