• Journal of Life Science
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• v.33 no.9
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• pp.736-745
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• 2023

Aging is a complex biological process characterized by a gradual decline in cellular and physiological functions. This natural process is associated with age-related diseases, including Alzheimer's disease, atherosclerosis, and hypogonadism, which are significant health concerns among older individuals and can significantly impact their quality of life. Researchers have found that epigenetic markers play a crucial role in regulating aging and age-related diseases. Epigenetic markers are heritable gene expression alterations that do not change in the DNA sequence. This review focuses on the involvement of various epigenetic marks, such as RNA methylation, DNA methylation, and microRNAs (miRNAs), in regulating gene expression patterns associated with age-related diseases, such as Alzheimer's disease, atherosclerosis, and hypogonadism. These epigenetic alterations can lead to the dysregulation of specific genes and signaling pathways, contributing to the development and progression of Alzheimer's disease, atherosclerosis, and hypogonadism. Understanding the molecular mechanisms behind these epigenetic modifications is essential for both the aging population and individuals seeking ways to promote overall well-being. By gaining deeper insights into how epigenetic marker alteration occurs during aging and age-related diseases, researchers can potentially develop targeted therapeutic strategies to alleviate the impact of these conditions and improve the quality of life for older individuals.

• The Journal of Engineering Geology
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• v.18 no.2
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• pp.145-152
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• 2008

A fault gouge zone which is about 25cm thick crops out along a small valley in Yangbuk-myeon, Gyeongju city. It is divided into greenish brown gouge and bluish gray gouge by color. Under the microscope, the gouges have a lot of porphyroclasts composed of old gouge fragments, quartz, feldspar and iron minerals. Clay minerals are abundant in matrix, defining strikingly P foliation by preferred orientation. Microstructural differences between bluish pay gouge and greenish brown gouge are as follows: greenish brown gouge compared to bluish gray gouge is (1) rich in clay minerals, (2) small in size and number of porphyroclasts, and (3) plentiful in iron minerals which are mostly hematites, while chiefly pyrites in bluish gray gouge. Hematites are considered to be altered from pyrites in the early-formed greenish brown gouge under the influence of hydrothermal fluids accompanied during the formation of bluish gray gouge that also precipitated pyrites. It is believed that the fault core including bluish gray gouge zone and greenish brown gouge zone was formed by progressive cataclastic flow. In the first stage the fault core initiates from damage zone of early faulting. In the second stage damage zone actively transforms into breccia zone by repeated fracturing. The third stage includes greenish brown (old) gouge formation in the center of the fault core mainly by particle grinding. In the third stage further deformation leads to the formation of new (bluish gray) gouge zone while old gouge zone undergoes strain hardening. Consequently, the whole gouge zone in the core widens.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.24 no.1
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• pp.17-25
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• 2024

Fabry disease (FD) is an X-linked lysosomal storage disorder. It is caused by mutations in the α-galactosidase A gene, which results in deficient or absent activity of α-galactosidase A (α-Gal A). This leads to a progressive accumulation of globotriaosylceramide (Gb3) in various tissues. Manifestations of Fabry disease include serious and progressive impairment of renal and cardiac function. In addition, patients experience pain, gastrointestinal disturbance, transient ischaemic attacks, and strokes. Additional effects on the skin, eyes, ears, lungs, and bones are often seen. Reduced life expectancy and deadly consequences are being caused by cardiac involvement. Chaperone therapy or enzyme replacement therapy (ERT) are two disease-specific treatments for FD. Thus, early detection of FD is critical for decreasing morbidity and mortality. Globotriaosysphingosine (lyso-Gb3) for identifying atypical FD variants and highly sensitive troponin T (hsTNT) for detecting cardiac involvement are both significant diagnostic indicators. This review aimed to offer a basic resource for the early diagnosis and update on the diagnosis of having FD. We will also provide a general diagnostic algorithm and information on ERT and its accompanying treatments.

