• Title/Summary/Keyword: 지방증

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Studies on the Lipid Metabolism of Soybean during its Germination-(Part 2) Changes on lipoxygenase activity and fatty acid composition in soybean during germination- (대두발아(大豆發芽)중 지질대사(脂質代謝)에 관한 연구-제2보(第2報) Lipoxygenase activity 및 지방산(脂肪酸)의 변화에 관하여-)

  • Shin, Hyo-Sun
    • Applied Biological Chemistry
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    • v.17 no.4
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    • pp.247-256
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    • 1974
  • The Merit variety of soybean (Glycine max L.), harvested in 1971 was germinated in the dark at $21{\sim}25^{\circ}C$ for 10 days. The soybean sprout were divided into cotyledons and seedling axis and subjected to the determination of lipoxygenase activity and fatty acid composition of triglycerides, free fatty acids, phosholipids and crude fat fractions at two-day intervals during the germination periods. The results are summarized as follows 1) The lipoxygenase activity in cotyledons declined sharply after second day, but the activity in seedling axis inclined slightly after second day. However, the decrease of lipoxygenase activity in cotyledons coincided with decrease of linoleic and linolenic acids in cotyledons and increase of lipoxygenase activity in seedling axis coincided with increase of those acids in seedling axis. 2) The iodine value of neutral fat in cotyledons decreased continuously, but the iodine value of the neutral fat in seedling axis remained almost constant. iodine value in cotyeldons was greater than in seedling axis. 3) In the fatty acid composition of triglycerides in cotyledons, palmitic acid did not changes significantly, stearic acid increased continuously, oleic acid changed irregularly, linoleic and linolenic acids continuously decreased significantly. But in the fatty acid composition of triglycerides in seedling axis, palmitic acid remained unchanged, linoleic and linolenic acids slightly increased continuously, stearic and oleic acids changed irregularly. 4) Composition of free fatty acids in cotyledons and seedling axis changed irregularly, suggesting that all fatty acids produced by hydrolysis of triglycerides by lipase are used(or either biosynthetic Purpose or energy Production at random. 5) Fatty acids with odd-numbered carbon chain were not detected in the triglycerides and free fatty acid fractions during the germination periods, suggesting that all fatty acids are utilized as $C_2$-unit in degradation and biosynthesis. 6) The changes of fatty acids composition of Phospholipid in cotyledons and seedling axis during the germination were similar to these of triglyceride fraction.

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Estimation of Heritabilities and Genetic Correlations on Preweaning Body Weights and Postweaning Traits in Swine (돼지의 이유전체중(離乳前體重)과 이유후형질(離乳後形質)에 대한 유전력(遺傳力)과 유전상관(遺傳相關)의 추정(推定))

  • Han, Sung Wook;Sang, Byung Chan;Lee, Han Ok
    • Korean Journal of Agricultural Science
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    • v.14 no.1
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    • pp.51-60
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    • 1987
  • The study was conducted to estimate the heritabilities, genetic and phenotypic correlations on preweaning body weight and postweaning traits. The data analysis were the record of 253 male pigs produced from 54 boars of Landrace, Hampshire, Large Yorkshire and Duroc purebreds raised at National Animal Breeding Institute from 1978 to 1983. The results obtained in this study are summarized as follows. 1. The heritabilities of body weight at birth, 21days and 56days were $0.233{\pm}0.160$, $0.485{\pm}0.185$ and $0.758{\pm}0.214$, respectively, and the heritabilities estimated on postweaning traits were $0.270{\pm}0.164$ for average daily gain, $0.350{\pm}0.174$ for feed requirement, $0.272{\pm}0.165$ for backfat thickness, $0.887{\pm}0.221$ for days to 90Kg and $0.565{\pm}0.195$ for selection index. 2. Genetic correlations of body weight at birth with 21 days and 56 days were 0.349 and 0.19& and body weight at 21 days with 56 days was 0.907, and daily gain with feed requirement, backfat thickness, days to 90 Kg and selection index were -0.552, 0.107, -0.903 and 0.716, and feed requirement with backfat thickness, days to 90Kg and selection index were -0.058, 0.699 and -0.942, and backfat thickness with days to 90 Kg and selection index were -0.237 and -0.025, respectively. 3. Phenotypic correlations of body weight at birth with 21 days and 56 days were 0.342 and 0.287, and body weight at 21 days with 56 days was 0.893 and daily gain with feed requirement, backfat thickness, days to 90Kg and selection index were -0.062, 0.093, -0.651 and 0.540, and feed requirement with backfat thickness, days to 90Kg and selection index were 0.105, 0.601 and -0.613, and backfat thickness with days to 90Kg and selection index were -0.040, -0.416, respectively.

