• Journal of Gastric Cancer
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• v.5 no.4 s.20
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• pp.288-294
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• 2005

Purpose: Superficially spreading (SS) early gastric cancer (EGC) is characterized by wide horizontal extension without deep vertical invasion. It is a relatively rare form of EGC, and it's clinicopathological (C-P) characteristics are not evident. This study aimed to clarify their C-P characteristics. Materials and Methods: We defined SS EGC as invading less than the submucosal layer that measured more than 60 mm in diameter or wider than $5{\times}5cm \;(25cm^2)$ in width. The C-P characteristics and prognosis were compared between 69 patients with SS EGC and 319 patients with the common type EGC (EGC except SS type). Results: For SS EGC lymph node metastases, Lauren's diffuse type, lymphatic invasion were significantly higher than in common type EGC. In patients with SS EGC, all of the metastatic lymph nodes were anatomically distributed within the paragastric region, with fewer along the left gastric artery and common hepatic artery. In 6 cases of SS EGC with resection marqins less than 10 mm, there was no death during the follow-up period (4 to 13 years after operation) if margins were not involved. Age (>58 yrs), tumor site (upper 1/3), lymph node metastasis, submucosal invasion were statistically significant poor prognostic factor in univariate survival analysis. In multivariate survival analysis, age and lymph node metastasis were independent prognostic factors. However, tumor diameter or width was not a significant prognostic factor. Conclusion: Although SS EGC has histologically distinct properties, gastrectomy with free surgical margins and appropriate lymph node dissection $(D1+{\beta})$ could be a suitable treatment.

• Korean Journal of Pharmacognosy
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• v.38 no.2 s.149
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• pp.101-107
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• 2007

This study was carried out to examine the in vitro effects of alginate (LVA) which is low viscosity alginic acid, on collagen type II synthesis of chondrocytes and the in vivo effect, orally administered, on cartilage degradation. Rabbit articular chondrocytes were cultured in 35 mm dishes and then LVA was treated. The effects of LVA of various viscosity (86.5 cP(LVA1),45.4 cP(LVA2), 21.2 cP(LVA3) and 9.6 cP(LVA4)) and various concentration (50, 100, 200 ${\mu}$g/ml of LVA4) on chondrocytes were determined by western blotting assay for the detection of collagen type II production. In western blotting assay, collagen type II production in chondrocytes were 1.00 in control,0.95 in LVA1, 1.41 in LVA2, 1.57 in LVA3 and 1.58 in LVA4. Collagen type II production of various concentration of LVA4 were 1.00 in control, 1.24 in 50 ${\mu}$g/ml of LVA4, 1.52 in 100 ${\mu}$g/ml of LVA4 and 1.86 in 200 ${\mu}$g/ml of LVA4. Osteoarthritis (OA) was induced in 24 rabbits by unilateral anterior cruciate ligament transection (ACLT) and randomly divided into 6 groups. The experimental group was given oral administration of 0.5 ml/kg of saline(control), 12.5 mg/kg of LVA (A12.5), 25 mg/kg of LVA (A25), 50 mg/kg of LVA (A5O), 75 mg/kg of LVA (A75) and 20 mg/kg of aceclofenac (AC) for 6 weeks after ACLT. All knees were harvested at 6 weeks after surgery and cartilage degradation was evaluated. Cartilage degradation in the control group was significantly more severe than that in the A25, A5O and A75 groups but AC group had no significant changes on the macroscopic grading scale.

• Journal of Nutrition and Health
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• v.41 no.1
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• pp.13-21
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• 2008

To determine whether indol-3-carbinol (BC, $C_9H_9NO$), an autolysis product of a glucosinolate and a glucobrassicin in vegetables, regulated tight junction proteins (TJ) and suppressed cell invasion in colon cancer cells, this experiment was performed. Our results indicate that I3C inhibit cell growth of HT-29 cells in a dose (0, 50, $100{\mu}M$) and time (0, 24 and 48h) dependent manner. Using the wound healing and matrigel invasion study, respectively, BC inhibits the cell motility and invasion of the ovarian cancer cell line. The TEER values were increased in HT-29 cells grown in transwells treated with BC, reversely, paracellular permeability was decreased in those of condition. Claudin-1, claudin-5, ZO-1 and occuldin have been shown to be positively expressed in HT-29 coloncancer cells. I3C occurs concurrently with a significant decrease in the levels of those of proteins in HT-29 cells. But E-cadherin level in the HT-29 was increased by I3C. The reduction of claudin-1 and claudin-5 protein levels occurred post-transcriptionaly since their mRNA levels are no difference by I3C. Therefore, our results suggest that I3C may be expected to inhibit cancer metastasis and invasion by tighten the cell junction and restoring tight junction in colon cancer cell line, HT-29.

