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Genes expression by using cDNA Microarray in Whallak-tang (활락탕(活絡湯)의 cDNA Microarray를 이용한 유전자 발현에 미치는 영향)

  • Sin, Cheol-Kyung;Lee, Chae-Woo;Yoo, Sun-Ae;Youn, Hyoun-Min;Jang, Kyung-Jeon;Song, Choon-Ho;Ahn, Chang-Beohm;Kim, Cheol-Hong
    • Journal of Pharmacopuncture
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    • v.11 no.4
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    • pp.5-14
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    • 2008
  • Objective This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-1). Results The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in $200{\sim}300%$ range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in $0{\sim}33%$ range. Conclusion These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.

A Study on the Characteristics of Daesoon Thought as Seen through the Articles in The Canonical Scripture: Focusing on Historical Figures (『전경(典經)』의 기사(記事)를 통해 살펴본 대순사상의 특징에 관한 연구 - 『전경』 속 인물을 중심으로 -)

  • Park Geon-woo
    • Journal of the Daesoon Academy of Sciences
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    • v.47
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    • pp.105-138
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    • 2023
  • The purpose of this study is to examine the significance of various figures in The Canonical Scripture and their contents. The Canonical Scripture (jeon-gyeong 典經) is a record of the beliefs and deeds of Kang Jeungsan, composed through the memories of the followers of Kang Jeungsan who followed the words of The Canonical Scripture. In other words, The Canonical Scripture is understood as the scripture of Daesoon Jinrihoe that contains the religious deeds and teachings of Kang Jeungsan. It is divided into seven parts and 17 chapters. Those seven parts, some of which contain more than one chapter, are as follows: Acts, Reordering Works, Progress of the Order, Dharma, Authority and Foreknowledge, Saving Lives, and Prophetic Elucidations. In particular, The Canonical Scripture records the deeds of historical figures from both China and Korea, and this prominently includes the life history of Kang Jeungsan, and this is an especially pronounced feature of the sections Acts, Progress of the Order, and Prophetic Elucidations. In addition, each chapter describes the teachings and faith-inspiring acts of Kang Jeungsan and presents the gist of the Daesoon Thought while referring to the lives and actions of various historical figures. In this paper, introductions to the figures that appear in each section are provided to help readers better understand the contents of The Canonical Scripture. Therefore, this study focuses on the major figures introduced in The Canonical Scripture in connection with the religious values of Daesoon Thought. Through this, a contribution is made to the academic development of Daesoon Thought by specifically exploring and examining the contents of the figures who appear in The Canonical Scripture. This is a surprisingly underdeveloped area of study in Daesoon Thought.

King Sejo's Establishment of the Thirteen-story Stone Pagoda of Wongaksa Temple and Its Semantics (세조의 원각사13층석탑 건립과 그 의미체계)

