• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.46-53
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• 2017

알츠하이머병은 치매를 유발하는 가장 주된 원인 질환으로 환자들은 인지장애를 겪게 된다. 현재 치료약으로 사용되는 약으로는 acetylcholinesterase 저해재가 있지만 이 약들의 효과는 미비하다. 그래서 인지기능에 영향을 미친다고 알려진 신경전달물질인 GABA, Glutamate, acetylcholine의 수치를 조절 할 수 있는 $5-HT_6$ receptor antagonist가 현재 개발되고 있다. 현재 여러 antagonist들이 임상실험 되었고, 인지 능력향상에 효과를 보이고 있다. 그러나, $5-HT_6$ receptor의 구조가 밝혀지지 않아 아직 원자적 수준의 결합 분석이 이루어지지 않았으므로 이 부분에 대한 연구가 필요하다. 따라서 본 연구에서는 Homology modeling을 통해 receptor의 구조를 예측하고, 현재 임상실험 중인 antagonist들 중 7개를 docking을 통해 단백질과 리간드의 결합을 예측하였다. Edison에서 Galaxy TBM과 Galaxy Refine을 사용하여 Homology modeling 한 결과 GPCR의 전형적인 모델에 특징적으로 긴 cterminal을 가졌다는 것을 확인 할 수 있었다. 생성된 구조를 가지고 Edison의 Dock 프로그램으로 7개의 antagonist가 어떠한 결합을 하는지 분석하였다. 그 결과, binding pose에 공통적으로 Trp102, Asp106, Val107, Pro177, Phe188, Val189, Ala192, Phe284, Phe285, Asn288, Thr306, Tyr310이 관여하는 것을 docking을 통해 알 수 있었다. 특히, Phe285는 7개의 antagonist 중에 4개와의 interaction을 하고 있는 것을 관찰하였다. 이 연구를 통하여 $5-HT_6$에 효과적으로 결합하여 치료효과를 낼 수 있는 신약을 개발할 수 있다.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.1373-1376
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• 2012

복무적합도 검사는 정신질환이나 사고가능성이 있는 병사를 감별하고, 입대 후 적응문제로 조기 전역할 수 있는 집단을 예측하는 신인성검사 중 하나로, 현재 군에서 징병 및 입영단계에 실시하는 인성검사이다. 이는 전체 검사대상자를 상대로 정신과적 문제 식별을 위한 개별면담이 불가능하기 때문에 위 검사를 통해 대상자를 효율적으로 선별하기 위함이다. 본 연구는 데이터 마이닝을 통해 복무적합도 검사의 판정을 예측 할 수 있을지 확인하고자 하였다. 이를 위해 데이터 마이닝의 기법 중 회귀분석의 로지스틱 회귀분석 기법이 복무적합도검사 판정에 우수한 성능을 보임을 확인하였고, 로지스틱 회귀분석의 추정된 회귀계수를 이용하여 만든 반응확률에 대한 예측 모형식은 높은 정분류율을 보였고 평가 결과 통계적으로 의미가 있음을 증명하였다. 따라서 본 연구 결과를 활용하면 소수의 문항으로 복무적합도 검사 이전의 선별용 검사 개발이나 자가 진단용 검사 개발로 활용이 가능 할 것으로 기대한다.

• Korean Journal of Psychosomatic Medicine
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• v.19 no.1
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• pp.20-27
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• 2011

Objectives: The present study aims to investigate the effects of physical illness on depression in North Korean Defectors. Methods: One hundred forty-four North Korean Defectors(20 males, 124 females) and 376 South Koreans 133 males, 243 females) in Incheon Metropolitan areas participated the present study. Face-to-face interview was conducted for demographic information including presence of physical illnesses. To investigate depressive symptoms, all participants were required to complete the Center for Epidemiologic Studies-Depression scale (CES-D). Results: After controlling gender, age, marital status, educational year, employment status and physical illness, North Korean Defectors showed higher CES-D score than South Koreans(${\beta}$=0.449, p<0.001). Within North Korean Defectors, the presence of physical illnesses independently was related to higher CES-D score(${\beta}$=0.243, p<0.001). However, within South Koreans, the presence of physical illnesses did not significantly predict CES-D score. North Korean Defectors with physical illness have higher CES-D score than North Korean Defectors without physical illness($26.8{\pm}13.8$ versus $19.7{\pm}12.7$). However, there was no significant differences of CES-D score between South Koreans with physical illness and South Koreans without physical illness($10.3{\pm}9.8$ versus $9.3{\pm}8.8$). Conclusion: Compared to South Koreans, North Korean Defector showed higher depressive symptoms independently from gender, age, education, employment, marriage. In addition, only North Korean Defectors showed the relationship between depression and physical illness. Our study suggests that depression should be assessed when North Korean Defectors have physical illness.

