• Korean Journal of Clinical Pharmacy
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• v.20 no.1
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• pp.66-71
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• 2010

주의력결핍 과잉행동장애는 미국에서 약 200만 명의 어린이에게 나타나는 심각한 만성 신경행동학적 장애이다. 주의력결핍 과잉행동장애 치료의 중심은 약물요법이다. 그러나 현재 환자의 약 30%는 주의력결핍 과잉행동장애를 적응증으로 갖도록 허가된 의약품들을 사용해도 적절한 치료효과를 얻지 못하고 있는 상황이다. Modafinil은 methylphenidate나 amphetamines와 같은 각성제와는 다른 약리학적 기전으로 중추신경계를 항진시킨다. 본 연구는 modafinil의 주의력결핍 과잉행동장애 치료효과에 대한 최신 지견을 얻고자, 1990년부터 2010년 3월까지 MEDLINE에 등재된 논문을 ADHD와 Modafinil이라는 MeSH terms로 검색하여 추출한 자료 중에서 대조군이 사용된 무작위 배정 및 이중맹검 임상연구 사례만을 선별하여 임상적 유용성을 평가하였다. 현재 modafinil은 주의력결핍 과잉행동 장애 치료제로 허가된 의약품은 아니지만 최근 여러 국가에서 시행된 연구들은 modafinil이 안전하고 효과적인 주의력결핍 과잉행동장애 치료제일 수 있다는 결과를 보여주고 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.2
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• pp.213-223
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• 1996

This study was performed to assess depression/anxiety of attention deficit hyperactivity disorder(ADHD) in children and adolescents and to use them as basic material for subdivied ADHD on phenomenological aspects. 51 hospitalized ADHD children and adolescents were assessed using the Korean form of the Kovacs' Children's Depression Inventory(CDI), Korean Form of the State-Trait Anxiety Inventory for Children(STAIC). Their data were compared to normal control of 50 mentally healthy children and adolescents in relation with the dermographic characteristic. The mean scores of CDI and STAIC-5(State) of ADHD group were statistically higher than those of the control group(p<0.01 or p<0.05). The mean scores of STAIC-T(Trait) of ADHD group were higher than those of the control group. These results suggest that the authors suggest that ADHD can be subdivide into pure ADHD, depressive ADHD and anxious ADHD by the comorbidity of the depression/anxiety.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.242-255
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• 1997

Characteristics of attention deficit of attention-deficit hyperactivity disorder(ADHD) were investigated by administering six computerized attention tests of Vienna Test System and four neuropsychological tests to children aged 6-12, with ADHD(n=21) and age-matched normal control children(n=22). The findings indicated that ADHD children show lower level of vigilance, more decline of performance in vigilance task on time, and impaired preparedness to response. They also have selective attention deficit on monitoring tasks, but did not have sustained attention deficit compared with normal control children. On the tasks wich overload their information processing capacity, ADHD children show more impulsive response pattern than normal control children. The performance of ADHD was worse than control on the neuropsychological tests sensitive to frontal lobe dysfunction. The presense 'These' attention deficits supports the theory that the defect of ADHD is due to the dysfunction of more than one brain region, including brain stem reticular formation and frontal lobe.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.4 no.1
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• pp.114-123
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• 1993

The authors applied Toddler Temperament Scale(TTS) to ADHD patient group, other disease group and normal control group to elucidate temperamental characteristics of ADHD patients in their toddler stage. 1) ADHD group showed significant difference from the control group in 'activity', 'rhythmicity', 'approach', 'adaptability', 'intensity', 'persistence' and 'threshold' categories. 2) ADHD group and other disease showed significant difference from the control group in 'adaptability' and 'persistence' categories. 3) ADHD group was significantly different from other disease group or control group in 'activity' and 'approach' categories. 4) In total scores of TTS, ADHD group and other diease group showed significant difference from control group. 5) Classification ratio of TTS for ADHD by discriminant analysis was 84.3%. Above results suggest that the ADHD patients may reveal characteristic traits in their toddler stage Further research should be focused on the development and refinement of assessment tools for the early detection and prevention for ADHD.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.976-979
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• 2008

As internet occupies a great deal of portion in our life, a lot of mental diseases become the points at issue relating to internet addiction. The purpose of this study is to examine whether internet addiction is related with Attention Deficit Hyperactivity Disorder that is characterized with sustained inattention, hyperactivity and impulsivity and then find out which sub-factors of internet addiction are influencing effective on Attention Deficit Hyperactivity Disorder. As result of applying reliability analysis, frequency analysis, cross tabulation analysis, t-test, ANOVA, Pearson's correlation analysis and multiple regression analysis, it shows the following research results.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.1-8
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• 2016

