• Title/Summary/Keyword: 장기 안정성

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4-week dose range finding toxicity test of Magnoliae Flos extract in Sprague-Dawley rats (Sprague-Dawley 랫드를 이용한 신이 추출물의 4주 반복 용량 결정 독성시험)

  • Park, Ju-Hyoung;Ahn, Eun-Kyung;Park, Kitae;Hwang, Min Hee;Cho, Young-Rak;Lee, Dong-Ryung;Choi, Bong-Keun;Oh, Joa Sub
    • Journal of Applied Biological Chemistry
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    • v.65 no.1
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    • pp.43-48
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    • 2022
  • Medicinal herb demonstrated in many pharmacological effects and recognized to be safe has been used for a long time. However, side effects including safety of medicinal herb have not been identified yet. The aim of the study was to estimate safety evaluation of Magnoliae Flos used for the treatment of pain, rhinitis, and pneumonia in Korea, China and Japan through four-week dose range finding toxicity test in male and female Sprague-Dawley rats. Magnoliae Flos was orally administered to male and female SD rats once a day for 28 days at 1,500 and 3,000 mg/kg. The safety evaluation was determined to examine clinical signs, mortality, body weight, food intake, hematology, serum biochemistry and relative organ weights and there were no significant changes related toxicity. Consequently, these findings indicates that Magnoliae Flos did not show any side effects including toxicity in dose range finding toxicity test and the no observed adverse effect level for Magnoliae Flos was estimated as more than 3,000 mg/kg.

Development of Autonomous Cable Monitoring System of Bridge based on IoT and Domain Knowledge (IoT 및 도메인 지식 기반 교량 케이블 모니터링 자동화 시스템 구축 연구)

  • Jiyoung Min;Young-Soo Park;Tae Rim Park;Yoonseob Kil;Seung-Seop Jin
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.28 no.3
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    • pp.66-73
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    • 2024
  • Stay-cable is one of the most important load carrying members in cable-stayed bridges. Monitoring structural integrity of stay-cables is crucial for evaluating the structural condition of the cable-stayed bridge. For stay-cables, tension and damping ratio are estimated based on modal properties as a measure of structural integrity. Since the monitoring system continuously measures the vibration for the long-term period, data acquisition systems should be stable and power-efficiency as the hardware system. In addition, massive signals from the data acquisition systems are continuously generated, so that automated analysis system should be indispensable. In order to fulfill these purpose simultaneously, this study presents an autonomous cable monitoring system based on domain-knowledge using IoT for continuous cable monitoring systems of cable-stayed bridges. An IoT system was developed to provide effective and power-efficient data acquisition and on-board processing capability for Edge-computing. Automated peak-picking algorithm using domain knowledge was embedded to the IoT system in order to analyze massive data from continuous monitoring automatically and reliably. To evaluate its operational performance in real fields, the developed autonomous monitoring system has been installed on a cable-stayed bridge in Korea. The operational performance are confirmed and validated by comparing with the existing system in terms of data transmission rates, accuracy and efficiency of tension estimation.

Parental Leave and Female Labor Supply in Korea (육아휴직 지원과 여성의 노동공급)

  • Kim, Jungho
    • KDI Journal of Economic Policy
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    • v.34 no.1
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    • pp.169-197
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    • 2012
  • It is often argued that the parental leave should be extended in order to help employees achieve the balance of work and family life. However, one should be careful in designing the parental leave since there is a tradeoff between the continuity of employment after childbearing and the depreciation of human capital due to the time off the work. The paper investigates whether the parental leave payment introduced in Korea in 2001 helped women's take-up of the leave and employment after giving birth. The results are as follows. First, the increase in the payment indeed raised the female take-up of the leave. Second, women returned to labor market less often after giving birth in the short run, but the size of the effect tends to decrease in the long run. However, the negative effect on returning to the same workplace after the birth remains significant in the long run. Lastly, there is no evidence that the share of women of childbearing age at workplace changed due to the increase in the parental leave payment. Although there is a limitation in that the analysis is based only on the employment covered by the Employment Insurance, these findings imply that the increase in the parental leave payment may not be an effective policy tool for promoting female labor market participation. On the other hand, it should be noted that it is necessary to pay attention to child development as well as female employment as an objective in order to make an overall judgement on the parental leave policy.

