• Title/Summary/Keyword: 주사시간

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Impact of the Planning CT Scan Time on the Reflection of the Lung Tumor Motion (전산화단층촬영 주사시간(Scan Time)이 폐종양운동의 재현성에 미치는 영향 분석)

  • Kim Su Ssan;Ha Sung Whan;Choi Eun Kyung;Yi Byong Yong
    • Radiation Oncology Journal
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    • v.22 no.1
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    • pp.55-63
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    • 2004
  • Purpose : To evaluate the reflection of tumor motion according to the planning CT scan time. Material and Methods : A model of N-shape, which moved aiong the longitudinal axis during the ventilation caused by a mechanical ventilator, was produced. The model was scanned by planning CT, while setting the relative CT scan time (T: CT scan time/ventilatory period) to 0.33, 0.50, 0.67, 0.75, 1.00, 1.337, and 1.537. In addition, three patients with non-small cell lung cancer who received stereotactic radiosurgery In the Department of Radiation Oncology, Asan Medical Center from 03/19/2002 to 05/21/2002 were scanned. Slow (10 Premier, Picker, scan time 2.0 seconds per slice) and fast CT scans (Lightspeed, GE Medical Systems, with a scan time of 0.8 second per slice) were peformed for each patient. The magnitude of reflected movement of the N-shaped model was evaluated by measuring the transverse length, which reflected the movement of the declined bar of the model at each slice. For patients' scans, all CT data sets were registered using a stereotactic body frame scale with the gross tumor volumes delineated in one CT image set. The volume and three-dimensional diameter of the gross tumor volume were measured and analyzed between the slow and fast CT scans. Results : The reflection degree of longitudinal movement of the model increased in proportion to the relative CT scan times below 1.00 7, but remained constant above 1.00 T Assuming the mean value of scanned transverse lengths with CT scan time 1.00 T to be $100\%$, CT scans with scan times of 0.33, 0.50, 0.57, and 0.75 T missed the tumor motion by 30, 27, 20, and $7.0\%$ respectively, Slow (scan time 2.0 sec) and Fast (scan time 0.8 sec) CT scans of three patients with longitudinal movement of 3, 5, and 10 mm measured by fluoroscopy revealed the increases in the diameter along the longitudinal axis Increased by 6.3, 17, and $23\%$ in the slow CT scans. Conculsion : As the relative CT scan time increased, the reflection of the respiratory tumor movement on planning CT also Increased, but remained constant with relative CT scan times above 1.00 T When setting the planning CT scan time above one respiration period (>1.00 T), only the set-up margin is needed to delineate the planning target volume. Therefore, therapeutic ratio can be increased by reducing the radiation dose delivered to normal lung tissue.

그람 양성균 감염증에서 Vancomycin 과 Teicoplanin 의 임상효과의 비교 연구

  • 최강원;오명돈;배현주
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.331-331
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    • 1994
  • 최근 개발된 Teicoplanin은 glycopeptide계의 항생제로서 vancomycin과 그 작용 기전이 비슷하지만, 근육 주사가 가능하고, 반감기가 길어서 하루 한번 주사하여도 되며, 빨리 주입하더라도 red man syndrome이생기지 않는 장점이 있다. 이 연구의 목적은 그람 양성균에 의한 감염증을 치료하는데 teicoplanin이 효과적이고 안전한지를 vancomycin과 비교하는 것이다. 대상 환자 및 방법: 서울대학교병원에 입원하여 그람 양성균 감염증이 확인되거나 강력히 의심되는 환자를 대상으로 하였다. 감염증의 종류는 패혈증, 골수염, 하기도 감염증, 감염성 관절염, 피부 및 연조직 감염증, 요로 감염증으로 하였다. 대상 환자를 무작위로 teicoplanin또는 vancomycin군에 무작위 배정하였다. Teinoplanin은 처음에 loading을 위하여 400mg씩 12시간마다 3회 주사하고 이후에는 증증 감염이면 하루에 400mg, 중등중이면 200mg씩을 주사하였다. Vancomycin은 500mg을 6시간마다 또는 1. 0g을 12시간마다 정맥주사하였다. 치료 기간은 요로 감염증 5-10일, 하기도 감염증 5-10일, 패혈증 14-21일, 골수염 21-42일, 세균성 관절염 21-42일, 피부 및 연조직 감염증 5-10일로 하였다.

