• The KIPS Transactions:PartD
• /
• v.8D no.5
• /
• pp.553-560
• /
• 2001

Bioinformatics is a discipline to support biological experiment projects by storing, managing data arising from genome research. In can also lead the experimental design for genome function prediction and regulation. Among various approaches of the genome research, the proteomics have been drawing increasing attention since it deals with the final product of genomes, i.e., proteins, directly. This paper proposes a data mining technique to predict the structural characteristics of a given protein group, one of dominant factors of the functions of them. After explains associations among amino acid subsequences in the primary structures of proteins, which can provide important clues for determining secondary or tertiary structures of them, it defines a sequence association rule to represent the inter-subsequences. It also provides support and confidence measures, newly designed to evaluate the usefulness of sequence association rules, After is proposes a method to discover useful sequence association rules from a given protein group, it evaluates the performance of the proposed method with protein sequence data from the SWISS-PROT protein database.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2013.10a
• /
• pp.713-716
• /
• 2013

The device performances of N-channel Tunneling FET have been characterized with different intrinsic length between drain and gate($L_{in}$), drain and source doping, permittivity and oxide thickness when the total effective channel length is constant. N-channel Tunneling FET of SOI structure have been used in characterization. $L_{in}$ was from 30nm to 70nm, dose concentration of drain and source were from $2{\times}10^{12}cm^{-2}$ to $2{\times}10^{15}cm^{-2}$ and from $1{\times}10^{14}cm^{-2}$ to $3{\times}10^{15}cm^{-2}$, permittivity was from 3.9 to 29, and oxide thickness was from 3nm to 9nm. The device performances were characterized by Subthreshold slope(S-slope), On/off ratio, and leakage current. From the simulation results, the leakage current have been reduced for long $L_{in}$ and low drain doping. S-slope have been reduced for high source doping, high permittivity and thin oxide thickness. With considering the leakage current and S-slope, it is desirable that are long $L_{in}$, low drain doping, high source doping, high permittivity and thin oxide thickness to optimize device performance in n-channel Tunneling FET.

• Journal of Genetic Medicine
• /
• v.7 no.2
• /
• pp.119-124
• /
• 2010

More than 7,000 rare Mendelian diseases have been reported, but less than half of all rare monogenic disorders has been discovered. In addition, the majority of mutations that are known to cause Mendelian disorders are located in protein-coding regions. Therefore, exome sequencing is an efficient strategy to selectively sequence the coding regions of the human genome to identify novel genes associated with rare genetic disorders. The "exome" represents all of the exons in the human genome, constituting about 1.5% of the human genome. Exome sequencing is carried out by targeted capture and intense parallel sequencing. After the first report of successful exome sequencing for the identification of causal genes and mutations in Freeman Sheldon syndrome, exome sequencing has become a standard approach to identify genes in rare Mendelian disorders. Exome sequencing is also used to search the causal genes and variants in complex diseases. The successful use of exome sequencing in Mendelian disorders and complex diseases will facilitate the development of personalized genomic medicine.

• Journal of Life Science
• /
• v.25 no.9
• /
• pp.1059-1071
• /
• 2015

Watermelon and melon are economically important Cucurbitaceae crops. Recently, the development of molecular markers based on the construction of genetic linkage maps and detection of DNA sequence variants through next generation sequencing are essential as molecular breeding strategies for crop improvement that uses marker-assisted selection and backcrossing. In this paper, we intended to provide useful information for molecular breeding of watermelon and melon by analyzing the current status of international and domestic research efforts on genomics and molecular markers. Due to diverse genetic maps constructed and the reference genome sequencing completed in the past, DNA markers that are useful for selecting important traits including yield, fruit quality, and disease resistances have been reported and publicly available. To date, more than 16 genetic maps and loci and linked markers for more than 40 traits have reported for each watermelon and melon. Furthermore, the functional genes that are responsible for those traits are being continuously discovered by high-density genetic map and map-based cloning. In addition, whole genome resequencing of various germplasm is under progress based on the reference genome. Not only by the efforts for developing novel molecular markers, but application of public marker information currently available will greatly facilitate breeding process through genomics-assisted breeding.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2003.10a
• /
• pp.210-219
• /
• 2003

