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Alexandrium pacificum(Group IV) isolated from Jangmok Bay, Korea: Morphology, phylogeny, and effects of temperature, salinity, and nutrient levels on growth (장목만에서 분리한 유독 와편모조류 Alexandrium pacificum(Group IV): 형태, 계통 분류와 온도, 염분 및 영양염 농도 차이에 따른 성장 변화)

  • Kyong Ha Han;Joo Yeon Youn;Kyeong Yoon Kwak;Zhun Li;Wonchoel Lee;Hyeon Ho Shin
    • Korean Journal of Environmental Biology
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    • v.40 no.3
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    • pp.290-300
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    • 2022
  • A strain of Alexandrium species was established by isolating cells from Jangmok Bay, Korea. Its morphology and molecular phylogeny based on LSU rRNA gene sequences were examined. In addition, growth responses of this Alexandrium species to changes in temperature, salinity, and nutrient concentrations were investigated. This Alexandrium species from Jangmok Bay had a ventral pore on the 1', which was morphologically consistent with previously described Alexandrium tamarense and A. catenella. Phylogenetic analyses revealed that this isolate was assigned to A. pacificum (Group IV) within A. tamarense species complex. In growth experiments, relatively high growth rates and cell densities of A. pacificum (Group IV) were observed at 15℃ and 20℃. This species also grew under a wide range of salinity. This indicates that this Korean isolate of A. pacificum (Group IV) is a stenothermic and euryhaline species. In growth responses to changes in nutrient levels, enhanced growth rates and cell densities of A. pacificum(Group IV) were observed with additions of nitrate and phosphate. In particular, rapid uptakes of phosphate by A. pacificum (Group IV) were observed in experimental treatments, indicating that the increase in phosphate concentration could stimulate the growth of A. pacificum(Group IV).

The Effects of Coupled Open Innovation of Small- and Medium-sized Enterprises on Firm Performance: Focusing on R&D and Non-R&D Innovation Cooperation Activities (중소기업의 결합형 개방형 혁신이 기업성과에 미치는 효과: R&D 및 R&D 이외의 혁신협력활동을 중심으로)

  • Ji-Hoon Park;Jungwoo Lee
    • Knowledge Management Research
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    • v.23 no.4
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    • pp.177-205
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    • 2022
  • Small- and medium-sized enterprises (SMEs) have strong incentives to engage in open innovation to enhance innovation efficiency and effectiveness due to their 'liability of smallness.' Previous research examined the performance effects of various open innovation practices, but whether coupled open innovation practices positively affect SMEs' firm performance is somewhat controversial. To resolve the issue, this study examined the effects of coupled open innovation activities on SMEs' firm performance using Heckman's two stage model to control endogeneity of the firms' self-selection bias in open innovation engagement. This study used the Korean Innovation Survey (KIS) 2020 collected by the Science and Technology Policy Institute (STEPI), and tested the effects of SMEs' coupled open innovation activities, R&D and non-R&D cooperation, on their innovative and financial performance indicators. The results showed that SMEs' R&D cooperation positively affects the new-to-market (NTM) product innovation only. Moreover, SMEs' non-R&D cooperation has positive effects on the product innovation, business process innovation, new-to-the-market product innovation, and new-to-firm (NTF) product innovation. However, the results showed that both R&D and non-R&D innovation cooperation activities have no significant effects on SMEs' financial performance indicators. This study contributes to research on SMEs' open innovation and provides insights for SMEs' managers and policymakers.

Application of the EIASS for Assessing Changes in Terrain Features in Development Initiatives: A Case Study in South Korea (환경영향평가정보지원시스템(EIASS)을 활용한 국내 주요 개발사업의 지형변화 검토)

