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Distribution of the Fasting Lipid Levels and Validation of the Reference Interval in Korean Adolescents (우리나라 소아청소년의 공복 혈중 지질 농도의 분포 및 참고범위의 타당성 검증)

  • Kwon, Seyoung;Na, Youngak
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.3
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    • pp.253-260
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    • 2018
  • With the growing prevalence of dyslipidemia in adolescents, its early detection and management is becoming increasingly important. This study overviewed the fasting lipid concentration distribution of adolescents according to the sex and age, and reviewed the percentile of its reference interval. This study targeted 2,713 adolescents aged between 10 and 19 (1,436 boys, 1,275 girls) based on the data from 2013 to 2016, Korean Health and Nutrition Examination Survey. The mean fasting lipid concentration of total cholesterol, LDL cholesterol, HDL cholesterol, non-HDL cholesterol, and triglyceride of girls was higher than those of boys. Although the $95^{th}$ percentile of the cholesterol value was 200 mg/dL in boys, which was equivalent to the diagnosis criterion, the mean value of girls was 208 mg/dL, staying between the $90^{th}$ and $95^{th}$ percentiles. The $95^{th}$ percentiles of the LDL cholesterol, non-HDL cholesterol, and triglyceride value were 123, 148, and 147 mg/dL in boys, respectively, and 131, 149, and 139 mg/dL in girls, respectively. Most of the criteria of dyslipidemia were at the proper level, within the $90^{th}$ and $95^{th}$ percentile. While the criteria of LDL cholesterol (130 mg/dL) was higher in boys, the triglycerides was higher in girls. In conclusion, criteria more suitable to Korean adolescents will need to be established with further studies.

설계홍수의 추정

  • Kim, Seung;Kim, Nam-Won;Kim, Hyun-Jun;Kim, Hyeong-Seop
    • Proceedings of the Korea Water Resources Association Conference
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    • 1996.01a
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    • pp.1-95
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    • 1996
  • 전국에 산재한 수위관측지점의 관측개시 이후의 모든 홍수위 자료를 구성하고 주요 지점의 개별 홍수사상에 대한 단위도를 유도하여 지점별 대표단위도를 작성하였다. 또한 유도된 대표단위도를 이용하여 미계측 지점에 대한 단위도와 첨두홍수량을 추정하였다. 연구 결과를 요약하면 다음과 같다. 1991년과 1992년에 이어서 1993년에도 홍수위자료의 수집과 정리에 역점을 두어 관업을 수행하였으며 조선하천조사서, 조선하천조사연보, 한국수문조사연보 등의 각종 문헌에 수록되어 있는 주요 홍수사상의 수문곡선을 판독하여 전국 220개의 수위관측지점에 대하여 총 5,735개 사상의 홍수위 자료를 구축하였으며 이를 자료집으로 구성하였다. 홍수사상에 대한 단위도를 유도하기 위하여 시우량자료는 기상청 자료를 중심으로 구성하였으며 효율적이고 안정적인 능형회귀방법을 이용한 단위도 유도 방법을 적용하여 사용자가 화면을 통해서 홍수사상과 유도된 1mm-1hr 단위도를 보고 적합한 단위도를 선택할 수 있도록 단위도 유도 프로그램을 개발하였다. 대부분의 홍수사상이 지정홍수위 이상인 범위만이 정리되었는데 지정홍수위 이하의 부분은 일수위로부터 읽은 값을 참고로 하고 대수보간을 하여 자료를 구성하도록 하였다. 개발된 단위도 유도 프로그램을 사용하여 지점별 홍수사상별로 단위도를 유도하여 유역별로 총 65개 지점에 대하여 952개의 단위도를 유도하였는데 한강 유역은 16개 지점에서 263개의 단위도를 유도하였고 낙동강 유역은 28개 지점에 460개 단위도를, 금강 유역은 7개 지점 82개 단위도를, 영산강 유역은 7개 지점에서 88개 단위도를, 섬진강 유역은 7개 지점에서 59개의 단위도를 유도하였다. 유도된 단위도들을 지점별로 평균하고, 이를 참고로 하여 Nash 모형을 이용한 지점별 대표단위도를 유도하여 정리하였다. 또한 유도된 대표단위도를 유역에 따라서 지점별로 비교하여 상하류간의 관계를 분석하였으며 신뢰할만한 결과로 판단되었다. 유도된 대표단위도의 첨두유량 및 첨두시간을 유역면적 등과 비교하여 그 관계를 검토하였다. 유역면적과 첨두유량 및 유역면적과 첨두시간의 관계는 비교적 일정한 경향을 보여주었으며 이를 이용하여 미계측 유역의 1mm-1hr 단위도를 추정하였다. 2년 빈도의 설계강우량에 대해서 유역면적이 50, 100, 1,000, 10,000, 20,000$\textrm{km}^2$인 경우 첨두홍수를 추정하였으며 유출률을 0.9로 할 때 4장에서 분석, 제시된 지점별 평균연최대홍수와 비슷한 값을 보여주었다. 따라서 미계측 유역에서는 설계강우량만 주어진다면 본 연구에서 추정된 미계측 유역의 단위도 추정 방법을 이용하여 첨두홍수를 추정할 수 있을 것으로 판단된다. 본 연구의 단위도 유도 대상 지점은 전국의 수위관측지점이었으나 5대강을 제외한 기타 수계에 있어서는 수위자료뿐만 아니라 유량측정성과도 미비하여 단위도 유도를 하지 못하였다. 또한 유역면적 500$\textrm{km}^2$ 이하에서는 홍수위 자료는 있어도 유량측정성과가 없는 지점이 많았고 육량측정성과가 수 회에 불과한 지점이 대부분이었기 때문에 단위도를 유도할 수 없었다. 따라서 분석된 결과를 소유역으로 연장하는 것은 다소 무리가 따르며 대략 어느 정도가 될 것이라는 참고자료로 이용하는 것이 바람직하다고 본다. 현재의 여건에서는 소유역의 유량측정성과를 확충하는 일이 급선무일 것이다. 유역면적이 작은 수위 관측 지점에 대한 지속적인 유량측정이 절실히 요구된다.