오페론(operon)은 보통 미생물에서 다수의 인접한 유전자들로 구성된 그룹으로 하나의 유전자처럼 공통된 프로모터에 의해 전사되는 단위이다. 오페론을 구성하는 유전자들은 기능적으로 서로 유사하거나 같은 물질대사경로(metabolic pathway) 상에 존재하는 특징을 지니기 때문에 이들은 중요한 의미를 가지며, 미생물 유전체 분석에서 오페론을 구성하는 유전자들을 예측하는 것은 상당히 중요하다. 오페론을 예측하는 이전 연구들로는 이미 알려진 오페론의 특징인 유전자간 거리나 오페론을 구성하는 평균 유전자 개수 등을 이용하는 방법, 마이크로어레이 발현 실험을 이용한 방법, 전유전체(whole genome)들 간의 보존된 유전자 집합(conserved gene cluster)을 이용한 방법 그리고 물질대사경로를 이용한 방법 등이 있다. 본 논문에서는 COG 기능(function) 거리, 유전자 간의 거리, 코돈 사용빈도(codon usage) 그리고COG 기능 거리와 유전자간 거리를 같이 적용한 방법을 이용하여 오페론 예측을 위한 전처리 모델을 생성하였다 전처리 모델을 E. coli 전유전체에 적용해본 결과, 알려진 오페론들의 약 90%가 이를 포함하였다. 따라서 본 논문에서 제시한 전처리 모델은, 추후 오페론 예측을 위한 좋은 도구로 활용할 수 있을 것이다.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.16 no.11 s.102
• /
• pp.1067-1074
• /
• 2005

Studied antenna's basic structure was circular micro-strip patch antenna. Bandwidth was broaden and back-radiation pattern was decreased because studied antenna had PBG on a ground for improvement in its defect which is skin-effects. And character of antenna according to different shape of PBG was observed. Finally, air-gap whose dielectric constant is lower than substrates was added between substrates sc respond frequency was higher despite small size antenna.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.27 no.5
• /
• pp.486-489
• /
• 2016

A horn antenna with corrugation structure and a PTFE(Polytetrafluoroethylene) teflon(relative permittivity=2.1) dielectric lens for good impedance matching characteristic and high gain performance is proposed in this paper. The proposed antenna shows measured return loss below -25 dB over the operating X band(8~12 GHz), the peak gain of 22.3 dBi at the center frequency(10 GHz) and has overall size of $110mm{\times}110mm{\times}135mm$. Considering the performance of the proposed antenna, it is suitable for being inserted in a radar level transmitters, particularly for gas tanks on vessels or off-shore plants containing gas with very low reflectivity and relative permittivity such as LNG or LPG.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2006.02a
• /
• pp.11-18
• /
• 2006

