• Journal of Korean Ophthalmic Optics Society
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• v.14 no.3
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• pp.51-57
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• 2009

Purpose: The purpose of this study was to determine if monocular and binocular accommodative facility tests would be useful in diagnosing general binocular dysfunctions. Methods: 95 symptomatic children, who were selected from comprehensive vision tests, were classified into four groups (29 subjects with accommodative dysfunctions, 28 subjects with vergence dysfunctions, 25 subjects with combined accommodative and vergence dysfunctions, 13 subjects with normal binocular functions). Monocular and binocular accommodative facility was measured with ${\pm}$2.00 D flipper lenses. Results: Statistical analysis revealed that binocular accommodative facility measurement was significantly lower than monocular accommodative measurement in the vergence dysfunction group (p<0.01). However, there were no differences between monocular and binocular accommodative facility measurements in the group of accommodative or combined accommodative and vergence dysfunction (p>0.05). In addition, subjects with general binocular dysfunctions performed significantly poorer than subjects with normal binocular function on monocular and binocular accommodative facility (p<0.000). Conclusions: As a result of this study, monocular and binocular accommodative facility test, which could differentiate dysfunction from normal as well as between dysfunctions, indicated useful means for diagnosis of general binocular dysfunctions.

• The Monthly Diabetes
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• s.220
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• pp.3-4
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• 2008

간은 우리 몸의 중요한 역할을 하며 이러한 간에 급성 또는 만성적 문제가 생기는 경우 여러 합병증이 유발 되지만 특히 당뇨병 환자에서는 혈당 조절 기전의 중요한 요소인 간 이상으로 인하여 혈당 조절 균형이 깨지면서 심한 혈당조절의 이상을 초래하게 된다.

• The Korean Journal of Vision Science
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• v.20 no.4
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• pp.453-459
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• 2018

Purpose : This study was to investigate the change of accommodative functions by different color density and color of colored lenses. Methods : Participant had a normal NPC and no dyschromatopsia, phoria and eye disease, also had no histories of eye surgery in 31 students of university. Their accommodative functions were measured according to 50%, 80% density of the gray, blue, brown lens and non-colored lenses. Tests of accommodative functions performed include amplitude of accommodation, accommodative facility, relative accommodation, and accommodative lag. Results : The amplitude of accommodation and accommodation lag were increased when wearing the colored lens. Negative relative accommodation was more increased when wearing the colored lens than achromatic. Positive relative accommodation increased when wearing the blue color lens density by 50%. Also, accommodation facility increased when wearing the colored lens, but, as the density of the color increased, the accommodation facility was decreased. Conclusion : As since the accommodation function changes according to density of the colored lenses, working distance and environment of the wearing colored lens should be considered when selecting density and color of colored lenses.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.321-321
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• 1994

다양하고 복잡한 기전에 의하여 정교히 조절되고 있는 면역 체계의 비정상적인 기능에 비롯된 자가 면역 질환을 개선, 치료하기 위하여 지금까지 많은 면역 조절제가 개발되어 온 바 있으며, 이들의 면역 조절 기전은 약물에 따라 그 효능에 있어 차이가 크고 독성등의 부작용등으로 인해 그 사용이 현저히 제한되고있는 경우가 많아 보다 안전하고 효능있는 새로운 면역 조절제의 개발은 아직도 매우 중요한 의의를 지니고 있다. 이러한 관점에서 본 연구실에서는 천연물로부터의 새로운 면역 조절제의 검색을 수행하여 온 바 있으며, 그중 Brazilin이 Low-dose Streptozotocin의 반복 투여에 의해 유도되는 당뇨병 상태의 면역 조절 기능에 미치는 영향에 대해서 검색하고자 하였다. 실험의 결과를 종합하여보면, Brazilin은 외부항원 (SRBC)의 유입시 정상 대조군에 비해 현저히 저하되어 있는 T cell의 기능을 정상 대조군 혹은 그 이상으로 증가시키는 효과를 나타내었으며, B cell의 기능 역시 활성화 시키는 것으로 관찰되었다. 이로부터 Brazilin은 Streptozotocin 유도 당뇨병 상태의 면역기능을 정상화시키는 면역 조절활성을 갖는 것으로 판단되었다.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.1
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• pp.109-114
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• 2009