• Science of Emotion and Sensibility
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• v.10 no.4
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• pp.603-611
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• 2007

Initially, this study was to develop reliable and effective alcohol-associated visual cues. Alcoholic picture cues were chosen from the Normative Appetitive Picture System (NAPS). Additional images consisted of Korean beer and mild liquor was pre-tested to select the pictures that would induce craving most intensely. The images that recorded the highest scores on a scale were chosen through the pre-test. And then, the reliability and validity were examined for the selected alcohol cues from NAPS and pre-test via another psychometric test. Secondly, the study was to investigate differences in craving between subjects with alcohol use disorders (AUDs) and non-alcoholic control subjects when exposed to the alcohol visual cues. Alcohol abusers with AUD (n=9) and demographically similar non-abusers (n=9) participated in this study. After given 5cc of alcohol, subjects were exposed to different types of stimuli (i.e., alcohol, nonalcoholic beverage, and visual control pictures and one rest (cross-hair)). Craving levels were rated through self-report on a Likert scale immediately after the presentation of visual cues. Results showed statistically significant differences between the AUD group and the control group in the Obsessive Compulsive Drinking Scale (OCDS) scores, pre-sip and post-sip alcohol craving. Also, the AUD group showed significantly a higher level of craving during alcohol cues compared to the control group. In conclusion, alcohol craving induced by alcohol cues among subjects with AUD was found to be different from that of non-abusers.

• Journal of Veterinary Clinics
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• v.22 no.1
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• pp.21-25
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• 2005

This study was performed to assess therapeutic effect of the tibial plateau leveling osteotomy (TPLO) in dogs with experimentally transected cranial cruciate ligaments (CrCL). Nine healthy adult Beagle dogs were transected left CrCL under general anesthesia. The dogs were assigned to TPLO and non-TPLO control groups. The TPLO procedures for correcting the CrCL rupture in the left stifle of dogs were performed under sterile conditions. Before TPLO procedures, all dogs were screened by orthopedic and radiographic examinations. Dogs were lameness free for the previous three months, and when examined at the walk and trot on a hard surface, in a straight line and on a circle. Lateral and craniocaudal radiographs were done to confirm the soundness of the both knee joint in dogs and not detectable lesions were diagnosed. The dogs were intravenously injected with a 10 mci/kg of 99mTechnetium-methylene diphosphonate (99mTc-MDP) under general anesthesia. Scintigraphs were obtained using a large field of view gamma camera equipped a parallel-hole, low-energy about 3 hours after intravenous injection of 99mTc-MDP. Before CrCL transection and 4, 8, and 12 weeks after the procedures, scintigraphy were conducted. Bone uptake of the left stifle joint increased after the procedures in all dogs. When the bone uptake from the TPLO procedure was compared with that of the control, there was a significant difference (p < 0.05). At 12 weeks after the TPLO procedure, the dogs showed normal anatomical posture and gait. It is concluded that TPLO procedure was effective in reconstruct of the stifle joint in dogs with CrCL rupture.

• Journal of Life Science
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• v.27 no.2
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• pp.194-201
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• 2017

Rapeseed (Brassica napus L.) is an oil crop classified as Brassicaceae, and it is widely grown worldwide. To develop a drought-resistant rapeseed, the ${\beta}$-glucosidase 1 (AtBG1) gene was introduced into rapeseed because drought- and salt-resistance phenotypes were observed when the AtBG1 gene was overexpressed in arabidopsis. Newly developed genetically modified crop must be proved to be safe. Safety assessments are based on the historical usage and scientific reports of a crop. In this study, we examined the potential acute oral toxicity of AtBG1 protein expressed in genetically modified (GM) rapeseed and calculated the minimum lethal dose at 6 weeks in both male and female ICR mice. AtBG1 protein was fed at a dose of 2,000 mg/kg body weight in five male and five female mice according to the marginal capacity concentration of OECD, 2,000 mg/15 ml/kg. Mortalities, clinical findings, and body weight changes were monitored for 14 days after dosing, and postmortem necropsy was performed on day 14. This study showed that no deaths occurred in the test group, and AtBG1 protein did not result in variations in common symptoms, body weight, and postmortem findings between the two groups. This showed that the minimum lethal dose of AtBG1 protein expressed in transgenic rapeseed exceed 2,000 mg/kg body weight in both sexes.

