• Korean Journal of Biological Psychiatry
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• v.2 no.2
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• pp.248-251
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• 1995

정신분열병의 약물치료에서 중요한 역할을 하는 도파민의 기전은 지금까지 5종류의 수용체들이 발견되고 클론되면서, 새롭고 보다 근본적인 유전학적 접근을 통해 규명될 수 있게 되었다. 특히, 도파민 수용체 D4 (DRD4)는 막단백질의 세포질쪽 세번째굴곡에 48-bp반복 다형성배열을 가지고있다. 이러한 다형성 반복배열이 신호전달에 참여할 가능성이 높은 막단백질의 세포질쪽 굴곡에 있다는것은, 각 개인의 항정신병약물에 대한 민감성의 차이를 포함하여 정신분열병에 대한 개개인의 유전적 차이를 진단할 수 있는 가능성을 제시한다. 이러한 가능성을 검증하기 위하여 주로 손쉽고 빠른 중합효소연쇄반응(PCR)을 사용하여 DRD4의 아형들을 분류하게 되는데, DRD4의 PCR은 그 반복배열과 그 주변배열의 높은 GC함량(78% G+C) 때문에 일반적인 PCR 방법을 변형시켜 사용해야한다. DRD4의 아형을 분류하기 위해 변형된 PCR은 통상적으로 7-deaza dGTP와 10% DMSO를 사용하게된다. 이러한 DRD4 PCR은 대부분의 경우 성공하지만, 항상 모든 시료에서 PCR이 성공되는것은 아니었으며 반복적으로 시도하여 증폭시킬 수 있었다. 이러한 어려움은 대부분이 template DNA에 문제가 있을것으로 의심되며 DNA정제 또는 template DNA를 제한효소로 적절하게 무작위절단하여 성공율을 높일 수 있었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.1
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• pp.110-119
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• 1996

Heller recognized the children exhibiting developmental regression after normal period of development and proposed the term 'dementia' infanilis for the condition and reported it 1908. But the foolowing studies were insufficient, the diagnostic concept was not definded, and various names such as dementia infantilis, Heller's syndrome, disintegrative psychosis and childhood disintegrative disorder have been used for that condition. Recently the term childhood disintegrative disorder fir that condition was proposed as independent disease entity by DSM-IV and ICD-10, and the interset in that condition is increasing now. But because of insufficient previous studies on that condition, the definite concept, the characteristics, the relationship with autism or other similar conditions, the treatment and prognosis of that condition are not clear by this time, therefore we have not seen the official report on the condition in our country. These authors experienced a case considered as childhood disintegrative disorder and report it with the review of literatures.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.137-142
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• 2012

Background & Purpose: It is well known that Extrapyramidal symptoms (EPS) is induced by atypical antipsychotic agents less frequently than by typical antipsychotic agents. The purpose of this study was to evaluate differences in rates of the use of antiparkinson agent, most commonly prescribed for the management of EPS, between patients with atypical agents and those with typical agents. Methods: This cross-sectional study was conducted in a retrospective way with the Electronic Medical Record (EMR) of the 312 patients for whom the Antipsychotics were prescribed by the Psychiatry Department of the Inje University Ilsan Paik Hospital, from January of 2005 to February of 2011. They received either typical agents (N=15) or atypical agents (N=297) and those 2 groups were compared in terms of antiparkinson agent use. Also, we assessed the difference between individual atypical antipsychotic agents regarding antiparkinson agent use. Results: There was no significant difference in the rates of antiparkinson agent use between the two groups (the typical agent 13.33% vs. the atypical agent 9.76%, p = 0.6512). Meanwhile, the rates of antiparkinson agent use with aripiprazole versus quetiapine (aripirazole 25% vs. quetiapine 3.57%, p = 0.003) were significantly different, Also the rates of antiparkinson agent use with aripiprazole versus risperidone (aripiprazole 25% vs. risperidone 9.52%, p = 0.0216) had a statistical meaning. Conclusions: There was no significant difference in the rates of antiparkinson agent use between patients with atypical agents and those with typical agents. However the rate of antiparkinson agent use was significantly lower with aripiprazole compared with quetiapine or risperidone.

