Purpose : To evaluate the survival and prognostic factors in patients with stage III non-small cell lung cancer treated with curative radiotherapy alone or combined with chemotherapy Materials and Methods : A retrospective analysis was undertaken of 35 patients who had locally advanced non-small-cell lung cancer and treated with curative radiotherapy in Department of Therapeutic Radiology, Kangdong Sacred Heart Hospital, from January 1991 through December 1993. According to AJCC staging, 15 patients were stage IIIA, and 20 were stage IIIB. Radiotherapy was delivered with 1 8-2 Gy per fraction/day. 5 days per week using 6 MV X-ray, to a total dose ranging from 48.8 Gy to 66.6 Gy (median, 61.2 Gy) in 4 to 9 weeks. Ten patients received neoadjuvant or concurrent chemotherapy with FIP (5-FU, ifosfamide, and cisplatin) or FP (5-FU and cisplatin) Results : For all Patients, median survival was 6 months. 1-year and 2-year survival rates were 23.3% and 6.7%, respectively The median survival was 8 months in stage IIIA and 5.5 months in stage IIIB. In patients treated with radiation therapy alone, median survival was 5 months and 1-year survival rate was 9%. In patients who received chemotherapy, median survival was 11 months and 1-year survival rate was 60%. The difference of survival between these two groups was statistically significant (p=0.03). Total radiation dose, degree of response, and Post-treatment ECOG score were also significantly associated with survival. But it was not affected by age, sex, pretreatment ECOG score, presence or absence of weight loss, tumor location. pathologic type, N stage, and degree of response to treatment. Conclusion : Conventional radiotherapy alone is unlikely to achieve long term survival in patients with stage III NSCLC. Radiotherapy with altered fractionation schedule or multimodality treatment combined with surgery and/or chemotherapy should be considered if feasible.
Kim, Mi-Jeong;Han, Seung-Beom;Kwak, Jin-Ho;Kwon, Doo-Young;Kim, Min-Su;Choi, Won-Il;Jeon, Young-June;Park, Jae-Yong;Jung, Tae-Hoon
Tuberculosis and Respiratory Diseases
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v.50
no.1
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pp.84-93
/
2001
Backgrounds : In the absence of distant metastasis, small cell lung cancer (SCLC) patients presenting with supraclavicular lymph node (SCLN) involvement and pleural effusion can benefit from thoracic radiotherapy. But there are some debate as to the prognostic significance of both SCLN involvement and pleural effusion. The purpose of this study was to determine the prognostic significance of SCLN involvement and pleural effusion in SCLC. Methods : Two Hundred and fifteen patients with histologically confirmed small cell lung cancer, who were treated either at the Keimyung university Dongsan hospital and Kyungpook national university hospital from January 1994 to June 1998, were evaluated retrospectively. The patients were classified as having either limited or extensive stage using the Veterans Administration staging system. Results : SCLN was presented in 10.5% of patients(n=21). The median survival was 247 days for patients with SCLN(n=21) and 264 days for patients without(n=194) (p=0.52). After treatment, the median survival was 298 days for patients with SCLN(n=13) and 348 days for patients without(n=115) (p=0.52). SCLN involvement was not correlated with the presence of distant metastases. Median survival was 459 days for patients with a limited stage without SCLN(n=66), 650 days for those with a limited stage with SCLN (n=7) (p=0.96). Pleural effusion was presented in 24.7% of patients(n=52). The median survival was 198 days for patients with pleural effusion(n=52) and 275 days for patients without(n=163) (p<0.05). After treatment, the median survival was 294 days for patients with a pleural effusion(n=25) and 286 days for patients without(n=103) (p=0.39). The presence of pleural effusion was not correlated with that of distant metastases. The median survival was 395 days for patients with a limited stage without a pleural effusion(n=63), 451 days for those with a limited stage with pleural effusion(n=10) (p=0.92). Conclusionsa : In this study, SCLN involvement does not explain the poor survival rate and the relevance to extensive staged disease. Furthermore, the existence of a pleural effusion did not correlated with the presence of distant metastases. However, the presence of a pleural effusion appears to be a minor prognostic factor in our study. Therefore supraclavicular lymph node involvement and the presence of a pleural effusion in SCLC are not poor prognostic factors, which does not justify any amendment to the staging system currently used.