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난소를 제거한 생쥐 자궁조직에서 ADAM-8, -9, -10, -12, -15, -17, -TS1의 발현

  • 김지영;배인희;이승재;최영민;김해권
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 2003.10a
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    • pp.59-59
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    • 2003
  • ADAM은 metalloprotease/disintegrin domain을 가진 transmembrane glycoprotein으로서 지금까지 30종류 이상의 ADAM 및 10종류 이상의 ADAM-TS 단백질이 알려져 있다. 이들의 기능은 포유동물의 수정 시 sperm-egg binding과 fusion, myoblast fusion, integrin과의 결합 등에 직접 관여하거나, TNF-alpha 등의 생체신호전달물질이 세포로부터 분비될 때에 이들의 구조를 변화시켜 활성화시키는 효소로서의 작용, 그리고 dendritic cell differentiation 등에 관여하는 것으로 알려져 있다. 본 연구에서는 난소가 제거된 생쥐를 이용하여 자궁조직의 ADAM-8, -9, -10, -12, -15, -17 그리고 -TS1의 gene의 발현이 $17 \beta $-estradiol에 의하여 조절되는 지를 알아보았다. 생후 6 - 8주 된 암컷 생쥐의 난소를 제거하고, 2 주 후에 $17 \beta $-estradiol ($E_2$), progesterone ($P_4$) 혹은 이 둘 혼합액 ($E_2 + P_4$)을 sesame oil에 녹여 근육주사하였다. 2, 6, 12 시간 후 각각 자궁 조직을 얻고 유전자의 발현 양상을 알아보기 위하여 시료로부터 total RNA을 추출하여 역전사 중합효소반응 (RT-PCR)을 실시하였다. Densitometry를 이용, rpL7에 대한 ADAMS의 mRNA 발현 양을 상대적으로 분석하였다. 그 결과 ADAM-8과 -15는 6시간째에서, ADAM-10과 -TS1은 2시간째에서 sesame oil을 주사하거나 $P_4$만을 주사한 군보다 E$_2$를 주사한 군에서 mRNA의 양이 현저하게 증가하였고 ADAM-12는 2시간째에서 ADAM-17은 12시간째에서 sesame oil을 주사하거나 $P_$만을 주사한 군보다 E$_2$를 주사한 군에서 mRNA의 양이 현저하게 증가하였다. 이러한 결과로 미루어 ADAM-8, -10, -15 그리고 TS1은 progesterone에 의하여, ADAM-12와 17은 $17 \beta $-estradiol에 의하여 유전자의 발현이 upregulation 되는 것으로 생각되어진다.

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The feature of scanning path algorithm shown at natural visual search activities of space user (공간사용자의 본능적 시선탐색활동에 나타난 주사경로 알고리즘 특성)

  • Kim, Jong-Ha;Kim, Ju-Yeon
    • Science of Emotion and Sensibility
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    • v.17 no.2
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    • pp.111-122
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    • 2014
  • This study has analyzed the scanning path algorithm shown at the process of exploring spatial information through an observation experiment with the object of lobby in subway station. In the estimation of observation time by section, the frequency of scanning type was found to increase as the observation time got longer, which makes it possible that the longer the observation lasts the more the observation interruptions occur. In addition, the observation slipped out of the range of imaging when any fatigue was caused from the observation or the more active exploration took place. Furthermore, when the trend line was employed for the examination of the changes to the scanning type by time section, "concentration" "diagonal or vertical" showed a sharp and a gentle increases along with the increase of time section respectively, while "circulation. combination, horizontal" showed a reduction. The observation data of the subjects observing a space include various visual information. The analysis of the scanning type found at "attention concentration" enabled to draw this significant conclusion. The features of increase and decrease of scanning types can be a fundamental data for understanding the scanning tendency by time.

수유모돈의 조기발정과 임신

  • Kim, Myeong-Jin
    • The Korea Swine Journal
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    • v.6 no.9 s.61
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    • pp.118-121
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    • 1984
  • 수유모돈 56두로 4차에 걸쳐 PMS와 HCG로 발정을 유도, 임신시키는 시험을 실시하였다. 분만25일된 수유모돈에 PMS 1,500IU를 근육주사하고 그후 96시간에 HCG1,000IU를 근육주사하면 수유중인 모돈에 발정이 온다. HCG주사후 24시간과 36~42시간에 2회 수정하여 임신시켰다.

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Assessment of the Rock Strength using Borehole Acoustic Scanner (초음파 주사검층 방법을 이용한 암반강도 평가에 관한 연구)

  • Lee Kwangbae;Heo Seung;Song Young-Soo;Song Seungyup;Kim Haksoo
    • Geophysics and Geophysical Exploration
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    • v.7 no.4
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    • pp.225-233
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    • 2004
  • The purpose of this study is to provide the geo-technical information by assessment of the in-situ rock strength using the reflected wave energy and travel time data acquired by the borehole acoustic scanner. In order to compare and analyze the relationship between the uniaxial compressive strength and the reflected wave energy, the laboratory test and the borehole acoustic scanning were conducted for the set of specimens, such as mortar, concrete, and rock samples which have different rock type. Finally, we verified the applicability of the reflected wave energy acquired by the borehole acoustic scanner to quantitatively estimate the in-situ rock strength.