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Anti-hyperlipidemic and anti-obesity effects of Sparassis latifolia fruiting bodies in high-fat and cholesterol-diet-induced hyperlipidemic rats (고지방과 고콜레스테롤 식이 급여에 의해 고지혈증이 유도된 흰쥐에서 꽃송이버섯 자실체의 항고지혈증과 항비만 효과)

  • Im, Kyung-Hoan;Baek, Seung-A;Choi, Jaehyuk;Lee, Tae-Soo
    • Journal of Mushroom
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    • v.19 no.1
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    • pp.23-32
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    • 2021
  • This study investigated the anti-hyperlipidemic and anti-obesity effects of Sparassis latifolia (S. latifolia) fruiting body powder in rats fed with a high fat and cholesterol diet (HFD). Rats were fed a normal control diet (ND), an HFD, an HFD supplemented with 5% fruiting body powder of S. latifolia (HFD+SL), or an HFD supplemented with 0.03% simvastatin (HFD+SS), for 6 weeks. The HFD group demonstrated considerable increase in body weight gain, the food efficiency ratio (FER), and plasma cholesterol and triglyceride levels, compared to the ND group. In contrast, the HFD+SL and HFD+SS groups showed significantly reduced body weight gain, food intake, and plasma cholesterol and triglyceride levels compared to the HFD group. In particular, the HFD+SL and HFD+SS diets significantly suppressed the occurrence of non-alcoholic fat deposits in the liver. Taken together, these results suggest that dietary supplementation of the fruiting body powder of S. latifolia in an HFD could lower the risks of hyperlipidemia, atherogenesis, and obesity and may be used as a functional food to manage cardiovascular disease and fecal lipid and cholesterol levels.

Prevalence of Diabetes Mellitus and Associated Diseases in Yeungnam Province Area (영남지방에서의 당뇨병 유병율과 이에 관련돈 질환의 빈도에 관한 연구)

  • Cho, Ihn-Ho;Choi, Jung-Gyu;Yun, Sung-Chul;Choi, Soo-Bong
    • Journal of Yeungnam Medical Science
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    • v.4 no.2
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    • pp.65-73
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    • 1987
  • To know the prevalence of the diabetes mellitus and associated diseases, we analysed the data of the 3,088 subjects who were examined with the Computed Automated Medi-Screening Test System which consisted of 65 parameters including blood glucose determination fasting and one hour after 100g of oral glucose load. We grouped the subjects by the modified criteria of National Diabetic Data Group. Followings are the results of the various analysis : 1. The prevalence of diabetes mellitus and impaired glucose tolerance is 2.27% and 18.26% respectively. 2. The prevalence of diabetes mellitus is 2.63% In male and 1.66% in female. There is no statistically significant difference between male and female. 3. There is tendency of increasing prevalence of diabetes mellitus as the age increases. From second to eighth decade, the prevalence of diabetes mellitus Increases as 0.0, 0.45, 0.67, 2.28, 3.47, 5.36, 10.00% respectively. 4. There is no statistically significant difference of prevalence of obesity between normal and diabetes: that is, 18.03%, 22.86% respectively.($P{\geq}0.1$) 5. There is no statistically significant difference of prevalence of impaired glucose tolerance and diabetes between non-obese and obses group. ($P{\geq}0.1$) 6. There is statistically significant increases of frequency of proteinuria, azotemia, hypertension as the glucose tolerance decreases. ($P{\leq}0.05$)

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Transdermal Permeation of Xanthan Gum Bases on the Water-soluble and Lipophilic Antihyperlipoproteinemic Drugs (수용성과 지용성 항고지단백혈증제에 대한 Xanthan Gum 기재에서의 경피투과)

  • 이석우;임윤택;공승대;황성규;이우윤
    • KSBB Journal
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    • v.16 no.3
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    • pp.253-258
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    • 2001
  • Recently, there were many studies not only to enhance drug delivery effect but to reduce side effect. Drug delivery system(DDS) is able to improve efficiency with decreasing side effect of drug dosage. Among these application fields, DDS is often used as the method of drug dosage into the epidermic skin. We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying DDS. We investigated the permeation of xanthan gum containing drug in rat skin using borizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug with oxiniacic acid and also for lipophilic drug with clofibrate. The permeation rate of lipophilic drug was found to be faster than that of water-soluble drug in vitro. The rate differences of both water-soluble drug and lipophilic drug according to drug content were negligible. We used glycerin, PEG 600 and oleic acid as enhancers. These results showed that skin permeation rate of each drug across the composite was mainly dependent on the property of base and chemical property of drug etc.. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer base as a transdermal delivery system of antihyperlipoproteinemic agent.

