• Korean Journal of Health Education and Promotion
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• v.24 no.5
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• pp.87-101
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• 2007

Objectives: This study identified the labor union associates' perception and participation status on SHEW and analyzed these two Constructs correlations with Safety and health education at work(SHEW) in manufacture and construction industries. Methods: Self-administered survey was successfully finished by 103 labor union associates (91 employed in 78 manufacturing companies and 12 employed in 12 constructing companies over 12 areas). Two questionnaires, survey direction slip, the official letter to ask survey participation from Korea Ministry of Labor, and a posted envelop to return were delivered to each workplace labor union office in conveniently selected companies. Most participants' companies were at least medium to large in manufacturing industry and most associates were men and married. A survey questionnaire examined demographic characteristics, SHEW status (participation status included), and perceptions of SHEW. Results: Overall, manufacturing companies had better infrastructures for SHEW, employer support for SHEW, and current educators' competencies than constructing companies. These infrastructures for SHEW were closely correlated with company labor union participation on SHEW and the correlation coefficients were greater than any other expectations or needs variables for SHEW. Conclusions: The primary strategies for better participation and support from labor union need to be developed in supporting for organizational infrastructures related to SHEW and strengthening safety and health education training programs for supervisors or educators at work.

• Korean Journal of Clinical Pharmacy
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• v.11 no.2
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• pp.49-56
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• 2001

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is a naturally existing molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioefuivalence of two ALC tablets, $Nicetile^{TM} (Dong-A Pharmaceutical Co.) and $L-Cartin^{TM}$ (Kuhn Il Pharmaceutical Co.), according to the guidelines of Korea Food and Drug Administration (KFDA). The ALC release from the two ALC tablets in vitro was tested using KP VII Apparatus II method in various dissolution media (pH 1.2, 6.0 and 6.8). Twenty six normal male volunteers, $24.46\pm3.67$ years in age and $64.45\pm5.54$ kg in body weight, were divided into two groups and a randomized $2\times2$cross-over study was employed. After one tablet containing 500 mg of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. The dissolution profiles of the two ALC tablets were similar in all the dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were $0.35\%,\;0.93\%\;and\;2.34\%$ respectively, when calculated against the $Nicetile^{TM} tablet. The powers $(1-\beta)\;for\;AUC_t$ , and Cmax were $98.72\%\;and\;85.48\%$, respectively. Minimum detectable differences $(\Delta)\;at\;\alpha=0.05\;and\;1-\beta=0.8$ were less than $20\%,\;(e.g.,\;13.21\%\;and\;18.42\%\;for\;AUC_t,\;and\;C_{max}$ respectively). The $90\%$ confidence intervals were within $\pm20\%\;(e.g.,\;-7.38\sim8.09\;and\;-9.86\sim11.72\;for\;AUC_t,\;and\;C_{max}$, respectively). These two parameters met the criteria of KFDA for bioequivalence, indicating that $L-Cartin^{TM}$ tablet is bioequivalent to $Nicetile^{TM} tablet.

• 대한공업교육학회지
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• v.35 no.2
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• pp.124-139
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• 2010

This study has its purpose of researching on the relevant variables which affect the attitude toward engineering science and brain dominance for the department of engineering students. The results of this study are as follows: First, the department of engineering students' attitude toward engineering science has shown the order of cognitive element (3.73), definitional element (3.05) and behavioral element (2.86), and in the actual context it is considered that it is necessary to establish a teaching-learning strategy which can reinforce the behavioral elements such as experiments and practices as well as can improve engineering-related cognitive ability. Second, the attitudes toward engineering science according to their brain dominance thinking (Type A: analyst, Type B: Administrator, Type C: Cooperator, and Type D: Jointer) have no significant difference, but the students of Type A who have the characteristics of 7 analyzing thinking have shown high academic accomplishment. Based on these results of study, it is necessary to make a change of the current teaching-learning stratery in accordance with the types of thinking of the students from the teaching-learning perspective. In particular, in order to develop the weak dominance properties and thinking type of individual learners, the change in teacher's recognition that the teacher's teaching-learning strategy and practice is important has to take precedence.

