• 대한예방한의학회지
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• 제19권1호
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• pp.35-46
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• 2015

Objective : This study aims to investigate legal and regulatory status of traditional and complementary medicine (T&CM) focusing on regulation on health practitioners and health practice in 33 countries. Method : 33 countries were selected based on several factors such as interest of Korean medical doctors, strategic importance, and distribution over the world. The questionnaire was distributed to Korean embassies in 33 countries in March 2014 through Ministry of Foreign Affairs, and the answers from those countries were collected from April to September. 24 countries that provided sufficient information were included in the analysis. Results : 18 countries have law or regulation on T&CM. Only five countries regulate T&CM practitioners as medical personnel or health practitioner by law, and 12 countries have regulation on license or certificate. Half of 24 countries recognize license of T&CM practitioners issued abroad. There are nine countries that recognize T&CM practice as medical practice, and four of them regulate acupuncture as medical practice by western medical doctors or a few health practitioners recognized by the government. There are six countries that do not recognize T&CM practice as medical practice by law, but regulate it as practice that affect public health, and these countries have law or regulation on T&CM. Conclusion : As T&CM have great impact on public health, many countries have recently legislated law or regulation on T&CM. Rapid change in regulatory status of T&CM affects globalization of Korean medicine. Thus, development of timely strategies will be essential for it.

• 대한한의학원전학회지
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• 제23권2호
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• pp.63-87
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• 2010

Natural Medicine is a medical system that tries to find the cause and cure of the disease in the nature emphasizing on natural healing power of human body. The most important value of traditional medicine in east Asia lies on the fact that this medicine is a medical culture and natural medicine that was selected by instinct and human nature reflecting the best possible remedy by the wisdom of evolution, and views the living phenomenon based on relation and circulation. This medicine is a natural medicine that tries to recover and promote the natural healing power by vitality and is a system that cumulates various empirical information about unique and complicated life phenomenon as a legacy of evolution in the body and the disease. The understanding of variation and adaptation of human species should be based on thorough knowledge of origin, instinct and nature of human as well as knowledge of survival and adaptation of human and environment based on evolution. And through this insight, the prevention and treatment of modern diseases should be developed. In this regards, traditional medicine in east Asia should be highlighted again as a study on adaptation and harmony of penetrating the cultural history of mind which has led the history of biological body and change of society and culture, and the repository of practical wisdom and knowledge.

• 한국전통의학지
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• 제15권1호
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• pp.106-112
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• 2006

The aim of this study was to investigate the cytotoxic effect and its mechanism on Radix Aconiti(RA) extract in lung cancer cell lines. RA extract treatment decreased the cell viability in a dose-dependent fashions in lung cancer cells including A549, H460, H23 and H157 cells. Many investigators reported that A549 and H460 cells expressed wild-type p53, but H23 and H157 cells preserved mutated p53. After treatment with RA extract in A549 and H460 cells, we measured the expression of p53 protein levels using Western blot. analysis. In both cells treated with RA extracts, p53 protein expressions were increased in a dose-dependent manner. In our experiments, RA extracts also have cytotoxic effects in H23 and H157, which have mutated p53. Treatment with RA extract decreased bcl-2 protein expressions in both cells. These results suggest that RA extracts have cytotoxic effects via p53 expression increase and bcl-2 inhibitable pathways in A549, H460 cells and H23, H157 cells, respectively.

• 한국전통의학지
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• 제15권1호
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• pp.97-105
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• 2006

To study on antioxidant effects in the liver of 40-week-old mouse, the sample were orally pretreated 5mg/kg/day for 5 days with red ginseng saponin components(total saponin, protopanaxadiol saponin, protopanaxatriol saponin, ginsenoside-Rd, ginsenoside-Re, compound-K) for 5 days. The ability of saponin to protect the mouse liver from oxidative damage was examined by determining the activity of superoxide dismutase(SOD), glutathione peroxidase(GPx) and the contents of glutathione, the level of malondialdehyde, The only protopanaxadiol among the ginseng saponin fractions was significantly increased the hepatic SOD activity(p<0.01). The red ginseng saponin induced a slight increase of GPx activity, especially ginsenoside Rd, compound K and protopanaxatriol treatments significantly increased its activity. The content of glutathione was significantly increased by total saponin, protopanaxadiol and ginsenoside Rd(p<0.01), but the oxidized glutathione level was lowered in all the red ginseng saponin. Finally, the level of malondialdehyde was significantly decreased by ginsenoside Rd and protopanaxadiol. In conclusion, protopanaxadiol and ginsenoside Rd among the saponin fraction were especially increased in the activity of hepatic antioxidative enzyme and decreased the lipid peroxidation that was expressed in term of MDA formation. This comprehensive antioxidant effects of red ginseng saponin seems to be by a certain action of saponin other than a direct antioxidant action.

