• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.1 no.1
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• pp.79-89
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• 1998

Purpose: Though many antiviral or immunomodulatory agents have been used in patients with chronic HBV hepatitis, interferon is considered to be the only effective therapeutic agent so far. Among immunomodulatory agents, thymodulin, the oral form of thymosin, is currently in clinical trial. We compared the efficacy of alfa-interferon therapy alone with a combined therapy of alfa-interferon and thymodulin in children with chronic active hepatitis B. Method: Twenty three children aged 4.4~13.7 years who were known to be positive for HBsAg and HBeAg in serum for at least 6 months and who had biopsy-proven chronic active hepatitis were given either combined therapy of alfa-interferon and thymodulin or alfa-interferon alone, and all children were HBV DNA positive in their serum at the beginning. Follow-ups have been done for at least 1 year after a 6 month course of therapy and clearance of viral replication markers has been evaluated. Results: 1) During follow up period, 11 (48%) children were seroconverted to anti-HBe and were cleared of HBV DNA from their serum. However, 2 of them relapsed after discontinuance of interferon therapy. 2) Seroconversion occurred more frequently among those who had not been vertically transmitted, had elevated serum ALT levels and low HBV DNA levels before interferon therapy. 3) There was no significant advantage of the combined therapy with thymodulin compared to interferon therapy alone. Conclusion: Combined therapy of alfa-interferon and thymodulin failed to demonstrate synergistic effect. We think that combination therapies of alfa-interferon with other antiviral or immunomodulatory agents need to be studied in order to achieve better therapeutic responses.

• Tuberculosis and Respiratory Diseases
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• v.60 no.3
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• pp.297-303
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• 2006

Background : Pulmonary tuberculosis is frequently accompanied with complications such as bronchiectasis, cavities, fibrosis and a deterioration of the lung function. However, there is little information available on the pathogenesis of these complications in pulmonary tuberculosis. Among the many factors involving in tissue remodeling, transforming growth factor-${\beta}1$ ($TGF-{\beta}1$) is a potent stimulus of the extracellular matrix fomation and a mediator of potential relevance for airway wall remodeling. Therefore, this study examined the relationship between the radiological changes and the $TGF-{\beta}1$ level in patients with pulmonary tuberculosis. Methods : Serum and bronchoalveolar lavage fluid (BALF) were collected from total of 35 patients before treating them for active pulmonary tuberculosis, and the $TGF-{\beta}1$ levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BALF levels were recalculated as the epithelial lining fluid (ELF) levels using the albumin method. pulmonary function test (PFT) and high resolution computed tomography (HRCT) were performed before and after treatment. Results : There was a strong correlation between the serum $TGF-{\beta}1$ level and the presence of cavities (r=0.404, p=0.006), even though the BAL $TGF-{\beta}1$ level showed a weak correlation with complications. In addition, there was no correlation between the $TGF-{\beta}1$ levels before treatment and the changes in the PFT and HRCT during treatment. Conclusion : There is a correlation between the serum $TGF-{\beta}1$ level and cavity formation in pulmonary tuberculosis before treatment. However, further study will be needed to confirm this.

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.95-103
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• 1998

Purpose : To find and solve the common problems of peritoneal dialysis(PD) by analysing the clinical data of pediatric PD performed in Korea. Methods : 264 cases of CAPD and acute PD had been performed from Nov.1987 to Oct. 1997 in 17 institutions of pediatric nephrology in Korea. Results : CAPD was performed in 114 cases. The mean age of the patients was $10.5{\pm}6.6$ years and male to female ratio was 1.4:1. The original renal diseases of ESRD were proven in 92 cases($80\%$). The common renal disease of ESRD were FSGS($17\%$), reflux nephropathy ($11\%$), chronic glomerulonephritis($9.6\%$). Mean duration of CAPD was $20{\pm}16.9$ months. Peritonitis was the most common complication and incidence was one episode/18.2 patient-months. Other complications were exit site infection in 10 cases, obstruction in 7 cases, leakage of dialysate in 6 cases. The most common etiologic organism of peritonitis was staphylococcus aureus and the next was staphylococcus coagulase(-). Acute PD was performed in 150 cases. Most common underlying causes were congenital heart disease, hemolytic uremic syndrome, sepsis and dehydration. The mean duration was $10.3{\pm}11.3$ days. The most common complication was peritonitis($20.6\%$). The most common etiologic organism was staphylococcus aureus and coagulase(-), acinetobactor and pseudomonas. Conclusion : Reflux nephropathy should be emphasized in early diagnosis and treatment to prevent ESRD. Incidence of congenital anomaly($7\%$) as a original disease of ESRD was relatively low in Korea. Growth status was not significantly improved after CAPD. In acute PD, the incidence of peritonitis was rapidly increased at 2weeks after beginning of dialysis.