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Bilateral Extraocular Muscle Metastasis of Nasal Rhabdomyosarcoma Mimicking a Thyroid Associated Orbitopathy: A Case Report (갑상선 안병증으로 오인된 비강 내 횡문근육종의 양쪽 외안근 전이: 증례 보고)

  • Shin, Jin-Ho;Lee, Jeong-Hyun;Lim, Hyun-Kyung;Lee, Ha-Young;Park, Jee-Won;Baek, Hye-Jin;Choi, Young-Jun;Ahn, Jin-He;Baek, Jung-Hwan
    • Investigative Magnetic Resonance Imaging
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    • v.15 no.2
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    • pp.176-180
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    • 2011
  • Metastases to the orbit usually affect the intraorbital fat and bone than the extraocular muscles. Metastasis to the extracoular muscles commonly occurs unilaterally, and diffuse enlargement of the bilateral extraocular muscles due to metastasis is extremely rare. In this report, we will describe a case of diffuse metastasis to the bilateral extraocular muscles from nasal rhabdomyosarcoma masquerading as thyroid associated orbitopathy. We will also discuss about the MR imaging findings helpful for differential diagnosis from thyroid associated orbitopathy.

Measurement and Analysis of Low Flow in the Cheonggecheon Watershed (청계천 유역 갈수량 측정 및 분석)

  • Noh, Seong Jin;Kim, Hyeon Jun;Jang, Cheol Hee;Kim, Dong Pil;Hong, Il Pyo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2004.05b
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    • pp.1067-1071
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    • 2004
  • 도시 유역의 물순환 특성을 종합적으로 이해하기 위해서는 갈수량 자료의 구축이 필수적이다. 하지만 지금까지의 인구는 주로 치수분야에 한정되어 대부분의 자료 또한 홍수기에 대해서만 자료가 구축되어 있으며 상대적으로 갈수기에 내한 자료와 관련 연구는 부족한 편이다. 본 연구에서는 청계천 유역의 기존 수문자료를 이용하여 유역의 유출 특성을 분석하고 갈수량을 측정하여 청계천 유역의 물순환 특성을 파악하기 위한 기초자료를 구축하였다. 청계천은 서울의 서북쪽에 위치한 인왕산과 북한산의 남쪽 기슭, 남산의 북쪽 기슭에서 시작하여 서에서 동으로 종로, 세운상가, 동대문 등 서울의 도심부를 흐르는 유로연장 13.75 km, 유역 면적 $50.96 km^2$의 도시하천으로 중량천의 제1지류인 지방2급 하천이며, 정릉친, 성북천을 제1지류, 월곡천을 제2지류로 포함한다. 청계천은 도시화로 인해 1950년대부터 1970년대까지 점차 복개되었다가 2003년 7월부터 5.9 km의 본류구간에 대한 복원공사가 진행 중이다. 청계천은 홍수기 이후 유량이 급격히 줄어 11월 이후에는 다음 홍수기까지 강바닥이 완전히 들어나는 일종의 간헐천으로 홍수기를 제외한 시기의 자료는 전무한 실정이다. 본 연구에서는 유역내 8개의 모니터링 지점을 선정하여 2003년 9월 이후, 월 2회 이상 갈수량 자료를 현장 측정${\cdot}$분석하였다. 청계천 유역은 복원공사 완공 후에는 유역의 물순환 특성이 대폭 바뀔 것이 예상되는 지역으로 본 연구에서 구축된 갈수량 자료는 청계천 유역의 물순환계 변화를 분석하고 건전한 물순환 체계의 유지${\cdot}$관리를 위한 기본 자료가 될 것으로 판단된다., 바늘꽃과, 속새과, 십자화과, 장미과, 사초과, 삼과, 현삼과, 닭의장풀과가 각 1종씩 조사되었으며, 조사지점(II)인 1km지점에서는 15과 26종으로, 벼과가 4종, 마디풀과, 국화과가 3종, 버드나무과, 십자화과, 콩과가 2종씩, 바늘꽃과, 속새과, 자라풀과, 장미과, 사초과, 백합과, 현삼과, 골풀과, 닭의장풀과가 각 1종씩으로, 조사지점( I )보다 좀 더 많은 종이 분포하는 것으로 조사되었다. 또한 어류는 조사지점( I )에서 3회에 걸쳐 총 396개체가 채집되어 3목 8과 21종이었다. 이 중 한국 고유종은 11종이었고, 외래 어종은 검정우럭과 2종이 조사되었으며, Zacco platypus(피라미), Zacco temmincki(갈겨니), Acheilongnathus koreanus(칼납자루), Odontobutis platycephala(동사리), Coreoleuciscus splendidus(쉬리) 순으로 분포하고 있었고, Acheilognathus signifer(묵납자루)는 댐 건설 전에는 많이 분포하였으나 현장조사에서 서식을 확인 할 수 언어 개체수의 큰 감소내지 멸종된 것으로 추정되었다.에서 동시에 시행하였다. 수술 후 1년 내 시행한 심초음파에서 모든 환아에서 단지 경등도 이하의 승모판 폐쇄 부전 소견을 보였다. 수술 후 조기 사망은 없었으며, 합병증으로는 유미흉이 한 명에서 있었다. 술 후 10개월째 허혈성 확장성 심근증이 호전되지 않아 Dor 술식을 시행한 후 사망한 예를 제외한 나머지 6명은 특이 증상 없이 정상 생활 중이다 결론: 좌관상동맥 페동맥이상 기시증은 드물기는 하나, 영유아기에 심근경색 및 허혈성 심근증 또는 선천성 승모판 폐쇄 부전등을 초래하는 심각한 선천성 심질환이다