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Pullout Characteristics of MC Anchor in Shale Layer (셰일지반에 설치된 MC앵커의 인발특성)

  • Lee, Bongjik;Kim, Josoon;Lee, Jongkyu
    • Journal of the Korean GEO-environmental Society
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    • v.13 no.1
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    • pp.53-61
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    • 2012
  • In this study, the research on MC anchor has been developed as composite type has done. MC anchor exerts bearing pressure on pre-bored hole where the end fixing device is expanded. Therefore, the uplift capacity is to be increased and it has the characteristics that the anchor body is not eliminated from the ground even if the grouting is not carried out properly. Furthermore, it reduces the loss of tension and raises the construction availability by inserting the reinforced bar as well as the anchor cable, while it can improve the long-term stability because the nail is expected to play the role when the loss of the anchor cable is occurred in a long-term. However, because the resistance mechanism of the compound anchor such as MC anchor is different from friction anchor, the estimation method of the uplift capacity by the frictional force of the ground and the grout is not proper. Particularly, in domestic cases, the problem to overestimate or underestimate the uplift capacity is expected because the design method considering the soil characteristics about the compound anchor has not been developed. Therefore, in this study, in order to evaluate the characteristics of MC anchor and a kind of compound anchor, we measured the uplift, the tension and the creep by nine anchors tests in shale ground that the fluctuation of the strength is great. In addition, we analyzed the test result comparing to the result of the general friction anchor and evaluated the characteristics of MC anchor movement to gather the results. As a result of the test, we found the effect that the uplift capacity is increased in shale ground comparing to the general friction anchor.

Linked (Semi-constrained) Total Elbow Arthroplasty (연결형(반구속형) 주관절 인공 관절 치환술)

  • Jung, Hong Jun;Jeon, In-Ho;Chun, Jae-Myeung;Lee, Tae Kyoon
    • Clinics in Shoulder and Elbow
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    • v.16 no.2
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    • pp.170-177
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    • 2013
  • Total elbow arthroplasty is still in its infancy compared with other arthroplasties, such as knee or hip arthroplasties. Implant design has been evolving with clinical experiences; however, there are only limited data on the long-term clinical outcome of elbow arthroplasty in the literature. The design of total elbow prostheses can be divided into three categories: linked (constrained or semi-constrained), unlinked (unconstrained), and convertible types. The choice between an unlinked (unconstrained) implant and a linked (semi-constrained) implant depends on joint stability and adequacy of the bone stock. Linked elbow arthroplasty has provided high patient satisfaction, and pain relief thanks to proper patient selection, advancement of implant design, improvement in cement techniques, meticulous surgical technique, and appropriate postoperative rehabilitation. Concerns remain about the use of this implant in young or high-demand patients. This article focuses on the linked (semi-constrained) prostheses, which provides an overview of the current state of linked total elbow arthroplasty.

우리나라 수입함수추정(輸入函數推定)에 있어서 수입단가(輸入單價)와 수입물가(輸入物價)의 비교(比較)