• 한국전통의학지
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• 제15권1호
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• pp.83-89
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• 2006

Many naturally occurring plant extracts are studied for their beneficial effects for health and particularly on cancer. Apoptosis, or programmed cell death, occurs in both normal and pathological conditions, including cancer. Dysregulation of apoptosis allows transformed cells to continually and uninhibitedly enter the cell cycle, thus perpetuating the sequence of mutation, genomic instability and, finally, oncogenesis. To investigate the apoptosis-Inducing effect of the extract of Fructus Trichosanthis (EFT) on leukemic HL-60 cells and its mechanism, HL-60 cells in vitro in culture medium were given different doses of the extract. The inhibitory rate of cells were measured by microculture tetrazolium assay, cell apoptotic rate was detected by flow cytometry, morphology of cell apoptosis was observed by DAPI fluorescence staining, and the activations of caspases and PARP were detected using Western blotting analysis. The extract could activate the caspase-3 and caspase-8, induce PARP cleavage, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was in dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by DAPI fluorescence staining especially. These results will provide strong laboratory evidence of EFT for clinical treatment of acute leukemia.

• 한국전통의학지
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• 제15권1호
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• pp.77-82
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• 2006

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

• 한국전통의학지
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• 제15권1호
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• pp.70-76
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• 2006

The aim of this study was to investigate the effect of ethanol extract of Fagopyrum escuentum(FE) on the melanogenesis. To determine whether ethanol extract of FE suppress melanin synthesis in cellular level, B16F10 melanoma cells were cultured in the presence of different concentrations of FE ethanol extract. In the present study, the author examined the effects of FE ethanol extract on cell proliferation, melanin contents, tyrosinase activity. Cell proliferation was slightly increased by treatment with ethanol extract of FE (25-200 ${\mu}$g/ml). The ethanol extract of FE effectively suppressed melanin contents at a dose of 100 ${\mu}$g/ml. It was observed that the color of cell pellets was totally whitened compared with the control. The ethanol extract of FE inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. These results suggest that the ethanol extract of FE exerts its depigmenting effects through the suppression of tyrosinase activity. And it may be a potent depigmetation agent in hyperpigmentation condition.

• 한국전통의학지
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• 제15권1호
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• pp.49-55
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• 2006

Objective: <千金方(Qianjinfang)> which documents a great amount of prescription of Acupuncture and moxibustion bikes an important role during the development of acupuncture and moxibustion. Thus, it have given rise us to the research-situation of Tang Dynasty China of previous period. This study was to outline the rules of choosing acupoints as well as the prescriptions of contemporary times in reference with <千金方(Qianjinfang)>, and to discuss the conception of acupuncture and moxibustion in <千金方(Qianjinfang)>. Method: Based on <千金方(Qianjinfang)>, the parameters were categorized to a certain scope, syndromes in different type were classified. Also numbers of acupoints, route of meridians locations, utilities of special acupoints even prescription methods were statistically analyzed in reference with <千金方(Qianjinfang)>. Results & Conclusion: Acupuncture prescription in <千金方(Qianjinfang)> was mostly presented by single acupoint and this was basic prescription of its rule of choosing acupoints. Choosing acupoint for the majority of various diseases started from choosing meridians with the disorder, but no rules for choosing acupoints was clear. There was basically various methods in choosing acupoints, but little were used by Biao-Ii meridian choosing method (表裏經配穴.) In the high frequency of use, wu-shu acupoints was higher used than other specific acupoints (特定穴). While wu-shu acupoints treated the major parts of the diseases, shu-mo acupoints were strictly used on system. Consequently : The theoretical basis originating the choosing rules of the acupoints and prescriptions was shown in <千金方(Qianjinfang)> as representative clinical reference, through which it was valuable to analyze the prescription rule and specificity of the acupoints.

• 대한한의학원전학회지
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• 제34권1호
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• pp.67-87
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• 2021

Objectives :The purpose of this paper is to evaluate the significance of the 『Joseonbogeonsa』 by examining North Korea's perspective in its documentation of the history of medicine, and to further understand North Korea's perception of Korean Traditional Medicine. Methods : The focus of examination was on the perspective of historical description as shown in the first chapter of the 『Joseonbogeonsa』. Its unique features were made clear through comparison with historical texts of medicine of South Korea such as the 『History of Medicine in Korea』, and the 『History of Korean Medicine』. In order to grasp the current of historical research in North Korea, various Traditional Medicine related dictionaries and academic journals of North Korea along with the 『Joseontongsa』 were examined. Results & Conclusions : The historical views of the 『Joseonbogeonsa』 could be categorized as nation-focused, materialistic, and nationalistic. These are core elements that make up North Korea's self-reliance ideology, which influenced the interpretation of medical facts. While the text is valuable in that it introduced new historical material along with its interpretation, and argued for a more independent development of Traditional Medicine, its limitation of interpreting historical material from a conclusive, pre-determined standpoint cannot be overlooked. The North Korean 'Goryeo Medicine' is defined by its historical nature rather than academic characteristics, and its significance is determined by its clinical efficacy rather than theoretical value.

