• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.2015-2025
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• 1991

A long and light-weight forearm of the vertical 2 DOF robot manipulator with a heavy payload driven by parallel drive mechanism is modelled as a Euler-Bernoulli beam with a tip mass subjected to a high speed rotation. Governing equation is obtained by Hamilton's principle and represented as state variable form using the perturbed variables which describe the perturbed errors at the manipulator's final configuration. Digitial optimal control and observer theory are used to suppress the forearm vibration and control the positions of the joint angles with measured/estimated state feedback. Computer simulations and experimental results are obtained and compared each other.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.349-356
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• 2020

The heat release rate (HRR) and fire growth rate of fire for the solid combustibles consisting of multi-materials was measured through the ISO 9705 room corner test, and the computational analysis in a closed compartment was performed to simulate a fire using the heat release rate prediction model provided by a Fire Dynamics Simulator (FDS). The method of predicting the heat release rate provided by the FDS was divided into a simple model and a pyrolysis model. Each model was applied and computational analysis was performed under the same conditions. As the solid combustible consisting of multi-materials, a cinema chair composed mostly of PU foam, PP, and steel was selected. The simple model was over-predicted compared to the predicted heat release rate and fire growth rate using the pyrolysis model in a closed compartment.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.1
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• pp.218-221
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• 2004

This study was performed to investigate the effect of rosiglitazone, a new antidiabetic agent, on in vivo synthesis of bone collagen. The mice were divided into low-fat diet group (LF), high-fat diet group (HF), and high-fat diet with rosiglitazone (6.3 $\mu\textrm{g}$/kcal diet) group (HF-Rosi), The synthesis of bone collagen was measured by stable isotope-mass spectrometric technique using $^2$$H_2O$ as a tracer. The $^2$$H_2O$ labeling protocol consisted of an initial intraperitoneal injection of 99.9% $^2$$H_2O$, to achieve approximately 2.5% body water enrichment followed by administration of 4％ $^2$$H_2O$ in drinking water for 3 weeks. Although body weight gain and daily diet intake were not significantly different between groups, HF-Rosi had slightly higher body weight gain and daily diet intake than LF and HF. In addition, HF-Rosi showed significantly higher body fat content than LF and HF. Bone collagen synthesis was reduced in HF than LF and further decreased by the treatment of rosiglitazone. These results suggest rosiglitazone affect body fat content and bone turnover in mice.

• Progress in Medical Physics
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• v.2 no.2
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• pp.129-139
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• 1991

The method of etching tracks in PN-3 dosimeter has been applied to tracks of recoil protons from a neutron source. Both the etch and the detection response of PN-3 has been studied as a function of etched-track diameters against various parameters. We could obtain very useful informations about charge, energy, and mass of particles and the relationship between the track etching rate and the track forming procedure in order to analyze the particle recorded in the solid state track detector. The best etching condition could be found by means of changing the etching circumstances for various energies and particles in order to detect the charged particle accurately. It could be influenced widely that the polymer plastic detector could develep the detecting technique for the low energy level neutron and could be used as a neutron dosimeter in the radiation field such as the nuclear power station, the medical institute and the nondtructive testing institute.

• Proceedings of the KIEE Conference
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• 1999.07d
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• pp.1520-1522
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• 1999

저 전압용 형광체는 최근에 활발히 연구가 진행되고 있으며 가장 대표적인 형광체가 ZnO : Zn 녹색 형광체이다. ZnO : Zn 형광체는 자체발광형 형광체로써 ZnO을 환원분위기 하에서 열처리를 함으로써 얻을 수 있다. 본 연구에서는 자발착화 연소반응법(Glycine Nitrate Process)을 이용하여 ZnO : Zn 분말을 합성하고 형광특성 및 분말특성을 알아보았다. 출발물질로는 Zn Nitrate와 Glycine을 이용하였고 자발연소 반응이 발생하는데 적절한 글리신의 양을 확인하기 위해서 글리신과 양이온의 비를 변화시키며 ZnO를 합성하였다. 그리고 Zn Excess가 생겨난 양과 그에 따른 형광특성을 관찰하기 위해 $N_2$ 분위기에서 각기 $500^{\circ}C,\;750^{\circ}C,\;950^{\circ}C$의 온도에서 열처리를 행하였다. 제조된 ZnO 분말의 입자형태와 결정상태는 SEM과 XRD를 이용하여 분석하였고 TG-DTA를 측정하여 열처리 온도에 따른 질량감소(ZR excess)를 관찰하였다. 또 Particle size analyzer로 분말의 크기를 알아보았고 형광체로써의 발광특성을 살펴보기 위해 PL을 이용하여 발광피크를 관찰하였다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.11a
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• pp.378-382
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• 1999