  • Yu, Yun-Ha
    • KDI Journal of Economic Policy
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    • v.17 no.3
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    • pp.3-54
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    • 1995
  • 외환(外換) 및 자본자유화(資本自由化)의 진전에 따라 환율(換率)의 변동폭이 커지면서 환율(換率)이 국제수지(國際收支)에 미치는 영향에 대한 관심이 높아지고 있다. 환율(換率)이 국제수지(國際收支)에 미치는 효과는 일차적으로 우리나라 수출입함수(輸出入函數)의 가격탄력성(價格彈力性)에 의해 결정되므로 정확한 탄성치(彈性値)를 추정하는 일은 이론적으로나 정책적으로 매우 중요한 의미를 갖는다. 본고에서는 우리나라 수입함수(輸入函數)의 소득(所得) 및 가격탄성치(價格彈性値) 추정에 있어서 사용 가능한 두가지의 가격지수(價格指數), 즉 수입단가(輸入單價)와 수입물가(輸入物價) 중 어느 것을 사용하는 것이 바람직한 것인지를 살펴보고 이중 이론적으로 우월한 지수를 이용하여 수입함수(輸入函數)의 소득(所得) 및 가격탄성치(價格彈性値)를 추정하고자 하였다. 분석으로부터 얻는 중요한 결론(結論)은, 우리나라의 경우 수입함수(輸入函數)의 분석에 있어서 수입단가(輸入單價)보다는 수입물가(輸入物價)를 이용하는 것이 더 적합하리라는 점이다. 이는 또한 우리나라 실질(實質)GNP의 추계에 있어서 현재의 수입단가(輸入單價) 이용방식에서 수입물가(輸入物價) 이용방식으로 편제방법을 바꾸는 것이 바람직하다는 것을 의미한다. 이같은 결론은 이론적, 실증적인 변에서 아래와 같은 네가지 이유에 근거한다. 먼저 이론적인 면에서는 첫째, 수입단가(輸入單價)가 물가지수(物價指數)로서 갖추어야 할 통계적 일관성을 갖추지 못하고 있다는 점을 지적할 수 있다. 즉 수입단가(輸入單價)는 어느 일정 규격조건(規格條件)의 상품가격(商品價格)을 일관성 있게 추적하는 것이 아니므로 잡다한 품질규격의 평균가격(平均價格)으로 나타날 가능성이 높으며 이러한 변에서 가격변화(價格變化)를 정확히 반영하지 못한다. 둘째, 수입단가지수(輸入單價指數)는 가격변화(價格變化)가 전혀 없을 때에도 총수입(總輸入)의 품목별 구성(構成)이 바뀌면 변동하는 속성을 지니고 있어 가격변동(價格變動) 상황(狀況)을 오도할 가능성을 지니고 있다. 다음으로 실증적인 면에서는 첫째, 수입단가(輸入單價)를 이용한 수입함수(輸入函數)에서는 가격변수(價格變數)의 계수(係數)가 이론상 기대되는 것과는 반대되는 부호를 가짐으로써 수입함수(輸入函數))로서의 기본적인 요건을 만족시키지 못하는 것으로 나타나고 있다. 둘째, 단가지수(單價指數)를 이용한 경우 소득(所得)과 상대가격(相對價格)을 회귀변수로 하는 수입함수(輸入函數)에서 장기안정적인 균충관계(均衝關係)가 존재하지 않은 것으로 판명되었다. 반면 수입물가(輸入物價)를 이용한 수입함수(輸入函數)에서는 각 변수의 계수(係數)가 이론적 기대치에 부합하였으며 장기안정적인 균충관계(均衝關係)가 성립하는 것으로 나타나고 있다. 한편 미국에서는 수출입단가지수(輸出入單價指數)의 문제점에 대한 오랜 연구 결과, 1989년부터 단가지수(單價指數)의 편제를 아예 중단하는 조치를 취한 바 있으며, GNP추계에 있어서도 종래의 수출입단가(輸出入單價) 대신 수출입물가(輸出入物價)를 이용하는 방식으로 그 편제방법을 변경한 바 있다.

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Performance Assessment of Two-stream Convolutional Long- and Short-term Memory Model for September Arctic Sea Ice Prediction from 2001 to 2021 (Two-stream Convolutional Long- and Short-term Memory 모델의 2001-2021년 9월 북극 해빙 예측 성능 평가)

  • Chi, Junhwa
    • Korean Journal of Remote Sensing
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    • v.38 no.6_1
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    • pp.1047-1056
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    • 2022
  • Sea ice, frozen sea water, in the Artic is a primary indicator of global warming. Due to its importance to the climate system, shipping-route navigation, and fisheries, Arctic sea ice prediction has gained increased attention in various disciplines. Recent advances in artificial intelligence (AI), motivated by a desire to develop more autonomous and efficient future predictions, have led to the development of new sea ice prediction models as alternatives to conventional numerical and statistical prediction models. This study aims to evaluate the performance of the two-stream convolutional long-and short-term memory (TS-ConvLSTM) AI model, which is designed for learning both global and local characteristics of the Arctic sea ice changes, for the minimum September Arctic sea ice from 2001 to 2021, and to show the possibility for an operational prediction system. Although the TS-ConvLSTM model generally increased the prediction performance as training data increased, predictability for the marginal ice zone, 5-50% concentration, showed a negative trend due to increasing first-year sea ice and warming. Additionally, a comparison of sea ice extent predicted by the TS-ConvLSTM with the median Sea Ice Outlooks (SIOs) submitted to the Sea Ice Prediction Network has been carried out. Unlike the TS-ConvLSTM, the median SIOs did not show notable improvements as time passed (i.e., the amount of training data increased). Although the TS-ConvLSTM model has shown the potential for the operational sea ice prediction system, learning more spatio-temporal patterns in the difficult-to-predict natural environment for the robust prediction system should be considered in future work.