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Impedance and Read Power Sensitivity Evaluation of Flip-Chip Bonded UHF RFID Tag Chip (플립-칩 본딩된 UHF RFID 태그 칩의 임피던스 및 읽기 전력감도 산출방법)

  • Yang, Jeenmo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.4
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    • pp.203-211
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    • 2013
  • UHF RFID tag designers usually ndde the chip impedance and read power sensitivity value obtained when a tag chip is mounted on a chip pad. The chip impedance, however, is not able to be supplied by chip manufacturer, since the chip impedance is varied according to tag designs and fabrication processes. Instead, the chip makers mostly supply the chip impedances measured on the bare dies. This study proposes a chip impedance and read power sensitivity evaluation method which requires a few simple auxiliary and some RF measuring equipment. As it is impractical to measure the chip impedance directly at mounted chip terminals, some form test fixture is employed and the effect of the fixture is modeled and de-embeded to determine the chip impedance and the read power sensitivity. Validity and accuracy of the proposed de-embed method are examined by using commercial RFID tag chips as well as a capacitor and a resistor the value of which are known.

Establishment of Safety Factors for Determining Use-by-Date for Foods (식품의 소비기한 참고치 설정을 위한 안전계수)

  • Byoung Hu Kim;Soo-Jin Jung;June Gu Kang;Yohan Yoon;Jae-Wook Shin;Cheol-Soo Lee;Sang-Do Ha
    • Journal of Food Hygiene and Safety
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    • v.38 no.6
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    • pp.528-536
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    • 2023
  • In Korea, from January 2023, the Act on Labeling and Advertising of Food was revised to reflect the use-by-date rather than the sell-by-date. Hence, the purpose of this study was to establish a system for calculating the safety factor and determining the recommended use-by-date for each food type, thereby providing a scientific basis for the recommended use-by-date labels. A safety factor calculation technique based on scientific principles was designed through literature review and simulation, and opinions were collected by conducting surveys and discussions including industry and academia, among others. The main considerations in this study were pH, Aw, sterilization, preservatives, packaging for storage improvement, storage temperature, and other external factors. A safety factor of 0.97 was exceptionally applied for frozen products and 1.0 for sterilized products. In addition, a between-sample error value of 0.08 was applied to factors related to product and experimental design. This study suggests that clearly providing a safe use-by-date will help reduce food waste and contribute to carbon neutrality.