  • Sujung Heo;Dong Kun Lee;Eunsub Kim
    • Journal of Environmental Impact Assessment
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    • v.32 no.6
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    • pp.407-418
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    • 2023
  • This study conducted an analysis of terrain change indicators in major development projects in Korea, examining the correlation between terrain change indicators to derive foundational terrain change metrics based on different land use and slope types. The aim is to contribute to sustainable development by enhancing the efficiency of land utilization and landscaping, while minimizing environmental impacts in future development endeavors. Additionally, to apply the research findings in practical contexts, domestic regulations related to terrain were surveyed, and the compatibility and usability between these regulations and research analysis results were discussed. Based on this, the study seeks to explore strategies for more accurate and useful utilization of terrain change indicators in future research. As a result, in the tourism development, terrain changes predominantly occur in the order of flat land, hillly land, and mountain land, with the analysis indicating higher terrain changes in undulating hilly and mountainous lands compared to flat land. Furthermore, in industrial complex development, very steep (20°-30°) and extreme (30°-40°) slopes; in urban development projects, steep slope (15°-20°); in athletic service facility and tourist development, steep (15°-20°) and very steep (20°-30°) exhibit higher average terrain change indicators compared to other slope categories. The findings of our study can contribute to the formulation of strategies aimed at minimizing terrain disturbance in future domestic development projects and serve as foundational data for environmental impact assessments.

A global-scale assessment of agricultural droughts and their relation to global crop prices (전 지구 농업가뭄 발생특성 및 곡물가격과의 상관성 분석)

  • Kim, Daeha;Lee, Hyun-Ju
    • Journal of Korea Water Resources Association
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    • v.56 no.12
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    • pp.883-893
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    • 2023
  • While South Korea's dependence on imported grains is very high, droughts impacts from exporting countries have been overlooked. Using the Evaporative Stress Index (ESI), this study globally analyzed frequency, extent, and long-term trends of agricultural droughts and their relation to natural oscillations and global crop prices. Results showed that global-scale correlations were found between ESI and soil moisture anomalies, and they were particularly strong in crop cultivation areas. The high correlations in crop cultivation areas imply a strong land-atmosphere coupling, which can lead to relatively large yield losses with a minor soil moisture deficits. ESI showed a clear decreasing trend in crop cultivation areas from 1991 to 2022, and this trend may continue due to global warming. The sharp increases in the grain prices in 2012 and 2022 were likely related to increased drought areas in major grain-exporting countries, and they seemed to elevate South Korea's producer price index. This study suggests the need for drought risk management for grain-exporting countries to reduce socioeconomic impacts in South Korea.

Embryogenesis and plant regeneration of Panax ginseng Meyer via anther culture and ploidy assessment using flow cytometry (인삼 약 배양을 통한 배 발생과 식물 재분화 및 유세포 분석기를 이용한 배수성 검정)

  • Jung-Woo Lee;Kyong-Hwan Bang;Dong-Hwi Kim;Jang-Uk Kim;Young-Chang Kim;Ick-Hyun Jo
    • Journal of Plant Biotechnology
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    • v.50
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    • pp.19-26
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    • 2023
  • Korean ginseng (Panax ginseng Meyer) is an economically important plant because of it is rich in saponins. It is mainly cultivated in Asia, including Korea and China. Since ginseng requires a long breeding period due to juvenility, homozygote production techniques, such as anther culture, must be urgently established. In the present study, callus induction and embryogenesis through anther culture were observed in P. ginseng. Murashige and Skoog medium was used as the basal medium suitable for callus induction. When the medium was supplemented with 3% sucrose, the callus induction rate was high and the callus size was large. Cold pretreatment did not significantly affect callus induction and embryogenesis. Embryogenesis was the most efficient when the embryo-formation medium was supplemented with 1.0 or 3.0 mg/L 2,4-dichlorophenoxyacetic acid. Cultivar significantly affected anther culture efficiency. Specifically, 'Cheongseon' showed the highest embryo-formation efficiency, whereas no embryogenesis occurred in 'Sunun'. Ploidy assessment revealed the haploid status of the induced calli. Embryos derived from anther culture formed shoots upon transfer to germination medium, although no difference in ploidy was noted between the induced callus and control. Overall, the anther culture conditions established in the present study may contribute to the production of homozygous P. ginseng plants in the future.

