• Journal of Life Science
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• v.31 no.4
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• pp.389-399
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• 2021

This study determined the effects of Centella asiatica leaf on H₂O₂ induced cell cycle arrest, mitochondrial activity, and proinflammatory cytokine production in human dermal fibroblast (HDF) cells. We used an 80% methanol extract of C. asiatica, its ethyl acetate fraction, and asiaticoside, the major constituent of C. asiatica. The C. asiatica extract, its ethyl acetate fraction, and asiaticoside attenuated G1 cell cycle-arrest and the apoptotic effect caused by H₂O₂-induced oxidative stress. The cells treated with C. asiatica extract, its ethyl acetate fraction, and asiaticoside secreted lower levels of TNF-α and IL-6. The antioxidant effect of asiaticoside was higher than that of C. asiatica extract and its ethyl acetate fraction. Treatment with C. asiatica extract, its ethyl acetate fraction, and asiaticoside also increased the mitochondrial membrane potential and restored normal mitochondrial morphology. Following H₂O₂ stress induction, cells treated with C. asiatica extract, its ethyl acetate fraction, and asiaticoside showed increased mitochondrial oxygen consumption rates and decreases in the TLR4-MyD88-TRAF6-p65 pathway activity. These findings suggest that C. asiatica extract, its ethyl acetate fraction, and asiaticoside have antioxidant and anti-inflammatory effects, as well as the ability to control the mitochondrial activities of HDF cells.

• Journal of Digital Convergence
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• v.20 no.2
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• pp.447-454
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• 2022

The purpose of this study was to strengthen the practicality of preliminary teachers in preparation for future education, to respond to structural changes in the teacher training system due to a decrease in the school-age population, and to seek a future-oriented direction for the curriculum of teacher training institutions. To this end, we analyzed the competency diagnosis items of the teacher training institutes in the 5th cycle from 2019 to 2020, and based on the proposal for the development plan for the teacher training system announced by the Ministry of Education in July 2021 and the contents of the 4 discussions, content was presented. The results were as follows. First, to nurture creative and convergence-type talents, teacher training institutions need to develop multi-curricular competency and reorganize the curriculum into a future-oriented curriculum. Second, in order to foster the competence of teachers and preliminary teachers in teacher training institutions, it is essential to strengthen the competence of teachers through the introduction of the metaverse, general teaching methods, and ICT-using teaching methods. Third, teachers' training institutions will introduce and strengthen the 'education practice teacher homeroom system' to strengthen school field-oriented practical competencies, 'dedicated mentor-mentee' centered on seniors and juniors, 'monitoring system' led by university professors, and 'probationary teacher system'

• Journal of Advanced Technology Convergence
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• v.1 no.2
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• pp.69-73
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• 2022

The purpose of this study was to identify the influencing factors of subjective health status among the subjects of the 7th year 3 (2018) National Health and Nutrition Examination Survey, and to help provide programs for improving subjective health status in the future. Data from the 7th Korea National Health and Nutrition Examination Survey(2018) were used. Variables were age, gender, age, subjective health status, subjective body shape recognition, weight change over the past year, usual stress level, walking days per week, and strength training days per week. The higher the number of walking days per week, the lower the usual stress perception level. As the number of strength training days per week increased, the level of stress perception was lower (p<.001). The subjects' subjective health status was found to have a negative effect on their usual stress perception (β=-.759), subjective body shape (β=.111), age (β=.421), and number of days walking per week. (β=.968). Based on this study, it is intended to provide basic data for preparing programs to help improve stress perception and subjective health status in the future.

• Journal of Nutrition and Health
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• v.55 no.3
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• pp.330-347
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• 2022

Folate, a water-soluble vitamin, acts as a coenzyme for one-carbon metabolism in nucleic acid synthesis and amino acid metabolism. Adequate folate nutritional status during the periconceptional period is known to prevent neural tube defects. In addition, insufficient folate intake is associated with various conditions, such as anemia, hyperhomocysteinemia, cardiovascular disease, cancer, cognitive impairment, and depression. This review discusses the rationale for the revision of the 2020 Korean dietary reference intakes for folate, and suggestions for future revisions. Based on the changes in the standard body weight in 2020, the adequate intake (AI) for infants (5-11 months) and the estimated average requirements (EARs) for 15-18 years of age were revised, but there were no changes in the recommended nutrient intakes (RNIs) and tolerable upper intake levels (ULs) for all age groups. Mean folate intake did not reach RNI in most age groups and was particularly low in women aged 15-29 years, according to the results of the 2016-2018 Korea National Health and Nutrition Examination Survey (KNHANES). The percentages of folate intake to RNI were lower than 60% in pregnant and lactating women, but serum folate concentrations were higher than those in other age groups, presumably due to the use of supplements. Therefore, total folate intake, from both food and supplements, should be evaluated. In addition, the database of folate in raw, cooked, and fortified foods should be further expanded to accurately assess the folate intake of Koreans. Determination of the concentrations of erythrocyte folate and plasma homocysteine as well as serum folate is recommended, and quality control of the analysis is critical.