Objective : The purpose of this study was to determine the reliability of Test of Playfulness (ToP) in Attention Deficit Hyperactivity Disorder (ADHD) children. Methods : Twenty ADHD children participated in this study. To determine inter-rater reliability, two raters was evaluated by Test of Playfulness scores and analyzed Kappa coefficient and total agreement and intraclass correlation coefficient (ICC). Results : Total agreement was the range of 75%~95% and the Kappa coefficients was the range of. 45~1.00. Analyzing inter-rater reliability by ICC showed very high reliability: Intrinsic motivation was .96, internal control was .98, suspension of reality was .90, framing was .98, total score was .99. Conclusion : A reliability of Test of Playflness of children with ADHD showed that high. On the basis of this study, it will provide availability for clinical evaluation of children with ADHD, and basic study on the play of children with ADHD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.2
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• pp.179-189
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• 1996

Objective : This study was conducted to find out the electrophysiological abnormalities of the patients with attention-deficit/hyperactivity disorder(abbr. ADHD) through identifying the profiles of the event-related potentials. Methods : Through measuring event-related potentials of 20 patients with ADHD and 16 normal control children using Oddball paradigm, we evaluated the latencies and amplitudes of each wave form. Results : In the group older than 9 years old, the latencies that reflect selective attention and discriminative capacity of the patients with ADHD were significantly longer than those of normal controls, which suggests that patients with ADHD be more distractible to non-significant stimuli and that they be in lark of sustained attention and discriminative ability. Conclusions : We concluded that the patients with ADHD are more distractible to trivial stimuli than normal children but they lack discriminative, sustained ability of attention.

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.285-297
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• 2014

The purpose of this study is to examine the associations among attention deficit/hyperactivity, social withdrawal, peer relationships, and depression in early adolescence. Gender differences in the associations were also examined. This study investigated these relationships and the gender differences using structural equation modeling multi-group analysis. The third wave data from Korea Children and Youth Panel Survey (KCYPS) of fourth graders were analyzed. The results indicated that attention deficit/hyperactivity had significant effects on depression directly and indirectly through social withdrawal and peer relationships. These results suggest that new programs should be developed to prevent or alleviate depression associated with attention deficit/hyperactivity among adolescents. Specifically, social withdrawal and peer relationships need to be emphasized in planning prevention or intervention programs to promote mental health of adolescents with attention deficit/hyperactivity.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.12 no.1
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• pp.25-50
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• 2001

Using Fourier transformation and wavelet analysis, we compared the auditory event-related potentials of the patients with attention deficit-hyperactivity disorders(abbr. ADHD, 13 boys) and normal control children(8 boys). Amplitudes of the event-related potentials which were calculated via Fourier transformation were compared between the groups and between conditions(non-target versus target) in each group. To the non-target stimuli, the patients with ADHD showed significantly greater amplitudes across almost all of the electrode sites and frequencies. To the target stimuli, the incidents which ADHD patients showed much higher amplitudes than normal controls significantly decreased, while those of the reverse results increased significantly. These results were consistent with the comparison results about negative difference wave(abbr. Nd wave) using Fourier transformation. In summary, it was proved that non-target stimulus which should be ignored elicited more robust electrical response from the patients with ADHD than normal children, but the target stimulus which reguired active processing did much less electrical activity in the patients. For the patients, they showed much inhibited electrical response to the target stimuli in some electrodes and frequency ranges. Normal children were more strongly stimulated by the target stimuli in almost all electrodes and frequency ranges than the patients, but less in prefrontal leads and frontal leads. Wavelet analysis results proved that early responses(0-300msec) to the nontarget stimuli of the patients were significantly greater than the normal controls in prefrontal, anterior frontal, some parts of temporal, and occipital lobes and that late response(300-370msec) were significantly lesser than normal children in parietal and central electrodes. Target stimuli elicited significantly higher electrical activity in both group than non-target stimuli did. Prefrontal and frontal lobes showed stronger responses in the patients than normal children irrespective of stimulus condition, but parietal and temporal lobes did higher activities in normal children than the patients only to the target stimuli. In conclusion, the patients with ADHD showed much greater responses to the stimuli which should be ignored, but failed to activated the necessary processes to the target stimuli. Also, we found that the frequency-dimension analysis and wavelet analysis were useful for the signal processing such as event related potentials.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.1
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• pp.44-51
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• 1996

Objective : The authors investigated family environemtn of ADHD referred to child psychiatric clinics. Method : Seventy two patients were grouped into pure ADHD and comorbid ADHD. Patient's lither and mother conducted the Korean Form of the Family Environment Scale(K-FES). And then, scores were compared with that of 77 normal controls. Results : Among subscales of K-FES, expressiveness, achievement orientation and organization were scored significantly lower in ADHD mothers' reporting than ADHD fathers' And only organization subscale was scored significantly lower in ADHD fathers' reporting than controls' In post hoc comparison, subscales of expressiveness, moral-religious emphasis and organization were significantly lower in mothers' reporting of pure ADHD and comorbid ADHD than of controls, and only organization subscale was significantly lower in fathers' reporting of comorbid ADHD than of controls. Conclusion : Parents of ADHD patients agreed that their families were not well organized, and each perceived somewhat differently on the family environment. Further study is needed to eludicate whether specific family environment causes ADHD or is caused by behavior of ADITD patients.