• Journal of Society of Preventive Korean Medicine
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• v.1 no.1
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• pp.55-58
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• 1997

It is well known that Poncirus trifoliata harmonizes the Stomach dissipates the Nodules of Liver and manages Vitality. This herb has been used for stomachache, vomitting, nausea, abdominal distension and swelling of testis in the Oriental Medicine. A major components of Poncirus trifoliata consist of a various flavonoids such as poncirin, naringin, hesperidin, neohesperidin, rhoifolin, poncimarin, poncitrin. Generally pharmacological activities of an oriental medicinal drug may be different due to diverse origin, harvest season and storage Period. In this study, we aimed to measure the contents of poncirin and naringin, major flavonoid of this herb, to determine the quality of Poncirus trifoliata.

• Journal of Life Science
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• v.26 no.12
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• pp.1466-1469
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• 2016

A group of traditional folk medicines obtained from the fruits of Rutaceae plants, such as Ponciri Fructus Immaturus (PFI) from Poncirus trifoliata Raf., Aurantii Fructus Immaturus (AFI) and Aurantii Pericarpium (AP) from Citrus aurantium L., and Aurantii Nobilis Pericarpium (ANP) from Citrus unshiu Marc., has been widely used for improving poor gastrointestinal function in East Asia, including in China and Korea. In the present study, the effects of Rutaceae-fruit-derived folk medicines on gastrointestinal motor function were investigated and compared by measuring in vivo gastric emptying and intestinal transit in mice. Among the aqueous and ethanolic extracts of some Rutaceae-fruit-derived folk medicines, an ethanolic extract of AP (AP-E) significantly accelerated intestinal transit in a dose-dependent manner without affecting gastric emptying. Furthermore, the intestinal transit rate of AP-E was the highest among all extracts examined in this study, including aqueous extracts of PFI, AFI, and ANP, of which the activities of accelerating intestinal transit have been already reported.

• 대한상한금궤의학회지
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• v.8 no.1
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• pp.145-153
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• 2016

Objectives : This case report presents the effect of Jisilchija-tang on hyperhidrosis. The patient was diagnosed with Eumyangyukchahoonobok-byung based on Shanghanlun provisions. Methods : According to Shanghanlun seven meridian patterns diagnostic system, we diagnosed the patient as Eumyangyukchahoonobok-byung and she has been suffering from hyperhidrosis. The patient was treated with Jisilchija-tang. and it was provided for 3 months. Results : After the treatment, the degree of hyperhidrosis reduced from 10 to 2 on VAS. Conclusions : This case study show an effectiveness of using Jisilchija-tang according to Diagnostic system based on Shanghanlun provisions on hyperhidrosis.

• The Journal of Pediatrics of Korean Medicine
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• v.6 no.1
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• pp.15-32
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• 1992

This study was done to know the effect of Giyuetang on the inflammatory response, contact hypersensitivity (CH), and rosette forming capacity of spleen cells. The effects of Jiyutang with Fructus Immaturus Ponciri on the inflammatory response were evaluated by measuring the production of such reactive oxygen intermediate(ROI) as $O_2^-$ and $H_{2}O_2$ in the peritoneal neutrophils and macrophages. The effects of Jiyutang with Fructus Immaturus Ponciri on the CH were evaluated by checking the ear swelling response against dinitrofluorobenzene(DNFB). The administration of Jiyutang with Fructus Immaturus Ponciri on the mouse decreased the amount of ROI in both neutrophils and macrophages. Jiyutang with Fructus Immaturus Ponciri depressed CH without affecting the rosette forming capacity of spleen cells. The results of this study showed that Jiyutang with Fructus Immaturus Ponciri might have anti-inflammatory effects by decreasing the amounts of ROI in the phagocytes and suppressing the CH, without affecting the rosette-forming capacity of spleen cells.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.457-459
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• 2018

