• Title/Summary/Keyword: 조구등

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조구등(Uncaria Hooks)의 성분에 관한 연구

  • 박만기;박정일;김종문;한방희
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.47-47
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    • 1993
  • 조구등(Uncaria Hooks)은 한방에서 고혈압, 동맥경화 및 편두통의 치료제로 널리 사용되는 셍약이다. 한방에서 조구등은 오래 달이면 약효가 감소하고 약 15분 정도 달이는 것이 가장 약효가 강하다고 알려져 있다. 본 연구는 이러한 조구등의 수치에 환한 연구의 일환으로 조구등으로부터 혈압 강하 성분을 관리하고 이들 성분이 생약을 달이는 과정에서 어떻게 변화하는지를 알아보고자 하였다.

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Analysis of Alkaloids in Uncaria Hooks (조구등 중의 알칼로이드 분석)

  • Park, Man Ki;Park, Jeong Hill;Kim, Jong Moon;Han, Sang Bum;Han, Bang Hee;Kang, Jong Seong
    • Analytical Science and Technology
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    • v.6 no.4
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    • pp.395-399
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    • 1993
  • Corynoxeine, rhynchophylline, isocorynoxeine, isorhychophylline were isolated from Uncaria hooks and determined by HPLC. Their contents were : isocorynoxeine 0.21%, isorhynchophylline 0.16%, corynoxeine 0.28%, rhynchophylline 0.23%, respectively. Corynoxeine and isocorynoxeine, rhynchophylline and isorhychophylline were interconverted each other by heat treatment.

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The Effect of Inhibition of Uncaria rhynchophylla as an Inhibitor of Melanogenesis and an Antioxidant in B16F10 Melanoma Cells (B16F10세포에서 멜라닌 생성 억제제 및 항산화제로서 조구등의 억제 효과)

  • Dong, Yuanyuan;Woo, Young Min;Cha, Ji Hyun;Cha, Jae Young;Lee, Nai Wei;Back, Min Woo;Park, Joon-sung;Lee, Sang-Hyeon;Ha, Jong-Myung;Kim, Andre
    • Journal of Life Science
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    • v.30 no.12
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    • pp.1033-1041
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    • 2020
  • Many people of all ages wish to have lighter skin for cosmetic reasons, and natural products attract more attention than chemically synthesized compounds. Uncaria rhynchophylla is widely used in Asia as a traditional herbal medicine. In order to find novel skin whitening agents, the present study evaluated the antioxidant activity and potential tyrosinase-inhibiting properties of U. rhynchophylla. Specifically, this study analyzed the antioxidant capacity of a 70% ethanolic extract of U. rhynchophylla as well as its effects on tyrosinase activity and melanin synthesis. Total mRNA levels were examined using reverse transcription polymerase chain reaction. The results revealed that U. rhynchophylla extracts exhibit great antioxidant capacity and significant levels of polyphenol and flavonoid compounds. U. rhynchophylla extracts can also powerfully inhibit tyrosinase activity. This same capacity was observed in melanoma B16F10 cells; that is, U. rhynchophylla extracts suppressed intracellular tyrosinase activity and reduced the amount of melanin in treated cells. In addition, a 1 mg/ml concentration of U. rhynchophylla extract significantly reduced the mRNA expression levels of tyrosinase. U. rhynchophylla extracts decrease tyrosinase and inhibit melanogenesis in B16F10 cells. This finding suggests that U. rhynchophylla has great potential as a natural whitening agent in skincare products.

조구등의 혈압강하작용과 성분연구

  • 박정일;김종문;한방희;박만기;김상미;천선아;이은방
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.237-237
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    • 1994
  • 혈압강하작용은 oxyindole계 분획에서 제일 강력하였으며, 다음이 hetero-yohimbine계 분획이며, 극성 alkaloid계 분획이 제일 약하였다. 특히, oxyindole계 및 hetero-yohimbine계는 epinephrine의 승압작용을 길항하지 아니하였으므로 이들의 혈압강하작용은 혈관의 수축작용을 길항하는 기전과는 무관함을 알 수 있었다. 반면에 화학적으로는 hetero-yohimbine계 분획에서 hirsuteine, corynantheine 및 hirsutine을 분리하였고 극성 alkaloid 분획에서는 3$\alpha$-dihydrocadambine을 분리 동정하였으며 전자 3종의 alkaloid는 열(10$0^{\circ}C$)에 안정하고 후자는 불안정함을 확인하였다.

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Anticonvulsant Effect of Uncariae Ramulus et Uncus. I. -Anticonvulsant Effect of Ethyl Acetate Fraction- (조구등(釣鉤藤) 성분의 항경련 효과 I. -에틸아세테이트 분획의 항경련 효과-)

  • Kim, Dong-Young;Kim, Hoe-Young;Park, Min-Soo;Lee, chung-Gyu;Choi, Jong-Won
    • Korean Journal of Pharmacognosy
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    • v.27 no.1
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    • pp.53-57
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    • 1996
  • To elucidate the activities of Uncaria Ramulus et Uncus, which has been used as anticonvulsant and antihypertensive in oriental region, the methanolic extract and its fractions were applied to inhibition of convulsion onset. The ethyl acetate fraction showed dose-dependent inhibitory activity against pentylenetetrazole-induced seizure.