바이오칩의 대표 주자인 DNA 칩은 점차 분자생물학의 주요 도구로 인식되고 있다. 쓰임새 또한 다양해져 기초 생물학, 기능 유전체학 연구뿐만 아니라 임상 현장에서의 적용을 위한 연구가 활발히 진행되고 있다. 임상분야에서 최근 주목 받고 있는 분야가 DNA 칩을. 이용한 질병진단 및 예후 측정이다. 개별 환자 세포의 분자유전학적 상태는 DNA 칩의 유전체 프로파일링(genome-wide profiling)으로 상세히 파악될 수 있으므로, DNA 칩은 질병의 세부아형 진단, 약물에 대한 개인 민감도 측정, 정확한 예후 측정을 통한 환자의 세심한 관리 등 미래 의료의 핵심이라 할 수 있는 개인별 맞춤 치료(personalized medicare)를 가능하게 하는데 지대한 역할을 할 것으로 기대되고 있다. 특히 수많은 질병 중에서 현대인의 난치병으로 손꼽히는 암은 DNA 칩 분석의 주요 적용 대상이다. 암에 연관된 복잡한 메커니즘을 기존의 단일 표지자로 진단하는 데는 한계가 있기 때문에, DNA 칩을 이용해 질병의 특정 phenotype과 관련 있는 암의 특이 패턴을 전사체 수준에서 분석하여 새로운 형태의 분자유전학적 표지자(transcriptional molecular signature)를 발굴하는 것이다 본 발표에서는 이러한 연구에 쓰이는 DNA 칩 분석 방법들과 실제 위암 데이터에 적용한 사례에 대해 논의하고자 한다. 연세의대 암전이 연구센터의 17K cDNA 칩을 이용하였으며, 진단 및 예후 측정을 위한 여러 분석 방법을 수행하였다.

• Proceedings of the Materials Research Society of Korea Conference
• /
• 1993.05a
• /
• pp.122-122
• /
• 1993

Perovskite형 PMN 은 약 -12$^{\circ}C$에서 Curie 최대치를 (Tm)를 가지며 1KHz에서 매우 5598;은 유전상수(~18000)를 갖기 때문에 유전체로의 응용이 큰데, PMN의제조시 쉽게 생성되는 Pyrochlore상은 일반적으로 매우 낮은 유전률(⊆210)을 가져 계의 전체 유전률을 크게 저하시키는 것으로 알려져 있으며 이런 이유로 이제까지의 연구의 초점의 주로 제조공정중 Pyrochlore 상의 첨가량 및 입자크기에 따른 PMN-Pyrechlore 2상혼합체에서 Prochlore 상의부피분률을 변화시킬 때 유전물의 변화률 GEM(General Effective Media)식을 이용하여 논의하고자한다. Pyrochlore상의 입자크기가 클 경우 2상혼합체 PMN 의 유전률은 Pyrocholre 상의 양이 증가함에 따라 서서히 감소하였으나 입자크기가 작은 겨우 급겨한 갑소를 보였다. 결국 2상의 입자크기 차이는 2상혼합체인 PMN의유전류과 밀접하 ㄴ관계가 있으며. 또한 유전률이 급격히 떨어지는 임계부피분률이 달라짐을 확인할 수 있었다. 또한 Pyrochlore상의첨가량이 증가함에 따라 2상혼합체인 PMN의 유전률의 변화는 GEM식 적용에 있어서는 임계부피률과 t값을 정확히 정하는 것이 중요한데 임계부피분률의 설정은 Perovskite PMN 과 Pyrochlore상의 입자 크기비를 이용하여 Kusy 이론을 기초로 결정하였으며, t 값은 퍼콜레이션 Power-law식에 적용시켜 정하였다였다

• Anatomy & Biological Anthropology
• /
• v.31 no.4
• /
• pp.105-119
• /
• 2018

Archaeogenetics is an academic discipline that aims to establish scientific facts of human history by integrating ancient DNA analyses with archaeological and anthropological evidence. After ancient DNA research was initiated about 30 years ago, it has been innovated so rapidly that the range of analysis has been extended toward the whole genome sequence of ancient genomes in recent 10 years. By this development, researchers have been able to study in detail the origins and migration patterns of hominin species and ancient human populations by approaches of evolutionary genetics. This study has reviewed main principles of the archaeogenetic analysis and the current trends of ancient genome studies with recent achievements. While sampling techniques and statistical analyses have been improved, typical research methods have been established by the findings on hominins and ancient western Eurasia populations. Recently, archaeogenecists have been applying the methods to studying those in other geographical areas. Nonetheless, there is still the lack of ancient genome research about populations in Eastern Asia including the Korean peninsula. This review ultimately aims to predict possibilities and promise of future ancient genome studies of ancient Korean populations.