• (The) Research of the performance art and culture
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• no.32
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• pp.371-397
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• 2016

The function of the Duhak nongak(農樂) in Jecheon consist of Ceremony, Labor, and Entertainment. Before the commemorative rites for village god village people beat a small gong. This is a evidence of the drive away evil spirits in New Year's Eve of the lunar year. Before harden house site village peoples beat musical instrument noisily. In order to press hard the god of the earth they play musical instrument. Musical instrument not a simple musical instrument, but a purify and wish tool. When weeding a rice paddy Durae organized in Sangpung village. Durae are less effective than communal sharing of labor in weeding effect. Nonetheless, Nongak carried out core function in Durae. In order to participate Nonngak concours, peoples made a Pangut. From independence to 1970s people combine traditional nongak and Pangut. Since then village people played Pangut. From 1990s Pangut was played by Duhak Nonngak Preservation Association. Through the participation Nonngak concours, Duhak nongak was regrouped. Finally this nongak prepared Taeguk-jin, Snail-jin, Cross-jin, Sabang-jin, Sanggyeonrae Bans anggyeonrae-jin, Palbang-jin, Rope making and individual play. Duhak Nonngak promptly met the needs of the times. So, they could play Pangut. The feature of the Duhak Nonngak is that active cognition, highly skilled musician a patron and scouting a competent leader.

• Korean Journal of Heritage: History & Science
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• v.37
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• pp.151-168
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• 2004

The Mireuk Temple Stone pagoda is the largest scale of the existing Stone Pagoda in Korea. A research until now postulates that the Stone pagoda at Mireuk Temple site is composed of nine stories total. However it does not have any records of the detail, dimension, and related methods, etc, even though it is a tectonically large scale building. Only one source of the description is based upon a story which is a sort of Korean myth or traditional story (Samkukyousa, Mu dynasty), although a historical description from a myth or a story is a polemical issue and still needed research in order to prove the truth. One of the ways to make a proof of the truth is an architectural research from the typology of the plane. The types of the plane are differentiated from each era. Therefore, the typology of the plane presents a reason or a proof for the age of the pagoda. Furthermore, the typology of the plane is crucial part in the research of the historical style and it could help the historical style of the Mireuk temple stone pagoda. Research until now shows that the Mireuk temple stone pagoda is the genesis of the stone pagoda shaped after wooden one. It is impossible to find any previous one from the stone pagoda at Mireuk Temple site in Korea. So it is easier to find any previous example from the history of China because Buddhist pagoda-most pagodas are something to do with Buddhism-in Korea is introduced by India via China. This research presents the periodical variation of stone and brick pagoda in both countries. It concludes that the Mireuk temple stone pagoda has $7^{th}$ century's plane type.

• Journal of the Daesoon Academy of Sciences
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• v.21
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• pp.29-97
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• 2013