• Journal of the Korea Society of Computer and Information
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• v.27 no.11
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• pp.181-190
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• 2022

In this paper, we use a LiDAR sensor and an image camera to detect a left-turning waiting vehicle in two ways, unlike the existing image-type or loop-type left-turn detection system, and a left-turn traffic signal corresponding to the waiting length of the left-turning lane. A system that can efficiently assign a system is introduced. For the LiDAR signal transmitted and received by the LiDAR sensor, the left-turn waiting vehicle is detected in real time, and the image by the video camera is analyzed in real time or at regular intervals, thereby reducing unnecessary computational processing and enabling real-time sensitive processing. As a result of performing a performance test for 5 hours every day for one week with an intersection simulation using an actual signal processor, a detection rate of 99.9%, which was improved by 3% to 5% compared to the existing method, was recorded. The advantage is that 99.9% of vehicles waiting to turn left are detected by the LiDAR sensor, and even if an intentional omission of detection occurs, an immediate response is possible through self-correction using the video, so the excessive waiting time of vehicles waiting to turn left is controlled by all lanes in the intersection. was able to guide the flow of traffic smoothly. In addition, when applied to an intersection in the outskirts of which left-turning vehicles are rare, service reliability and efficiency can be improved by reducing unnecessary signal costs.

• Journal of the Daesoon Academy of Sciences
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• v.32
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• pp.109-136
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• 2019

The purpose of this study is to look at the concept of Gaebyeok as used by Kang Jeungsan (姜甑山) from a civilizational perspective. The combination of East Asian civilization during the period of Korea's port-opening and the subsequent inflow of Western powers with material civilization all at the forefront in the late Joseon Korea, served as the driving force for a new civilizational transition. Unlike the Chuk-sa Party and the Gae-hwa Party, modern Korean religions that emphasized Gaebyeok also responded to Western civilization and suggested a new view of civilization. Kang Jeung-san, resisting discrimination and oppression, presented a civilization built upon mutual beneficence while criticizing Western civilizations which centered on reason. Amid this process of the spread of modern Western civilization, Jeungsan declared the construction of a new civilization to the people who were negatively impacted by various social factions, such as class and gender discrimination, political corruption, exploitation via political corruption, and the inflow of Western powers. Jeungsanist Thought developed criticisms of materialism and human alienation, and this resulted in the claim of Gaebyeok. This was an expression of efforts to build a new civilization that aimed to harmonize, integrate, and thrive. The new civilization envisioned by Jeungsan was that of a society run according to mutual beneficence, and it can be summarized as a 'Civilization of Harmonious Union' that integrates philosophical thought and civilizational models of both East and West. This could also be referred to a 'Civilization of Public-commons and Harmony between Divine Beings and Human Beings (神人公共).' The life of Jeungsan was a life spent in the service of curing the world to save the lives of humanity. Since then, his 'movement of mutual beneficence' as observed in Mugeuk-do and Taegeuk-do were also efforts to build the new civilization envisioned by Jeungsan.

• Korean Journal of Food Science and Technology
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• v.54 no.1
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• pp.28-34
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• 2022

Glioblastoma is the most common primary malignant brain tumor and has an extremely poor prognosis. Glioblastoma stem cells (GSCs) contribute to tumor initiation, recurrence, and resistance to therapy, and are thus a key therapeutic target. The peel of Citrus unshiu Markovich has been used in traditional medicine in East Asia to treat various diseases. In this study, we investigated the anticancer activity and molecular mechanism of the chloroform extract of this natural product (CECU) in U87MG GSCs. The results show that CECU inhibited the proliferation, tumorsphere formation, and migration of U87MG GSCs by causing cell cycle arrest at the G0/G1 phase and apoptosis. In addition, CECU downregulated key cancer stemness regulators, including CD133, Oct4, Nanog, integrin α6, ALDH1A1, and STAT3 signaling in U87MG GSCs. Furthermore, CECU significantly suppressed in vivo tumor growth of U87MG GSCs in a chorioallantoic membrane model. Therefore, CECU can be utilized as a natural medicine for the prevention and treatment of glioblastoma.