지난 해 롤스로이스의 무인 선박 개발 프로젝트(AAWA) 본격화 등 선박과 관련된 무인 자동화 기술 개발이 활발해지면서 국내의 R&D 사업이 많이 증가하였다. 특히 국내에서는 퍼지 모델을 이용한 RVC 지능 시스템 등 퍼지 이론을 사용한 기술들이 최근까지도 발표되고 있다. 퍼지 모델을 결정하기 위해선 해당 시스템에 대한 전문 지실뿐만이 아니라 다양한 환경에서의 반복적인 실험과 수정을 필요로 하기 때문에 시뮬레이터를 만들어 실험하게 되는데 다양한 환경에서의 반복적인 실험과 수정을 필요로 하기 때문에 시뮬레이터를 만들어 실험하게 되는데 대부분의 연구에서 시뮬레이터가 제작되는 비용과 시간에도 불구하고 해당 퍼지 모델을 위해서만 쓰이게 된다. 따라서 본 논문에서는 다양한 환경에서 퍼지 모델을 반복 실험할 수 있도록 시뮬레이터를 개발하였으며 기존의 퍼지 모델 일부를 본 시뮬레이터에 적용하여 같은 실험을 할 수 있음을 보이고 이를 통해 퍼지 모델을 만드는데 드는 시간과 비용을 줄일 수 있음을 보였다.

• Microbiology and Biotechnology Letters
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• v.30 no.2
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• pp.177-183
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• 2002

The extracts from approximately 40 different Korean traditional medicines were prepared to investigate the antimicrobial activities against poultry disease-related bacteria. Among tested, the extracts of Schizandra chinensis (SC), Melia azedarach (MA), Caesalpinia sappan (CS) and Rhus javanica (RJ) exhibited significant antimicrobial activities against Salmonella gallinarum, whereas the extracts of Elsholtzia ciliata (EC), Myristica fragrans (MF), Alpinia katsumadai (AK), Poncirus trifoliata (PT), Prunella vulgaris (PV), CS and RJ exhibited antimicrobial activities against Staphylococcus aureus. Minimum inhibitory concentrations (MIC) of MA, CS and RJ extracts against S. gallinarum were 1.2 mg/ml, whereas MIC of RJ extract for S. aureus was 0.6 ㎎/ml, which was the lowest among tested. The antimicrobial activities of SC and RJ extracts against S. gallinarum were reduced, but those of AK and CS extracts against S. aureus were not affected by heating treatment. The antimicrobial activities of SC extract against S. gallinarum and those of EC, PT and RJ extracts against S. aureus were stable by acid treatment but unstable by alkaline treatment. those of CS extract was not effected by either acid or alkaline treatment. The growth of all bacteria was significantly inhibited within 24 hours by the addition of at least 100 ppm and 300 ppm of RJ and CS extracts, respectively, compared with the control group. In conclusion, these findings suggest that RJ and CS extracts may play important roles for antimicrobial activities against poultry disease-related bacteria.

• Food Science and Preservation
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• v.12 no.5
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• pp.449-454
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• 2005

The objective of this study was to investigate the effect of drying methods on the physicochemical characteristics of Ponciri fructus. Immature fruits of Poncirus trifoliata were harvested, dried by shade, infrared, or freeze drying, and powdered to size of 20 mesh. Then, extracted for 3 hrs with hot-water or 40% ethanol(80$\circC$℃). Freeze dried powder showed significantly higher L and -a value. The content of hesperidin was not affected by drying methods. The yield was the highest from freeze drying. Water extracts showed significantly more browning color, and higher acidity and total sugar content than those of ethanol extracts. Acidity and total sugar of water extracts were the highest in infrared drying and freeze drying, respectively. Browning color, pH, acidity and total sugar of ethanol extracts were not affected by the drying methods. The results suggest that freeze drying has a beneficial effects to enhance the quality of Ponciri fructus.

