• Journal of Life Science
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• v.30 no.5
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• pp.483-490
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• 2020

The ubiquitin system uses ligases and deubiquitinases (DUBs) to regulate ubiquitin position on protein substrates and is involved in many biological processes which determine stability, activity, and interaction of the target substrate. DUBs are classified in six groups according to catalytic domain, namely ubiquitin-specific proteases (USPs); ubiquitin C-terminal hydrolases (UCHs); ovarian tumor proteases (OTUs); Machado Joseph Disease proteases (MJDs); motif interacting with Ub (MIU)-containing novel DUB family (MINDY); and Jab1/MPN/MOV34 metalloenzymes (JAMMs). Otubain 1 (OTUB1) is a DUB in the OTU family which possesses both canonical and non-canonical activity and can regulate multiple cellular signaling pathways. In this review, we describe the function of OTUB1 through regulation of its canonical and non-canonical activities in multiple specifically cancer-associated pathways. The canonical activity of OTUB1 inhibits protein ubiquitination by cleaving Lys48 linkages while its non-canonical activity prevents ubiquitin transfer onto target proteins through binding to E2-conjugating enzymes, resulting in the induction of protein deubiquitination. OTUB1 can therefore canonically and non-canonically promote tumor cell proliferation, invasion, and drug resistance through regulating FOXM1, ERα, KRAS, p53, and mTORC1. Moreover, clinical research has demonstrated that OTUB1 overexpresses with high metastasis in many tumor types including breast, ovarian, esophageal squamous, and glioma. Therefore, OTUB1 has been suggested as a diagnosis marker and potential therapeutic target for oncotherapy.

• Journal of the Korea Society of Computer and Information
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• v.16 no.12
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• pp.1-10
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• 2011

As requirements of embedded system get complicated, the tool for analyzing the reliability of embedded software is being needed. A probabilistic modeling is used as the way of analyzing the reliability of a software and to apply it to embedded software controlling multiple devices. So, it is necessary to specialize that to embedded software. Also, existing reliability analyzers should measure the transition probability of each condition in different ways and doesn't consider reusing the model once used. In this paper, we suggest a reliability analyzer for embedded software using embedded software Markov chin model and a unit testing tool. Embedded software Markov chain model is model specializing Markov chain model which is used for analyzing reliability to an embedded software. And a unit testing tool has host-target structure which is appropriate to development environment of embedded software. This tool can analyze the reliability more easily than existing tool by automatically measuring the transition probability between units for analyzing reliability from the result of unit testing. It can also directly apply the test result updated by unit testing tool by representing software model as a XML oriented document and has the advantage that many developers can access easily using the web oriented interface and SVN store. In this paper, we show reliability analyzing of a example by so doing show usefulness of reliability analyzer.

• Korean Journal of Psychosomatic Medicine
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• v.21 no.2
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• pp.122-131
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• 2013

Objectives: This study aimed to examine the point prevalence of anxiety, depression and the associated risk factors in hospitalized patients with cancer. Methods: A total of 114 patients with cancer who admitted to the Cancer Center in St. Mary's Hospital were enrolled for a day. The patients were asked to complete Hospital Anxiety and Depression Scale(HADS). Sociodemographic and cancer related clinical variables were also evaluated. Results: The point prevalence of anxiety and depression was 10.5% and 34.2%, respectively, as assessed with HADS. Logistic regression models revealed that distant metastasis was significantly associated with anxiety in patients with cancer and previous chemotherapy and Low socioeconomic status were significantly associated with depression. Conclusions: Our results indicate that more than one third of patients with cancer suffer from either anxiety or depression. In addition, previous chemotherapy as well as low socioeconomic status and distant metastasis were associated risk factors of anxiety and depression, respectively. These findings suggest the need for screening and systematized psychosocial intervention for psychological distress in hospitalized patients with cancer.

• Journal of the Korean association of regional geographers
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• v.21 no.4
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• pp.739-750
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• 2015

This study aims to investigate the possibility of crime prevention through CCTV by analyzing the appropriateness of the CCTV location, whether it is installed in the hotspot of crime-prone areas, and exploring the crime prevention effect and transition effect. The real crime and CCTV locations of case city were converted into the spatial data by using GIS. The data was analyzed by hotspot analysis and weighted displacement quotient (WDQ). The results demonstrated that there was no significant effect in the installation of CCTV on crime prevention. This indicates that CCTV should be installed and managed in a more scientific way reflecting local crime situations. In terms of CCTV, the methods of spatial analysis such as GIS, which can evaluate the installation effect, and the methods of economic analysis like cost-benefit analysis should be developed. In addition, these methods should be distributed to local governments across the nation for the appropriate installation of CCTV and operation. This study intended to find a design guideline of the optimum CCTV installation. In this regard, this study is meaningful in that it will contribute to the creation of a safe city.

• Journal of Radiation Protection and Research
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• v.36 no.3
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• pp.160-167
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• 2011

This study conducts cross-comparison through verification of treatment planning of using beam spoiler and bolus, according to the dose variation of different tumor bed and metastatic lymph node cancers, against ionization and optically stimulated luminescence detectors(OSLDs), in head and neck radiotherapy. Verification of treatment planning examined the feasibility of inserting detectors through simulated solid dry water slabs under identical irradiated conditions from treatment planning system to measure beam spoiler and 0.5, 1 cm bolus. In addition, two detectors were cross-compared for verification of treatment planning accuracy and reliability within ${\pm}$2%. The study found that, given a beam spoiler thickness of 0.5 cm and beam spoiler-to-skin distance of 10 cm subjected to optimal dose distribution given for metastatic lymph node cancers, the bolus low-level skin dose was less, and the tumor bed dose reduced slightly. Additionally, two detectors were cross-compared for accuracy within ${\pm}$1%. Accordingly, The use of beam spoiler was determined that reduces skin side effects and can deliver an optimal dose distribution for tumor, and to apply to future clinical studies should be performed.

