• 대한본초학회지
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• 제22권3호
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• pp.109-116
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• 2007

Objective : In order to elucidate hyperlipidemic effects of the fruits of Poncirus trifoliata and Citrus aurantium, our experimental study was performed on hyperlipidemia rats induced by Triton WR-1339. Method : The hyperlipidemia rats induced by intraperitonial injection of triton WR-1339 were treated with the fruits of P. trifoliata (rare and preparata) and C. aurantium 50 and 200mg/kg. The amount of triglyceride. total cholesterol. HDL-cholesterol, LDL-cholesterol, AST. and ALT levels were measured. Results: The levels of triglyceride. total cholesterol and LDL-cholesterol were significantly reduced in fruits of P. trifoliata (rare and preparata) and C. aurantiu. Simvastatine treated group compared with those of control but the level of HDL-cholesterol was incresed. The level of AST and ALT were not significantly reduced by the treatment to the fruits of P. trifoliata (rare and preparata) and C. aurantium. Conclusion : In the hyperlipidemia rats induced by triton WR-1339. the fruits of P. trifoliata (rare and preparata) and C. aurantium showed a hyperlipidemic effect.

• 한국경영과학회지
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• 제14권2호
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• pp.27-42
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• 1989

REA 모델은 EA 모델의 구성요소인 측면을 역할측면, 연산측면, A-PART-OF 측면, IS-A 측면, 속송측면 등의 5개 측면으로 분류한 모델이다. EATPS 는 사용자 인터페이스모듈, 지식생성 모듈, 인스턴스 관리 모듈, 스키마 구조관리 모듈, 무걸성검사 모듈등의 5개 모듈로 구성된 지능적 지식표현 시스템의 REA 모델에 의해 대화식 (interactive) 으로 생성하고 관리한다. 본눈문에서는 EATPS 의 구성과 기능, 지식 정의언어인 EAKDL 의 구조및 대화식 형성, 지식생성 모듈의 구성과 기넝, 클래스 생성 모듈의 기능과 알고리즘, 그리고 상속추론메카니즘을 도입한 생성모듈의 기능 및 알고리즘을 제시하였다.

• 대한상한금궤의학회지
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• 제9권1호
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• pp.115-123
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• 2017

Objective : The purpose of this paper is to report the improvement of patient with Chronic Fatigue Syndrome(CFS) treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed with Eumyangyeokchahunobok-byung, number 393 provision, and took Jisilchija-tang herb medication for 75days. The changing symptom of chronic fatigue syndrome was estimated by QOL-CFS(Chalder Fatigue Scale) and VAS(Visual Analogue Scale). Results : The QOL-CFS changed 21 to 8 and VAS changed 10 to 1. Conclusions : It is existing theory that Eumyangyeokchahunobok-byung is caused by 'having too much sex relation'. But the author diagnosed Eumyangyeokchahunobok-byung as 'Symptoms worsen when awaken at night, and sleep at day caused by poor sleep pattern' according to the palaeography about shanghanlun, and got a good results.

• 한국식품영양과학회지
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• 제29권3호
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• pp.375-379
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• 2000

이산화황 함유량에 대해 한약재를 대상으로 실험하였으며, 한약을 달여서 탕으로 섭취하는 점을 감안하여 한약을 달인 액을 시료로 이산화황 함량을 조사하여 소비자들이 한약을 달여서 섭취하는 과정에 안전성을 검토하고자 실험을 실시하여 다음과 같은 결과를 얻었다. 생약재 중 이산화황 함유량은 국산 14건중 맥문동(16.9 ppm), 백작약(56.0), 산약(67.7)이 검출되었으며, 수입산은 13건 중 금은화(653.4 ppm), 길경(628.9), 반하(37.1), 백부근(11.7), 부자(82.4), 상백피 (82.7), 석창포(98.0), 패모(497.0),에서 이산화황이 검출되었다. 구입 시기 및 장소를 달리하여 구입한 생약재는 시기나 장소가 달라지면서 생약재에 함유된 이산화황 함량이 서로 차이가 있음을 알 수 있었다. 국산과 수임산과의 이산화황 함량 차이를 조사한 결과 국산의 경우에는 천화분 1건(29.5 ppm)을 제외한 나머지 시료에서 불검출을 보였으나, 수입산의 경우 13건중 7건(건지황, 과루인, 지실, 구기자, 남성, 우슬, 천화분)이 검출되어, 수입산이 국산보다 이산화황을 더 많이 함유하고 있는 것으로 나타났다. 약탕기로 한약액을 달여서 검사한 결과 최초 구입한 생약재의 함유량보다 이산화황 함량이 감소하는 경향을 보였으나, 원래 생약에 다량 함유되어 있는 경우에는 최종 잔류되는 함유량도 높게 나타났다.

• 대한수의학회지
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• 제2권1호
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• pp.15-26
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• 1962

Decoctions of two Korean indigenous crude drugs. Radix Jingyu(the dried root of Aconitum pseudo-laeve Nakai var. erectum Nakai form. Genuinum Nakai) and Fructus ponciri (the transversely sliced and dried unripe fruit of Poncirus trifoliata Rafinesque), are being utilized by the inhabitants in certain parts of southeastern district of Korea with an empirical belief that these serve as effective insecticides for cattle ticks. Of the two species of cattle ticks so far identified in Korea, Boophilus microplus and Haemaphysalis bispinosum, the former was employed in this experiment as the species occupies nearly 99 percent of the tick population. The results of the experiments herein reported seen to indicate that although the killing power of aqueous extracts of the drugs is minimal, the repellent effect against the ticks, especially of Radix Jingyu, is excellent. It may be of interest to note that the aqueous extract of Radix Jingyu has not proved to be inferior to any of the most effective cattle repellents commercially available. Further studies on these Korean indigenous crude drugs as cattle tick repellents are indicated to find whether active ingredients can be extracted in a hope to materialize an extensive application of these drugs in the field.