• KSBB Journal
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• v.17 no.6
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• pp.537-542
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• 2002

To screening of antimicrobial activity, 95% ethanol and hot water extracts of roots, fruits, leaves, radix and stems of 50 species of traditional herbal medicines were examined. For their growth inhibitory effects on two food-born microorganisms, S. aureus and E. coli O157:H7, by the paper disc diffusion method and the minimum inhibitory concentration(MIC) test. Moutan radicis Cortex and Achyranthis Radix showed the highest inhibitory activities on both S. aureus and E. coli O157:H7. The Inhibition zones of Moutan radicis Cortex on S. aureus and E. coii O157:H7 were 22 mm and 24 mm respectively, and the corresponding inhibition zone of Achyranthis Radix were 23 mm and 22 mm. The MIC or Achyranthis Radix on S. aureus was 156.25 $\mu$g/mL, and the MIC or Achyranthis Radix and Moutan radicis Cortexas on E. coli O157:H7 were 625 $\mu$g/mL and 312.5 $\mu$g/mL, respectively. Their antimicrobial activities in ethanolic extracts were significantly higher than in hot water extracts. In the various solvent fractions prepared from ethanol extract, the ethyl acetate fraction of Achyranthis Radix and the CHCl$_3$ fraction of Moutan radicis Cortexas showed strongest activity.

• Korean Journal of Food Science and Technology
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• v.29 no.6
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• pp.1288-1294
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• 1997

For screening antimutagenic effects, the effects of 95 medicinal plants on the mutagenicity of aflatoxin $B_1$ $(AFB_1)$ and benzo(a)pyrene [B(a)P] were investigated using the SOS chromotest with Escherichia coli PQ37. The mutagenicity induced by $AFB_1$ or B(a)P was reduced over 26% by 2 kinds and 8 kinds of medicinal plant, respectively. Eight plants (Bupleurum falcatum, Corydalis ternata, Gasfrodia elata, Ostericum koreanum, Pinellia ternatia, Poncirus trifoliata, Prunus armeniaca and Rehmannia glutinosa) were also shown to have inhibitory effects on both $AFB_1$ and B(a)P. The mutagenicity induced by $AFB_1$ or B(a)P was increased over 20% by 46 kinds and 2 kinds, respectively, and 8 medicinal plants (Chrysanthemum indicum, Cinnamomum cassia, Cyperus rotundus, Morus bombycis, Patrinia scabiosaefolia, Petasites japonicus, Polygonum multiflorium, Thyja orientalis) increased significantly the mutagenicity of both mutagens. However the 8 plants themself did not show the mutagenicity in SOS Chromotest with S-9 mix alone. This result suggests that the above 8 plants may have the co-mutagenic activities. In two bacterial mutation system, SOS Chromotest and Ames test, the mutagenic or antimutagenic activities of some medicinal plants wire similar except Ostricum koreanum, Eugenia caryophyllata and Scutellaria baicalensis.

• Journal of Pharmacopuncture
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• v.2 no.1 s.2
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• pp.63-71
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• 1999

Counts of RBC and proportion of packed cell volume(PCV) showdc no difference among treatment groups. the values of hemoglobin in rat showed a tendeuy to increase in herbal-acupuncture group, however the values of hemoglobin in guineapig and rabbit showed no significant difference in the treatnent groups. the count of WBC showed high in the chishiI(BL52) herbal-acupuncture group. The proprtion of neutrophils showed no significant difference in rabbit, however the values in guinea-pig and rat showed a tendency to increased in herbal-acupuncture groups. The proportion of lymphocytes in rabbit and guinea-pig showed a tendency to decreast in herbal-acupuncture groups, however the values in rat showed no significant difference. The proportion of Eosinophils and monocytes showed no significant difference in all the treated groups. Results from this study indicated that shinsu(BL23) and chishil(BL52) herbal-acupuncture with palmijihwangtang elivate the biglogical function in Rabbit Guinea-pig and Rat.