Purpose: This study was designed to investigate the condition of refractive correction on wearing glasses currently of elementary school children and their accommodative ability in Jinju city. Methods: Objective refraction, subjective refraction, amplitude of accommodation, negative and positive accommodation, accommodative facility, and dynamic retinoscopy were examined on 60 elemenary school children who aged 8~12 wearing myopiacorrected glasses. Results: The condition of refractive corrections was distributed that a case of full correction was 11.7%, a case of low correction with more than 0.8 visual acuity (VA) was 10%, and a case of low correction with less than 0.8 VA was 78.3% in wearing glasses currently. In results from examination of accommodative ability, the number of children having accommodative anomaly is 8 persons (13.3%), they were divided into accommodation insufficiency (4 persons), accommodative facility insufficiency (2 persons), accommodation excess (1 person), and accommodation insufficiency related to ocular function (1 person). Conclusions: It is demanded a periodic inspection of refractive correction to growing children, and the refractive correction after due consideration to accommodative ability is really needed.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.201-210
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• 2015

Purpose: In order to aggregate effect of the improvement of binocular vision function by vision therapy, total mean effect size, mean effect size by dependent variables, and effect size by characteristics of the subjects and characteristics of treatment were analyzed by meta-analysis. Methods: We analyzed data from 14 Korean National primary studies, which reported effects of vision therapy programs, using meta-analysis. Results: The effect size of total mean was 1.207, which showed high effect. The mean effect size according to the subcategory of the binocular dysfunctions was the highest for vergence dysfunctions group (2.989), followed by accommodative dysfunctions group (0.868) and group with both vergence dysfunctions and accommodative dysfunctions (0.692). The effect size according to the characteristics of the subjects was the highest in the vision therapy conducted in the binocular dysfunctions group (2.509) that had no other dysfunctions. The mean effect size according to the number of programs was the highest (2.310) for 7 times a week. Vision therapy for improving the binocular functions was the most effective (2.019) in 8 weeks later from vision therapy start. Conclusions: It can prove that the therapy for the improvement of binocular vision function is effective through that each result of the vision therapy effect is converted to mean effect size, and being objectifying the mean effect size.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.177-184
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• 2012

Purpose: In this study, the effect of the eye movement direction on visual function related to accommodation was investigated when playing computer games for a certain period of time. Methods: Total 60 subjects in 20s who had the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to play computer games separately in horizontal and vertical directions for 40 and 90 minutes and then measured their accommodative amplitude, accommodative facility, accommodative lag and relative accommodations. Thevisual function when not doing the computer game was regarded as a control value, and further compared and analyzed. Results: The accommodative amplitude, accommodative facility, accommodative lag and relative accommodations showed the tendency of decrease after the computer game for 40 minutes, and more reduced values of the visual functions were shown when the computer game extended up to 90 minutes except positive relative accommodation. Positive relative accommodation had a tendency to increase slightly after the computer game for 90 minutes. Meanwhile, the change of the visual functions was primarily influenced by the eye movement in horizontal direction rather than by the eye movement in vertical direction during computer game when analyzed by the direction of eye movement. Conclusions: Over all accommodative functions tended to decrease with the extended VDT working time by computer game, and the frequent eye movement in horizontal direction during VDT tasks could be the main cause of eyestrain since the eye movement in horizontal direction rather than vertical direction significantly affected the change of accommodative function.

• Journal of Nutrition and Health
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• v.45 no.6
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• pp.541-551
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• 2012