• Korean Journal of Biological Psychiatry
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• v.10 no.1
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• pp.54-61
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• 2003

Object : This cross-sectional study was performed in order to evaluate the prevalence of tardive dyskinesia among the hospitalized schizophrenic patients. Methods : Four hundred nineteen hospitalized schizophrenic patients(male=263, female=156) were recruited for this study. They were treated with antipsychotics for more than 3 months. The prevalence of tardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale. Results : The prevalence of tardive dyskinesia was 35.6%(Male=36.9%, Female 33.3%). There were no significant differences in the prevalence of tardive dyskinesia among male and female schizophrenic patients. The prevalence of tardive dyskinesia among the patients over 30years old was much higher than those below 30years old. There were no significant correlations between the prevalence of tardive dyskinesia and the duration of hospitalization, the total amount of antipsychotics. The frequently involved parts of the body in the schizophrenic patients who have tardive dyskinesia were tongue, upper extremity, lips and perioral area, jaw, lower extremity, muscles of facial expression trunk, respectively. Conclusions : There was significant correlation between the age and the prevalence of tardive dyskinesia in the antipsychotic-treated schizophrenic patients. There were no correlations between the prevalence of tardive dyskinesia and gender difference, the duration of hospitalization, the total amount of antipsychotics.

• Korean Journal of Psychosomatic Medicine
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• v.1 no.1
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• pp.59-66
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• 1993

A comparison was made between workers exposed to organic solvents and those not exposed to them regarding stress perception and psychopathology, using GARS scale and SCL-90-R. The exposed group scored significantly higher than the non-exposed group in stress perception relevant to job-wort changes in relationship, sickness or injury, financial, and overall global area. The exposed group was significantly higher in somatization scale than the non-exposed group. However, there was no significant correlation between duration of exposure and psychopathology. In each of the groups. female workers showed more psychopathology than male ones. Age showed significantly nagative correlation with psychopathology. These results suggest that the exposed group shows higher stress perception and more psychopathology than the non-exposed group. Thus. it is emphasized that health policy makers as well as employers should pay more attention to health. espcially mental health for the workers exposed to organic solvents.

• Journal of Korean Academy of Nursing
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• v.5 no.1
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• pp.48-58
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• 1975

대부분의 정신과적 위기 (자살시도.도주 공격적 파괴적행동.싸움 등)는 노여움이 원인이 되는데 심한 불안. 초초나 또는 규칙등을 위반하였을 때에. 고지식한 병원직원들의 마구 다툼에 의해서 자신의 권리나 존엄성을 모욕 받았다고 생각될 때 그것에 대한 반응으로 일어나게 된다. 이러한 환자들의 흥분및 공격적 파괴적 행동들에 대해서 우리 간호원들은 과연 겁내야 하며 곧 진정제를 투여하거나 강박의를 입혀야 하는가 하는 것이 이 연구의 촛점이다. 본인은 이러한 환자들의 위기상황에 성급한 행동들이 주어지기에 앞서 과학적이고 체계적인 간호적 이해가 따른다면 환자들의 태도는 휠씬 달라질 수 있을 것이라는 가정하에 국립정신 병원에서 1973년 6월 1일부터 9월30일까지 실험군 10명. 통제군 10명의 환자에게 관찰기 (5일). 간호기(5일). 후반기 (5일)로 나누어 실험군에는 간호기에 유효적절한 과학적 체계적 간호를 실시하고. 통제군에는 실시하지 않음으로써 그 효과도를 검증하였다. 환자의 치료에는 간호적 치료이외에도 약물요법, 정신치료. 충격요법 등 관계 요인이 많으므로. 이러한 기간동안의 환자의 행동변화가 간호적 치료 (Nursing Therapy)에 의해 변화된 것인가를 확인하기 위해 검증하였다. 그 결과는 다음과 같다. (P<.01) 표6. 7에서 관찰기. 간호기. 후반기 동안의 정신과 응급 행동의 빈도는, 실험군에서는 15.4. 7.0. 2.9 로 감소되어 p <.01의 수준에서 의미 있는 변화임이 밝혀졌고, 통제군에서는 10.6. 6.9. 6.6으로 행동빈도가 감소되었으나 p >.05의 수준에서 의미 있는 변화가 아님을 보이고 있다. 위의 결과들로 미루어 본 연구는 다음과 같은 결론을 내릴 수 있을 것이라고 생각한다. \circled1환자의 위기 행동에 관한 사전의 이해없이 무조건의 안정제 투여와 강박의 사용은 금해야 할 것이다. \circled2유효 적절한 자학적 체계적 간호치료 (Scientific & Systematic Nursing Therapy 로서 정신과적 위기는 해 결될 수 있을 것이다. \circled3간호원은 치료적 요원의 역할을 담당할 수 있을 것이다. 본 논문을 시종 지도하여 주신 이부영선생님과 조언을 주신 이은옥 선생님. 이귀향 선생님. 그리고 국립정신병원의 김종해선생님, 보건대학원의 이영환 선생님께 진심으로 감사를 드리며. 아울러, 실험에 협력하여 주신 모든 분들께도 감사를 드립니다.

