• Journal of Periodontal and Implant Science
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• v.36 no.2
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• pp.397-408
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• 2006

치주질환은 치아 지지조직의 파괴로 튿정 지어지는 감염성 질환으로서 이것은 주로 조직의 교원질 성분을 분해시키는 MMP(matrix metalloproteinase)에 의해 이루어진다. 한편, 여러 연구에서 당뇨병과 치주질환의 심도와의 관계에 대한 논의가 있어왔으며 당뇨병이 치주염을 포함한 구강 감염에 대한 감수성을 증가시키며 역으로 만성 치주염의 염증성 매개물질에 의해 인슐린 작용이 방해받을 수 있음을 보고하였다. 본 연구의 목적은 만성 치주염 환자와 제 2형 당뇨병을 동반한 만성 치주염 환자의 치은조직에서 MMP-13과 elastase의 발현 양상을 비교하여 병리 기전의 차이점을 규명하고, 두 단백질간의 상호관계를 알아보기 위한 것이다. 경북대 병원 치주과에 내원한 환자의 비당뇨 환자의 정상 치은 부위, 비당뇨 환자의 만성 치주염 부위, 제 2형 당뇨병 환자의 만성 치주염 부위에서 각각 8개의 변연 치은을 채득하여 액화 질소에 급속 동결시켰다. 모든 조직 샘플에서 동량의 단백질을 western blotting을 통해 분석하여였고, densitometer를 이용하여 정량한 후 ANOVA 분석으로 통계처리 하였다. 결과분석에서 MMP-13은 제 2형 당뇨를 가진 환자의 염증성 조직에서 가장 높게 발현되었고 전신적으로 건강한 환자의 염증성 조직과 정상 조직에서는 유사한 양상을 보였으며 그 차이는 통계적으로 유의하였다. 또한 elastas는 그룹간에 유의한 차이 없이 유사한 양상으로 발현되었고, 염증성 조직에서도 당뇨병의 유무에 관계없이 유사하게 나타났다. 한편 조직내 MMP-13과 elastase의 발현 양상간에 유의한 상관관계는 보이지 않았다. 결론적으로 MMP-13은 당뇨병을 동반한 환자의 치은 염증초직에서 유의하게 증가되어 나타났으며, 전신적으로 건강한 환자의 염증조직과 당뇨를 동반한 환자의 염증조직에서 MMP-13과 elastase의 발현양상은 큰 상관관계가 발견되지 않았다.

• Journal of IKEEE
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• v.23 no.2
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• pp.495-501
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• 2019

This paper proposes a variable passive harmonic filter for reduction and improvement of harmonics and power factor of single-phase uninterruptible power supply(UPS) with full bridge rectifier. Recently, UPSs have excellent harmonic and power factor operation characteristics by applying 2-level or more levels of power conversion methods. On the other hand, the single-phase UPS of the full bridge rectifier seriously causes the third, fifth, and seventh harmonics, and the power factor reduction on the grid side. Therefore, we present a variable passive harmonic filter for eliminating (2n+1) order harmonics and improving the power factor generated by the full bridge rectifier operation. In order to evaluate the performance of the proposed variable harmonic filter, the its validity is verified by various simulations and experiments.

• 한국벤처창업학회:학술대회논문집
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• 2023.04a
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• pp.29-38
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• 2023

그간 Venture Debt은 벤처기업의 스케일업을 촉진하는 수단으로 인식되어 왔으나, 경기하강 국면에서는 투자유치가 여의치 않은 벤처기업에 유동성을 제공하는 자금공급수단으로서의 중요성이 부각된다. 한편, 2023년 3월 SVB의 파산으로 Venture Debt 취급기관의 지속가능성에 대한 우려가 부각되었다. 이에 본 연구에서는 대출재원의 지속가능성을 염두에 두고, 경기침체기 대안적 자금 공급수단으로서 Venture Debt 활성화방안을 연구하였다. 선행연구들은 주로 전통적 Venture Debt을 분석대상으로 하였으나, 본 연구에서는 벤처생태계의 성장과 경기사이클 변화에 따라 다양해지고 있는 Venture Debt을 유형별로 분석하였다. Venture Debt 유형을 전통적, Growth형, 유동성 지원형으로 구분하고, 각각 SVB, EIB(유럽투자은행), 해외 벤처유동성 지원사례를 중심으로 구조적 특징과 차이점을 분석하였고, 직접대출방식과 BDC 등 간접대출방식을 비교 분석하였다. 이와 함께, 경제성, 시장성, 대출재원 확보가능성 차원에서 국내 도입환경에 대한 실무적·법률적 검토를 병행하였다. 본 연구에서는 국내 활성화방안으로 채권형 BDC 활성화를 통한 민간재원 활용, 벤처전용 유동성지원 프로그램 마련, 제2데스밸리 극복을 위한 Growth형 벤처대출 도입, 독립형 워런트 발행을 위한 법적 근거 마련 등을 제안한다.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.05a
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• pp.383-386
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• 2006

Several HTPB/AP and HTPB/AP/HMX propellants were investigated experimentally for ignition characteristics in subatmospheric pressure. The threshold ignition pressure was 4psia for HTPB/AP composite propellant. The partial replacement of AP in HTPB/AP composite propellant by $5\sim15%$ of HMX, HNIW showed improvements in the threshold pressure was below 0.4psia. This appears to be due to the exothermic dissociation characteristics of HMX and HNIW at lower temperature $(\sim220^{\circ}C)$ than that of AP. The ignition substance B/KNO3 was coated thinly on the propellant surface for better ignition effect. As a result, ignition delay time of 15% was improved. NC is applied to $B/KNO_3$ ignition substance as a secondary binder and $NC-B/KNO-3$ suspension solution is coated to the propellant surface.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.3
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• pp.22-28
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• 2000

제조업의 경쟁력 제고를 위하여 시작된 선도 기술개발 사업의 하나인 '첨단생산시스템기술개발' 사업은 제 1 단계에서 FMS 핵심 기술 개발을, 제 2 단계에서는 CIM 기술 개발을 수행하였다. 1,2단계 기술 개발의 연속성 위에서 제 3 단계에서는 지능형 생산시스템(IMS: Intelligent Manufacturing System)을 구현하기 위하여 1999년 11월부터 연구가 시작되었다.