• Journal of the Microelectronics and Packaging Society
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• v.27 no.4
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• pp.119-125
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• 2020

Transition metal dichalcogenides (TMDCs), two-dimensional atomic layered materials with direct bandgap in the range of 1.1-2.1 eV, have attracted a lot of research interest due to their high response to light and capability to build new types of artificial heterostructures. However, the large-area synthesis of high-quality and uniform TMDC films with vertical-stacked heterostructure still remains challenge. In this study, we have developed a metal-organic chemical vapor deposition (MOCVD) system for TMDCs and conducted a systematic study on the growth of single-layer TMDCs and their heterostructures. In particular, using a bubbler-type organometallic compound sources, the concentration and flow rate of each source can be precisely controlled to obtain uniformly single-layered MoS2 and WS2 films over the centimeter scale. In addition, the MoS2/WS2 vertical heterostructure was achieved by growing WS2 film directly on the MoS2 film, as confirmed by electron microscopy, UV-visible spectrophotometer, Raman spectroscopy, and photoluminescence spectroscopy.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.53-66
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• 2007

A series of model tests were performed to investigate the soil arching effect in embankments supported by piles with geosynthetics. In the model tests, model piles with isolated cap were inserted through the holes in a steel plate, which could be operated up and down. Then geosynthetics was laid on the pile caps below sand fills. The settlement of soft ground was simulated by lowering the plate. As the plate was lowered, the soil arching was mobilized in the embankments. The deformation of both the sand fills and geosynthetics were captured by camera. Also the loads acting on pile cap and the tensile strain of geosynthetics were monitored by data logging system. Model tests showed that the embankment loads transferred on pile cap by soil arching Increased rapidly with settlement of the soft ground. In case of the absence of geosynthetics, the loads acting on pile caps dropped to residual value after peak value, whereas loads on pile caps gradually increased until constant value in case of geosynthetic-reinforced. This illustrated that reinforcing with the geosynthetics has a good effect to restrain the settlement of embankments. Also, the deformation shape of geosynthetics between pile caps was circular. The embankment loads transferred on pile caps can be estimated by considering both soil arching and tensile strain of geosynthetics in embankments supported by piles with geosynthetics.

• Journal of the Korean Geotechnical Society
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• v.22 no.4
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• pp.11-19
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• 2006

For the last decade, the hi-directional testing method has been advantageous over the conventional pile load testing method in many aspects. However, because the hi-directional test uses a loading mechanism entirely different from that of the conventional pile load testing method, many investigators and practicing engineers have been concerned that the hi-directional test would give inaccurate results, especially about the pile head settlement behavior. Therefore, a hi-directional load test and the conventional top-down load test were executed on 1.5 m diameter cast-in-situ concrete piles at the same time and site. Strain gauges were placed on the piles. The two tests gave similar load transfer curves at various depth of piles. However, the top-down equivalent curve constructed from the hi-directional load test results predicted the pile head settlement under the pile design load to be about one half of that predicted by the conventional top-down load test. To improve the prediction accuracy of the top-down equivalent curve, a simple method that accounts for the pile compression is proposed. It was also shown that the strain gauge measurement data from the hi-directional load test could reproduce almost the same top-down curve.

• The Journal of Bigdata
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• v.7 no.2
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• pp.31-41
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• 2022

Steel is one of the most fundamental components to mechanical industry. However, the quality of products are greatly impacted by the surface defects in the steel. Thus, researchers pay attention to the need for surface defects detector and the deep learning methods are the current trend of object detector. There are still limitations and rooms for improvements, for example, related works focus on developing the models but don't take into account real-time application with practical implication on industrial settings. In this paper, a real-time application of steel surface defects detection based on YOLOv4 is proposed. Firstly, as the aim of this work to deploying model on real-time application, we studied related works on this field, particularly focusing on one-stage detector and YOLO algorithm, which is one of the most famous algorithm for real-time object detectors. Secondly, using pre-trained Yolov4-Darknet platform models and transfer learning, we trained and test on the hot rolled steel defects open-source dataset NEU-DET. In our study, we applied our application with 4 types of typical defects of a steel surface, namely patches, pitted surface, inclusion and scratches. Thirdly, we evaluated YOLOv4 trained model real-time performance to deploying our system with accuracy of 87.1 % mAP@0.5 and over 60 fps with GPU processing.

• Radiation Oncology Journal
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• v.8 no.1
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• pp.103-109
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• 1990

A computerized system for database of radiotherapy Patient and for its application was developed in 1987 and has been utilized till now. A radiotherapy Planning computer (Eclipse S-140) operated under AOS (Advanced Operating System) is the main processing unit of the system which was programmed with Fortran-5. Records of 30,000 patients can be separately registered and data of 5 courses of radiotherapy delivered to one patient can be separately registered but structurally linked together. The same environment is allowed for 60 follow-up data. Our system's utility is very convenient to use and provides simple or conditional list of records or items, periodic statistics concerning many parameters and survival or complication analysis of stored database or data manually put in. Structure, operation and several retrieval formats by data processings are reported.