• Title/Summary/Keyword: 장기노화

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Partial Thickness Rotator Cuff Tears (회전근 개 부분 파열)

  • Sin, Sang-Jin;Jang, Gi-Yeong
    • 대한관절경학회:학술대회논문집
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    • 2009.10a
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    • pp.14-22
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    • 2009
  • 회전근 개 부분 파열은 노화의 과정 중 생기는 무증상의 병변 또는 견관절 기능 장애의 잠재적인 원인으로 생각되었다. 발병 원인은 해부학적인 원인에 의한 충돌 또는 반복적 미세 외상 등이 원인으로 이해되고 있으며 병리생태에 관한 이해가 깊어지고 진단 기구, 즉 초음파나 자기공명영상, 관절경 등의 발달로 발생률이 과거에 비해 증가하고 있다. 그러나 회전근 개부분 파열은 질환 자체보다 전층 파열로 진행하는 일종의 질환 스펙트럼(disease spectrum)의 개념으로 전층 파열에 비해 현재까지 발표된 연구 자료가 많지 않다. 즉 회전근 개 부종, 견봉과의 마찰로 생긴 염증성 건병증, 회전근 개 섬유화 및 부분 또는 전층 파열로 진행되는 회전근 개 병변의 스펙트럼의 일부로 간주되는 경우가 많다. 본 종설은 회전근 개 부분 파열의 진단, 파열 분류, 수술의 적응증 및 수술 방법과 그 결과에 대해 논하고자 한다.

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간장내 Superoxide Dismutase 측정법

  • 임동윤;고석태
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.149-149
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    • 1993
  • 목적:동식물세포에는 superoxide(0$_{-2}$)의 불균화 반응을 촉매하는 superoxide dismutase (SOD)가 존재한다. 이 효소의 생리적 의의는 지금까지도 명확하게 되어있지 않는면이 많지만, 그 의의를 명확하게 하기위해서도 측정법의 확립이 필요하다. 방법: SOD측정 방법으로는 1) Cytochrome C method 2) Nitroblue tetrazoliun method (NBT법) 3) 면역학적 방법 4) 화학발광법 등이 있다. 실험 재료는 흰쥐, mouse, 토끼의 간을 이용하였으며, 또한, 노화 및 암세포를 이용한 방법을 이용하였다. 결과: Cytochrome C 방법을 통해서 각 장기조직 (신장, 간장, 폐)에서 SOD를 측정하였으며 SOD 활성이 낮은 암조직이나 배양세포에서는 NBT 방법이 측정방법으로 적합한 것으로 나타났으며 ,간장세포내에서의 SOD의 존재부위를 확인하는 방법으로는 면역 황금 표지방법을 사용하므로 간장 mitochondria 내에 Cu, Zn-SOD가 존재함을 알 수 있었다.

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Effect of Training Methods on the Growth and Development of Hydroponically Grown Cucumber Plants (정지법의 차이가 양액재배 오이의 생육에 미치는 영향)

  • 이범선;정순주;박순기;서범석;이정필
    • Proceedings of the Korean Society for Bio-Environment Control Conference
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    • 1999.11a
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    • pp.196-199
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    • 1999
  • 국내의 오이 양액재배기술은 그 역사가 짧을 뿐만 아니라 아직은 학문적인 전문성이나 기술적인 세분화 및 다양화 정도에 있어서 양액재배가 발전된 선진국에 비해 저위 수준에 머물러 있다. 특히, 양액재배 오이는 생육이 빨라 수확시기가 단축되므로 수확기가 단기간에 집중되는 반면, 후기에는 초세가 약화되기 쉬우므로 수확량이 좋지 않은 점이 지적되고 있으며, 저일조ㆍ저온기에 정식되는 작형에서는 과실의 착과율이 저하되는 경우가 많으므로 고형배지경에 있어서 배지의 선택이나 근권온도, 산소 등의 관리에 주의를 기울임과 동시에 정지적엽방법의 개선과 전문적인 요구되는 양액관리기술의 체계적 정립을 통해 오이양액재배시 문제가 되는 조기노화의 원인을 사전에 방지하므로써 장기재배가 가능토록 함과 동시에 양액재배 오이의 생산성과 품질을 획기적으로 향상시킬 수 있는 재배법과 기술체계의 확립이 시급하다. (중략)

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Ocean Scanning Multispectral Imager (OSMI) (태양광 보정계의 발사후 최초 측정에 대한 분석)