뇌법은 도교의 중요한 법술로서 당송(唐宋)이래 매우 흥했는데, 북송의 임영소 등이 신소파(神霄派)를 개창한 이후에 도교 법문을 대표하는 영역이 되었다. 그로부터 각종의 뇌법이 천하에 성행하였고, 도교에는 새로운 뇌신들이 거듭 나타나게 되었다. 그 대표적인 것이 뇌법신앙의 구진천존(九宸天尊)인데, 이 아홉 천존들은 도교의 최고신인 삼청성조(三清聖祖)의 통치 하에 있는 것으로 간주되었다. 『옥추보경』은 북송 때 탄생하였는데 이 경전이 세상에 널리 발간되어 구천응원뇌성보화천존에 대한 신앙이 형성된 것은 남송 시기 백옥섬(白玉蟾) 이후이다. 『옥추보경』은 구천응원뇌성보화천존의 법문(法門)을 선양하기 위한 방책으로 천존의 성호를 부를 것을 권장한다. 법문을 염송하는 것은 매우 쉽고도 간단하여 누구나 할 수 있었으므로 사회적으로 크게 확대되었다. 특히 『봉신연의』와 『서유기』와 같은 문예소설에 뇌성보화천존이 등장함으로 해서, 민중들은 뇌성보화천존을 더욱 널리 숭배하게 되었다. 현재도 중국의 민간에서 이 신격에 대한 신앙은 매우 보편적이다. 구천응원뇌성보화천존은 옥청진왕(玉清真王)의 화신(化身)이다. 뇌성보화천존은 시방에 그 형체를 나타내고, 중생들을 고뇌로부터 구제하고 이끈다. 36천을 주재할 권능이 있으며, 자비로운 모습으로 모든 겁에 응한다. 또 뇌성보화천존의 주변에는 뇌공(雷公), 우사(雨師), 풍백(風伯)을 비롯한 십대원사(十大元帥)와 등백온원사(鄧伯溫元帥), 신한신원사(辛漢臣元帥) 등의 신장들이 보인다. 이러한 신장들은 양송(兩宋) 시대에 출현하였으며 대다수가 뇌부의 제신들이다. 뇌성보화천존 신앙을 구현하기 위한 재초 의식에는 천지 제신(諸神)이 강림하기를 청하는 뇌정사과(雷霆謝過)와 죄를 뉘우치고 복을 비는 참의(懺儀) 또는 참회문식(懺悔文式) 등이 있다. 이런 법식들은 매우 전문적인 것이고, 일반인들에게는 법문을 염송하는 간편한 방법인 십자천경법(十字天經法)이 널리 퍼졌다. 즉 늘 경건한 마음으로 천존의 성호를 오랫동안 염송하게 되면 공덕원만(功德圓滿)의 경지에 도달할 수 있다는 것이다. 『옥추보경』은 민중의 세계에 깊은 영향을 끼치고 광범위하게 알려져 그 주해나 주석본만도 이십여 종에 이르렀고 송원 이래의 핵심적인 도교 문헌의 하나로 자리매김하였다. 『옥추보경』은 일본과 한국 등지에도 급속히 전파되었다. 한국에는 고려시대에 신소뇌법(神霄雷法)이 전해졌는데, 특히 고려 예종 13년(1118년) 7월에 중국 도교 의학이 고려에 전승되었을 때의 도교 의학이 『옥추보경』을 위주로 한 치료법이었다. 그리고 그 흔적은 조선의 허준이 주편한 『동의보감』에서도 찾아볼 수 있다. 조선의 민간에서는 많은 사람들이 『옥추보경』을 송독하였고 거기에 수록된 부록(符籙)을 운용하였으며 이로써 병을 몰아내고 잡귀를 물리쳐 생명을 지키기를 바랐다. 현대 한국에서는 구천응원뇌성보화천존강성상제에 대한 신앙이 크게 성행하고 있으니, 그 종단이 바로 대순진리회이다. 대순진리회는 증산 성사께서 인세에 강림하시기 전에 구천대원조화주신이며, 화천 후 구천응원뇌성보화천존상제의 위에 임하였다고 신앙한다. 즉 증산이 천존상제의 화신이라 믿는 것이다. 이것과는 좀 다르지만, 인간이 신의 화신이 되는 신성한 변화를 뇌법에서는 '변신(變神)'이라고 부른다. 변신은 내련(內煉)을 행할 때나 시법(施法)시에 도인들이 필히 진입해야 할 특이한 정신 상태로서, 자아의 존재를 망각하고 신진(神真)으로 변화하여 인신합일(人神合一)을 이루는 것을 의미한다. 이러한 변신은 대순진리회의 수도 목적인 도통과도 한편으로는 유사한 면이 있다고 생각된다. 대순진리회가 목적하는 지상신선실현이 의미하는 것은, 사람이 도를 깨닫는 노력을 통해 신의 경지에 도달하는 것이 아니라 인간의 본질과 천성을 회복하여 이에 상응하는 신과 합일하는 것이라는 점에서 뇌법의 변신과 유사한 점이 있다고 할 것이며 이에 대해서는 추후 연구과제로 남겨둔다.

• Science of Emotion and Sensibility
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• v.10 no.2
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• pp.243-252
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• 2007

Anti-depressant and anti-anxiety effects of Saccharomyces cerevisiae extract and its hydrolyzed fraction. The purpose of the present study was to examine the effect of Saccharomyces cerevisiae extract (SCE) and its hydrolyzed fraction (SCE-40) on depression and anxiety-related behaviors in mice. Actions of SCE and SCE-40 on serotonin, norepinephrine and GABAergic systems in the rat cerebral cortex membranes were also examined. SCE and SCE-40 significantly reduced the immobility time in the forced swimming and tail suspension test in mice. Duration time of the open arms in the elevated plus maze test was significantly increased in the SCE and SCE-40-treated groups, compared with the saline-treated control group. SCE and its fraction SCE-40 significantly inhibited serotonin and norepinephrine transporter and GABA receptor binding, compared to the saline-treated group. In addition, serotonin and norepinephrine reuptake were significantly suppressed by SCE and SCE-40. These results demonstrate that SCE and SCE-40 produce anti-depressant and anti-anxiety effects through enhancing central serotonin, norepinephrine and GABAergic transmissions. These results suggest that SCE and SCE-40 as functional food might prove to be an effective antidepressant and anti-anxiety agent.