• Journal of Animal Science and Technology
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• v.51 no.5
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• pp.369-378
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• 2009

Protein fractionation was evaluated from whole crop silages of rye (RS), wheat (WS), triticale (TS), oat (OS), barley (BS), and rice straw silage (RSS), and in vitro trial was carried out to examine the effect of silage and extraction of soluble protein on fermentation characteristics, total gas production and degradation. Soluble protein of silages was extracted with borate-phosphate buffer, and fermentation characteristics, gas production and degradation of silages were estimated by incubating anaerobically the mixed solution of strained rumen fluid and artificial saliva (1:1, v/v) containing dried and ground silages placed in nylon bag at $39^{\circ}C$ up to 48h. Soluble protein (SP) content was lowest for RSS as 2.11% in total CP compared to those for other silages. Highest A fraction (NPN) was observed from RS (74.33% of total CP) while those from TS and RSS were relatively low (48%). B2 fraction was relatively higher for RS, RSS and WS than for TS and BS. $B_3$ fraction was lowest in WS among silages. C fraction (27.07) in RSS was higher than in other silages (1.40~9.93%). pH in incubation solution was increased (P<0.01~P<0.001) for extracted silages up to 12h but decreased (P<0.01) at 48h for non-extracted ones. Contents of ammonia-N (P<0.001) and total VFA (P<0.01~P<0.001) were higher for non-extracted silages than for extracted ones. Acetate proportion was increased (P<0.001) in buffer extracted silages while those of propionate and butyrate were decreased (P<0.001) up to 24h incubation. Increased (P<0.001) total gas production was obtained from non-extracted silages up to 12h while gas production was increased (P<0.01) in extracted ones thereafter. In vitro degradation of dry matter and CP was increased (P<0.001) in non-extracted silages but that of neutral detergent fiber was increased (P<0.001) in extracted ones without difference among silages. Difference in mean values of degradability for each silage prior to- and post extraction with borate buffer, however, was not found among silages. It may be concluded that high NPN content of silages may reduce the protein availability in silages and borate buffer soluble components in silages can stimulate the early stage of fermentation.

• Journal of the Korean Association of Geographic Information Studies
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• v.19 no.4
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• pp.146-156
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• 2016

In this study, we developed a large fire forecasting system using critical weather conditions, such as strong winds and effective humidity. We incorporated information on forest type prior to large fires using an incident case study. The case study includes thirty-seven large fires covering more than 100 ha of damaged area over the last 20 years. Dangerous large fire regions were identified as areas of more than 30 ha of Korean red pine and the surrounding two kilometers. Large fires occur when wind speeds average 5.3 m/s with a maximum of 11.6 m/s and standard deviation of 2.5 m/s. Effective humidity for large fires average 30% with a minimum of 13% and standard deviation of 14.5%. In dangerous Korean red pine stand areas, the large fire 'Watch' level is issued when effective humidity is 30-45% for more than two days and average wind speed is 7-10 m/s. The 'Warning' level is issued when effective humidity is less than 30% for more than two days and average wind speed is more than 11 m/s. Therefore, from now on, the large fire forecasting system can be used effectively for forest fire prevention activities based on a selection and concentration strategy in dangerous large fire regions using severe weather conditions.