Implant overdenture using milled bar and attachment in partially edentulous mandible: a case report (하악 부분 무치악 환자에서 Milled Bar와 부착장치를 이용한 임플란트 피개의치 수복 증례)

  • Kim, Min-Jung;Huh, Jung-Bo;Jeong, Chang-Mo;Yun, Mi-Jung;Lee, So-Hyoun;Jo, Yong-Bum
    • The Journal of Korean Academy of Prosthodontics
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    • v.60 no.1
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    • pp.71-79
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    • 2022
  • Excessive crown height space increases can cause crestal bone loss and screw loosening after prosthesis is placed. Milled bar and implant overdenture can be used as a treatment method for partially edentulous patients who have severe alveolar bone loss and excessive crown height space. Milled bar can provide primary splinting effect and stability between implants. Also, milled bar with additional retention device such as Advanced Dental Device-Treatment Of Choice (ADD-TOC) and magnet can provide additional retention force for implant overdenture. In this case, the patient has a partially edentulous mandible that has severe alveolar bone loss and multiple number of teeth loss after excision due to leiomyosarcoma. Because of the long-term loss of mandibular molars, the opposing teeth were extruded. Maxillary left molars were corrected to the occlusal plane through molar intrusion, and mandibular left molar region were treated with implant overdenture, using milled bar with ADD-TOC and magnet after implant placement. The clinical result was satisfactory on the aspect of esthetic and masticatory function.

Stability Analysis of Open Pit Slopes in the Pasir Coal Field, Indonesia (인도네시아 Pasir 탄전에서의 노천채탄장 사면의 안정성 해석)

  • 정소걸;선우춘;한공창;신희순;박연준
    • Tunnel and Underground Space
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    • v.10 no.3
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    • pp.430-440
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    • 2000
  • A series of studies such as geological logging data analysis, detailed geological survey, rock mass evaluation, in-situ and laboratory tests, rock strength and mechanical properties of the rock were concerned. The stability of the slope were carried out inorder to design the pit slope and individual benches using the stereographic projection analysis and numerical methods in Roto Pit of Pasir coal field. The bedding plane was one of the major discontinuities in the Roto Pit and the dip of which is about 60$^{\circ}$ in the northern part and 83$^{\circ}$ in the southern part. The dip of bedding becomes steeper from north to south. The plane and toppling failures are presented in many slopes. In laboratory test the average uniaxial compressive strength of mudstone was 9MPa and that of weak sandstone was 10MPa. In-situ test showed that the rocks of Roto north mining area are mostly weak enough to be classified in grade from R2(weak) to R3(medium strong weak) and the coal is classified in grades from R1(Very weak) to R2(Weak). The detailed stability analysis were carried out on 4 areas of Roto north (east, west, south and north), and 2 areas of Roto south(east and west). In this paper, the minimum factor of safety was set to 1.2 which is a general criterion for open pit mines. Using the stereographic projection analysis and the limit equilibrium method, slope angles were calculated as 30∼36$^{\circ}$ for a factor of safety greater than 1.2. Then these results were re-evaluated by numerical analysis using FLAC. The final slope angles were determined by rational described above. A final slope of 34 degrees can guarantee the stability for the eastern part of the Roto north area, 33 degrees for the western part, 35 degrees for the northern part and 35 degrees for the southern part. For the Roto south area, 36 degrees was suggested for both sides of the pit. Once the pit slope is designed based on the stability analysis and the safety measures, the stability of slope should be checked periodically during the mining operations. Because the slope face will be exposed long time to the rain fall, a study such aspreventive measures against weathering and erosion is highly recommended to be implemented.

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A Development of Floating Dock Control Simulator for Skid Launching System (Skid Launching System을 위한 Floating Dock Control Simulator의 개발)

  • Kim, Jee-Hun;Lee, Jang-Yong;Park, Sok-Chu
    • Journal of Navigation and Port Research
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    • v.32 no.1
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    • pp.1-7
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    • 2008
  • Since the shipbuilding industry is at its peak to assimilate the large volume of orders in recent years, the Floating Dock has been an alternative to the dry dock which takes a certain period of time to build. Hence the use of Floating Dock is steadily increasing. Since the Skid Launching System(SLS) is used in Floating Dock, the balancing of the ship while launching is important and achieved by adjusting the Ballast tank of the Floating Dock. In this paper a Floating Dock Control Simulator for SLS is developed through the on-line interface of VRC(Valve Remote Control), Tank Level & Draft Measuring System and Valve Control algorithm on Simulation Tank Plan.