• 한국HCI학회:학술대회논문집
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• 2009.02a
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• pp.1316-1320
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• 2009

Since most information is readily available these days, the shear volume of the information simply overwhelms people, rather than helping them as a form of useful knowledge. Thus, the quantity of information someone owns doesn't possess much significance. The possibility to well-utilize the quality information is much more important these days. Electronic culture map service is being provided these days to introduce various cultural information to people around the world. But its service is limited to 'visualization, collection, and integration of the data.' Which means, electronic culture maps are no more than a simple data collector. The main purpose of this thesis is to develop a new kind of knowledge/information service method which overcomes these shortcomings. To achieve this goal, at first, the thesis will take a close look at the characteristics and functions of Chosunjock culture maps, and then, it will clarify the definition of data, information, knowledge of cultural resources. And secondly, nd thirdly, the thesis will look up the Wayfinding contents, User Experience Design, User Context, and Organic design for knowledge/information service. And lastly, the thesis will develop the knowledge/information service, specifically based on Chosunjock cultural resources.

• Journal of Pharmaceutical Investigation
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• v.31 no.2
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• pp.131-136
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• 2001

Tofisopam is a new type of tranquilizer valuable for the relief of anxiety and tension in a wide range of emotional disorders. Tofisopam has the therapeutic characteristics of a minor tranquilzer and a mild stimulatory effect. The purpose of the present study was to evaluate the bioequivalence of two tofisopam tablets, $Grandaxin^{TM}$ (Hwan In Pharmaceutical Co., Ltd.) and $Tofim^{TM}$ (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.11\;{\pm}\;2.83$ years in age and $65.43\;{\pm}\;7.64\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 50 mg of tofisopam was orally administered, blood was taken at predetermined time intervals and the concentrations of tofisopam in serum were determined using HPLC method with UV detector. The pharmacokinetic parameters such as $AUC_t$, $C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$, C_{max}\;and\;T_{max}$ between two tablets based on the $Grandaxin^{TM}$ were -5.59%, 2.22% and -13.18%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.10$ and $1-{\beta}=0.8$ were less than 20% (e.g., 14.95% and 19.34% for $AUC_t\;and\;C_{max}$, respectively). The powers $(1-{\beta})$ at ${\alpha}=0.10$, ${\Delta}=0.2$ for $AUC_t$ and $C_{max}$ were 95.21% and 81.93%, respectively. The 90% confidence intervals were within {\pm}20%$ (e.g., $-15.64{\sim}4.45$ and $-10.77{\sim}15.21$ for $AUC_t\;and\;C_{max}$, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that $Tofim^{TM}$ tablet is bioequivalent to $Grandaxin^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
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• v.31 no.2
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• pp.125-130
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• 2001

Bucillamine is a novel cysteine derivative with two free intramolecular sulfhydryl groups, and has a preventive and therapeutic effect on adjuvant arthritis, suggesting its antirheumatic action. With respect to the effect on the immune system, bucillamine-exerted such immunoregulating actions are to nomalize an excessive reduction or acceleration in immune reaction. It is useful not only in patients with early stage of rheumatoid arthritis (RA) but also in those with active RA retained for more than 10 years. The purpose of the present study was to evaluate the bioequivalence of two bucillamine tablets, $Rimatil^{TM}$ (Chong Kun Dang Pharmaceutical Co., Ltd.) and $Bucilin^{TM}$ (Kuhn Il Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.67{\pm}2.09$ years in age and $65.03{\pm}6.73\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After three tablets containing 100 mg of bucillamine per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of bucillamine in serum were determined using GC/MS with mass selective detector. Pharmacokinetic parameters such as $AUC_t$, $C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$, $C_{max}\;and\;T_{max}$ between two tablets were -0.29%, -3.20% and 8.22%, respectively, when calculated against the $Rimatil^{TM}$ tablet. The powers $(1-{\beta})$ for $AUC_t\;and\;C_{max}$ were 84.31 % and 91.16%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.10$ and $1-{\beta}=0.8$ were less than 20% (e.g., 18.58% and 16.51% for $AUC_t\;and\;C_{max}$, respectively). The 90% confidence intervals were within ${\pm}20%$ (e.g.,$-12.77{\sim}12.20$ for $AUC_t$ and $-14.30{\sim}7.90$ for $C_{max}$). Two parameters met the criteria of KFDA for bioequivalence, indicating that $Bucilin^{TM}$ tablet is bioequivalent to $Rimatil^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
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• v.33 no.4
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• pp.311-317
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• 2003