• Journal of Korean Orthopaedic Sports Medicine
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• v.4 no.1
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• pp.43-48
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• 2005

Purpose: The purpose of this study is to assess the result of conservative treatment in displaced radial head fracture. Materials and Methods: We analyzed 15 cases of displaced radial head fracture who were treated conservatively from April 1992 to May 2002. Follow-up period was more than 1 year. They were all males and the average age of patients was 20.2($11{\sim}24$) years. The average follow-up period was 13.4($12{\sim}15$) months. They were able to do active pronation and supination more than 70 degrees initially, who were applied long arm splint less than 1 week. The functional rating index modified after B.F. Morrey and no further displacement and union state of fragment in simple X-ray were used in follow-up assessment. Results: On the basis of the functional rating index modified after B.F. Morrey that included elements of pain, motion, strength, and stability, the results were 8 excellent, 7 good in patients who were treated conservatively, who had union and no further displacement of fragment in follow-up. Conclusion: We conclude that if they are able to do active pronation and supination more than 70 degrees initially, we take them to do early range of motion exercise after subsiding swelling, which can restrict limitation of range of motion exercise and return to the living early.

• Korean Journal of Psychosomatic Medicine
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• v.11 no.2
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• pp.205-213
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• 2003

Objectives: The authors intended to evaluate long-term outcome of group cognitive behavioral therapy(GCBT) for panic disorder and examined the variables to predict high end-state functioning in 12 months follow-up. Methods: 236 patients meeting DSM-IV criteria for panic disorder were assessed by STAI, ASI, BDI, BSQ, PBQ, ACQ at pre & post treatment, and were asked about the frequency of panic attacks during recent one month. We executed stepwise discriminant analysis on the clinical variables at pre treatment assessment to find the variables for discriminating between high end-state function(HES) and low end-state function(LES). Results: After GCBT, 82.6% of panic patients maintained high end-state functioning at 12 months follow-up. The results of discriminant analysis showed that BDI and BSQ at pre treatment assessment were significant variables to predict end-state functioning at 12 months follow-up. The hit ratio of discriminant analysis was 69.2%. Conclusion: These results suggest that the therapeutic effect of GCBT can be maintained through 12 months. Especially, it is likely that patients who were less depressed and who had less experienced the fear of physical symptoms at pre-treatment can maintain HES.

• Journal of Digital Convergence
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• v.14 no.4
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• pp.101-110
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• 2016

With the result of Korean national senior's real life state survey analysis that is triennially conducted based on Article 5 of Welfare of the Aged Act, this study categorized the senior according to age norm cognition, and figured out the characteristic of each category, and analyzed their needs for life satisfaction and hoping activities. Because the senior at present are on higher level of health, education, and economy than 20 to 30 years ago, it is about time to repeat discussion about the policies established in the past in terms of society, culture, industry, welfare, employment, and participation as a convergence approach. As a result of analysis study, the senior divided into three groups:, resignation type, progressiveness type, and saving appearances type. Their life satisfaction level and hoping activities by senior segment groups are different. By results of this study, the preservation of income for senior will be needed, and they don't want volunteer activities so that there are another policy system will be needed to vitalize senior's social participation for their healthy physical and mental life. Korean senior were satisfied with family members relationship, -although Korean senior's life satisfaction level is not higher so that the new policy to care senior by senior system will be reviewed more actively.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.278-278
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• 2012