• Childhood Kidney Diseases
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• v.3 no.2
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• pp.109-116
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• 1999

Purpose: Insulin-like growth factor(IGF)-I and -II are peptide growth factor whose activity is modulated by interaction with the family of six IGF-binding proteins(IGFBPs). IGF-I is detected in rat kidney and has metabolic and growth effects. This study was designed to examine temporal expression of IGFBPs in kidney during renal development and postischemic regeneration in rat. Method: The expression of IGFBPs in kidney during renal development from 15th day of gestation to adult life by using Northern blot analysis. We also examined the renal IGF-IGFBP axis in uremic rat by using Northern blot and immunohistochemistry. Results: The mRNA of IGFBP-1 and -3 were not or barely detected in fetal stages. However, the mRNA level of IGFBP-1 and -3 were increased gradually from day 7 after birth to adult. In contrast, the mRNA of IGFBP-2 and -5 were highly expressed in fetal stages and maintained almost same levels until day 7 (IGFBP-2) or day 30 (IGFBP-5) after birth, then their levels decreased markedly. The mRNA of IGFBP-4 were expressed moderately in fetal kidney and increased gradually after birth. Interestingly, the mRNA of IGFBP-1 and-4 were induced up to 3-5 fold during maximum regeneration period and were recovered to normal levels after acute ischemic injury. In contrast, the mRNA level of IGFBP-3 and-IGFBPrP-1 were decreased slightly at 1 day after ischemic injury, then recovered to normal level during maximum regeneration period. Conclusion: There were differential expressions of IGFBPs in kidney that can modulate IGF action on developing, differentiating, maintaining, and regenerating renal structure and function.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.803-810
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• 2007

An analytical method capable of predicting various stress-strain responses in axially loaded concrete confined with FRP (fiber reinforced polymers) composites in a rational manner is presented. Its underlying idea is that the volumetric expansion due to progressive microcracking in mechanically loaded concrete is an important measure of the extent of damage in the material microstructure, and can be utilized to estimate the load-carrying capacity of concrete by considering the corresponding accumulated damage. Following from this, an elastic modulus expressed as a function of area strain and concrete porosity, the energy-balance equation relating the dilating concrete to the confining device interactively, the varying confining pressure, and an incremental calculation algorithm are included in the solution procedure. The proposed method enables the evaluation of lateral strains consecutively according to the related mechanical model and the energy-balance equation, rather than using an empirically derived equation for Poisson's ratio or dilation rate as in other analytical methods. Several existing analytical methods that can predict the overall response were also examined and discussed, particularly focusing on the way of considering the volumetric expansion. The results predicted by the proposed and Samaan's bilinear equation models correlated with observed results with a reasonable degree, however it can be judged that the latter is not capable of predicting the response of lateral strains correctly due to incorporating the initial Poisson's ratio and the final converged dilation rate only. Further, the proposed method seems to have greater benefits in other applications by the use of the fundamental principles of mechanics.

• Clinics in Shoulder and Elbow
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• v.11 no.1
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• pp.57-61
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• 2008

Tuberculous arthritis on the sternoclavicular joint is an uncommon disease and a delayed diagnosis can be due to the obscure clinical symptoms. We should suspect tuberculous arthritis in patients with slowly progressive pain, swelling, mild fever and a previous history of tuberculosis. Early diagnosis is important through conducting a thorough physical examination and performing laboratory tests and radiologic study. Tuberculous arthritis on the sternoclavicular joint should be treated with a combination of systemic antituberculous agents and thorough surgical debridement in marked damaged joints. When performing this operation, it is important not only to minimized the injury of the costoclavicular ligament, but also to avoid injury to the surrounding the vital structures such as the mediastinum and pleura after aggressive resection or radical debridement. We describe here 2 cases of the tuberculous arthritis on the sternoclavicular joint: one case had a good result after surgical debridement with using an anti-tuberculous agent, and the other had fatal complications such as mediastinal abscess and pleural effusion after the operation.

