• Clinical and Experimental Pediatrics
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• v.46 no.4
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• pp.370-375
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• 2003

Purpose : It has been suggested that the exposure to aeroallergens during early infancy after birth is important in the subsequent development of sensitization and allergic diseases. In Korea, the level of house dust mites as one of the important aeroallergens is known to be the highest in autumn. The aim of this study was to test whether the distribution of month of birth bears a relationship to the presence of mite sensitization in children with respiratory allergy. Methods : Skin prick tests and methacholine provocation tests were performed on 1,327 patients with chronic respiratory symptoms who visited Seoul National University Children's Hospital from January 1995 to May 2002. An analysis of patients' month of birth distribution according to the presence of mite sensitization was performed. Results : Atopic subjects who had at least one positive skin test numbered 864(65.1%); and non-atopic subjects numbered 463(34.9%). Among atopic subjects, 787(59.3%) had positive skin tests to mites and 77(5.8%) had positive skin test only to minor allergens. A significantly greater than expected number of mite atopic subjects were born in the months between August and November(P=0.03), however, the birth month of non-atopic subjects didn't show a consistent seasonal preference. Asthma patients numbered 543(40.9%). Among these, atopic asthmatics numbered 421(77.5%) and non-atopic asthmatics, 122(22.5%). Dust-mite atopic asthmatics numbered 387(91.9%) out of 421 atopic asthmatics. Dust-mite atopic asthmatics were born significantly higher in the season lasting from August to November in comparison to non-atopic asthmatics(P=0.002). Conclusion : Month of birth seems to be related with sensitization to allergens. Our results show that August to November is the risk period for the development of mite sensitization in Korea.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.3
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• pp.188-195
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• 2016

Neutrophils and lymphocytes are essential inflammatory cells in the pathogenesis of allergy. In this study, we evaluated the role of house dust mite (HDM) in the interaction between allergic lymphocytes and neutrophils. The extract of Dermatophagoides pteronissinus (DP) showed a stronger anti-apoptotic impact on neutrophil apoptosis in the coculture of allergic neutrophils with allergic lymphocytes when compared with that in allergic neutrophils alone. DP increased IL-6, IL-8, MCP-1, and GM-CSF in allergic lymphocytes, and the increased cytokines were inhibited by rottlerin-an inhibitor of the protein kinase C (PKC) ${\delta}$, as well as by SB202190-a p38 MAPK inhibitor. DP activated p38 MAPK in a time-dependent manner. The activation of p38 MAPK was suppressed by PAR2i, which is a protease-activated receptor (PAR) 2 inhibitor, and rottlerin. Both aprotinin-a serine protease inhibitor-and E64-a cysteine protease inhibitor-were not effective on cytokine secretion of lymphocytes. These results, despite increased cytokines in allergic lymphocytes via DP, did not show any differences between asthma and allergic rhinitis. Molecules, including cytokines, released by DP in lymphocytes inhibited the migration of neutrophils. This finding may further elucidate the pathogenic mechanism of allergic diseases due to HDM.

• Korean Chemical Engineering Research
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• v.43 no.1
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• pp.136-139
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• 2005

One of the most efficient ways to prevent the allergic symptoms due to house dust mite allergens is to cover up the bed with beddings which is weaved out of a certain kind of textile. Therefore, in this study, the effectiveness of specified cover was verified by measurement of decreased amount of dust and house dust mite allergens. As a result, use of specified cover didn't fully prevent exposure of house dust mite allergens. But there are decreasing effect of exposure of house dust mite allergens and amount of dust.

• 건강소식
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• v.36 no.10
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• pp.20-20
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• 2012

가을에는 일교차가 커지면서 차고 건조해진 공기에 알레르기비염과 천식 등 알레르기 질환이 쉽게 발생한다. 특히 알레르기비염의 주요 원인은 집먼지 진드기나 곰팡이, 애완동물의 털, 꽃가루 등이다. 그렇다면 집안 곳곳 숨어있는 곰팡이와 진드기를 예방하고 제거할 수 있는 방법은 무엇일까?

