• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.622-624
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• 2015

Tumor hypoxia caused by the unique characteristics of solid tumor sites such as lowered vascular density, irregular vasculature, longitudinal oxygen gradient, and unbalanced oxygen consumption has decreased therapeutic efficacy in several clinical trials such as radiation, chemotherapy, and surgery. Hence, tumor oxygenation studies at microvascular levels are important to provide better understanding of the complexity of microvasculature oxygen transport and exchange with tissue. However, polarographic microelectodes, was employed to measure $pO_2$ at the microvasculature level, but it is difficult to perform and does not provide significant spatial and temporal information of oxygen delivery. In this research, we introduce the hyperspectral imaging system able to provide a wide range of vascular characteristics by spatial maps on hemoglobin saturation information for better understanding of the relationship between blood oxygen delivery, hypervascularity, aberrant angiogenesis at microvasculature levels during tumor growth.

• Journal of the Korea Society of Computer and Information
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• v.20 no.4
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• pp.69-76
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• 2015

We present microscopy based hyperspectral imaging system that successively shows high spatial (micrometer) and temporal resolutions (milisecond), and acquired pseudocolor hemoglobin saturation map a result of various image processing techniques can provide additional information such as oxygen transport, abnormal vascularity and therapeutic effects besides structural and physiological measurements in various diseases. To increase understanding of vascular defects several optical methods of imaging for preclinical/clinical assessment have been developed so far. However, they have some limitations for outcoming resolution and user satisfaction level compared to its cost. A hyperspectral imaging system has shown a wide range of vascular characteristics associated with hypervascularity, aberrant angiogenesis or abnormal vascular remodeling in many diseases. This vascular characteristic is considered as a key component to diagnose and detect a type of disease as evidenced by them.

• Electronics and Telecommunications Trends
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• v.34 no.1
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• pp.86-97
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• 2019

Over the past 30 years, significant developments have been made in hyperspectral imaging (HSI) technologies that can provide end users with rich spectral, spatial, and temporal information. Owing to the advances in miniaturization, cost reduction, real-time processing, and analytical methods, HSI technologies have a wide range of applications from remote-sensing to healthcare, military, and the environment. In this study, we focus on the latest trends of HSI technologies, analytical methods, and their applications. In particular, improved machine learning techniques, such as deep learning, allows the full use of HSI technologies in classification, clustering, and spectral mixture algorithms. Finally, we describe the status of HSI technology development for skin diagnostics.

• Conservation Science in Museum
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• v.28
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• pp.109-136
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• 2022

This study analyzes the , one of the three panels of 《Welcoming Banquets for the Governor of Pyeong-an》, a documentary painting of the late Joseon Dynasty, with the aim to identify the coloring materials used in the painting. The painting was first imaged at each wavelength in order to minimize the potential problems in the process of analyzing specific parts. This study applied X-rays to identify ink, gold, and organic and inorganic pigments and used infrared rays to find ink and copper-based pigments. It also applied hyperspectral imaging to distinguish organic pigments from black, blue, and green materials. It also analyzed spots selected for each color to identify the following materials: white lead (white), ink/indigo (black), a combination of red lead and cinnabar (red), pink dye, purple dye, iron oxides (brown), orpiment/dye (yellow), malachite/malachite and yellow dye/indigo (green), azurite/white lead and indigo/indigo (blue), indigo and cochineal (violet), and gold leaf (gold). It is expected that more efficient analysis will be made possible by securing a sufficient library for each wavelength.

• Food Science and Preservation
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• v.21 no.6
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• pp.838-843
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• 2014

In this study, near-infrared spectroscopy was used to observe the drying non-uniformity of vegetables such as spring onions, onions, and garlic, which are commonly used for seasoning. For the warm-air convection drying method, the vegetables showed drying non-uniformity, which is due to the unevenness of the wind temperature and humidity depending on the height and position of the drying tray. The second derivative spectra between the vegetable samples with different drying degrees were compared. The peak at around 1,390~1,400 nm, which is assigned to weak hydrogen bonds of water, was changed during drying whereas the peak near 1,420 nm, which represents strong hydrogen (H-) bonds of water, was not changed, indicating that water with weak H-bonds evaporates first during drying, and that water with strong H-bonds remains after drying. The hyperspectral NIR imaging technique combined with principal-component analysis made it possible to discriminate the dried vegetables according to their drying degree.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.715-717
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• 2016

Conventional drug carriers such as liposomes, nanoparticles, polymer micelles, polymeric conjugate and lipid microemulsion for cancer chemotherapy shield normal tissues from toxic drugs to treat cancer cells in tumors. However, inaccurate tumor targeting uncontrolled drug release from the carriers and unwanted accumulation in healthy sites can limit treatment efficacy with current conventional drug carriers with insufficient concentrations of drugs in the tumors and unexpected side effects as a result. In this research, we examined the use of sickle red blood cells as a new drug carrier with novel tumor targeting and controlled release properties. Sickle red blood cells show natural tumor preferential accumulation without any manipulation and controlled drug release is possible using a hemolysis method with photosensitizers.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.12
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• pp.2395-2400
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• 2016

Conventional drug carriers such as liposomes, nanoparticles, polymer micelles, polymeric conjugate and lipid microemulsion for cancer chemotherapy shield normal tissues from toxic drugs to treat cancer cells in tumors. However, inaccurate tumor targeting uncontrolled drug release from the carriers and unwanted accumulation in healthy sites can limit treatment efficacy with current conventional drug carriers with insufficient concentrations of drugs in the tumors and unexpected side effects as a result. Sickle red blood cells show natural tumor preferential accumulation without any manipulation due to the adhesive interaction between molecular receptors on the membrane surface and counter-receptor on endothelial cells. In addition, structural changes of microvascular in tumor sites enhances polymerization of sickle red blood cells. In this research, we examined the use of sickle red blood cells as a new drug carrier with novel tumor targeting and controlled release properties to quantify its therapeutic effects.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.958-960
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• 2015

Sickle cells possess a unique combination of traits that may enable their use as models for novel synthetic tumor targeting controlled release drug carriers with the ability to treat disseminated tumors in advanced metastatic disease. In this study, we assess the ability of light-activated release sickle cells to enhance tumor delivery of the fluorescent dye calcein by delayed photolysis controlled release compared to free systemic administration of calcein. Sickle cells from mouse models of the disease were shown to preferentially accumulate in tumors compared to adjacent tissue, in 4T1 tumors in mice on a time scale about 12 hours. Sickle cells photosensitized with protoporphyrin IX achieved delayed release of 50% of contents 8-16 hours after photoactivation, which was deemed useful for in vivo delivery of cargo to tumors given the tumor accumulation time of the sickle cells. Sickle cells may be useful as a model for new synthetic drug carrier particles with delayed photolysis controlled release properties.