• Korean Journal of Clinical Pharmacy
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• v.30 no.2
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• pp.81-86
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• 2020

Background: The number of patients with dementia continues to increase as the age of aging continues to grow. Psychiatric symptoms caused by senile dementia are controlled using antipsychotics. However, these antipsychotics can lead to Parkinson's disease, and abuse of dopamine derivatives such as levodopa among Parkinsonian drugs can lead to psychosis. Therefore, we evaluated the patterns of prescribed antipsychotics and antiparkinsonian drugs in patients with senile dementia. Methods: We used data from the sample of elderly patients from the Health Insurance Review and Assessment Service (HIRA-APS-2016). We analyzed the patterns of prescribing antipsychotics and antiparkinsonian drugs including prescribed daily dosage, period of prescription, and number of patients with both antipsychotics and antiparkinsonian drugs for senile dementia. Results: Among the 159,391 patients with dementia included in this analysis, 4,963 patients (3.1%) and 16,499 patients (10.4%) were prescribed typical and atypical antipsychotic drugs, respectively. The most frequently prescribed typical antipsychotic was haloperidol (4,351 patients with dementia), whereas the atypical agent was quetiapine (12,719 patients). The most frequently prescribed antiparkinsonian drugs were in the order of levodopa/carbidopa, benztropine, and ropinirole. In addition, 1,103 and 3,508 patients prescribed typical and atypical antipsychotics, respectively, were co-prescribed antiparkinsonian drugs. Conclusions: Atypical antipsychotics were the preferred prescription in patients with senile dementia. The prescription dose was relatively low; however, the average treatment duration was mostly long-term. Selection of antipsychotics and/or antiparkinsonian drugs should be made carefully in senile dementia and the causal relationship of adverse drug reactions needs further study.

• Korean Journal of Biological Psychiatry
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• v.5 no.1
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• pp.122-128
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• 1998

Objective : This study was a open clinical trial aimed at exploring the effectiveness of combined treatment with estrogen and antipsychotics to the chronic female schizophrenics. Method : 40 female patients who met DSM-VI criteria for schizophrenia who were chronically ill were randomly assigned to estrogen group(EG) and control group(CG). EG patients were received estrogen 1.25mg for 8weeks in addition to their routine antipsychotic regimens. CG patients were received their routine antipsychotic regimens only. Both groups were evaluated by PANSS(Postive and Negative Syndrome Scale), CGI(Clinical Global Impression) at 0, 4, 8 week during the trial period and compaired with each other. Results : 40 female patients have completed the study during 8weeks. EG was significantly improved in PANSS and CGI scores than CG during the 8weeks. In EG patients, all symptom subtypes(positive symptoms, negative symptoms, general psychopathology symptoms) of PANSS were significantly improved and positive symptoms were most significantly improved at 8week. Conclusions : This results support the clinical value of combined estrogen therapy among chronic female schizophrenics.

• Korean Journal of Biological Psychiatry
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• v.20 no.3
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• pp.97-103
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• 2013

Objectives We aimed to identify the neuroimaging marker for prediction of the use of atypical antipsychotics (AAP) in dementia patients. Methods From April 2010 to March 2013, 31 patients who were diagnosed as dementia at the psychiatric department of Soonchunhyang University Hospital, completed the brain magnetic resonance imaging scan and cognitive test for dementia. Ten patients were treated with AAP for the improvement of behavioral and psychological symptoms of dementia (BPSD) and the other 21patients were not. Using T1 weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of brain, areas of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and white matter hyperintensities (WMH) have been segmented and measured. Multivariate logistic regression models were applied for assessment of association between AAP use and the GM/WM ratio, the WMH/whole brain (GM + WM + CSF) ratio. Results There was a significant association between AAP use and the GM/WM ratio (odds ratio, OR = 1.18, 95% confidence interval, CI 1.01-1.38, p = 0.037), while there was no association between AAP use and the WMH/whole brain ratio (OR = 0.82, 95% CI 0.27-2.48, p = 0.73). Conclusions The GM/WM ratio could be a biological marker for the prediction of AAP use and BPSD in patients with dementia. It was more likely to increase as dementia progress since atrophy of WM was more prominent than that of GM over aging.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.2 no.1
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• pp.125-134
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• 1991

In an attempt to study sex differences in child behavior disorders, 834 clinic-refered children(582 boys and 252 girls) between the ages of 6 to 11 were assessed using CBCL parental form and the data were factor analysed to form empirically derived syndromes for each sex. The analyses yielded eight behavior disorder syndromes for boys and ten, for girls. Six syndromes(aggressive, hyperactive, delinquent, social withdrawal, emotional lability, physical complaints) were found in both sexes while obsessive, depressive and psychotic syndromes were organized differently in boys and girls. There were also considerable differences in item composition of the six syndromes common to box sexes, suggesting that clinical features of common behavior disorders such as aggression and hyperactiveity might be different for boys and girls despite their apparent similarity. The results were discussed in terms of culturally shared attitudes and beliefs concerning sex differences in behaviors.