• The Journal of the Acoustical Society of Korea
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• v.17 no.3
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• pp.52-58
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• 1998

본 논문에서는 시간 지연이 없는 서브밴드 필터 구조를 사용한 능동 소음 제어 시 스템을 제안하였다. 제안된 시스템은 기준 입력 신호와 2차 경로의 전달 함수를 컨볼루션하 여 만들어지는 filtered reference 신호가 서브밴드내에서 생성될 수 있도록, 2차 소음원과 오차 센서 사이의 전기·음향학적인 경로를 나타내는 2차 전달 함수를 각 서브밴드로 재구 성함으로써, 알고리듬 구현시 계산량을 감소시킨다. 또한 2차 경로의 전달함수가 시간에 따 라 변화하는 경우에도 능동 소음 제어 시스템의 소음 제어 성능을 유지할 수 있도록, 각 밴 드마다 두 개의 적응필터를 사용한 on-line 시스템 인지 구조를 제안하여 on-line 시스템 인 지에 필요한 계산량을 감소시켰다. 본 논문에서 제시한 능동 소음 제어 시스템의 제어 성능 과 on-line 시스템 인지 성능을 모의 실험을 통하여 검증하였다.

• Journal of the Korea Society of Computer and Information
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• v.14 no.5
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• pp.175-182
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• 2009

We extracted protein signal delivery path from protein interaction data, using location information and weight of protein. We obtained the protein interaction data by experimenting in two-hybrid system using Yeast. We simulated function's data of Hypotonic Shock comparing to signal delivery path provided in KEGG from the results. We measured process running period as well. In future, this research can be key to discover the origin of various genetic diseases and develop treatment.

• Ceramist
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• v.7 no.1
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• pp.5-10
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• 2004

약물 전달 시스템(Drug Delivery System; DDS)이란 기존 의약품의 부작용을 최소화하고 효능 및 효과를 최대화 시켜 약물을 효율적으로 전달하도록 제형을 설계하고 약물치료를 최적화하는 기술을 말한다. 약물전달은 전달경로, 약물의 종류 및 전달기술의 형태에 따라 구분될 수 있으며 지금까지의 약물전달소재는 유기소재로서 생체 분해성과 친화성을 갖는 천연 또는 합성고분자를 전달체로 하여 경구형, 경피투여형, 흡입형 그리고서방형 주사제 등이 이용되고 있다.(중략)

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38B no.11
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• pp.911-923
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• 2013

Multipath routing is one of challenging issues for improving the reliability of end-to-end data delivery in wireless sensor networks. Recently, a disjointedness and management of path have been studying to enhance the robustness and efficiency of the multipath routing. However, previous multipath routing protocols exploit the disjointed multipath construction method that is not to consider the wireless communication environment. In addition, if a path failures is occurred due to the node or link failures in the irregular network environment, they maintain the multipath through the simple method that to construct a new extra path. Even some of them have no a method. In order to cope with the insufficiency of path management, a hole detouring scheme, to bypass the failures area and construct the new paths, was proposed. However, it also has the problem that requires a heavy cost and a delivery suspension to the some or all paths in the hole detouring process due to the centralized and inflexible path management. Due to these limitations and problems, the previous protocols may lead to the degradation of data delivery reliability and the long delay of emergency data delivery. Thus, we propose a flexible disjoint multipath routing protocol which constructs the radio disjoint multipath by considering irregular and constrained wireless sensor networks. It also exploits a localized management based on the path priority in order to efficiently maintain the flexible disjoint multipath. We perform the simulation to evaluate the performance of the proposed method.

• The Journal of the Acoustical Society of Korea
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• v.27 no.3
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• pp.154-162
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• 2008

Signals in an underwater channel get distorted by multipath propagation. In this paper, pre-coding method is suggested which helps comprehending the signals with minimum equalization. The signals are transformed based on the knowledge of the impulse response of the channel. Proposed pre-coding method is tested by simulations based on the ray theory and through water tank experiments. In weak multipath environment, in case of an SNR of about 20 dB, BER is $10^{-3}{\sim}10^{-4}$, while in strong multipath environment, similar BER is achieved with SNR of about 30 dB. In order for the pre-coding method to be used for underwater vehicles, channel prediction method utilizing the waveguide invariant is suggested and tested.

• Journal of KIISE:Databases
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• v.30 no.6
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• pp.573-584
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• 2003

Recent massive data generation by genomics and proteomics requires bioinformatic tools to extract the biological meaning from the massive results. Here we introduce ROSPath, a database system to deal with information on reactive oxygen species (ROS)-mediated cell signaling pathways. It provides a structured repository for handling pathway related data and tools for querying, displaying, and analyzing pathways. ROSPath data model provides the extensibility for representing incomplete knowledge and the accessibility for linking the existing biochemical databases via the Internet. For flexibility and efficient retrieval, hierarchically structured data model is defined by using the object-oriented model. There are two major data types in ROSPath data model: ‘bio entity’ and ‘interaction’. Bio entity represents a single biochemical entity: a protein or protein state involved in ROS cell-signaling pathways. Interaction, characterized by a list of inputs and outputs, describes various types of relationship among bio entities. Typical interactions are protein state transitions, chemical reactions, and protein-protein interactions. A complex network can be constructed from ROSPath data model and thus provides a foundation for describing and analyzing various biochemical processes.