  • 조영민
    • Proceedings of the KSRS Conference
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    • 2000.04a
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    • pp.131-136
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    • 2000
  • Ocean Scanning Multi-spectral Imager (OSMI)는 다목적 실용위성 (KOMPSAT) 1호기 아리라위성에 탑재되어 1999년 12월 21일 발사된 해양 관측 기기이다. OSMI는 발사후 3년 이상 생물학적 해양지리학 연구를 위해 전세계 바다색을 관측하는 임무를 수행할 것이다. OSMI는 센서 성능의 궤도상 보정을 위해 태양광 보정과 암흑 보정을 수행한당. 태양광 보정은 궤도상에서 장기간에 걸친 해양 결상계의 노화에 따른 성능 변화 감지 및 보정에 있다. 발사 직후의 초기 태양과 보정 측정 자료는 추후 성능 변화 감지에 대한 기준이 될 뿐만아니라 발사 직후 OSMI 센서 성능 파악 및 점검에도 사용될 수 있으므로 매우 중요하다. 태양광 보정의 구조 및 광학적 특성을 분석하고 OSMI 주요 관측파 장대역별로 태양광 보정계의 출력신호량을 예측하였다. 초기 운영 기간동안 얻은 OSMI 태양광 보정계의 발사후 최초 측정 자료를 분석하고 발사전 예측 성능과 비교하였다. 이 연구는 OSMI 센서 보정 및 영상 품질 이해에 유용할 것이다.

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Effects of Postharvest Treatment of Plastic Film, Ethylene Scrubber, and Prolong on the Market Quality in 'Niitaka' Pears during Storage and Simulated Marketing (동양(東洋) 배 '신고(新高)'의 저장전(貯藏前) Plastic Film, Ethylene 제거제(除去劑) 및 Prolong처리(處理)가 저장(貯藏)과 유통조건(流通條件)에서 상품성(商品性)에 미치는 영향(影響))

  • Lee, Jae Chang;Hwang, Yong Soo
    • Korean Journal of Agricultural Science
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    • v.19 no.2
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    • pp.145-152
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    • 1992
  • This experiment was planned to find a proper postharvest handling technique of 'Niitaka' pears for storage. The effect of polyethylene film wrapping, ethylene scrubber, and Prolong application on maintanence of freshness were compared in prestored fruit.(60 days at $0^{\circ}C$). Weight loss was confirmed to be a major factor responsible for freshness loss during storage. Polyethylene film wrapping greatly reduced weight loss during storage but increased light skin browning. Also, in long-term storage, polyethylene film wrapping appeared not to be appropriate due to the severe occurrence of tissue senescence and/or senescence breakdown. Prolong application was found not to be effective on reducing weight loss as well as keeping freshness. Ethylene scrubber in polyethylene film wrapping effectively reduced the occurrence of light skin browning.

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A Study on the Skin Anti-wrinkle Effect of Novel Palmitoyl Tripeptide (신규한 Palmitoyl Tripeptide의 피부 주름개선 효과에 관한 연구)

  • Bae, Soon-Min;Ahn, Yong-Hoon;Jung, Jin-Kyo;Hwang, Jeong-Geun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.1
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    • pp.65-69
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    • 2010
  • Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.

The Effect of Swimming Exercise on Telomere Length & Expression of Telomere Repeat Binding Factor 2 in Rats (수영 운동이 흰쥐의 Telomere 길이와 TRF 2 발현에 미치는 영향)

  • Kim, Sang Hoon;Lee, Jeong Pil;Yoon, Jin-Ho;Oh, Jae-Keun
    • 한국노년학
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    • v.29 no.2
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    • pp.657-667
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    • 2009
  • The aim of the present study was to investigate the effects of swimming exercise on growth-related telomere length and expression of TRF 2 in different tissues of SD rats. The telomere lengths of all the tissues analyzed were longer in the standard group than either in aged-control group or in two aged-exercise groups, suggesting growth-induced attrition of telomere lengths. On the other hand, it was also found that swimming exercise could attenuate this growth-related telomere attrition in the heart tissue of the long-term group only, with no significant attenuating effects of aerobic exercise on either liver telomere length or soleus muscle telomere length. Also, in the heart, TRF 2 expression was significantly lower in control group compare to standard group. But, there was significantly higher in long term exercise group compare to control group. There was positive correlation between telomere length and expression of TRF 2 in heart tissue. This study implies that the swimming exercise performed for longer periods of time can contribute to growth process of heart by regulation of telomere length and TRF 2 expression. In the growth process, the regular swimming exercise will provide a meaningful advantage for various physiological processes.