In our previous work, we reported consumers' perceptions of body shape and weight control. In an ongoing effort, we analyzed the purchasing behavior, intake patterns, future purchasing decisions, and degree of satisfaction in individuals consuming dietary formula for weight control (DF) or heath/functional foods (HFFs) by using the same survey questions. Portfolio analysis for marketing strategy was also investigated. Subjects were divided into two groups according to consumption of DF or HFF during the previous year : DF group (n = 89) and HFF group (n = 110). Average intake frequency was $1.7{\pm}0.7$ per day for HFFs and $1.5{\pm}0.9$ per day for the DF, and the most prevalent form was pill (58.2%) for HFFs and bar (42.7%) for DF. Duration of intake was $3.1{\pm}2.3$ months for HFFs versus $3.9{\pm}3.5$ months for DF. The average degree of satisfaction was $3.6{\pm}0.6$ on a 5-point scale, meaning 'relatively satisfied'. For the weight control method to be used in the future, 44.5% of the HFF group selected 'HFFs' while 47.2% of the DF group selected 'DF', showing a tendency to use the current product type in the future. The average planned period for the intake was $3.8{\pm}3.7$ months for HFFs and $3.0{\pm}2.4$ months for DF (p < 0.05). The HFF group emphasized efficacy, functional ingredients of the products, reliable products, and higher satisfaction, whereas the DF group emphasized the added materials in addition to weight control effects.

• Journal of Life Science
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• v.29 no.9
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• pp.1034-1046
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• 2019

The mitochondria is the major cellular organelle of energy metabolism for the supply of cellular energy; it also plays an important role in controlling calcium regulation, reactive oxygen species (ROS) production, and apoptosis. Mitochondrial dysfunction causes various diseases, such as neurodegenerative diseases, Lou Gehrig's disease, cardiovascular disease, mental disorders, diabetes, and cancer. Most of the diseases are age-related diseases. In this review, we focus on the roles of mitochondrial dysfunction in cancer. Mitochondrial dysfunction induces carcinogenesis and is found in many cancers. The factors that cause mitochondrial dysfunction differ depending on the types of carcinoma, and those factors could cause cancer malignancy, such as resistance to therapy and metastasis. Mitochondrial dysfunction is caused by a lack of mitochondria, an inability to provide key substances, or a dysfunction in the ATP synthesis machinery. The main factor associated with cancer malignancy is mtDNA depletion. Mitochondrial dysfunction would leads to malignancy through changes in molecular activity or expression, but it is not known in detail which changes lead to cancer malignancy. In order to explore the relationship between mitochondrial dysfunction and cancer malignancy in detail, mitochondria dysfunctional cell lines are constructed using chemical methods such as EtBr treatment or gene editing methods, including shRNA and CRISPR/Cas9. Those mitochondria dysfunctional cell lines are used in the study of various diseases caused by mitochondrial dysfunction, including cancer.

• Journal of Korean Academy of Nursing
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• v.18 no.2
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• pp.211-219
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• 1988

운동학습이론인 감각운동 통합이론을 본 연구의 개념적 틀로하여 한방병원에 입원한 뇌졸중 환자 중 구강인두 기능이 저하된 환자를 대상으로 감각운동자극이 구강인두 기능에 미치는 효과를 조사하기 위하여 1988년 3월초부터 5월 중순까지 예비실험 연구하였다. 감각운동자극을 주기 전에 구강인두기능을 시정하고 대상자 전원에게 저하된 구강인두기능에 따라 감각운동자극을 선택하여 하루 3번 매식후 30분전에 주었으며, 이를 일주일 동안 계속하였다. 일주일 후 다시 구강인두기능을 측정하여 자극을 주기전, 후의 기능정도를 paired t-test로 비교 분석하였으며 다음과 같은 성적을 얻었다. 1. “자극을 주기 전보다 준 후에 머리와 목운동 조절점수가 높을 것이다”라는 제1가설은 지지되었다(t＝-2.71, df＝5, p＝.042). 2. “자극을 주기 전보다 준 후에 씹는 능력이 증가되었으나, 통계적으로는 유의하지 않았다(t＝-2.00, df＝5, p＝.102). 3. “자극을 주기 전보다 준 후에 입술운동의 조절점수는 높을 것이다”라는 제3가설은 지지되었다(t＝-4.77, df＝5, p＝.005). 4. “자극을 주기 전보다 준 후에 혀 운동 조절점수가 높을 것이다”라는 제4가설은 지지되었다(t＝-3.61, df＝5, p＝.015). 5. 자극을 주기 전보다 준 후에 연하능력이 증가되었으나 통계적으로는 유의하지 않았다(t＝-2.24, df＝5, p＝.076). 이상의 결과로 감각운동자극은 연하장애환자의 구강인두기능을 증진시키는데 효과적인 방법이라고 할 수 있다.