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분포형 수문매개변수 산정을 위한 GIS의 활용 - 금강상류유역을 중심으로 -

  • 정승권;정동양
    • Proceedings of the Korea Water Resources Association Conference
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    • 2004.05b
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    • pp.809-813
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    • 2004
  • 강우시 유역 내에서 발생하는 수문특성을 구명하고자 하는 연구는 지속적으로 진행되고 있다. 특히 최근 몇년간 집중호우로 인한 홍수피해가 매우 실각한 수준으로 발생하였고, 이에 지방 소하천을 포함한 전국의 하천정비사업이 새로운 설계홍수빈도를 토대로 진행되고 있다. 우리나라의 강우특성은 여름철에 편중되는 특성을 지니고 있어 홍수시의 홍수방어 대책 등 치수에 많은 어려움이 있는 것이 현실이다. 집중호우로 인한 피해는 전 세계적인 문제로 제기되고 있으며, 이에 강우-유출 관계를 규명하고자 하는 노력이 지속적으로 이루어지고 있다. 강우-유출과정은 시간적, 공간적 다변성을 지닌 수문학적 인자에 의해 좌우되기 때문에 이러한 문제를 해결하기 위해 다년간의 강우-유출 자료를 바탕으로 알고리즘을 생성하고, 이를 바탕으로 정확한 모의가 가능한 수문 모형 및 시스템들을 개발하는데 노력을 기울이고 있다(심순보 등, 1998, 신사철 등, 2002). 그러나 이러한 모형들은 많은 매개변수와 다양한 정보들을 필요로 하게 되어 이들을 처리하는데 많은 어려움이 따른다. 따라서 최근에는 GIS(Geographical Information System)를 활용하여 유역과 분수계를 결정하고 하천형태학적인 특성인자를 추출하는 자동화된 유역정보 추출기술 개발에 대한 관심이 집중되고 있다(Bhaskar, 1992, Francisco, 1995, Yeon, 1999). 이에 본 연구에서는 GIS기법을 이용하여 지형자료로부터 하천연장, 배수면적, 지체시간, 도달시간 등 유역내의 분포형 수문매개변수를 추출하였고 추출된 매개변수를 통해 강우-유출식을 적용하여 분포형 유출량을 산정하는데 활용하고자 한다.ansverse Mercatro) 지구좌표계의 DEM 자료로 변환하였다. 또한 유역의 고도차를 이용한 흐름특성 분석을 위해 수치고도자료를 이용하여 유역흐름특성을 분석할 수 있는 TOPAZ(Topographic PArameteri-Zation) 프로그램을 이용하였다. TOPAZ 프로그램을 통해 분석된 각 격자별 분포형 수문 매개변수는 적합한 관계식을 통해 분포형 유출량을 모의하는데 적용된다.다 정확한 유입량 예측이 가능할 것으로 사료된다.이 작은 오차를 발생하였으며, 전체적으로 퍼프 모형이 입자모형보다는 훨씬 적은 수의 계산을 통해서도 작은 오차를 나타낼 수 있다는 것을 알 수 있었다. 그러나 Gaussian 분포를 갖는 퍼프모형은 전단흐름에서의 긴 유선형 농도분포를 모의할 수 없었고, 이에 관한 오차는 전단계수가 증가함에 따라 비선형적으로 증가하였다. 향후, 보다 다양한 흐름영역에서 장${\cdot}$단점 분석 및 오차해석을 수행한 후에 각각의 Lagrangian 모형의 장점만을 갖는 모형결합 방법을 제시할 수 있을 것으로 판단된다.mm/$m^{2}$로 감소한 소견을 보였다. 승모판 성형술은 전 승모판엽 탈출증이 있는 두 환아에서 동시에 시행하였다. 수술 후 1년 내 시행한 심초음파에서 모든 환아에서 단지 경등도 이하의 승모판 폐쇄 부전 소견을 보였다. 수술 후 조기 사망은 없었으며, 합병증으로는 유미흉이 한 명에서 있었다. 술 후 10개월째 허혈성 확장성 심근증이 호전되지 않아 Dor 술식을 시행한 후 사망한 예를 제외한 나머지 6명은 특이 증상 없이 정상 생활 중이다 결론: 좌관상동맥 페동맥이상 기시증은 드물기는 하나, 영유