Cable Tension Force Management Using Vibration Method at Cable Stayed Bridge Construction Stages (진동법을 이용한 사장교 시공단계별 케이블 장력관리)

  • Park, Yeon-Soo;Cheon, Dong-Ho;Cheon, Yang-Bae;Kang, Kyoung-Koo
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.9 no.4
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    • pp.127-134
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    • 2005
  • Design and construction of long-span bridge are recently increasing by development of computer technology. Specially, cable stayed bridge and suspension bridge having cable component are representative of long-span bridge may do. Therefore, this paper a present a methodology for cable tension force monitoring in cable-stayed bridge under construction using acceleration data acquired by the vibration method. To improve accuracy construction, all stay cables are measured, according to 4-step construction stage and change of temperature.

Evaluation of Pregnancy and Thyroid Function (임신과 갑상선 기능의 평가)

  • Park, Chang-Eun
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.1
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    • pp.1-10
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    • 2018
  • During early pregnancy, before the development of a functioning thyroid gland, thyroid stimulating hormone (TSH) is a very sensitive marker of thyroid dysfunction during pregnancy. Normal values have been modified during gestation with a downward shift. The fetus is influenced by the TSH supplied by the mother. TSH and free thyroxine (FT4) concentrations vary during pregnancy and conventional units can vary between laboratories. A downward shift of the TSH reference range occurs during pregnancy, with a decrease in both the lower and upper limits of maternal TSH, relative to the typical non-pregnant TSH reference range. Each laboratory produces its own reference TSH and FT4 concentrations because there are many different assays that yield different results in pregnancy. Therefore, automated immunoassays used for serum FT4 analysis are still used widely, but the important considerations discussed above must be noted. The use of population-based, trimester-specific reference ranges remains the best way to handle this issue The slight downward shift in the upper reference range of TSH occurring in the latter first trimester (7~12 weeks) of pregnancy, typically not observed prior to 7 weeks. Their use indicates high or low levels in a quantitative manner independent of the reference ranges. These data highlight the importance of calculating population-based pregnancy-specific thyroid parameter reference intervals. A precision medicine initiative in this area will require the collection and analysis of a large number of genetic, biological, psychosocial, and environmental variables in large cohorts of individuals. Large prospective randomized controlled trials will be needed to resolve these controversies.

Study of the determination of 226Ra in soil using liquid scintillation counter (액체섬광계수기를 이용한 토양 중 226Ra 분석 방법 연구)

  • Jung, Yoonhee;Kim, Hyuncheol;Chung, Kun Ho;Kang, Mun Ja
    • Analytical Science and Technology
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    • v.29 no.2
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    • pp.65-72
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    • 2016
  • This study presented an analytical method for detecting radium in soils using a liquid scintillation counter (LSC). The isotope 226Ra was extracted from soil using the fusion method and then separated from interfering radionuclides using the precipitation method. Radium was coprecipitated as sulfate salts with barium (Ba) and then converted into Ba(Ra)CO3, which is soluble in an acidic solution. The isotope 222Rn, the decay progeny of 226Ra, was trapped in a water immiscible cocktail and analyzed by LSC. The pulse shape analysis (PSA) level was estimated using 90Sr and 226Ra standard solutions. The figure of merit was the highest at PSA 80, while the alpha spillover was the lowest at PSA 80. The counting efficiency was 243 ± 2% in a glass vial. This analytical method was verified with International Atomic Energy Agency (IAEA) reference materials, including IAEA-312, IAEA-314, and IAEA-315. The recovery ranged from 60–82%, while the relative bias between the measured value and the recommended value was less than 10%. The minimum detectable activity was 2.1 Bq kg−1 with dry mass 1 g, the background count rate of 0.02 cpm, the recovery rate of 70% and counting time of 30 min.

