• Journal of Sasang Constitutional Medicine
• /
• v.12 no.1
• /
• pp.216-227
• /
• 2000

1. Purpose For many years, Taeumin Chungsimyoinjatang(太陰人 淸心蓮子湯, CS) has been used in Sasang(四象) constitutional medicine as a therapeutic agent for cerebral disease. The effects of CS on the vascular system is not well-known. The purpose of this study is to make it clear the effects of SJ and composing drugs on blood pressure(BP) and regional cerebral blood flow(rCBF). 2. Method We measured BP with Pressure Transducer, rCBF with Laser-Doppler flowmeter. Propranolol and methylene blue were used to determine the mechanisms of CS effects. 3. Results and Conclusion BP was not affected by CS in rats, and rCBF was significantly increased by CS in rats. rCBF was increased by Nelumbinis Semen(蓮于肉), Ophiopogonis Radix(麥門冬), Asparagi Radix(天門冬), Polygalae Radix(遠志), Zizyphi Spinosae Semen(酸棗仁), Longnae Arillus(龍眼肉), Raphani Semen, Chrysanthemi Flos(甘菊) in rats. The increase of rCBF is mediated by adrenergic ${\beta}$- receptor and guanylyl cyclase which is enzyme producing cyclic GMP.

• Journal of Sasang Constitutional Medicine
• /
• v.13 no.1
• /
• pp.70-78
• /
• 2001

ADR유발성 심근독성에 대한 심근세포의 손상기전을 규명하기 위해 ADR의 독성을 MTT정량, NR정량, LDH활성도 및 심박동을 측정하였다. 배양된 심근세포에서 청심연자탕 전탕액의 심근세포 보호효과는 LDH활성도 측정과 심박동 측정을 통해 관찰할 수 있었다. 이 실험을 통해 다음과 같은 결과를 얻을 수 있었다. 1. ADR은 배양심근세포에서 세포의 생존능력을 떨어뜨렸고, LDH의 활성도를 높였으며, 심박동수를 감소시켰다. 2. 청심연자탕 전탕액은 배양심근세포에서 ADR에 의해 증가된 LDH 활성도를 유의하게 감소시켰다. 3. 청심연자탕 전탕액은 배양심근세포에서 ADR에 의해 감소된 심박동을 유의하게 증가시켰다. 이상의 결과를 통해 ADR은 신생 마우스에서 적출해낸 배양 심근세포에서 독성효과를 나타냈음을 알 수 있었으며, 청심연자탕 전탕액은 ADR에 의해 유발된 심근세포독성에 매우 효과적으로 방어효과를 나타냄을 알 수 있었다.

• Journal of Sasang Constitutional Medicine
• /
• v.10 no.1
• /
• pp.235-252
• /
• 1998

1. Background and Purpose : I intended to be helpful to understand constitutional symptoms of a disease and an application of the prescription through a clinical study of Taeumin Chongsim Yonja Tang. 2. Methods : I studied 125 patients(62 men and 63 women) treated with Taeumin Chongsim Yonja Tang in constitutional clinic of Dongguk Pundang Oriental Hospital. And then I investigated the characteristics of Chongsim Yonja Tang treated patients, remedial values and side effects. 3. Results : Taeumin Chongsim Yonja Tang was used in all age groups both men and women. There were 60 kinds of chief complaints including numbness of hands and feet, headache and fatigue etc. The distributions of remedial values were slightly improved(60.8%), much improved(15.2%), no improved(24.0%) and there was no aggravated patient. Using the prescription, mostly I prescribed only Taeumin Chongsim Yonja Tang without any changing, and added 2-3 herbs to the prescription according to the symptoms of a disease. Taeumin Chongsim Yonja Tang was affected in remedial values by the period of sufferring from illness, treatment and medication. Side effects were diarrhea, indigestion and so on.

• Journal of Sasang Constitutional Medicine
• /
• v.11 no.2
• /
• pp.251-266
• /
• 1999

1. Purpose : The purpose of this study was to determine the effects of Chungsimyeunjatang on the cerebral neurons injured by hydrogen peroxide($H_2O_2$). 2. Methods : I observed cell viability in mouse cerebral neurons exposed to hydrogen peroxide by NR assay and MTT assay and determined lipid peroxidation and amounts of LDH release in mouse cerebral neurons exposed to hydrogen peroxide. After administration of Chungsimyeunjatang water extracts, I observed significant changes of cell viability, lipid peroxidation and amounts of LDH release in mouse cerebral neurons exposed to hydrogen peroxide. 3. Results : Hydrogen peroxide showed neurotoxicity. Cell viability in mouse cerebral neurons exposed to hydrogen peroxide decreased in NR assay and MTT assay. Lipid peroxidation and amounts of LDH release in mouse cerebral neurons exposed to hydrogen peroxide increased. Chungsimyeunjatang was very effective in blocking hydrogen peroxide-induced neurotoxicity.