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Gizzard Impaction with Bile Stasis in Captive Oriental White Storks (Ciconia boyciana) (사육하는 황새에서 담즙정체를 동반한 사낭경색)

  • Han, Jae-Ik;Son, Hyoung-Won;Mo, In-Pil;Chang, Dong-Woo;Kim, Su-Kyung;Park, Shi-Ryoung;Na, Ki-Jeong
    • Journal of Veterinary Clinics
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    • v.26 no.6
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    • pp.659-662
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    • 2009
  • The Korea Institute of Oriental White Stork Rehabilitation Research (KIOWSRR) is breeding oriental white storks for residential rehabilitation in South Korea. Three oriental white storks were referred with anorexia and depression. Two storks were died before examinations and one stork was died after 1 day of fluid therapy. On necropsy, salmon-colored subcutaneous and visceral fats were examined in all storks. Multiple focal necroses on liver surface were also examined. In gizzards, many gravels and grasses were severely tangled; therefore, it produced a large mass that blocked digestive system of the storks. Small intestinal segments of the stork, which was dead after the fluid therapy, were severely adhesive. On histopathology, diffuse necroses with/without inflammation were examined in the liver, gizzard and intestine in all storks. Bile stasis was additionally examined in the liver. According to the results of the examinations, all storks were diagnosed as gizzard impaction caused by parorexia.

Anti-Oxidative and Anti-Inflammatory Effects of the Solvent Fraction from Theobroma cacao L. Extract (카카오(Theobroma cacao L.) 용매 분획물의 항산화 및 항염증 효과)

  • Kim, Young-Sun;Lee, Jin-Young;Cho, Young-Je;An, Bong-Jeun
    • Journal of Life Science
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    • v.22 no.10
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    • pp.1330-1338
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    • 2012
  • Solvent extracts of Theobroma cacao L. (TCL) were investigated for anti-oxidative and anti-inflammatory effects in order to consider TCL as a functional ingredient for cosmetic products. TCL(A) extract was fractioned according to polarity with $CHCl_3$, EtOAc, n-BuOH, and water. Following TCL(A) fractionation, the electron-donating ability of the n-BuOH and EtOAc solvent fractions (each 100 ${\mu}g/ml$) was about 76.2% and 53.9%, respectively. The superoxide anion radical inhibitory effect of the n-BuOH and EtOAc solvent fractions (each 50 ${\mu}g/ml$) was about 76.09% and 51.4%, respectively. Results of lipid oxidation showed that $Fe^{2+}$ had a greater chelating effect than $Cu^{2+}$. The $Fe^{2+}$ chelating effect of the EtOAc solvent fraction (50 ${\mu}g/ml$) was about 64%. Hyaluronidase inhibition related to the anti-inflammatory effect was 53.0% with EtOAc at 100 ${\mu}g/ml$, while the lipoxygenase inhibitory effect was about 51.32% at 10 ${\mu}g/ml$. The anti-inflammatory activity in the EtOAc fraction inhibited the generation of nitric oxide. Results also showed that iNOS protein expression increased in RAW264.7 cells. In contrast, at 100 ${\mu}g/ml$ EtOAc, iNOS and COX-2 protein expression significantly decreased in LPS-stimulated RAW 264.7 cells.