Asia-Pacific Journal of Business Venturing and Entrepreneurship
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v.16
no.4
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pp.195-209
/
2021
According to the 2019-2020 social media usage survey conducted by the Seoul e-commerce center, 5 out of 10 consumers have experienced shopping through social media. The cost of traditional advertising media has been reduced and advertising spending on social media has risen by 74%, indicating that social media is becoming a more important marketing element. While the number of users of social media has increased and corporate marketing activities have increased accordingly, research has been conducted in various aspects of marketing such as user motivation for social media, satisfaction, and purchase intention. There was no subdivided study on the differences in the social media usage frequency of consumers in actual purchasing behavior. This study attempted to identify differences in consumer characteristics by cluster in the agrifood purchase situation by grouping them by type according to the frequency of use of social media for consumers who purchase agri-food online. Product involvement, product need, and online purchase channel Consumer characteristics such as demographic distribution, perceived risk, and eating and lifestyle in each cluster were checked for the three agrifood purchase situations including choice, and types for each cluster were presented. To this end, questionnaire data on the frequency of social media use and online agrifood purchase behavior were collected from 245 consumers, and the validity of the measurement variables was secured through factor analysis and reliability analysis. As a result of cluster analysis according to the frequency of social media use, it was divided into three clusters. The first cluster was a group that mainly used open social media, and the second cluster was a group that used both open and closed social media and online shopping malls; The third cluster was a group with low online media usage overall, and the characteristics of each cluster appeared. Through regression analysis, the effect on product involvement, product need, and purchase channel selection when purchasing agri-food online through each of the three clusters was confirmed through regression analysis. As a result of the regression analysis, the characteristic of cluster 1 in the situation of purchasing agri-food online is a male in his 30s living in a rural area who has no reluctance to purchase agri-food on social media or online shopping malls. The characteristics of cluster 2 are mainly consumers who are interested in purchasing health food, and the consumer characteristics are represented. In the case of cluster 3, when purchasing products online, they purchase after considering quality and price a lot, and the consumer characteristics are represented as people who are more confident in purchasing offline than online. Through this study, it is judged that by identifying the differences in consumer characteristics that appear in the agri-food purchase situation according to the frequency of social media use, it can be helpful in strategic judgments in marketing practice on social media customer targeting and customer segmentation.
Park, Geon;Yun, Young-Jo;Kil, Sung-Ho;Rho, Hoe-Eun
Journal of the Korean Institute of Traditional Landscape Architecture
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v.37
no.4
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pp.60-72
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2019
The purpose of this study was to identify detailed factors that affect visitor satisfactions of the plants on display, environments of pedestrian road and facility of each theme garden by conducting a survey of visitors to Jade Garden. The 400 data including 100 copies per theme garden were used for statistical analysis. The statistical techniques used in the survey analysis include multi-regression analysis, t-test, and analysis of variance(ANOVA). As a result of the analysis, most of theme gardens tended to have the greatest impact on the satisfaction of the plants on display and the lowest level of facility satisfaction. According to detailed factors analysis of the satisfaction of plants on display satisfaction of plant diversity and the method of plant display were most affected in most of the theme gardens. Among them, promoting the satisfaction of plant diversity is necessary to plant various species, but in case of Ginkgo Maze Garden, a type of tree community as one tree(Ginkgo biloba), the satisfaction of plants diversity did not show a rising-up value. Therefore, it was confirmed that the appropriate degree of plants diversity depends on the theme or environment of the garden. In the case of the pedestrian-road-satisfaction, the width of the pedestrian road was the most affected, It was analyzed that whether the point of intersection can be easily available during peak season has a significant impact on the satisfaction of visitors. In the case of facility satisfaction, it was analyzed that the presence of rest and convenience facilities had the most direct influence on visitors, so the facility diversity had the greatest influence. Therefore, it is necessary to more systematically categorize and consider the influential detailed factors such as plants diversity and methods of plant display, width of pedestrian road and facilities diversity for the management and development of the arboretum.