저 전압용 형광체는 최근에 활발히 연구가 진행되고 있으며 가장 대표적인 형광체가 ZnO Zn 녹색 형광체이다. ZnO : Zn 형광체는 자체발광형 형광체로써 ZnO을 환원분위기 하에서 열처리를 함으로써 얻을 수 있다. 본 연구에서는 자발착화 연소반응법(Glycine Nitrate Process)을 이용하여 ZnO : Zn 분말을 합성하고 형광특성 및 분말특성을 알아보았다. 출발물질로는 Zn Nitrate와 Glycine을 이용하였고 자발연소 반웅이 발생하는데 적절한 글리신의 양을 확인하기 위해서 글리신과 양이온의 비를 변화시키며 ZnO를 합성하였다. 그리고 Zn Excess가 생겨난 앙과 그에 따른 형광특성을 관찰하기 위해 $N_2$ 분위기 에서 각기 50$0^{\circ}C$, 75$0^{\circ}C$, 95$0^{\circ}C$의 온도에서 열처리를 행하였다. 제조된 ZnO 분말의 입자형태와 결정상 태는 SEM과 XRD를 이용하여 분석하였고 TG-DTA를 측정하여 열처리온도에 따른 질량감소(Zn excess)를 관찰하였다. 또 Particle size analyzer로 분말의 크기를 알아보았고 형광체로써의 발광특성을 살펴보기 위해 PL을 이용하여 발광피크를 관찰하였다.

• Journal of the Korean Society of Propulsion Engineers
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• v.7 no.2
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• pp.1-6
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• 2003

Triplet(FOF or OFO) injectors are commonly applied to liquid rockets which use LOX and hydrocarbon propellants. The FOF type injector has been known to have an advantage for the although to show lower combustion performance as compared by the OFO type. However, a large disparity between oxidizer and fuel orifice diameters of the FOF type injector may reduce both the combustion efficiency and stability so that as FOOF split triplet injector which splits a single oxidizer orifice into double orifices was designed. In the present study, spray characteristics of the FOOF injector were investigated and compared with those of the FOF injector undo. cold flow conditions. Mass distributions of oxidizer and fuel for both injectors were measured by using a PLLIF (Planar Liquid Laser Induced Fluorescence)technique, and each drop size was also measured by using an instantaneous photographic method. From the experimental results, we found out that FOOF shows more stable mixing efficiencies than the FOF. As for the drop size of both oxidizer and fuel, there was not a large difference between two injector types.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.6
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• pp.90-94
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• 2021

With the increased interest on quiescent place for residential place, the noise generation from facilities needs to be minimized. One important noise source include sounds from operation of elevators. The elevator operates between floors and generates significantly annoying sounds to the nearby living spaces. It is recognized as the significant contributor inducing noise annoyance to residents. Elevator is supported to the building structure at several locations for movements between floors. In this study, the vibration reduction by use of polymer concrete on the support location was demonstrated. By measuring and comparing the vibration generation when supported on cement and polymer concrete, the noise reduction performance was evaluated. The polymer concrete was made in the form of being inserted into the wall that imitates the hoistway. The impact vibration was induced to the bracket and vibration transfer magnitude was measured. The damping ratio was evaluated through normalization and curve fitting of transient response, and comparison was performed for each resin mixing ratio. By use of polymer concrete, it was possible to reduce the vibration generation in an effect manner without sacrifice on the structural rigidity.

• 한국가시화정보학회:학술대회논문집
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• 2005.04a
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• pp.87-112
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• 2005