Synergistic Inhibition of Burkitt's Lymphoma with Combined Ibrutinib and Lapatinib Treatment (Ibrutinib과 Lapatinib 병용 치료에 의한 버킷림프종의 상호 작용적 억제)

  • Chae-Eun YANG;Se Been KIM;Yurim JEONG;Jung-Yeon LIM
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.4
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    • pp.298-305
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    • 2023
  • Burkitt's lymphoma is a distinct subtype of non-Hodgkin's lymphoma originating from B-cells that is notorious for its aggressive growth and association with immune system impairments, potentially resulting in rapid and fatal outcomes if not addressed promptly. Optimizing the use of Food and Drug Administration-approved medications, such as combining known safe drugs, can lead to time and cost savings. This method holds promise in accelerating the progress of novel treatments, ultimately facilitating swifter access for patients. This study explores the potential of a dual-targeted therapeutic strategy, combining the bruton tyrosine kinase-targeting drug Ibrutinib and the epidermal growth factor receptor/human epidermal growth factor receptor-2-targeting drug Lapatinib. Ramos and Daudi cell lines, well-established models of Burkitt's lymphoma, were used to examine the impact of this combination therapy. The combination of Ibrutinib and Lapatinib inhibited cell proliferation more than using each drug individually. A combination treatment induced apoptosis and caused cell cycle arrest at the S and G2/M phases. This approach is multifaceted in its benefits. It enhances the efficiency of the drug development timeline and maximizes the utility of currently available resources, ensuring a more streamlined and resource-effective research process.

Research on Supplier's Absorptive Capacity, Knowledge Creation, Intellectual Capital and Competitive Advantage (공급업체의 흡수능력, 지식창출, 지적자본 및 경쟁우위에 관한 연구)

  • Si-Chao Wang;Yan-Nan Li
    • Journal of Digital Convergence
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    • v.21 no.3
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    • pp.1-14
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    • 2023
  • This raises the question of how competitive advantage can be created, prompting firms to enhance their capacity for change. In this context, the role of knowledge creation becomes increasingly vital. This research aims to explore the role of intellectual capital and how to improve knowledge cration ability through absorptive capacity framework. It examines the links among knowledge acquisition, learning of new knowledge, knowledge creation, intellectual capital, and competitive advantage, drawing from both internal and external sources. The study focuses on small and medium-sized supplier firms in Korea, with data collected from 15 industries, totaling 106 responses. The research model employs structural equation modeling (SEM) and utilizes AMOS 22 for analysis. As anticipated, all hypotheses were supported. The study provides robust evidence that absorptive capacity is a pivotal factor in cultivating suppliers' competitive advantage. Furthermore, it posits that intellectual capital should be viewed as a criucial component of suppliers' knowledge stock, significantly enhancing the impact of absorptive capacity on their competitive edge. Future studies should aim to validate the research model in different international settings or across multinational corporations to enhance its generalizabulity.

Evaluation of hydrologic risk of drought in Boryeong according to climate change scenarios using scenario-neutral approach (시나리오 중립 접근법을 활용한 기후변화 시나리오에 따른 보령시 가뭄의 수문학적 위험도 평가)

  • Kim, Jiyoung;Han, Young Man;Seo, Seung Beom;Kim, Daeha;Kim, Tae-Woong
    • Journal of Korea Water Resources Association
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    • v.57 no.3
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    • pp.225-236
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    • 2024
  • To prepare for the impending climate crisis, it is necessary to establish policies and strategies based on scientific predictions and analyses of climate change impacts. For this, climate change should be considered, however, in conventional scenario-led approach, researchers select and utilize representative climate change scenarios. Using the representative climate change scenarios makes prediction results high uncertain and low reliable, which leads to have limitations in applying them to relevant policies and design standards. Therefore, it is necessary to utilize scenario-neutral approach considering possible change ranges due to climate change. In this study, hydrologic risk was estimated for Boryeong after generating 343 time series of climate stress and calculating drought return period from bivariate drought frequency analysis. Considering 18 scenarios of SSP1-2.6 and 18 scenarios of SSP5-8.5, the results indicated that the hydrologic risks of drought occurrence with maximum return period ranged 0.15±0.025 within 20 years and 0.3125±0.0625 within 50 years, respectively. Therefore, it is necessary to establish drought policies and countermeasures in consideration of the corresponding hydrologic risks in Boryeong.