  • Nam, Dongsin
    • MISULJARYO - National Museum of Korea Art Journal
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    • v.101
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    • pp.12-46
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    • 2022
  • Completed in 1467, the Thirteen-story Stone Pagoda of Wongaksa Temple is the last Buddhist pagoda erected at the center of the capital (present-day Seoul) of the Joseon Dynasty. It was commissioned by King Sejo, the final Korean king to favor Buddhism. In this paper, I aim to examine King Sejo's intentions behind celebrating the tenth anniversary of his enthronement with the construction of the thirteen-story stone pagoda in the central area of the capital and the enshrinement of sarira from Shakyamuni Buddha and the Newly Translated Sutra of Perfect Enlightenment (圓覺經). This paper provides a summary of this examination and suggests future research directions. The second chapter of the paper discusses the scriptural background for thirteen-story stone pagodas from multiple perspectives. I was the first to specify the Latter Part of the Nirvana Sutra (大般涅槃經後分) as the most direct and fundamental scripture for the erection of a thirteen-story stone pagoda. I also found that this sutra was translated in Central Java in the latter half of the seventh century and was then circulated in East Asia. Moreover, I focused on the so-called Kanishka-style stupa as the origin of thirteen-story stone pagodas and provided an overview of thirteen-story stone pagodas built around East Asia, including in Korea. In addition, by consulting Buddhist references, I prove that the thirteen stories symbolize the stages of the practice of asceticism towards enlightenment. In this regard, the number thirteen can be viewed as a special and sacred number to Buddhist devotees. The third chapter explores the Buddhist background of King Sejo's establishment of the Thirteen-story Stone Pagoda of Wongaksa Temple. I studied both the Dictionary of Sanskrit-Chinese Translation of Buddhist Terms (翻譯名義集) (which King Sejo personally purchased in China and published for the first time in Korea) and the Sutra of Perfect Enlightenment. King Sejo involved himself in the first translation of the Sutra of Perfect Enlightenment into Korean. The Dictionary of Sanskrit-Chinese Translation of Buddhist Terms was published in the fourteenth century as a type of Buddhist glossary. King Sejo is presumed to have been introduced to the Latter Part of the Nirvana Sutra, the fundamental scripture regarding thirteen-story pagodas, through the Dictionary of Sanskrit-Chinese Translation of Buddhist Terms, when he was set to erect a pagoda at Wongaksa Temple. King Sejo also enshrined the Newly Translated Sutra of Perfect Enlightenment inside the Wongaksa pagoda as a scripture representing the entire Tripitaka. This enshrined sutra appears to be the vernacular version for which King Sejo participated in the first Korean translation. Furthermore, I assert that the original text of the vernacular version is the Abridged Commentary on the Sutra of Perfect Enlightenment (圓覺經略疏) by Zongmi (宗密, 780-841), different from what has been previously believed. The final chapter of the paper elucidates the political semantics of the establishment of the Wongaksa pagoda by comparing and examining stone pagodas erected at neungsa (陵寺) or jinjeonsawon (眞殿寺院), which were types of temples built to protect the tombs of royal family members near their tombs during the early Joseon period. These stone pagodas include the Thirteen-story Pagoda of Gyeongcheonsa Temple, the Stone Pagoda of Gaegyeongsa Temple, the Stone Pagoda of Yeongyeongsa Temple, and the Multi-story Stone Pagoda of Silleuksa Temple. The comparative analysis of these stone pagodas reveals that King Sejo established the Thirteen-story Stone Pagoda at Wongaksa Temple as a political emblem to legitimize his succession to the throne. In this paper, I attempt to better understand the scriptural and political semantics of the Wongaksa pagoda as a thirteen-story pagoda. By providing a Korean case study, this attempt will contribute to the understanding of Buddhist pagoda culture that reached its peak during the late Goryeo and early Joseon periods. It also contributes to the research on thirteen-story pagodas in East Asia that originated with Kanishka stupa and were based on the Latter Part of the Nirvana Sutra.