• Journal of KIISE:Information Networking
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• v.29 no.2
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• pp.174-180
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• 2002

With the invention of MPLS and the Improvement in traffic engineering, multipath packet forwarding and dynamic load control has become a reality. A dynamic load control, while it can improve network efficiency by controlling loads between paths according to the network state, can lead to unstable and oscillating state because of the staleness of the state information. In this paper, we propose a efficient load control scheme which remains stable. The proposed scheme introduces prediction to reduce the staleness of state message and to prevent oscillation.

• The KIPS Transactions:PartA
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• v.12A no.6 s.96
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• pp.557-562
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• 2005

Throughput and latency of interconnection network are important factors of the performance of multiprocessor systems. The dual-link CC-NUMA architecture using point-to-point unidirectional link is one of the popular structures in high-end commercial systems. In terms of optimal path between nodes, several paths exist with the optimal hop count by its native multi-path structure. Furthermore, transaction latency between nodes is affected by congestion of links on the transaction path. Hence the transaction latency may get worse if the transactions make a hot spot on some links. In this paper, I propose a dynamic transaction routing algorithm that maintains the balanced link utilization with the optimal path length, and I compare the performance with the fixed path method on the dual-link CC-NUMA systems. By the proposed method, the link competition is alleviated by the real-time path selection, and consequently, dynamic transaction algorithm shows a better performance. The program-driven simulation results show $1{\~}10\%$ improved fluctuation of link utilization, $1{\~}3\%$ enhanced acquirement of link, and $1{\~}6\%$ improved system performance.

• Journal of Life Science
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• v.14 no.5
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• pp.752-760
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• 2004

The function of the [4Fe-4S] cluster containing iron (Fe-) protein in nitrogenase catalysis is to serve as the nucleotide-dependent electron donor to the MoFe protein which contains the sites for substrate binding and reduction. The ability of the Fe protein to function in this manner is dependent on its ability to adopt the appropriate conformation for productive interaction with the MoFe protein and on its ability to change redox potentials to provide the driving force required for electron transfer. The MgADP-bound (or off) conformational state of the nitrogenase Fe protein structure described reveals mechanisms for long-range communication from the nucleotide-binding sites to control affinity of association with the MoFe protein component. Two pathways, termed switches I and II, appear to be integral to this nucleotide signal transduction mechanism. In addition, the structure of the MgADP bound Fe protein provides the basis for the changes in the biophysical properties of the [4Fe-4S] observed when Fe protein binds nucleotides. The structures of the nitrogenase Fe protein with defined amino acid substitutions in the nucleotide dependent signal transduction pathways of the Switch I and Switch II have been determined by X-ray diffraction methods. These two pathways have been also implicated by site directed mutagenesis studies, structural analysis and analogies to other proteins that utilize similar nucleotide dependent signal transduction pathways. We have examined the validity of the assignment of these pathways in linking the signals generated by MgATP binding and hydrolysis to macromolecular complex formation and intermolecular electron transfer. The results provide a structural basis for the observed biophysical and biochemical properties of the Fe protein variants and interactions within the nitrogenase Fe protein-MoFe protein complex.

• Journal of Plant Biotechnology
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• v.44 no.3
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• pp.264-270
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• 2017

Brassinosteroid (BR), a plant steroid hormone, plays a critical role in the growth and developmental processes through its canonical signaling and crosstalk with various internal and external signaling pathways. Recent studies have revealed the essential interplay mechanisms between BR and ABA during seed germination and early seedling establishment. However, molecular mechanisms for this important signaling crosstalk are largely unknown. To understand the crosstalk between BR-mediated signaling pathways and ABA functions during early seedling development, we carried out a comparative genome-wide transcriptome analysis with an Agilent Arabidopsis $4{\times}44K$ oligo chip. We selected and compared the expression patterns of ABA response genes in ABA-insensitive bes1-D mutant with wild type seedlings on which ABA was exogenously applied. As a result, we identified 2,353 significant differentially expressed genes (DEGs) in ABA-treated bes1-D and wild type seedlings. GO enrichment analysis revealed that ABA signaling, response, and metabolism were critically down-regulated by BR-activated signaling pathways. In addition, the genome-wide transcriptome analysis data revealed that BR-regulated signaling pathways were tightly connected to diverse signal cues including abiotic/biotic stress, auxin, ROS etc. In this study, we newly identified the molecular mechanisms of BR-mediated repression of ABA signaling outputs. Also, our data suggest that interplay among diverse signaling pathways is critical for the adaptive response of the plant to various environmental factors.