Journal of Nutrition and Health
- Volume 17 Issue 4
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- Pages.313-319
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- 1984
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- 2288-3886(pISSN)
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- 2288-3959(eISSN)
The Change of Food Intake in Morphine Treated Rat
몰핀이 흰쥐의 Food Intake 에 미치는 영향
- Kim, Ha-Rriet (Dept. of Food and Nutrition, Seoul National Univ.) ;
- Cho, Kang-Hee (Dept. of Food and Nutrition, Seoul National Univ.)
- Published : 1984.12.30
Abstract
The effect of morphine on food intake on freely fed Sprague - Dawley rats was examined Opiate receptor binding assay was used to investigate the possibility of the opioid system involved in food intake regulation of normal rats. When rats were treated with 5mg morphine per kg body weight, subcutaneously, the food intake of the rats for the first 2 hours was increased 125% of the control rats. The effect of morphine on food intake of male and female rats were greater when the morphine was injected at 10 : 00 a.m than that in the rats administered the morphine at 4 : 00 p.m. The morphine effect was not significant in older rats and female was more responsive than male rats. In morphine treated rats, opioid receptor density has exhibited 33% reduction as measured by the
몰핀의 투여량, 몰핀을 주사하는 시간, 쥐의 나이에 따라서 몰핀이 food intake에 미치는 효과 유무를 Sprague-Dawley 쥐를 이용해 조사하였다. 또한
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