조선시대 『옥추보경』(玉樞寶經) 중의 신장(神將)에 관한 연구

  • 인즈화
    • Journal of the Daesoon Academy of Sciences
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    • v.22
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    • pp.133-275
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    • 2014
  • 『옥추보경』(玉樞寶經)은 송대의 유명한 도교 경전으로 정식 명칭은 『구천응원뇌성보화천존설옥추보경』(九天應元雷聲普化天尊說玉樞寶經)이다. 송·원시대 이후 『옥추보경』은 중국 각 지역에 광범위하게 전해지면서 많은 영향을 끼쳤으며, 명나라의 세종(世宗)과 신종(神宗)은 『옥추보경』을 새로 간행하여 직접 서문을 쓰고 동시에 매우 숭앙하였다. 『옥추보경』의 집주본이 조선에 전해진 시기는 대략 명대 시기로 보고 있으며, 조선시대에 전해졌던 『옥추보경』 집주본은 융경(隆慶) 4년(1570)에 전라도 무등산(無等山) 안심사(安心寺)에서 최초로 발간되었다. 그러나 당시 안심사 판본은 첫 페이지와 경문 중의 또 다른 페이지가 없는 불완전한 판본이었다. 옹정(擁正) 11년(1733)에 송몽삼(宋夢三), 서두추(徐斗樞) 등의 제안에 따라 영변(寧邊) 묘향산(妙香山) 보현사(普賢寺)에서 『옥추보경』을 새로 간행하게 되었다. 하지만 이 또한 불완전한 판본이었으며, 병진년(1736)에 잃어버린 두 페이지를 우연히 찾게 되면서 완전한 판본을 이루게 되었다. 이후 광서(光緖) 무자년(1888)에 김흡(金潝)이 『옥추보경』을 새로 교정하였고, 계룡산(鷄龍山)에서 이를 다시 간행하였다. 명대의 『도장』에 수록된 『옥추보경』 집주본에는 신장도(神將圖)가 포함되어 있지 않았다. 하지만 조선시대 세 종류의 판본은 모두 신장도(神將圖)가 포함되어 있다. 이 외에도 조선시대 간행본과 비슷한 판본으로 영국의 대영도서관 소장본과 일본 천리대학(天理大學) 도서관의 소장본 및 중국 국가 도서관 고적관의 소장본이 있다. 그런데 안심사 판본은 41명, 보현사 판본은 47명, 계룡산 판본은 48명의 신장도가 포함되어 있으며, 대영도서관은 45명, 중국 국가 도서관은 45명 등으로 차이가 있다. 이러한 판본들에 수록된 신상의 수가 다른 이유는 아직 명확하지 않다. 이에 본문에서 필자는 먼저 계룡산 판본 『옥추보경』에 근거하여 48신장의 내력에 대한 초보적인 고찰을 진행하였다. 언어상의 문제로 『옥추보경』과 관련된 한국의 연구 성과를 반영하지는 못했지만, 『옥추보경』의 48장과 대순진리회의 『전경』에 등장하는 48장이 어떠한 연관이 있는지를 조명하는 데 유의미한 기초 작업이 될 것으로 전망한다. 이를 토대로 나아가 대순진리회의 48신상도와 『옥추보경』의 판본간의 형태적 특징에 주목하여 면밀한 상호 분석을 시도함으로써 대순진리회의 신앙체계와 『옥추보경』의 관련성을 규명하는 데 일조할 수 있기를 기대한다.

Dasan's commentary on The Meaning of learning(學) and ming(命) in Confucius Analects analects (다산 정약용의 『논어』 「학이(學而)」 및 「부지명(不知命)」장(章) 주석에 대한 고찰)

  • Lim, Heon-gyu
    • (The)Study of the Eastern Classic
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    • no.69
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    • pp.531-561
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    • 2017
  • This article's aim is to contrast Dasan's commentary with Chu-tzu' and old commentary on The Meaning of learning(學) and ming(命) in Confucius Analects analects. Confucius Analects analects began with Confucius said, " Is it not pleasant to learn with a constant perseverance and application?"(1:1), and closed with Confucius said, "Without recognizing the ordinances of Heaven, it is impossible to be a superior man. We can consider Confucian analects as theory of science. I've tried to define the meaning of learning(學) in Confucius Analects, at first. The Meaning of learning in Confucian analects have 1) Technology, 2) the way of human relation, 3) liberal ar, and 4) 'learning to become a sage. Chu-tzu defines learning(學) in Confucius Analects as 'learning to become a sage'. Dasan's considered learning(學) as science in general. Chu-tzu' and old commentary defined zhiming(知命) in Confucius Analects is 'to know the fact that there is destiny in man's life(ex, life and death). Dasan reinterpreted ming(命) in Confucius Analects as human mind-nature.