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by meas of a direct, selective action on smooth muscle in arterial resistance vessels. Futhermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutial Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The felodipine release from the two felodipine formulations in vitro was tested using KP VIII Apparatus II method at pH 6.5 buffer solution. Twenty six healthy male subjects, $22.73{\pm}1.78$ years in age and $66.66{\pm}7.28\;kg$ in body weight, were divided into two groups and a radomized $2{\times}2$ cross-over study was employed. After two tablets containing 5 mg as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance rage of log(0.86) to log(1.25) $(e.g.,\;log(0.86){\sim}log(1.20)\;and\;log(0.89){\sim}log(1.23)\;for\;AUC_t,\;C_{max},\;respectively)$. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

• Journal of KIISE:Computing Practices and Letters
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• v.6 no.3
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• pp.364-372
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• 2000

Subcategorization, defining dependency relation between predicates and their complements, is an important source of knowledge for resolving syntactic and semantic ambiguities arising in analyzing sentences. This paper describes a Korean subcategorization dictionary, particularly annotated with semantic roles of complements coupled with thesaural semantic hierarchy as well as syntactic dependencies. For annotating roles, we defined 25 semantic roles associated with surface case markers that can be used to derive semantic structures directly from syntactic ones. In addition, we used more than 120,000 entries of thesaurus to specify concept markers of noun complements, and also used 47 and 17 predicate patterns for verbs and adjectives, respectively, to express dependency relation between predicates and their complements. Using a full-fledged thesaurus for specifying concept markers makes it possible to build an effective selectional restriction mechanism coupled with the subcategorization dictionary, and using the standard predicate patterns for specifying dependency relations makes it possible to avoid inconsistency in the results and to reduce the costs for constructing the dictionary. On the bases of these, we built a Korean subcategorization dictionary for frequently used 13,000 predicates found in corpora with the aid of a tool specially designed to support this task. An experimental result shows that this dictionary can provide 72.7% of predicates in corpora with appropriate subcategorization information.

• Journal of Chest Surgery
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• v.41 no.5
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• pp.625-629
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• 2008

Background: When it comes to esophageal cancer operations, the prevalence of anastomotic complications that adversely affect quality of life is related to the type of anastomotic procedure and the operative site. We studied outcomes related to a safe anastomotic method used in Ivor Lewis esophagogastrectomy for preventing anastomotic leakage and stricture formation. Material and Method: Between May 2003 and April 2007, 18 patients with esophageal cancer underwent this type of esophagogastrectomy. Four people were lost to follow-up. There were 17 men (94.4%) and 1 woman. The mean patient age was 61 years (range, $46{\sim}73$ years). Result: The mean follow-up period was 17.2 months (range, $1{\sim}45$ months). There was no anastomotic leakage. There was one benign anastomotic stricture (5.6%) requiring esophageal balloon dilatation, which was accomplished with a 25 mm circular stapler. Conclusion: We experienced relatively good postoperative results using a safe anastomotic method in the Ivor lewis operation for preventing anastomotic complications. These results suggest that this anastomotic method is effective in reducing the incidence of benign anastomotic complications.

• Journal of Korea Water Resources Association
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• v.38 no.7 s.156
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• pp.517-526
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• 2005

In Korea, the methods of estimating groundwater recharge can categorized into two groups. One is baseflow separation method by means of groundurater recession curve, the other is water level fluctuation method by using the data from groundwater monitoring wells. Baseflow separation method is based on annual recharge and lumped concept, and water-table fluctuation method is largely dependent on monitoring wells rather than water budget in watershed. However, groundwater recharge rate shows the spatial-temporal variability due to climatic condition, land use and hydrogeological heterogeneity, these methods have various limits to deal with these characteristics. For this purpose, the method of estimating daily recharge rate with spatial variability based on distributed rainfall-runoff model is suggested in this study. Instead of representative recharge rate of large watershed, the subdivided recharge rate with heterogeneous characteristics can be computed in daily base. The estimated daily recharge rate is an advanced quantity reflecting the heterogeneity of hydrogeology, climatic condition, land use as well as physical behaviour of water in soil layers. Therefore, the newly suggested method could be expected to enhance existing methods.