• KIPS Transactions on Software and Data Engineering
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• v.9 no.4
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• pp.129-136
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• 2020

PM2.5 which is a very tiny air particulate matter even smaller than PM10 has been issued in the environmental problem. Since PM2.5 can cause eye diseases or respiratory problems and infiltrate even deep blood vessels in the brain, it is important to predict PM2.5. However, it is difficult to predict PM2.5 because there is no clear explanation yet regarding the creation and the movement of PM2.5. Thus, prediction methods which not only predict PM2.5 accurately but also have the interpretability of the result are needed. To predict hourly PM2.5 of Seoul city, we propose a method using random forest with the adjusted bootstrap number from the time series ground data preprocessed on different sources. With this method, the prediction model can be trained uniformly on hourly information and the result has the interpretability. To evaluate the prediction performance, we conducted comparative experiments. As a result, the performance of the proposed method was superior against other models in all labels. Also, the proposed method showed the importance of the variables regarding the creation of PM2.5 and the effect of China.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.4
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• pp.319-326
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• 2015

Short root anomaly (SRA) is very rare, but can be problematic for physicians because patients with SRA are more vulnerable to root resorption with orthodontic forces. During the mixed dentition period, it may be difficult to diagnose generalized SRA. This article reports the treatment of an orthodontic patient with SRA at the early mixed dentition stage. Despite local tooth loss, a relatively favorable outcome was obtained without excessive root resorption. Ultimately, orthodontic therapy is possible for patients with generalized SRA, but precautions should be taken to avoid complications, such as tooth loss or root resorption.

• Journal of the Korea Society of Computer and Information
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• v.28 no.3
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• pp.111-117
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• 2023

The oral cavity is a window into the health of the whole body and a gateway for many harmful bacteria. It is a very important part of our body. The biggest advantage of genetic testing is that it can systematically prevent and manage diseases by examining bacteria in the oral cavity and predicting systemic diseases that may occur in our body through big data AI algorithm analysis. Therefore, in this paper, the researcher's family conducts genetic testing directly to derive the results. In this study, in November 2022, 4 family members of the researcher listened to a prior explanation from 1 dentist and 1 dental hygienist at J Dental Clinic, a preventive dental clinic located in Seoul, and after filling out the consent form, oral examination and genetic testing were performed. Genetic testing was performed with Dr.^*** for adults and He^***** products for middle and elementary school students. Genetic testing, which is currently being conducted in Korea, has the advantage that subjects can access it relatively easily without drawing blood, but it also has limitations such as time and cost. Nevertheless, I think it is a part to be highly evaluated in that systemic diseases can be predicted through oral microorganisms.

• Journal of the Korean Society of Radiology
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• v.82 no.5
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• pp.1163-1185
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• 2021

Sudden cardiac death is an unexpected death originating from the heart that occurs within an hour of the onset of symptoms. The main cause of sudden cardiac death is arrhythmia; however, diagnosing underlying structural heart disease significantly contributes to predicting the long-term risk. Cardiovascular CT and MR provide important information for diagnosing and evaluating structural heart disease, enabling the prediction and preparation of the risk of sudden cardiac death. Therefore, we would like to focus on the various structural heart diseases that increase the risk of clinically-important sudden cardiac death and the importance of imaging findings.

