• Tuberculosis and Respiratory Diseases
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• v.60 no.2
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• pp.205-214
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• 2006

Background : Acute exacerbations form a major component of the socioeconomic burden of COPD. As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported. The aim of this study was to determine predictors of long-term mortality after hospitalization for acute exacerbation of COPD. Methods : We performed a retrospective cohort study of consecutive patients admitted to the hospital for COPD exacerbation between 2000 through 2004. Patients who had died in hospital or within 6-months after discharge, had tuberculosis scar, pleural thickening or bronchiectasis by chest radiography or had been diagnosed with malignancy during follow-up periods were excluded. Results : Mean age of patients was 69.5 years, mean follow-up duration was 49 months, and mean $FEV_1$ was 1.00L (46% of predicted). Mortality was 35% (17/48). In the multivariate Cox regression analysis, heart rate of 100/min or more (p=0.003; relative risk [RR], 11.99; 95% confidence interval [CI], 2.34-61.44) and right ventricular systolic pressure (RVSP) of 35mmHg or more (p=0.019; RR, 6.85; 95% CI, 1.38-34.02) were independent predictors of mortality. Conclusion : Heart rate and RVSP in stable state may be useful in predicting long-term mortality for COPD patients admitted to hospital with acute exacerbation.

• Korean Chemical Engineering Research
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• v.44 no.1
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• pp.58-64
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• 2006

We successfully isolated human anagen hair follicles from human scalp skin by microdissection and tried to culture them under various conditions. First we confirmed negative effect of serum on human hair follicle organ culture. As a next step serum-free medium compositions, Philpott medium, IMDM, and DHGM (Dongguk hair growth medium) were tried. Philpott medium is a general medium for hair organ culture based on Williams' E medium and DHGM is a special self-developed medium containing high amino acids and vitamins (B group) composition. As results, hair follicle in Philpott medium and IMDM showed anagen phase morphological structure, but rapid loss of hair elongation, low alkaline phosphatase expression, and very low expression of CK19. It is thought these hair follicles rapidly regressed from apoptosis. However, hair follicles in DHGM showed long term anagen phase morphological structure, continuous hair elongation, high alkaline phosphatase, and CK19 expression. These results demonstrate that high amino acids and vitamins (B group) composition are essential to in vitro long term human hair follicle organ culture and this culture medium will be useful in basic study of hair biology or application study to the development of alopecia treatment drugs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.3
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• pp.541-550
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• 2015

The importance of efficient enterprise network management has been emphasized continuously because of the rapid utilization of Internet in a limited resource environment. For the efficient network management, the management policy that reflects the characteristics of a specific network extracted from long-term traffic analysis is essential. However, the long-term traffic data could not be handled in the past and there was only simple analysis with the shot-term traffic data. However, as the big data analytics platforms are developed, the long-term traffic data can be analyzed easily. Recently, enterprise network resource efficiency through the long-term traffic analysis is required. In this paper, we propose the methods of collecting, storing and managing the long-term enterprise traffic data. We define several classification categories, and propose a novel network resource efficiency through the multidirectional statistical analysis of classified long-term traffic. The proposed method adopted to the campus network for the evaluation. The analysis results shows that, for the efficient enterprise network management, the QoS policy must be adopted in different rules that is tuned by time, space, and the purpose.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.422-430
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• 2016

We investigated the abundance and composition of the zooplankton community around Dokdo in the East Sea from 2006 to 2015. Zooplankton samples were collected in the surface mixed layer by vertical hauls using a standard type net at the monitoring stations. There were no clear long-term trends in the average temperature and salinity, but relatively low salinity was recorded in the summer of 2013 and 2015. The average abundances of zooplankton in the summer increased by two orders of magnitude from $317inds./m^3$ in 2008 to $10,242inds./m^3$ in 2015. This long-term increase was accompanied by a slight increase in the chlorophyll-a concentration and a decrease in the catch of potential crucial predators (anchovy, mackerel pike, squid, herring and horse mackerel) in the study area. The dominant zooplankton, accounting for most of the long-term increase, consisted of appendicularian (Oikopleura spp.), which showed a steady increase since 2012, summer species such as Noctiluca scintillans and the cladoceran Penilia avirostris, which showed an abrupt increase, and the copepod Paracalanus parvus s.l., which showed a rapid increase after its first occurrence in summer 2010. These results suggest that the long-term increase of zooplankton could be related to the increase in the concentration of prey and the decrease in the predation pressure of potential predators around Dokdo in the study area.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.5
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• pp.301-308
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• 2021

It is important to develop a digital SOC (Social Overhead Capital) maintenance system for preemptive maintenance in response to the rapid aging of social infrastructures. Abnormal signals induced from structures can be detected quickly and optimal decisions can be made promptly using IoT sensors deployed on the structures. In this study, a digital SOC monitoring system incorporating a multimetric IoT sensor was developed for long-term monitoring, for use in cloud-computing server for automated and powerful data analysis, and for establishing databases to perform : (1) multimetric sensing, (2) long-term operation, and (3) LTE-based direct communication. The developed sensor had three axes of acceleration, and five axes of strain sensing channels for multimetric sensing, and had an event-driven power management system that activated the sensors only when vibration exceeded a predetermined limit, or the timer was triggered. The power management system could reduce power consumption, and an additional solar panel charging could enable long-term operation. Data from the sensors were transmitted to the server in real-time via low-power LTE-CAT M1 communication, which does not require an additional gateway device. Furthermore, the cloud server was developed to receive multi-variable data from the sensor, and perform a displacement fusion algorithm to obtain reference-free structural displacement for ambient structural assessment. The proposed digital SOC system was experimentally validated on a steel railroad and concrete girder bridge.