최근 녹색도시를 지향하면서 도시 내에서의 물의 순환에 대한 관심이 높아지고 있으며 도시계획 단계에서부터 물의 순환을 고려하려는 시도가 이루어지고 있다. 국토해양부, 환경부, 소방방재청 및 지방자치단체들은 법령, 기준, 지침 및 조례 등을 제정하여 물순환을 도시개발 이전의 상태가 될 수 있도록 시설 설치를 유도하고 있다. 그러나, 개별시설들의 조합이 유역규모의 물순환에 미치는 영향 평가는 이루어지고 있지 못한 실정이다. 종래에는 홍수저감을 목적으로 홍수저류지와 침투시설에 대하여 설계하고 시공을 하였으나 장기적인 관점에서 LID 시설의 효과를 평가하여 도시 계획 단계에서 반영하지는 못하였다. 그리고 이들 개별 LID 시설(침투, 저류 등)에 대한 단위 시설의 규모 설계에 그치고 있어 개선 시설이 다중으로 조합되어 분산 계획되었을 경우, 유역 규모에서 물순환의 긍정적인 변화를 판단하기는 어려운 형편이다. 도시지역에서의 LID(Low Impact Development) 효과 분석과 연계된 유역 물순환 해석을 위하여 독일, 호주 및 미국에서는 STORM, Urban Developer, SUSTAIN(System for Urban Stromwater Treatment, and Analysis INtegratration) 및 SWMM LID(Storm Wastewater Management Model LID) 등의 모형을 출시하고 실무에 적용하고 있다. 그러나, 해외에서 개발된 기술은 국내의 유역 환경을 충분히 반영하기 어렵다. 저수지 혹은 하천에서의 취수 등과 같이 국내의 복잡한 물순환 형태를 반영하는데 한계가 있으며, 기존의 물순환 해석모형에 의한 LID 시설을 계획하는 방법은 홍수저감에 국한되어 있고, 하천 유량이나 지하수위 측정 자료가 부족한 대상지역에 대한 장기적인 유역 물순환 및 도시 개발과 같은 토지이용 변화가 물순환에 미치는 영향을 해석하는데 있어 제한이 있고, 개별적으로 설치된 LID 시설들이 유역의 물순환을 개선하는 효과를 종합적, 정량적으로 구현하는데 한계가 있다. 본 연구에서는 도시 개발 지역의 장기간에 걸친 물순환의 변화를 예측하고 물순환을 개선시키는 대안 시설의 효과를 사전에 평가하는 것을 목표로 김현준 등(한국건설기술연구원, 2011)이 개발한 유역 물순환 해석 모형인 CAT(Catchment hydrologic cycle Assessment Tool)을 이용하였다. 특히, CAT은 사용자의 목적에 맞는 다양한 물순환 개선시설(침투시설, 저류지, 습지, 빗물저장 시설, 리사이클 및 외부급수 등)의 구현 및 모의가 가능하도록 개발되었다. 대상유역으로는 경기도 Y지구를 선정하였으며 도시개발 시나리오(전원도시 및 산업도시 등)에 따른 LID 효과 분석을 실시하였다. 대상지역에 대한 도시유형별 개발계획에 따른 개발 전 후 물순환 변화량 분석 및 LID 시설 계획에 의한 물순환 개선효과를 살펴보면 1998년부터 2007년까지의 평균 강우량을 1,271mm라고 할 때 산업도시의 경우 도시 개발 전의 증발산, 직접유출 및 기저유출은 각각 53%, 29%, 19%로 나타났으며 도시 개발 후 35%, 54%, 12%로 직접유출이 개발 전에 비해 86%나 증가하여 개발에 따른 영향이 큰 것으로 나타났다. 따라서, 이러한 개발에 따른 영향을 최소화하기 위하여 LID 시설을 계획하여 효과를 분석한 결과 증발산, 직접유출, 기저유출이 44%, 34%, 13%로 나타나 도시 개발 후의 왜곡된 물순환 체계가 개발전의 수준과 근접하게 나타나 LID 시설의 긍정적인 효과를 검토할 수 있었다. 이상에서와 같이 CAT 모형을 사용하여 도시유역의 물순환 체계를 진단하고, LID 시설의 효과를 평가할 수 있게 됨으로써 향후 도시유역에 대한 물순환 정상화를 실현하기 위한 정책 수립에 기초자료를 제공하고, 설계 실무에 활용될 수 있을 것이다.

• Phonetics and Speech Sciences
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• v.14 no.1
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• pp.21-28
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• 2022

Previous studies have provided important findings on children's speech production development. They have revealed that essentially all aspects of children's speech shift toward adult-like characteristics over time. Nevertheless, few studies have examined the perceptual aspects of children's speech tokens, as perceived by naive adult listeners. To fill the gap between children's production and adults' perception, we conducted cross-sectional perceptual studies of monosyllabic words produced by children aged two to six years. Monosyllabic words in the consonant-vowel-consonant form were extracted from children's speech samples and presented aurally to five listener groups (20 listeners in total). Generally, the agreement rate between children's production of target words and adult listeners' responses increases with age. The perceptual responses to tokens produced by two-year old children induced the largest discrepancies and the responses to words produced by six years olds agreed the most. Further analyses were conducted to identify the sources of disagreement, including the types of segments and syllable structure. This study makes an important contribution to our understanding of the development and perception of children's speech across age groups.