Nerve Conduction Velocity among Farmers Exposed to Pesticides (일부 농약 폭로 농민들의 신경전도 검사에 관한 연구)

  • Lee, Won-Jin;Choi, Jin-Yong;Lee, Kun-Sei
    • Journal of agricultural medicine and community health
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    • v.24 no.1
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    • pp.1-11
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    • 1999
  • This study was carried out to find out if peripheral neuropathy was resulting from exposed to pesticides in farmers. Thirty four male farmers in rural area of Chungju were selected as a study group. According to the farm type and area, the group was subdivided into two groups: the high exposed group(n=20) and the low exposed group(n=14). Nerve conduction velocity tests were done on four nerves of the dominant arm(median motor, median sensory, ulnar sensory, and ulnar motor) and three nerves of the dominant leg(peroneal motor, sural sensory, and posterior tibial motor). On the nerve conduction study, all of the results were included normal range. But comparing to reference mean values, most of results were significantly decreased(P < 0.01 by t-test). And the median motor conduction velocity and the peroneal nerve latency were significantly increased in the high exposed group than the low exposed group and reference values. But we concluded that these findings are caused by age difference not pesticide exposure. In conclusion, we cannot find any abnormality of nerve conduction velocity caused by exposure to pesticide in this study group.

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A Study on the Life-time Prediction for the Rubber O-ring applied to decoy through the Accelerated Life Test (기만기 적용 고무 O-ring의 온도에 따른 가속수명시험을 통한 수명예측에 관한 연구)

  • Jo, Hee-Jin;Kim, Minwoo;Gwak, Hyerim
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.10
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    • pp.182-188
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    • 2016
  • A decoy is a weapon system that can protect vessels from an enemy's torpedo. Thus, the decoy should be able to operate in the field without any failure. Because the decoy can be inoperable once its sealing is broken and water permeates inside the system, the hermetic sealing capability considering the operational environment is mandatory. To be hermetically sealed, a rubber-type O-ring is generally used in a decoy system. The sealed performance of rubber-type products, however, tends to age and deteriorate with time. Therefore, the O-ring needs to be maintained or changed periodically. This paper proposes a method to estimate the proper maintenance period using the hardness and elongation percentage, which represents the performance of the O-ring product and test data from Accelerated Life Test (ALT) of the product. The O-ring used in this paper is a NBR type, and the temperature was chosen to be the main accelerating factor as referenced in many studies. The criteria for the failure of the O-ring was set for the product to be 50% degraded compared to the initial performance. In addition, the Korean standard KS M 6518 was adopted and referenced for the preparation of test samples and the calculation of estimates. The O-ring's predicted life was simulated by analyzing the test results from a computer program, and the optimized maintenance period for the product was determined.

Usefulness of the Waist Circumference-to-Height Ratio in Screening for Obesity in Korean Children and Adolescents (한국 소아청소년 비만에서 허리둘레-신장비의 유용성)

  • Gil, Joo-Hyun;Lee, Mi-Na;Lee, Hye-Ah;Park, Hye-Sook;Seo, Jeong-Wan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.13 no.2
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    • pp.180-192
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    • 2010
  • Purpose: To evaluate the feasibility and usefulness of the waist circumference-to-height ratio (WHTR) in screening for obesity in Korean children and adolescents. Methods: Data, including body mass index (BMI), waist circumference (WC), and height, were obtained from the national growth surveys for children and adolescents in 2005. The WHTR was calculated dividing WC by height in subjects 2~18 years of age. Overweight and obese were defined by BMI percentiles for age and gender. The receiver operating characteristic (ROC) analysis was performed to find out the optimal cutoff values of WHTR that matched BMI-determined overweight and obesity using the STATA program. The area under the curve (AUC), a measure of diagnostic power, of WHTR was compared to WC. The influence of age on WHTR was analyzed by the SAS program. Results: The WHTR significantly decreased with age, and had less correlation with age in the 6~18-year-old age group than the 2~5-year-old age group. Furthermore, the WHTR also had less correlation with age than WC in the 6~18-year-old age group. The AUC of WHTR in identifying overweight and obesity was significantly higher than the AUC of WC in the 6~18-year-old age group. The optimal cutoff values were 0.51 in boys and 0.49 in girls for obesity, and 0.48 in boys and 0.47 in girls for overweight, with all having the AUC>0.9. The optimal cutoff values of WHTR had a higher sensitivity for diagnosing obesity than WC${\geq}$90th percentiles. Conclusion: The WHTR is an easy, accurate, and less age-dependent index with high applicability in screening for obesity in children and adolescents.