Journal of the korean academy of Pediatric Dentistry
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v.36
no.3
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pp.440-447
/
2009
This study was performed to compare the wear resistance of sealant and flowable resins for analyzing the effect of flowable resin as a sealant in preventive resin restorations. Specimens were made and Vicker's hardness number and surface roughness were measured. SEM observations of the polished and abraded surfaces were established. Kruskal-Wallis rank test and Mann-Whitney U test at the significant level of ${\alpha}$=0.05 were used. The following results were obtained: 1. The microhardness was decreased among groups in following order: Z350 (3M ESPE, U.S.A), Estelite (Tokuyama Dental, Japan) and Ultraseal (Ultradent, U.S.A). There were significant differences in all groups (p<0.0001). 2. The surface roughness was decreased among groups in following order: Ultraseal XT plus, Palfique Estelite LV and Filtek Z350 flowable. However, there is no statistically significant differences in roughness among Estellite, Z350 and Ultraseal at the significance level of ${\alpha}$=0.05, with p=0.116 3. SEM observation of the unworn and worn surfaces revealed the qualitative differences in the wear appearance among groups. The results in this study indicate that flowable resin is better than sealant in aspect of physical properties.
Journal of the korean academy of Pediatric Dentistry
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v.44
no.3
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pp.335-340
/
2017
Composite resin becomes an essential material in pediatric dentistry. However, incremental filling of composite resin to minimize the polymerization shrinkage takes time. To reduce the polymerization shrinkage, clinicians and researchers have focused on bulk-filling materials. Bulk-base composite resin is newly introduced as bulk-filling composite resin. The purpose of this study was to evaluate microhardness profile of bulk-base composite resin according to the depth of cure. A high flow bulk-base material and a low flow bulk-base material were used for experimental group, and a conventional composite resin was used for control group. Each group consist of 20 specimens, $3.5{\times}3.5{\times}5.0mm$ mold was used to make specimen. Specimens were sectioned at the 2 mm and the 3 mm depth with milling machine. Microhardness profile was measured at the surface, 2 mm depth, 3 mm depth, and 4 mm depth. Microhardness of control group showed statistically significant difference (p < 0.05) according to the polymerization depth. In contrast, experimental group showed no statistically significant difference, except between 0 mm and 4 mm at HFB, 0 mm and 2 mm, 0 mm and 3 mm at MFB. At the surface and the 2 mm depth, the control group showed higher microhardness than the experimental groups (p < 0.05). However, at the 4 mm depth, the experimental groups showed significantly higher microhardness (p < 0.05). The results from this study, the bulk-base composite resin showed higher microhardness at the 4 mm and lower microhardness at the surface and the 2 mm depth. Therefore, if bulk-base resin overcomes the mechanical weakness, it could be considered using in pediatric dentistry.
This study developed the sex education program based on the 'reproduction and development' unit of the middle school science, and examined its effectiveness on middle school boys' sex-related knowledge and attitude towards sex. The sex education program consisted of six topics of the structures and functions of generative organs, the importance of life, abortion, the human generation process, venereal diseases and AIDS, and responsibility of self-determination on sexual behavior. The results indicated that the experimental group demonstrated the statistically higher scores of the knowledge on sex than the control groups' scores, especially in the subcategories of 'pregnancy and delivery' and 'sex-related health'. However, both groups did not display any statistical difference on the attitude toward sex. In the subcategory of the attitude towards sex, the experimental group showed the statistically higher scores on 'self-determination and selection' and 'a health relationship'. In addition, the Pearson correlation results indicated the strongest relationship between the attitude toward sex and 'the self-determination and selection'. These results implicated that the sex education program related to the unit of reproduction and development in the middle school science helps the middle school boys develop the better knowledge and attitude towards sex.