• 한국노년학
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• v.29 no.3
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• pp.953-970
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• 2009

The successful aging paradigm suggests that the elderly keep their social ties and actively participate in various activities in later life. Many Korean studies on aging, however, have overlooked the importance of various social activities and relationships beyond kinship. This article aims to investigate the perceived social activities among Korean elders to comprehend the subjectivity of successful aging. 613 respondents, over 50 years old, are selected from a national survey data which was collected by face-to-face interview based on the structured questionnaire. The respondents are classified into pre old (50-64), young old (65-74), old old (over 75). Major findings are as follows. The social activities are grouped into two sub-categories: 'relational activity' and 'productive activity'. The activity types are different by the age cohorts. Various activities are considered in terms of one's needs or motivations, and properly chosen based on the subjective evaluation during life course. Both demographic variables such as sex, area and social context variables such as marital status, living-together show influence on the activity type choices. Plans for later life and work ethics are important as well. Policies regarding social participation emphasizing productivity should positively consider relational motives, as perceived by the Korean elderly.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.69-69
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• 2020

식물체가 건조 스트레스를 받으면 각 기관 물질 생산의 변이, 분화 및 발달 억제를 통해서 식물의 생산활동을 현저히 저하시켜, 식물의 생장, 형태, 개체발생 및 대사생리에 영향을 미치는 것으로 연구되어 왔다. 최근 기후 온난화로 인해 온도가 점진적으로 상승하고 가뭄과 같은 이상기상이 빈번하게 발생함에 따라 많은 노지 작물의 농업 생산성이 약화되고 있다. 배추는 우리나라의 대표적인 식품 중 하나인 김치의 주재료로 연중 안정적인 생산과 공급이 필요시 되지만, 배추의 경우 건조 조건에서 엽육조직의 붕괴와 같은 생리장해가 발생되기 때문에 최근 발생되고 있는 이상 기후의 영향으로 안정적인 생산이 어려워지고 있는 실정이다. 하지만, 배추에서는 이상 기후에 대응이 가능한 내건성 품종의 육성을 위한 연구는 미흡한 실정이다. 따라서 본 연구에서는 내건성이 높은 배추 개발을 위한 기초소재를 찾는 것을 목적으로 농촌진흥청 유전자원센터에서 보존하고 있는 재래종 배추 30계통을 분양받아 강릉원주대학교 생명과학대학 내의 조직배양실을 이용하여 연구를 수행하였다. 배지는 Tissue Culture Square Dish(125×125×20mm)에 Agar를 녹여 40ml씩 분주하여 고체배지를 조성한 후, 건조 처리구 Polyrthylene glycol 6000(PEG) 0%(Control), 20%(Mild Stress), 30%(Severe Stress)를 설정하여 60ml씩 추가 분주하여 배양기 28℃에서 15시간 처리를 하였다. 분양받은 각 계통의 종자는 1% 차아염소산 나트륨으로 10분간 종자표면을 살균한 후, 5번 정도 멸균수로 헹군 후, 표면 살균한 재래종 종자를 고체배지 시험관에 6립씩 치상하였다. 식물체 생육은 각 처리구별 3반복으로 하였으며 주간 12시간 주기, 광도 2,400Lux, 온도 20℃의 조직배양실에서 치상 후 7일간 생육하였다. 치상 후 7일간 생육시킨 식물체를 채취하여 지상부생체중, 지하부 생체중, 뿌리 길이를 측정하였으며, 지상부와 지하부로 나누어 50℃에서 72시간 건조시킨 후, 건물 생산량을 조사하였다. 본 실험 결과 건조 처리(PEG-6000)는 배추의 생장을 저해하였지만, 생육 저해 정도는 계통간의 차이가 있는 것을 관찰할 수 있었으며 무처리구와 스트레스 처리구간의 생장량 변화 정도를 기반으로 군집분석을 수행한 결과 'IT110483'과 'IT104903' 계통이 실험에 공시된 계통들 중 상대적으로 강한 건조 내성을 가진 것을 확인할 수 있었다. 따라서, 재래종 배추 계통 중 일부는 건조내성이 강한 새로운 배추 품종을 육성하는데 있어 유용하게 이용될 수 있을 것으로 사료된다.

• Korean Journal of Remote Sensing
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• v.39 no.6_1
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• pp.1273-1281
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• 2023

Absolute radiometric calibration is a crucial process in converting the electromagnetic signals obtained from satellite sensors into physical quantities. It is performed to enhance the accuracy of satellite data, facilitate comparison and integration with other satellite datasets, and address changes in sensor characteristics over time or due to environmental conditions. In this study, field campaigns were conducted to perform vicarious calibration for the multispectral channels of the CAS500-1. Two valid field observations were obtained under clear-sky conditions, and the top-of-atmosphere (TOA) radiance was simulated using the MODerate resolution atmospheric TRANsmission 6 (MODTRAN 6) radiative transfer model. While a linear relationship was observed between the simulated TOA radiance of tarps and CAS500-1 digital numbers(DN), challenges such as a wide field of view and saturation in CAS500-1 imagery suggest the need for future refinement of the calibration coefficients. Nevertheless, this study represents the first attempt at absolute radiometric calibration for CAS500-1. Despite the challenges, it provides valuable insights for future research aiming to determine reliable coefficients for enhanced accuracy in CAS500-1's absolute radiometric calibration.