• Journal of Life Science
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• v.31 no.11
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• pp.995-1003
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• 2021

Chromatin remodeling regulates gene expression through epigenetic mechanisms. Aberrations in histone modification have been associated with depression-like behaviors in animal models. Additionally, growing evidence also indicates that epigenetic modification is associated with depression. p11 (S100A10) has been implicated in the pathophysiology of depression both in human and rodent models. In the present study, we investigated alterations in histone acetylation and methylation at the promoter of the p11 gene in the hippocampus of mice subjected to chronic unpredictable stress (CUS). C57BL/6 mice were exposed to CUS daily for 3 weeks. Depression-like behaviors were measured with the forced swimming test (FST). The levels of hippocampal p11 expression were analyzed by quantitative real-time polymerase chain reaction (PCR) and Western blotting. The levels of acetylated and methylated histone H3 at the promoter of p11 were measured by chromatin immunoprecipitation followed by real-time PCR. CUS-exposed mice displayed depression-like behaviors with prolonged immobility in FST. CUS led to significant decreases in the expression of p11 at both protein and mRNA levels. Meanwhile, there was a decrease in histone H3 acetylation (Ac-H3) and H3-K4 trimethylation (H3K4met3) and an increase in H3-K27 trimethylation (H3K27met3) at the p11 promoter. These results indicate that chronic stress causes the epigenetic suppression of p11 expression in the hippocampus.

• 한국노년학
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• v.29 no.2
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• pp.657-667
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• 2009

The aim of the present study was to investigate the effects of swimming exercise on growth-related telomere length and expression of TRF 2 in different tissues of SD rats. The telomere lengths of all the tissues analyzed were longer in the standard group than either in aged-control group or in two aged-exercise groups, suggesting growth-induced attrition of telomere lengths. On the other hand, it was also found that swimming exercise could attenuate this growth-related telomere attrition in the heart tissue of the long-term group only, with no significant attenuating effects of aerobic exercise on either liver telomere length or soleus muscle telomere length. Also, in the heart, TRF 2 expression was significantly lower in control group compare to standard group. But, there was significantly higher in long term exercise group compare to control group. There was positive correlation between telomere length and expression of TRF 2 in heart tissue. This study implies that the swimming exercise performed for longer periods of time can contribute to growth process of heart by regulation of telomere length and TRF 2 expression. In the growth process, the regular swimming exercise will provide a meaningful advantage for various physiological processes.

• KOREAN POULTRY JOURNAL
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• v.7 no.8 s.70
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• pp.96-99
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• 1975

지난 5월말 현재 돈육(부분육) 수출실적은 750만불로 목표액인 900만불의 83$\%$에 이르고 있으며, 수출의 호전으로 생돈가격이 폭등되어 kg당 650원이라는 예년에 볼 수 없었던 가격을 형성하고 있는 실정이다. 이러한 호경기가 장기간 계속되리라고는 아무도 예측할 수 없으므로 수급 조절면에 세심한 주의를 기우려야 할 것이며 종자의 개량, 사양관리의 개선, 새로운 기술도입과 합리적인 경영 등을 실현하여 우리나라 양돈업의 근대화에 박차를 가해야 하겠다. 지난 수년간의 경험을 되살려 무모한 증식이나 불량돈육의 생산으로 국제시장에서의 외면 등의 불행한 사태가 생기지 않도록 서로가 협조하여 80년대를 향한 축산번영을 위하여 총력을 기울여야 겠다.

• Journal of Scientific & Technological Knowledge Infrastructure
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• s.13
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• pp.62-71
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• 2004

생물정보 분야에 관한 방대한 보고서가 이미 여러 관련 정부기관에서 발간되었으므로 이 자료들을 조직적으로 종합하면 국내.외의 기술 현황 분석이 가능하다고 생각된다. 특히 각 보고서 작성을 위해 국내의 거의 모든 관련 연구자들이 장기간 참여하였으므로 생물정보학의 현황파악을 위해 필요한 자료를 대부분 포함하고 있다고 생각된다. 본 글은 현재까지 국내에서 조사된 생물정보 연구 및 기술 개발에 관한 내용을 정리하고 또 국외의 최근 보고서를 종합하여 정리 분석하고 이를 바탕으로 국가 과학기술정보 지원의 주관기관인 KISTI의 역할 및 임무에 관하여 생각해보려 한다.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1982.10a
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• pp.29-32
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• 1982

본 논문은 광섬유 케이블의 설계에 있어, 케이블 공정에 따른 광손실의 증가를 최소로하는 케이블의 구조 및 광케이블의 포설에 따른 잔류 응력의 억제 등, 장기간 동안 케이블의 전송특성을 유지하며, 광섬유의 파단 방지를 목표로 고려해야할 사항을 논하였다. 광섬유의 특성을 유지하기 위해서는 광섬유 제조시 사용되는 재질 및 적정 Dimension 설정이 필요하며 광섬유 파단 방지를 위해 CABLE내에 TENSION MEMBER를 수용하는 구조를 검토, 광섬유 CABLE 포설시 광섬유의 파단 확률을 감소시키며, 광섬유의 잔류응력을 억제하는 관점에서 케이블 구조를 설계하였다.