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Anticonvulsant Effect of Uncariae Ramulus et Uncus II. - Effects of Methanol Extract and Ethyl Acetate Fraction on Neurotransmitters related Components in Brain - (조구등 성분의 항경련효과 II. - 메탄올 추출물 및 에틸 아세테이트 분획의 뇌 신경전달 관련물질에 미치는 효과 -)

  • Kim, Dong-Young;Park, Jong-Cheol;Lee, Chung-Kyu;Choi, Jong-Won
    • Korean Journal of Pharmacognosy
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    • v.29 no.3
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    • pp.179-186
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    • 1998
  • The fractions of Uncariae Ramulus et Uncus seemed to be closely related with the levels of amino acids and other components which concerns with formation and metabolism of neurotransmitters in brain. The pretreatments of methanolic extract and its fractions prohibited the pentylenetetrazole (PTZ) induced convulsion. In such cases, lowered levels of ${\gamma}-aminobutyric$ acid and glutathione in brain were significantly recovered. And also the increased levels or activities of lipid peroxide, ${\gamma}-aminobutyric$ acid aminotransferase, xanthine oxidase, aldehyde oxidase, superoxide dismutase, catalase and glutathione peroxidase by PTZ-convulsion were lowered to normal state.

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Anticonvulsant Effect of Uncariae Ramulus et Uncus III. - Effects of Ursolic Acid and Hyperin on Neurotransmitters related Components in Brain Tissue In Vitro - (조구등(釣鉤藤) 성분의 항경련효과 III. - Ursolic Acid와 Hyperin이 In Vitro 뇌 신경전달 관련물질에 미치는 효과 -)

  • Kim, Dong-Young;Park, Jong-Cheol;Lee, Chung-Kyu;Choi, Jong-Won
    • Korean Journal of Pharmacognosy
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    • v.29 no.3
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    • pp.187-192
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    • 1998
  • The ethyl acetate fraction of Uncariae Ramulus et Uncus, which showed anticonvulsant effects against pentylenetetrazole (PTZ) treated mice, were subjected to column chromatography to isolate ursolic acid and hyperin from active eluate. Hyperin decreased the elevated activities of GABA-T and xanthine oxidase and lipid peroxide level dose-dependently in PTZ treated mice brain tissue in vitro, but no effect on superoxide dismutase activity. The effects on such enzyme and component seemed to be related with biosynthesis or metabolism of neurotransmitters.

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Antihyperlipidemic Effects of Bupleuri Radix, padix and Uncariae Ramulus et Uncus on Experimental Hyperlipidemia in rats (고지혈증 랫트를 이용한 시호, 작약, 조구등의 항고지혈 효과)

  • 노환성;고우경;박건구;조영환;박형섭
    • Biomolecules & Therapeutics
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    • v.5 no.1
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    • pp.43-47
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    • 1997
  • Effects of Bupleuri Radix, Paeonie Radix or Uncariae Ramulus et rncus on experimental yperlipidemia were studied. Hyperlipidemia was induced on male Wistar rats by feeding them on high holesterol diet for one week, as previously described by the authors. Blood lipid profile was verified on these ats by measuring total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL) and low ensity lipoprotein cholesterol(LDL). Then, the rats were followed by feeding normal diet. At the same time, ethanol extracts of the three individual herb medicines were orally administered to the rats for 4 weeks and the parameters above mentioned were monitored. Methanol extract of 5Bupleuri radix reduced the TC value significantly at 2 week point and Paeoneae Radix reduced the TC value at 4 week point in compare to control group, suggesting the antihyperlipidemic effect of the two herbal medicines in vivo. The extract of Uncariae Ramulus et Uncus however did not show antihyperlipidemic effect in our experiment.

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Hyaluronidase Inhibitor from Uncariae Ramulus et Uncus (조구등의 Hyaluronidase 저해물질)

  • Jeong, Sei-Joon;Ko, Yong-Seok;Ahn, Nyeon-Hyung;Kim, Youn-Chul
    • Korean Journal of Pharmacognosy
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    • v.29 no.3
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    • pp.169-172
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    • 1998
  • Hyaluronidase is one of the mucopolysaccharide-splitting enzyme and is related to the permeability of the vascular system and inflammation. An anti-hyaluronidase assay guided fractionation of the methanolic extract of Uncariae Ramulus et Uncus has furnished a pentacyclic triterpene, ursolic acid (compound I). Compound I exhibited hyaluronidase inhibitory activity with $IC_{50}$ value of 0.15 mM, and disodium cromoglycate showed the inhibitory activity with $IC_{50}$ value of 1.78 mM as a positive control.

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