사슴의 발정동기화 및 Ov-Sync. 방법에 따른 예정시각 인공수정 후 수태율 및 분만율

  • 이장희;김인철;이동원;류일선;박성재;서국현;김상우;유충현;정경용
    • Proceedings of the KSAR Conference
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    • 2001.10a
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    • pp.66-67
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    • 2001
  • 사슴의 예정시각 인공수정기술을 개발하기 위해 엘크 93 두에 대해 CIDR(InterAG, New Zealand)의 질내 14 일간 삽입방법으로 발정동기화처리하고 배란을 유기하기 위하여 제거시 PMSG(Folligon, Intevet, Holland) 200 IU(T₁) 또는 250 IU(T₂) 를 근육주사 한 후 60시 간에 Conceral/sup R/ 2㎖를 주사하고 인공수정 하거나, CIDR제거 후 24시간 때에 hCG(Folligon, Intevet, Holland) 500IU를 근육주사하고 12시간 후 (CIDR제거 후 36h) Receptal/sup R/ 2㎖를 주사하고 CIDR 제거 후 60 시간 때에 인공수정 (T₃) 하였으며, 수정 후 40일경에 초음파진단 (Sonovet-600, 6.5㎒ probe)으로 수태율을 조사하였다. (중략)

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Accumulation of Lipid Including Cholesterol in Murine Hepatocytes with Hyperlipidemia Induced by Triton WR-1339 (Triton WR-1339 주사에 의한 고지혈증 유발시 간세포내 지방 축적에 관한 형태학적 연구)

  • Park, In-Sick;Ahn, Sang-Hyun;Kim, Jin-Taek
    • The Journal of Dong Guk Oriental Medicine
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    • v.6 no.1
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    • pp.107-115
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    • 1997
  • Hapatic tissues of ICR mouse intraperitoneally injected with Triton WR-1339 were observed to investigate the morphologic change of liver by destruction of lipid metabolism as hyperlipidemia. The hepatic tissues were obtained at hour-24, 48, and 72 after triton injection that were fixed in fromol-calcium solution and were cryocut. These tissues were stained by H&E for general morphology, sudan black B for lipid, and perchloric acid-naphthoquinone method for cholesterol. The increase of hepatocyte having meshlike cytoplasm were shown in all hepatic lobules after triton injection and the hepatic plates were disappeared in the region aggregated meshlike hepatocyte. The number of blue black colored lipid drop and dark green colored asterisk shaped cholesterol particle in hepatic cytoplasm were increased than the saline injected mouse and the size of lipid drop was enlarged. As results indicated that the lipid metabolism were destructed by triton injection, subsequently hepatocyes accumulated with lipid including cholesterol.

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Assessment of Uterine Internal Temperature according to the Time of Convex Probe Injection using a Self-made Uterine Model Phantom (자체 제작한 자궁모형팬텀을 이용한 Convex probe 주사시간에 따른 자궁내부온도 평가)

  • Lee, Hyun-Kyung;Heo, Yeong-Cheol
    • Journal of the Korean Society of Radiology
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    • v.13 no.6
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    • pp.895-900
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    • 2019
  • Ultrasound is known to be harmless to the human body and is widely used in obstetrics and gynecology to confirm the diagnosis and development status of fetus. Diagnosis Although long - term use of ultrasound may cause changes in body temperature, studies on the uterine temperature changes due to ultrasound have been lacking. The purpose of this study was to investigate the change of temperature according to ultrasonic scanning time using a self - produced uterine model phantom. Ultrasound equipment and a 4MHz convex probe were used to construct the uterine model phantom similar to the human uterus using acrylic and pig uterus, which are tissue equivalents. Three probe type thermometers were installed to measure the inside of the acrylic water tank, the uterus, and the atmospheric temperature. The temperature of the uterine phantom was ascertained by measuring the temperature of the subject for 6 hours, 361 times. In this study, the possibility of human body temperature elevation due to ultrasound could be confirmed and this study will be used as the basic data of ultrasonic heat absorption study.

The Change of Food Intake in Morphine Treated Rat (몰핀이 흰쥐의 Food Intake 에 미치는 영향)

  • Kim, Ha-Rriet;Cho, Kang-Hee
    • Journal of Nutrition and Health
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    • v.17 no.4
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    • pp.313-319
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    • 1984
  • The effect of morphine on food intake on freely fed Sprague - Dawley rats was examined Opiate receptor binding assay was used to investigate the possibility of the opioid system involved in food intake regulation of normal rats. When rats were treated with 5mg morphine per kg body weight, subcutaneously, the food intake of the rats for the first 2 hours was increased 125% of the control rats. The effect of morphine on food intake of male and female rats were greater when the morphine was injected at 10 : 00 a.m than that in the rats administered the morphine at 4 : 00 p.m. The morphine effect was not significant in older rats and female was more responsive than male rats. In morphine treated rats, opioid receptor density has exhibited 33% reduction as measured by the $^{3}H-naloxone$ binding assay with whole brain homogenate. These results indicate that the increase of food intake by morphine for 2 hours after the injection may be mediated through the opioid system in rat brain.

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