• Applied Microscopy
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• v.31 no.1
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• pp.71-83
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• 2001

Laminin, a kind of multidomain glycoproteins, is mainly localized in the basement membranes of various tissues. It is known that laminin plays an important part in mammalian lung morphogenesis. The authors have undertaken this study to investigate the changes in the distribution of laminin, and to find out cells which synthesize laminin during the organogenesis and differentiation of the lung. The fetal and neoantal rats (Sprague-Dawley strain) were used as experimental animals. The immunohisto-chemical methods were employed for detection of laminin within the developing lung tissue and the immunegold cytochemical methods were performed for detection of cells which synthesize laminin according to each stage of development. The results are as follows; 1. During fetal life, strong immunoreactivity for laminin is maintained in the basement membranes of the blood vessels and the bronchioles, the extracellular matrix of the mesenchyme, and basal lamina of the alveolar septum in the fetal rat lung. 2. After birth, laminin immunoreactivity at the alveolar septum is gradually reduced. 3. During fetal life, laminin is mainly detected within the cytoplasm of the mesenchymal cells, the endothelial cells of blood vessels and the fibroblasts in fetal rat lung. 4. According to the differentiation of type I and type II pneumocyte after birth, laminin is detected within cytoplasm of the type I pneumocytes, type II pneumocytes and fibroblasts. It is consequently suggested that laminin is largely expressed in the developing lung and laminin may be also synthesized by the type II pneumonocytes at early newborn stages.

• Journal of Periodontal and Implant Science
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• v.37 no.sup2
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• pp.353-369
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• 2007

Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was divided into three groups. Group 1 (n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2 (n=8) is inflamed gingiva from patients with chronic periodontitis. Group 3 (n=8) is inflamed gingiva from patients with chronic periodontitis associated with type 2 diabetes. Tissue samples were prepared and analyzed by Western blotting. The quantification of $IL-1{\beta}$, MMP-13 and TIMP-1 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. 1. The expressions of MMP-13 and TIMP-1 showed increasing tendency in group 2 & 3 compared to group 1. 2. The expressions of $IL-1{\beta}$ & MMP-13 were showed increasing tendency in group 3 compared to group 2. 3. As $IL-1{\beta}$ levels were increasing, MMP-13 showed increasing tendency in group 3, and although $IL-1{\beta}$ , MMP-13 levels were increasing, TIMP-1 levels were similar expressed comparing to group 2. In conclusion, this study demonstrated that the expression levels of MMP-13 and TIMP-1 had increasing tendency in inflamed tissue. It can be assumed that $IL-1{\beta}$ and MMP-13 may be partly involved in the progression of periodontal inflammation associated to type 2 DM.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.5
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• pp.2524-2528
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• 2013

Cell opening characteristics dependent on the cell openers for the conventional formulation of a closed-cell polyurethane foam (PUF) was studied using 1-butanol and lithium salt of 12-hydroxystearic acid (Li-12HSA) as the reactive cell opening agents. While cell openining content of only 10.5 % was obtained for the sample with 4 phr of 1-butanol as the single reactive cell opener, that of 98.0% could be obtained for the sample with 2 phr of Li-12HSA as the reactive co-cell opener. As the results, it showed that a fully open-cell rigid PUF could be obtained by introducing a novel reactive cell opener, having a functional group able to form a bulky side-chain on the urethane networks, without severe loss of mechanical properties of the closed-cell PUF like cell size, bulk density, and thermal conductivity.

• The Journal of the Korea Contents Association
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• v.11 no.2
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• pp.397-407
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• 2011

The Open Position System is a new personnel management system started in korea, 1999.Open Position System have purpose to use outstanding talents and to expertise from both public and private sector. Korean government adapted open position system in order to use the right man in the right place. And Korean government incresae application of Open Position System. But, in spite of strong good point of Open Position System, We have limitation to apply Open Position System in police organization, generally. Because police have unique characteristics compare with other public organization. There is constant controversy concerning unique characteristics of police organization. Now, Korean police adopt Open Position System in few division: Chiep of Driver's License Agency, Director General for Audit and Inspection of Nation police Agency, Chiep of police hospital. Therefore, this study explore, extention possibility of Open Position System in Korean police.

• The Journal of the Korea Contents Association
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• v.18 no.1
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• pp.527-539
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• 2018

The purpose of this study is to analyze the cognizance of sexual minority by applying Q methodology, as well as to provide preliminary data for improving sexual minority's image. The study process let P sample, the study participants, use Q-sorting methodology to sort Q sample, which is composed of statements from July 1 to 20, 2017. 21 participants sorted 32 statements and 3 types of sexual minority cognizance were produced as a result. Those types are 1(N=8), 2(N=5), and 3(N=8), which are type friendly human rights enthusiast, type whereas negative stereotypical, and type neutralist. Friendly human rights enthusiast types agreed to ensure sex minority groups' rights as a general protection, whereas negative stereotypical types had strong discrimination and prejudice towards sex minority groups due to lack of related knowledge. Furthermore, neutralist types showed an objection to negative stereotypes against sex minorities, but they did not entirely agree to homosexuality either.