• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.3
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• pp.411-418
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• 2000

By calculating the location and size of the relative eddy formed in the rotating impellers with the logarithmic spiral vanes, a new simple but accurate slip factor is analytically derived. The proposed slip factor depends on only one parameter that is a function of the number of vanes and the vane exit angle. Predicted slip factor for various cases are compared with those estimated by a number of previous slip factors as well as a recent theoretical calculation by Visser et al. ( JFM, Vol. 268, pp. 107-141, 1994). It is found that the present slip factor yields almost similar results to Wiesner's which has been empirically formulated based on the theoretical calculation of Busemann.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.12
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• pp.991-997
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• 2014

This study investigated the swirling flow fields of a gun-type gas burner (GTGB) without a combustion chamber under cold flow conditions. Three velocity components and the static pressure were measured with a straight-type five-hole pressure probe (GHPP) using a non-nulling calibration method and compared with the results of an X-type hot-wire probe (X-probe) and computational fluid dynamics (CFD). The GHPP measured the velocity and static pressure for the swirling flow of the central region of the GTGB better than the X-probe but produced slightly worse results than the CFD.

• Analytical Science and Technology
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• v.24 no.5
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• pp.345-351
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• 2011

A liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS) method was developed and validated for the determination of finasteride in human serum. Beclomethasone was used as internal standard (IS) and liquid-liquid extraction (LLE) using methyl tert-butyl ether (MTBE) was carried out to isolate analyte. The mass transitions monitored in multiple reaction monitoring (MRM) in positive ion mode were m/z 373.2${\rightarrow}$305.2 for finasteride and m/z 409.3${\rightarrow}$391.2 for IS. Retention times of finasteride and IS were 5.81 and 5.46 min, respectively. The limit of quantitation (LOQ) was 0.1 ng/mL and the calibration curve showed good linearity in the range of 0.1~20.0 ng/mL ($R^2$=0.9997). The intra-day assay precision and accuracy were in the range 6.3~10.6% and 97.3~103.6%, respectively, and the inter-day assay precision and accuracy were in the range 0.8~5.2% and 99.8~102.5%, respectively. The sample extract recovery of the method was 80~83%.

• Analytical Science and Technology
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• v.25 no.1
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• pp.76-82
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• 2012

The determination and confirmation of dutasteride in human serum was performed by a liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS). Beclomethasone as an internal standard (I.S.) was added to the serum and the mixed sample was pretreated by liquid-liquid extraction (LLE) with methyl tert-butyl ether (MTBE). The mass transitions of dutasteride and I.S. monitored in multiple reaction monitoring (MRM) were m/z 529.6${\rightarrow}$461.5 and m/z 409.3${\rightarrow}$391.2, respectively, and the retention times were 6.45 and 5.46 min, respectively. The calibration curve was linear in the concentration range of 0.5~30.0 ng/mL ($R^2$= 0.9999) and the limit of quantitation (LOQ) was found to be 0.5 ng/mL. The recovery of dutasteride was shown to be 66~72%. The intra-day assay precision and accuracy were in the range 3.5~5.5% and 85.7~89.9%, respectively, and the interday assay precision and accuracy were in the range 4.2~5.8% and 90.8~95.8%, respectively.