• 대한한의학원전학회지
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• 제13권2호
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• pp.44-56
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• 2000

장개빈(張介賓)(1563-1640, 호시경악(號是景岳))시명말의학가이계승김원대의학전통적인물(是明末醫學家而繼承金元代醫學傳統的人物). 타재(他在) 류경도익(類經圖翼), 의역의(醫易義) 주장'의역동원'이논증의학여역학지회통성(主張'醫易同源'而論證醫學與易學之會通性). 타이성리학이론내연구의학(他以性理學理論來硏究醫學). 인이피칭위'유의'(因而被稱爲'儒醫'). 타광범지연구유가급제자백가지후(他廣範地硏究儒家及諸子百家之後), 이(以) 황제내경(黃帝內經) 여(與) 난경 위주(難經 爲主). 종합의가학설(綜合醫家學說). 타이(他以) '양상부족음본무여'지관념내설명인체내음양상태('陽常不足陰本無餘'之觀念來說明人體內陰陽狀態) 이반박주진형지자음론(而反駁朱震亨之滋陰論). 인이주장'부양억음'급'태극시명문'적학설(因而主張'扶陽抑陰'及'太極是命門'的學說). 타재(他在) 의역의(醫易義) 이부양억음내해설병리(以扶陽抑陰來解說病理). 관어태극-명문적론의야수성리학태극개념적영향(關於太極-命門的論議也受性理學太極槪念的影響). 단시(但是), 소위(所謂) '조원찬화'('調元贊化') '기사회생'적의학목적시속어도교양생론('起死回生'的醫學目的是屬於道敎養生論). 관어차점(關於此點), 연피칭위유의적성리학의가야병부예외(連被稱爲儒醫的性理學醫家也竝不例外). 일반인위 황제내경 시재전국 한대초기형성적(一般認爲 黃帝內經 是在戰國 漢代初期形成的). 야인위기의학체계반영저황로사상여음양오행론(也認爲其醫學體系反映著黃老思想與陰陽五行論). 장개빈수재성리학적립장내주장자기적이론(張介賓雖在性理學的立場來主張自己的理論). 단시대폭지접수도가급도교립장(但是大幅地接受道家及道敎立場). 타재(他在) 류경도익(類經圖翼), 태극도론(太極圖論), 이태극성위만물생명적근원(以太極成爲萬物生命的根源). 동시언급도도가여역위(同時言及到道家與易緯). 재장개빈(在張介賓), 태극시상통어도가발생론적개념(太極是相通於道家發生論的槪念). 야상통어태극적개념(也相通於太極的槪念). 재(在) 유경(類經), 섭생(攝生) 내간(來看). 타제요로장이외(他除了老莊以外). 우인용송대이후내단사상가강백단 이도순등적주장(又引用宋代以後內丹思想家强伯端 李道純等的主張), 인이전개자기적이론(因而展開自己的理論). 필자시위(筆者視爲), 장개빈재의학적양생방면상접수료이'성명쌍수'위기적송대이후내단사상(張介賓在醫學的養生方面上接受了以'性命雙修'爲基的宋代以後內丹思想). 병차타이연단적관점내이해부양억음(竝且他以煉丹的觀點來理解扶陽抑陰). 신위유의적장개빈능구장유도량자회통위일조의학체계적의거재어역학.(身爲儒醫的張介賓能구將儒道兩者會通爲一條醫學體系的依據在於易學). 장개빈재천인상응관념지하(張介賓在天人相應觀念之下), 용이음양변화지기구내변증천인관계(用以陰陽變化之機構來辨證天人關係). 재타적이론(在他的理論), 천지시속어 역(天地是屬於 易), 인시속어 의(人是屬於 醫), 단시양자귀위동일양적일리(但是兩者歸爲同一樣的一理). 재'원취제물(在'遠取諸物), 근취제신'적관점내강(近取諸身'的觀點來講), 타장'근취제신'적도리취어의학(他將'近取諸身'的道理取於醫學). 환유'원취제물'적도리취어역학(還有'遠取諸物'的道理取於易學), 인이모구귀납성일개원리(因而謀求歸納成一個原理). 타장자연현상적원리내재어인지생명(他將自然現象的原理內在於人之生命), 종여차정체적각도내간(從如此整體的角度來看). 가이설의학시상통어역학적(可以說醫學是相通於易學的). 역학대인여자연간적탐구(易學對人與自然間的探求), 비교측중어이론성(比較側重於理論性). 반이의학이역학이론위자(反而醫學以易學理論爲資). 관어자연여인지생명진일보지진행교구체성적연구(關於自然與人之生命進一步地進行較具體性的硏究). 총지(總之), 장개빈통과태극음양론(張介賓通過太極陰陽論), 부분유 도이참재'생명'적립장(不分儒 道而站在'生命'的立場), 광범지접납유도양가(廣範地接納儒道兩家). 유차(由此) 아문가이여도장개빈의서적가치병부한어의학가치(我們可以如道張介賓醫書的價値竝不限於醫學價値). 장개빈의서제시유 도량가가이회통어"생명사상"적철학상가능성(張介賓醫書提示儒 道兩家可以會通於"生命思想"的哲學上可能性).