• 약학회지
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• 제56권4호
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• pp.268-273
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• 2012

This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-${\beta}$ and PPAR-${\gamma}$ but not that of PPAR-${\alpha}$. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-${\beta}$ and PPAR-${\gamma}$ activations.

• Journal of Applied Biological Chemistry
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• 제62권3호
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• pp.275-280
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• 2019

약용식물 67종의 생리활성 부위를 대상으로 열수 추출물이 in vitro에서 xanthine oxidase의 활성에 미치는 효과를 확인하였다. 약용식물 중에서 황금, 지각, 하수오, 갈근, 청피, 복분자, 녹차 및 지실 추출물은 xanthine oxidase의 활성을 강력하게 저해하여 항통풍 천연소재로서의 활용 가능성이 높게 나타났다. 하수오 뿌리 추출물은 열과 pH에 대한 안정성이 우수하였고, 농도에 비례하여 xanthine oxidase의 활성을 저해하였다. 하수오 추출물은 2.0 mg/0.1 mL의 농도에서 xanthine oxidase에 대해 73.8%의 저해 효과를 나타내었다.

• 대한한의학원전학회지
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• 제36권3호
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• pp.27-54
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• 2023

Objectives : To determine the background against which Zhishi has been applied to treat Pi pattern, through examination of changes in Pi pattern treatments in a historical context. Methods : The properties and nature of Zhishi as written in multiple bencao texts were analyzed. In addition, understanding of the Pi pattern, the changes in its treatment were examined diachronically based on opinions of Zhang Zhongjing, Zhugong, and Li Dongyuan. Examples of Zhishi application in Pi pattern treating formulas were collected and their mechanisms analyzed. Results : Zhishi is strongly effective in relieving accumulation and stagnation, due to its properties of dispersing and lowering. The early view of contrasting Pi with Jiexiong shifted to viewing the Pi pattern as an inner damage, from the perspective of rising and lowering of the Qi mechanism based on the Spleen and Stomach. As a result, Zhishi became a key ingredient in the treatment of the Pi pattern. Conclusions : As the perspective of seeing Pi as one end of the Yin-Yang coupling with Jiexiong from the Shanghanlun shifted to seeing it as a problem of Qi mechanism of the Spleen and Stomach, Zhishi became a key ingredient in the formulas to treat Pi pattern. The complexity of Zhishi's direction made it appropriate to treat the changed Pi pattern.

• 동의생리병리학회지
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• 제23권1호
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• pp.50-56
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• 2009

The present study was designed to investigate the effects of Phamacopuncture therapy using Cervi Pantotrichum Cornu (PC) at BL23 BL52 on the regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, then the related mechanisms were also investigated. In addition, the present author also investigated the effects of phamacopuncture therapy at BL23.BL52 on the rCBF in cerebral ischemic rats. The results in normal rats were as follows; PC (3 mg/kg and 5 mg/kg) at BL23 BL52 significantly increased rCBF but decreased MABP. This result suggests that PC at BL23 BL52 significantly increased rCBF by dilating pial arterial diameter. Increase of PC (5 mg/kg)-induced rCBF was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase and methylene blue ($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Decrease of PC (5 mg/kg)-induced MABP was significantly increased by pretreatment with methylene blue but was decreased by pretreatment with indomethacin. These results suggested that the action of PC (5 mg/kg) was mediated by guanylate cyclase. The results in cerebral ischemic rats were as follows ; The rCBF was significantly and stably increased by PC (5 mg/kg) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in Control group. In conclusion, these results suggest that phamacopuncture therapy using Carthami flos at BL23 BL52 can increase rCBF in normal state, and improve stability of rCBF in ischemic state. In addition, the present author also suggest that related mechanisms are involved in guanylate cyclase pathway.

• 대한한방내과학회지
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• 제29권4호
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• pp.939-949
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• 2008

Objective : This study was carried out to investigate the effects of Jisildochehwan extract on indomethacin-induced gastric mucosal lesions of mice. as compared with misoprostol. Methods : Experimental mice were classified into four groups. No gastro-inflammation elicited mice were the normal group(NOR). Gastro-inflammation elicited mice were the control group (CON). Misoprostol-administered mice after gastro-inflammation elicitation were the misoprostol-administered group (MA). Jisildochehwan-administered mice after gastro-inflammation elicitation were the Jisildochehwan-administered group(JA). In this study, we examined superoxide dismutase(SOD) ability, anti-inflammatory ability arrangement of mucous-secreted cells. distribution of mucosal neck cells, mucosal surface cells. neutral mucous-secreted cells. PAS reaction. COX-1, $TNF-{\alpha}$, $NF-{\kappa}B$ p65 and iNOS. Results : The SOD ability of the Jisildochehwan group increased dose-dependently. The hemorrhagic erosion and the damage of arrangement of mucous-secreted cells increased in the CON group. but decreased in the MA and JA groups. The COX-1 positive were decreased in the CON group, but increased in the MA and JA groups. The distribution of mucosal neck cells and mucosal surface cells. PAS positive reaction of surface mucous cells were decreased in CON group, but increased in MA and JA group. $TNF-{\alpha}$, $NF-{\kappa}B$ p65 and iNOS increased in the CON group, but decreased in the MA and JA groups. In all the results, the effects were better in the JA group than in the MA group. Conclusion : Jisildochehwan extract was more effective than Misoprostol. Jisildochehwan has excellent protective effects on indomethacin-induced gastric mucosal lesions.