• Parasites, Hosts and Diseases
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• v.35 no.1
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• pp.9-17
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• 1997

During the period of 1933-1994, house dusts were collected from 65 homes at 10 different localities by operating electric vacuum cleaners. House dust mites were isolated from 10 g dust by applying the modified wet sieving method. Total 7,257 mites were collected and 23 species were identified. Among them, Demctophqgoines loyinaf (DF) was predominant (65. Soy) of the total) , followed by D. pteronvssinus (DP) (20.6%) and Tyrophagus nutrescentios (TP) (6.5%) . Rhizoglvphur robini, Sancqsscnin phvIlophogiann, Cheyletus trcussarti and Scheloribates latipes were the first findings from Korea. DF was predominant in Seoul (66.8%), Kwangju (63.6%), inland of Pusan (79.6%1, Inchon (96.5%), Taejon (83.9%), Chouju (87.15) and Chongiu (95.2%), whereas DP was predominant in Yongkwang-ub (72.5%) and Yongdo (island) of Pusan (64.9%), and TP in Chunchon (38.2%) The localities where DP and TP were predominant showed higher relative humidity in air (> 73% RH) . Among 62 study homes, DF, DP and TP were found in 24.6% of the homes, co-habitat of two species in 48.1% and one species in 27.3%. DF was predominant in 63.5% of the homes studied, DP in 29.6% and TP in 6.9%. In 10 g of the house dust, less than 99 mites were found in 49 homes (70.0%), 100-499 mites in 11 homes (15.7%), 500-999 mites in 3 homes (4.3%) and more than 1,000 mites in 2 homes (2.9%). No mite was found in 5 homes (7.1%). In order to evaluate environmental factors affecting the population density of house dust mites, house type, age of house construction, size of the house, number of the family and frequency of the cleaning were compared with the number of mites, and none of the above factors were statistically correlated with the mite density.

• Proceedings of the Korean Sanitation Conference
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• 2004.11a
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• pp.8-27
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• 2004

In this study, the sanitization effects of ozone and UV against pathogens and ticks were studied. The results indicate that in environments mimicking that of households, the number of pathogens was reduced by $99.0\%$ and $99.0\%$ by ozone and UV light, respectively. In addition, virus counts were also reduced by $100\%$. Optimization of experimental parameters showed that, under appropriate application, ticks are also eradicated by ozone and UV light. The ticks were divided into two groups, with the first group being treated with ozone only and the latter with ozone and UV light. The results from these experiments showed that, although ozone alone reduces the vitality of the ticks, the survival rate of the ticks was significantly more reduced when the ticks were exposed simultaneously to ozone and UV.

• 한국보건간호학회:학술대회논문집
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• 1996.11a
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• pp.89-89
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• 1996

• Journal of Life Science
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• v.3 no.4
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• pp.190-193
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• 1993

알러젠은 크게 옥외 알러젠과 옥내 알러젠으로 중요하게 취급되는 종류로는 집먼지, 집먼지 진드기, 바퀴류, 애완동물의 털이나 분비물 등이 알려져 있다. 이 가운데 바퀴류는 곤충강(class insecta)의 직시목(Order Orthoptera)에 속하는 종으로 아프리카 에티오피아에서 기원하여 무역의 발달과 더불어 유럽, 아시아, 아메리카 대륙 등으로 전파된 것으로 알려져 있으며, 4000여종의 바퀴중 30여종이 사람과 함께 집에서 살고 있다. 본 총설에서느 바퀴류의 생태 및 공통항원과 종특이항원에 대하여 간략하게 언급하였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.4
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• pp.749-752
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• 2006

The house dust mites are well known to the most important causative allergens of major allergic diseases like pediatric asthma, allergic rhinitis or atopic dermatitis. This study was done for assessment of naphthalene effect against breeding suppression of the house dust mites. Twenty live adult house dust mites(Dermatophaogoides pteronyssinus) were each inoculated on mixed culture media containing 0 mg (control), 1mg, 2 mg, 3 mg, 5 mg, and 10 mg naphthalene and incubated at $25^{\circ}C$ with a relative humidity of 75%. After 4 weeks mean number of live house dust mites were 191.5, 24.3, 1.3, 1.3, 0, and 0, respectively. Above results showing that the naphthalene can suppress of breeding the house dust mites in vitro.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2006.04a
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• pp.535-537
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• 2006