• 대한한약
• /
• s.4
• /
• pp.316-319
• /
• 2000

• Journal of Sasang Constitutional Medicine
• /
• v.15 no.1
• /
• pp.129-132
• /
• 2003

This case was designed to evaluate the improving effect of hepatitis on drug metabolism. Gleditsiae Spina(?甬刺) was included Taeumin' herb. but it maybe induced hepatitis on drug metabolism, if Taeumin take this herb long time. We use Taeyeumin Chungsimyeunjatang to the hepatitis on drug metabolism, and we improved it. so we report it.

• Journal of Sasang Constitutional Medicine
• /
• v.15 no.2
• /
• pp.166-179
• /
• 2003

In order to evaluate the antiallergic effects of CSYJT, studies were done. We measured the cytotoxic activity for cytokines transcript expression, production of IL-4, IgE, $IFN-{\gamma}$, proliferation of B cell in HRF plus anti-CD40mAb plus rIL-4 stimulated murine splenic B cells. and cytokines transcript expression of IgE in Mast cell The results were obtained as follows: 1. CSYJT decreased the expression of IL-4 in mast cell significantly. 2. CSYJT decreased the production of IL-4 significantly. 3. CSYJT decreased the expression of IgE in mast cell significantly. 4. CSYJT decreased the production of IgE significantly. 5. CSYJT increased the appearance of $IFN-{\gamma}$. The facts above prove that CSYJT is effective against the allergy. Thus, I think that we should study on this continuously.

• The Journal of Internal Korean Medicine
• /
• v.26 no.3
• /
• pp.685-691
• /
• 2005

A 33 year-old male who had been diagnosed with severe ulcerative and ankylosing spondylitis was treated and observed. Even though he had been treated with western medicine, he still complained of severe diarrhia, hemafecia, abdominal pain, general weakness, mild fever($37.8^{\circ}C$) and lower back pain. On radiologic examination, the lumbar view revealed the sacroliac joint space are irregular with adjacent bony sclerosis on both sides. He was treated with Chengsim Yeunja-Tang. Having been treated for 99 days, severity of ulcerative colitis changed from severe to mild ade, lower back pain reduced from nine to three, and all other symptoms improved.

• Journal of Sasang Constitutional Medicine
• /
• v.16 no.1
• /
• pp.12-19
• /
• 2004

Puporse This study is intended to distinct of Taeumin chungsimyeonjatang on the Shinchukpan Dongyi Suse Bowon through compare with early books' prescription by studying use of Sanyak and Yeonjayuk. Method This study is reserch to use of Sanyak and Yeonjayuk in early books, Dongyi Suse Bowon-Sasang-chobonkyeon, Gapobon Dongyi Suse Bowon, Shinchukpan Dongyi Suse Bowon and Dongyibogam, Taepyungheymin-hwajegukbang in sequence of date. with this, we study a base of virtue of Taeumin chungsimyeonjatang. Result and conclusion 1. Taeumin chungsimyeonjatang is a prescription of treatment Gonscratia and CVA. 2. Taeumin chungsimyeonjatang is base on Chungsimyeonjaum in Dongyibogam. 3. The chief virtue of Taeumin chungsimyeonjatang is accord with all prescription after 1894's Gapobon Dongyi Suse Bowon.

• Journal of Sasang Constitutional Medicine
• /
• v.12 no.2
• /
• pp.195-200
• /
• 2000

For many patients suffered from a terminal cancer, the best care is to extend a period and improve a quality of life. So that the pain, a major symptom of patients with terminal cancer, should be effectively controled. Otherwise it causes anorexia, nausea, vomiting, general weakness, loss of body weight, insomnia and becomes worse the condition of patients. The case is a report about a patient diagnosed as terminal gastric cancer and suffered abdominal pain. The patient was treated by Taeumin Chongsim Yonja Tang and the abdomnal pain decreased. This report described the process and contents about the way the patient was cured.