• Tuberculosis and Respiratory Diseases
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• v.47 no.3
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• pp.311-320
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• 1999

Background: In recent years, tuberculosis has re-emerged as a major health problem in both industrialized & developing countries. Recent advances in identifying & purifying antigens secreted in active tuberculosis infection have lead to the development of serological assays based on a number of immunodominant antigens. To date, the most sensitive and specific of these antigens has been the 38-kDa antigen. Method: Two rapid membrane-based serologic assays using antigen(38-kDa) from mycobacterium tuberculosis for the diagnosis of tuberculosis were evaluated in 22 patients with smear-positive pulmonary tuberculosis, 14 patients with inactive pulmonary tuberculosis, and 9 patients with non-tuberculous lung disease. Result: The evaluation of validity(sensitivity, specificity, positive predictive value, negative predictive value, false positivity and false negativity) of STAT-PAK ULTRA FAST$^{(R)}$ were 77.3%, 28.6%, 63.0%, 44.4%, 71.4 %, and 22.7% for differential diagnosis of active pulmonary tuberculosis and inactive pulmonary tuberculosis, respectively. The evaluation of validity of STAT-PAK ULTRA FAST$^{(R)}$ were 77.3%, 33.3%, 73.9%, 37.5%, 66.7%, and 22.7% for differential diagnosis of active pulmonary tuberculosis and non-tuberculosis. The evaluation of validity of ICT Tuberculosis$^{(R)}$ were 54.5%, 57%, 66.7%, 44.4%, 42.9%, and 45.5% for differential diagnosis of active pulmonary tuberculosis and inactive pulmonary tuberculosis. The evaluation of validity of ICT Tuberculosis$^{(R)}$ were 54.5%, 100%, 100%, 47.4%, 0%, and 45.4% for differential diagnosis of active pulmonary tuberculosis and non-tuberculosis. Conclusion: We concluded no effectiveness of STAT-PAK ULTRA FAST$^{(R)}$ & ICT tuberculosis$^{(R)}$on serologic diagnosis of pulmonary tuberculosis. In the future, further large-scale study should be needed for serologic diagnosis of pulmonary tuberculosis.

• Science of Emotion and Sensibility
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• v.9 no.2
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• pp.141-150
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• 2006

Since the late 1990s, 'smart clothing' has been developed in a various way to meet the need of users and to help people more friendly interact with computers through its various designs. Recently, various applications of smart clothing concept have been presented by researchers. Among the various applications, smart clothing with a health care system is most likely to gain the highest demand rate in the market. Among them, smart clothing for check-up of health status with its sensors is expected to sell better than other types of smart clothing on the market. Under this circumstance, research and development for this field have been accelerated furthermore. This research institution has invented biometric sensors suitable for the smart clothing, and has developed a design to diagnose various diseases such as cardiac disorder and respiratory diseases. The newly developed smart clothing in this study looks similar to the previous inventions, but people can feel more comfortable in it with its fabric interaction built in it. When people wear it, the health status of the wearers is diagnosed and its signals are transmitted to the connected computer so the result can be easily monitored in real time. This smart clothing is a new kind of clothing as a supporting system for preventing various cardiac disorder and respiratory diseases using its biometric sensor built-in, and is also an archetype to show how smart clothing can work on the market.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.729-737
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• 2019

Fatty pancreas is an abnormal process of lipid deposition in cells, resulting in increased fat tissue and obesity. The result is a risk factor for cardiovascular and metabolic diseases. The aim of this study was to evaluate the usefulness of pancreatic fat as a predictor of cardiovascular disease and metabolic syndrome in pancreatic ultrasonography. In 407 patients who underwent a comprehensive screening at the W Health Care Center in Busan from September 2. 2018 to December 31, 2018, the degree of fat deposition in the pancreas was evaluated as the degree of mild, moderate. Data on non-obstructive atherosclerosis, BMI, hyperlipidemia, hypertension, and diabetes were collected to assess the association of pancreatic fat deposition with cardiovascular disease and metabolic syndrome. In addition, we tried to analyze the correlation between liver dysfunction and thyroid dysfunction as the degree of fat pancreas increased. We examined the relationship between six parameters including atherosclerosis, BMI, hyperlipidemia, hypertension, diabetes, liver dysfunction, and thyroid dysfunction among patients with fatty pancreas. We concluded that the carotid intima-media thickness of atherosclerosis, which is a risk factor of cardiovascular disease, is most closely related to fatty pancreas.