The effects of long term endurance or resistance exercise training on anabolic and catabolic pathway in skeletal muscle of middle-aged rats (장기간의 지구성 운동 또는 저항성 운동이 중년 흰쥐의 골격근 내 단백질 동화 및 이화기전에 미치는 영향)

  • Jung, Su-Ryun;Kim, Ki-Jin;Kho, Jin-Ho
    • 한국체육학회지인문사회과학편
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    • v.55 no.6
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    • pp.691-700
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    • 2016
  • The purpose of this study was to investigate the effects of long-term endurance exercise or resistance exercise training on muscle anabolic/catabolic pathway. 50wks-old male Wistar rats(n=30) were randomly assigned for 3 groups (sedentary, endurance exercise, resistance exercise group). After 12-week of training, plantaris muscles were dissect to measure protein level. Akt/mTOR signal-related proteins were significantly increased only after resistance exercise training, but catabolic signal-related proteins, FoxO1 and MuRF1, were significantly decreased after resistance and endurance exercise training. After endurance exercise training, AMPK and PGC-1α protein levels were significantly increased. Therefore, the endurance exercise training has been shown to affect the protein balance of aging muscle through inhibition of muscle protein catabolism. The present results suggest the possibility that not only resistance exercise but also endurance exercise will be affectable to keep or increase muscle volume and capacity of middle-aged people.

Flexural Behaviors of GFRP Rebars Reinforced Concrete Beam under Accelerated Aging Environments (GFRP Rebar 보강 콘크리트 보의 급속노화환경에서의 휨 거동에 관한 연구)

  • Park, Yeon-Ho;Choi, Yeol
    • Journal of the Korea Concrete Institute
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    • v.25 no.2
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    • pp.137-144
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    • 2013
  • The use of fiber-reinforced polymer (FRP) reinforcing bars in concrete structures has been increased as an alternative of steel reinforcement which has shown greater vulnerability to corrosion problem. However, the long-term performance of concrete members with FRP reinforcement is still questioned in comparison to the used of steel reinforcement. This study presents the results of an experimental study on the long-term behaviors of GFRP (glass fiber reinforced polymer) bar reinforced concrete beams after exposed to accelerated aging in an environmental chamber with temperature of $46^{\circ}C$ ($115^{\circ}F$) and 80% of relative humidity up to 300 days. The objectives of this research was to compare strength degradation and change of ductility between GFRP reinforced concrete beams and steel reinforcement beams after accelerated aging. Two types (wrapped and sand-coated surface) of GFRP bars and steel were reinforced. in concrete beams. Test results show that the failure modes of GFRP bar reinforced concrete beams are very similar with traditional RC beams, and the change of load-carrying capacity of steel reinforcing concrete beam is greater than that of GFRP bar reinforcing concrete beam under the accelerated aging. Test result also shows that the use of GFRP reinforcing in concrete could be introduced more brittle failure than that of steel reinforcing for practical application. The deformability factor up to compression failures indicates no significant variation before and after exposure of accelerated aging.

Quality Stability and Antioxidant Activity of Red Ginseng Stored for Long Periods (장기저장 홍삼의 품질안정성과 항산화효과)

  • Choi K.J.;Lee K.S.;Ko S.R.;Jang J.G.;Park J.D.;Kim M.W;Sung H.S
    • Proceedings of the Ginseng society Conference
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    • 1988.08a
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    • pp.99-107
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    • 1988
  • Samples of red ginseng. which had been manufactured and packaged by the Korea Monopoly Corporation. were stored at ambient temperatures $(12-28^{\circ}C)$ and humidities $(55-68\%)$ for one to nine years to examine their overall quality stability and. in particular. antioxidant activity. The approximate compositions. contents of various solvent extracts. and TLC and HPLC patterns of ginsenosides in the samples which are otherwise susceptible to oxidation. were stable as judged by the changes of the TLC and GLC patterns of the lipids and fatty acids. It was also found that polyunsaturated fatty acids such as linoleic (C18: 2) and linolenic acid (C18: 3) present in the samples had been very stable during the long storage periods. The intensity of the brown color of the red ginseng samples increased significantly with storage time. The pH of the aqueous extracts of the samples also increased slightly during storage. The coloration changes seem to indicate that extensive browning reactions had occurred during storage. The reducing powers of aqueous and ethanol extracts and antioxidant activity of ethyl acetate extracts also increased with storage time. The increase in reducing powers and antioxidant activity appeared to be directly attributable to the increased amounts of non-enzymatic browning reaction products formed progressively during the long storage periods. Therefore. it seems that those antioxidative compounds. which will be progressively formed in red ginseng through non-enzymatic browning reactions during the manufacturing process and long-term storage. will not only contribute to their overall quality stability but also have some significant relationship with their antiaging pharmacological effects.

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