Journal of the Korean Institute of Traditional Landscape Architecture
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v.28
no.4
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pp.105-111
/
2010
This research aims to grasp the main factors of the image of Xi'an Ming City Wall Park and the harmony level with city walls and moat based on citizen's consciousness to improve the future design, field survey and the POE method are employed to analyze the image factor and harmony level of the Xi'an Ming City Wall Park. In the literature survey, the related materials were collected to obtain the most useful information for references, POE study of the Xi'an Ming City Wall Park were conducted. The instrument for survey is a questionnaire that includes a portion of questions regarding Xi'an Ming City Wall Park and the design intention of the surroundings of city wall. Data were analyzed using the Statistical Package for the Social Science (SPSS17.0 for Windows). Multiple regression analysis, and correlation analysis were employed along with the use of general descriptive data analysis. The factor analysis of the image of Xi'an Ming City Wall Park identified three factors, "environment" factor, "convenience" factor, "cultural aesthetics" factor, and the most important factor is "environment" factor. Among 14 landscape elements, paving, garden architectures and entrance spaces were identified as important variables which significantly affect the overall level of harmony with the city wall, and the space for rest; waterscape and paving were identified as important variables which significantly affect the overall level of harmony with the moat.
Journal of the Korean Institute of Traditional Landscape Architecture
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v.29
no.3
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pp.147-153
/
2011
What kinds of environmental adaptation did people during the Chosun era take when climate change due to drought was perceived and natural disasters occurred? Research hypotheses is 'More environmental improvement projects were conducted when climate disasters were experienced than rituals for rain calling. In this study, frequency samples for Rituals for Rain (RR, 祈雨祭) defined as abnormal climate of drought, Climate Disaster(CD) and Environmental Improvement Projects(EIP) were extracted from "Chosunwangjoshillok(朝鮮王朝實錄)". The analysis among RR, CD, and EIP were studied for a regression model. Research hypothesis was statistically tested. RR took placed the order of Sejong(世宗), Sukjong(肅宗) and Youngjo(英祖), while climate disasters were extracted under the Jungjong(中宗), Sungjong(成宗) and Taijong(太宗). EIP were most active under Youngjo(英祖), Sungjong(成宗) and Taijong(太宗). During the former part of the Chosun dynasty, abnormal climate was more seriously considered than climate disasters, while the opposite pattern was shown during the latter part. In a regression analysis between EIP and CD, the equation of EIP = 0.632CD was determined. As a test result, the study hypothesis the entire Chosun dynasty was dismissed. However, it is possible to statistically support that more EIP were conducted in order to adapt to the climate change during the latter part of the dynasty when climate disaster were experienced.
Kim, Ji Young;Woo, Jungmin;Lee, Sang Shin;Kim, Hea Won;Khang, Dongwoo;Rim, Hyo-Deog
Korean Journal of Psychosomatic Medicine
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v.22
no.1
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pp.13-22
/
2014
Objectives : Breast cancer has been the most prevalent female cancer in South Korea since 2001. Early detection of this disease is the most effective strategy for reducing mortality. The objective of this study was to identify factors which could predict advanced stage at diagnosis of breast cancer. Methods : Participants who were initially diagnosed with breast cancer and referred to the Stress Clinic of the Breast Cancer Center at Kyungpook National University Hospital were included. Through a semi-structured interview, the authors investigated psychosocial variables such as the extent of marital and family functioning and emotional-economic family burden as well as sociodemographic and health behavior-, health characteristic- and cancer-related variables. Results : Data were collected from 219 participants. One hundred and twenty(54.8%) subjects were diagnosed with advanced-stage breast cancer. Variables that were significantly different between the advanced-stage and early-stage groups included : monthly breast self examination(p<0.000), annual mammographic screening(p<0.000), mode of tumor detection(p<0.000), nature of the first symptoms(p<0.000), time to treatment after diagnosis(p<0.000), overloaded economic and family burden(p=0.018), marital functioning(p<0.000) and family functioning(p<0.00). Logistic regression analysis indicated that irregular annual mammography screening(OR=7.431 ; 95% CI 2.407-22.944) or a lack of screening(OR=25.299 ; 95% CI 7.855-81.482) and a dysfunctional marital relationship(OR=4.772 ; 95% CI 2.244-10.145) were significantly associated with advanced stage at diagnosis of breast cancer. Conclusions : We reconfirmed screening behavior to be a risk factor for delayed diagnosis of breast cancer. Our findings also emphasized the importance of psychosocial factors such as marital functioning in early detection of breast cancer. Psychiatric consultation in the area of martial functioning could be beneficial for increasing early detection in breast cancer.
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