A study on the school health education curriculum development focused on the health education course in primary school (국민학교 보건교육 교과과정의 개선방안에 대한 연구)

  • Kim, Hwa-Joong;Lee, In-Sook
    • Journal of the Korean Society of School Health
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    • v.5 no.1
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    • pp.36-63
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    • 1992
  • The purpose of this study was development of school health education curriculum in primary school based on analysis of the textbooks published in 1991. 1) The health education curriculum in primary school consisted of four major components such as health education aspects of the healthful school environments, health education aspects of school health services, health education course, and health instruction in related subjects. However, health instruction taught by physical education, biology, and other health related subjects was not systematic organization for health care. 2) A considerable amount of health knowledge and attitude, and some health practices was learned as the result of experiences in other courses, where there was little or no reference to health. It must be developed health edcation course separated from health related subjects. 3) Direct health insruction was represented by the health education course. The health education courses must be considered to be heart of the school health education curriculum. 4) The health education course developed by this study was consisted of eight health units and problems in the early elementary grade or health classes in the higher years. 5) The health education course developed by this study provided the opportunity for acquring new knowledge, attitude, and practice, for discarding the unhealtful attitude and strengthening the healthful attitude and practices of primary school students.

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Structural Adjustment of Domestic Firms in the Era of Market Liberalization (시장개방(市場開放)과 국내기업(國內企業)의 구조조정(構造調整))

  • Seong, So-mi
    • KDI Journal of Economic Policy
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    • v.13 no.4
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    • pp.91-116
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    • 1991
  • Market liberalization progressing simultaneously with high and rapidly rising domestic wages has created an adverse business environment for domestic firms. Korean firms are losing their international competitiveness in comparison to firms from LDC(Less Developed Countries) in low-tech industries. In high-tech industries, domestic firms without government protection (which is impossible due to the liberalization policy and the current international status of the Korean economy) are in a disadvantaged position relative to firms from advanced countries. This paper examines the division of roles between the private sector and the government in order to achieve a successful structural adjustment, which has become the impending industrial policy issue caused by high domestic wages, on the one hand, and the opening of domestic markets, on the other. The micro foundation of the economy-wide structural adjustment is actually the restructuring of business portfolios at the firm level. The firm-level business restructuring means that firms in low-value-added businesses or with declining market niches establish new major businesses in higher value-added segments or growing market niches. The adjustment of the business structure at the firm level can only be accomplished by accumulating firm-specific managerial assets necessary to establish a new business structure. This can be done through learning-by-doing in the whole system of management, including research and development, manufacturing, and marketing. Therefore, the voluntary cooperation among the people in the company is essential for making the cost of the learning process lower than that at the competing companies. Hence, firms that attempt to restructure their major businesses need to induce corporate-wide participation through innovations in organization and management, encourage innovative corporate culture, and maintain cooperative labor unions. Policy discussions on structural adjustments usually regard firms as a black box behind a few macro variables. But in reality, firm activities are not flows of materials but relationships among human resources. The growth potential of companies are embodied in the human resources of the firm; the balance of interest among stockholders, managers, and workers of the company' brings the accumulation of the company's core competencies. Therefore, policymakers and economists shoud change their old concept of the firm as a technological black box which produces a marketable commodities. Firms should be regarded as coalitions of interest groups such as stockholders, managers, and workers. Consequently the discussion on the structural adjustment both at the macroeconomic level and the firm level should be based on this new paradigm of understanding firms. The government's role in reducing the cost of structural adjustment and supporting should the creation of new industries emphasize the following: First, government must promote the competition in domestic markets by revising laws related to antitrust policy, bankruptcy, and the promotion of small and medium-sized companies. General consensus on the limitations of government intervention and the merit of deregulation should be sought among policymakers and people in the business world. In the age of internationalization, nation-specific competitive advantages cannot be exclusively in favor of domestic firms. The international competitiveness of a domestic firm derives from the firm-specific core competencies which can be accumulated by internal investment and organization of the firm. Second, government must build up a solid infrastructure of production factors including capital, technology, manpower, and information. Structural adjustment often entails bankruptcies and partial waste of resources. However, it is desirable for the government not to try to sustain marginal businesses, but to support the diversification or restructuring of businesses by assisting in factor creation. Institutional support for venture businesses needs to be improved, especially in the financing system since many investment projects in venture businesses are highly risky, even though they are very promising. The proportion of low-value added production processes and declining industries should be reduced by promoting foreign direct investment and factory automation. Moreover, one cannot over-emphasize the importance of future-oriented labor policies to be based on the new paradigm of understanding firm activities. The old laws and instititutions related to labor unions need to be reformed. Third, government must improve the regimes related to money, banking, and the tax system to change business practices dependent on government protection or undesirable in view of the evolution of the Korean economy as a whole. To prevent rational business decisions from contradicting to the interest of the economy as a whole, government should influence the business environment, not the business itself.

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