분무를 정량적으로 측정하는 것은 노즐의 설계와 개발을 위해서 뿐만 아니라 연소 시스템 전반의 효율 및 불안정성의 제거, 공해 저감 등의 요구 조건을 만족하기 위해서 중요하다. 이를 위해 이전에는 분무장 내에 수집관을 삽입하는 기계적 패터네이터(Mechanical Patternator)와 같은 삽입식 측정 방식을 이용하여 왔으나, 최근에는 고속카메라, Malvern particle analyzer, PDPA, 광학 패터네이터(Optical Patternator)와 같은 분무장을 교란시키지 않으면서도 빠른 측정이 가능한 가시화 기술들이 적용되고 있다. 특히 광학 패터네이터는 레이저 평면광을 이용하여 분무를 측정하는 비삽입식 기술로 단시간 내에 분무장 내 액체 연료의 질량 및 액적 크기의 단면 분포를 동시에 얻어낼 수 있는 장점을 갖고 있다. 그러나 분무 액적들의 수밀도가 증가하는 경우에는 이들 액적에 의한 입사광 및 신호 감쇠, 다중산란 등에 의한 오차가 심하게 발생하여, 기존의 PDPA, PLIF 등의 광학 기법으로는 충분히 신뢰할 만한 결과를 얻기가 어렵게 된다. 이러한 분무를 정량적으로 측정하기 위해서는 입사광의 감쇠뿐만 아니라 분무장 내 액적들에 의한 신호의 감쇠 과정에 대한 고려가 필요하다. 주면 액적들의 영향을 최소한으로 줄이기 위해서는 레이저 평면광을 사용하는 광학 패터네이터와 달리 레이저 광선을 분무장에 조사하여 고압에서 나타날 수 있는 다중 산란에 의한 오차를 최소화할 수 있다. 이러한 이미지 처리 기법을 이용하는 광학 선형 패터네이터(Optical Line Patternator)를 이용하여 기존 레이저 계측기법으로 측정이 곤란하였던 고압 환경 하에서의 스월 동축형 인젝터의 분무 특성을 해석할 수가 있다. 2015(년도) 6,388, 2025(년도) 13,367, 2035(년도) 18,756, 2045(년도) 22,595, 시장점유율 증가로 인한 수출액 증가분 누적(억원) : 2015(년도) 3,411, 2025(년도) 8,847, 2035(년도) 14,433, 2045(년도) 18,005 또한 시나리오 비교평가를 실시하여 본 결과, 본 연구에서 정의한 순편익 누적(Cumulative Net Profit) 변수를 적용하면 현재 연구비 추세 대비 $30\%$ 까지 연구비를 증가 시키는 것이 효율적임을 알 수 있었다.성, 생산 용이성, 제품 디자인의 우수한 정도가 a=0.01 수준 하에서 유의적으로 추정되었다. 이들 변수들 중에서 품질경쟁력에 가장 큰 영향을 미치는 측정변수는 제품의 기본 성능, 수명(내구성), 신뢰성, 제품 디자인의 순서로 추정되었다. 이것은 한국 제조업이 아직 산업 디자인이 품질경쟁력에 크게 영향을 미치는 성숙단계에 이르지 못하였음을 의미한다. (2) 제품 디자인에게 영향을 끼치는 유의적인 변수는 연구개발력, 연구개발투자 수준, 혁신활동 수준(5S, TPM, 6Sigma 운동, QC 등)이며, 제품 디자인은 우선 품질경쟁력을 높여 간접적으로 고객만족과 고객 충성을 유발하는 것으로 추정되었다. 상기의 분석결과로부터, 본 연구는 다음과 같은 정책적 함의를 도출하였다. 첫째, 신상품 개발과 혁신을 위한 포괄적인 연구개발 프로젝트를 품질 경쟁력의 주요 결정요인(제품의 기본성능, 신뢰성, 수명(내구성) 및 제품 디자인)과 연계하여 추진해야 할 것이다. 둘째, 기업은 디자인 경영 마인드 제고와 디자인 전문인력 양성을, 대학은 디자인 현장 업무를 통하여 창의력 증진과 기획 및 마케팅 능력 교육을, 정부는 디자

• Journal of Life Science
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• v.22 no.11
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• pp.1456-1462
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• 2012

Sorafenib is a multikinase inhibitor and an oral anticancer drug approved for the treatment of patients with advanced renal cell carcinoma and those with unresectable hepatocellular carcinoma. The purpose of this study was to develop an efficient method of the determination of sorafenib in human plasma using tandem mass spectrometry coupled with liquid chromatography (LC/MS/MS) and validate the method by the guidelines of the Korean Food and Drug Administration (KFDA). Plasma samples ($100{\mu}l$) were added with chlorantraniliprole as an internal standard and then mixed with the 0.1% formic acid-containing extraction solution composed of isopropyl alcohol and ethyl acetate (1:4, v/v). After centrifugation, the supernatant was concentrated at $45^{\circ}C$ under negative pressure and centrifugal force. The residue was reconstituted with a mobile phase and injected into the HPLC instrument using a reverse phase Waters XTerra$^{TM}$ C18 column (particle size $3.5{\mu}m$). Liquid chromatography was carried out within the run time of 5 min using a mobile phase composed of buffer (0.1% formic acid and 10 mM ammonium formate), methanol, and acetonitrile (1:6:3, v/v/v). The analytes were monitored by tandem mass spectrometry in the multiple reaction monitoring method programmed to detect sorafenib at 'm/z 465.2 ${\rightarrow}$ 252.5' and chlorantraniliprole at 'm/z 484.4 ${\rightarrow}$ 286.2' with positive electrospray ionization mode ($ES^+$). The result showed the proper linearity ($r^2$ > 0.99) over the range of 2,000-5,000 ng/ml with good accuracy (90.7-103.9%) and precision (less than 10%). The newly developed method using LC/MS/MS was validated by the guideline of KFDA and identified as more sensitive compared to the previous methods.