• Journal of the Korean Geotechnical Society
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• v.39 no.5
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• pp.5-12
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• 2023

This study investigates the existing models for estimating the shear strength of rock joints, presents related problems, and introduces a newly proposed model to overcome the problems. The results of many experimental tests show that the shear strength of a rock joint depends on many complex factors, including asperity angle, compressive strength, applied normal stress, friction angle, asperity cohesive strength, and progressive damage of asperities. However, the existing models do not account for these factors enough. To overcome these problems, Son (2020) developed a new model to estimate the shear strength of rock joints and confirmed its reliability by comparing with experimental results and existing models. In this paper, the developed model was used to investigate the various factors that affect the joint shear strength, and the results were compared and analyzed. Through this study, the factors that affect the shear strength of the rock joint could be identified in more detail.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.6
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• pp.601-607
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• 1992

In order to investigate the liver damage and hepatic protective systems in cadmium(Dd) administered rats, five different levels of Cd were injected intraperitoneally to male rats of sprague-Dawley strains weighing $250{\pm}15g.$ Levels of daily Cd administration were 0(control), 0.625(A), 1.25(B), 2.5(C) and 5mg(D)/kg of body weight and single inhection per day was done for consecutive two days. With increasing Cd dosed, serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase activities were increased. And at the same time, hepatic reduced glutathione contents were decreased, whereas the levels of oxidized form were increased. Liver lipid peroxide levels of A, B, C and D groups were 1.1, 1.5, 1.8 activities and vitamin E contents were progressively reduced in accordance with the increase in Cd dose. However, liver superoxide dismutase activities were not different between control and A group although it was higher in B and lower in C and D groups compared with control.

• Journal of the Society of Naval Architects of Korea
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• v.49 no.6
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• pp.521-527
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• 2012

It is well known that flexible composite material propeller has superior radiation noise characteristics with outstanding damping effects. In this paper, three flexible composite material propellers were produced using compression molding process, and their hydrodynamic performances and radiation noise characteristics were measured. One propeller, C1, was made up from carbon/epoxy composite laminates, and the other two ones, G1 and G2, from glass/epoxy ones. Their fiber arrays were selected by the progressive damage structural analysis of propellers using composite material model MAT_162 (Composite_DMG_MSC) linked with LS-DYNA code. Carbon/epoxy and glass/epoxy composite specimen tests were performed, their damage mechanisms were figured out, and their parameters were calibrated by their progressive damage structural analysis according to their damage criteria.

• PNF and Movement
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• v.14 no.2
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• pp.149-155
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• 2016

Purpose: The purpose of this study was to investigate the effects of using proprioceptive neuromuscular facilitation (PNF) exercise in the progressive sitting position on the dynamic balance ability of a patient with a cerebellar injury. Methods: The subject had ataxia due to cerebellar injury. The subject participated in a PNF bilateral scapular pattern exercise with stabilizing reversal technique during a progressive sitting position session as well as baseline for 20 minutes a day for 4 weeks. In the first session, PNF exercises were performed at a height of 40 cm for 10 minutes, and in the second session they were performed at 50 cm for 10 minutes from a lower center of gravity (COG) to a higher COG sitting position. We used the Berg Balance Scale (BBS), Five-Times-Sit-to-Stand Test (FTSST), and the Timed Up and Go Test (TUGT) to measure the subject's dynamic balance ability every two days through the entire session. Results: After participating in the program, the subject's dynamic balance ability improved compared to the first baseline, as measured by BBS (2 points increased), FTSST (5.3 sec decreased), and TUGT (2 sec decreased). The increase was also maintained in the second baseline session. Conclusion: PNF exercise using bilateral scapula patterns with a stabilizing reversal technique helps to enhance the dynamic balance ability of a cerebellar injury patient.