Protective effect of Juglans sinensis Dode extract (JS) on oxidant-induced apoptosis in renal epithelial cells (신세뇨관(腎細尿管) 상피세포(上皮細胞)에서 산화(酸化)로 유발(誘發)된 apoptosis에 대한 호도약침액(胡桃藥鍼液)의 방어효과(防禦效果))

  • Park, In-bum;Ahn, Chang-beohm;Jang, Kyung-jeon;Song, Choon-ho;Yoon, Hyoun-min;Kim, Cheol-hong
    • Journal of Acupuncture Research
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    • v.21 no.3
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    • pp.1-12
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    • 2004
  • Objective: This study was undertaken to evaluate the role of lipid peroxidation in oxidant-induced apoptosis and effect of JS on the apoptosis in opossum kidney (OK) cells, an established renal proximal tubular cells. Methods : Exposure of cells to 0.1mM tBHP for 2hr did not induce apoptosis, but subsequent incubation in normal culture medium for 18hr after tBHP treatment induced apoptotic cell death which is dependent of tBHP concentration. Results : JS decreased tBHP-induced apoptotic cell death in a dose-dependent fashion and at concentrations higher than 0.01 mg/ml completely prevented the apoptosis. tBHP-induced apoptosis was prevented by the lipid soluble antioxidant N,N'-diphenyl-p-phenylenediamine (DPPD) and water-soluble antioxidant Trolox. tBHP increased lipid peroxidation, which was inhibited by JS and DPPD. tBHP-induced DNA damage was prevented by JS and DPPD. Conclusion : These results indicate that tBHP induces apoptosis through a lipid peroxidation-dependent mechanism and JS exerts the protective effect against the apoptosis by preventing peroxidation of membrane lipids.

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Effect of Bee-venom Acupuncture on Upper Limb Spasticity of Stroke Patients (중풍 환자의 상지 경직에 대한 봉약침의 효과)

  • Noh, Ju-Hwan;Park, Jung-Ah;Cho, Sung-Woo;Youn, Hyoun-Min;Jang, Kyung-Jeon;Song, Choon-Ho;Ahn, Chang-Beohm;Kim, Cheol-Hong
    • Journal of Acupuncture Research
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    • v.27 no.4
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    • pp.115-125
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    • 2010
  • Objectives : The purpose of this study is to determine the effect of Bee-venom Acupuncture on upper limb spasticity control in stroke patients. Methods : Ten stroke patients with upper limb spasticity were randomly divided into two groups, a Bee-Venom Acupuncture group(group I) and a normal saline group(group II). After 1 week resting phase, this trial was used a cross-over trial. The numbers of Pharmacopuncture treatment were 3 times a week for 3 weeks. Modified Ashworth Scale(MAS), WMFT(Wolf Motor Function Test), The 10-second Test were used for evaluation of spasticity control before experiment, after 1 week, 2 weeks, 3 weeks. Results : Group I showed significant improvement(p<.05) in MAS, WMFT, The 10-second Test. But Group II showed no significant improvement(p<.05) in MAS, WMFT, The 10-second Test. The results showed significant difference in WMFT, The 10-second Test, but no significant difference in MAS between two groups. Conclusions : These results showed that Bee-venom Acupuncture might decrease upper limb spasticity and increase arm motor function in stroke patients. Further studies will be required to examine more cases in the long period for the effect on upper limb in spasticity by Bee-Venom Acupuncture.

Study on the Clinical Application of Acupoints in Bell's Palsy Patients by Using of DITI (적외선 체열촬영을 이용한 Bell's Palsy 환자의 임상적 활용 연구)

  • Jang, Sun-Hee;Kim, Jeong-Eun;Park, Jae-Heung;Noh, Ju-Hwan;Choi, Han-Na;Ahn, Chang-Beohm;Jang, Kyung-Jun;Yoon, Hyun-Min;Song, Choon-Ho;Hong, Sang-Hoon;Kim, Cheol-Hong
    • Journal of Acupuncture Research
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    • v.26 no.6
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    • pp.141-149
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    • 2009
  • Objectives : The purpose of this study is to find out proper method for clinical application of acupoints in Bell's palsy patients by using of digital infrared thermographic imaging(DITI). Methods : We investigated 44 cases of patients with Bell's palsy and checked thermal differences between abnormal and normal acupoint sites by using of DITI. Then we drew a comparison between acupoints of DITI and HBGS, ENoG, NET. We used Pearson's correlation for statistical analysis. Results : The HBGS was significantly correlated with ENoG, NET. The thermal difference of ST3 was significantly correlated with HBGS, Lip and Buccal abnormal site of NET. And the thermal differences between ST3 and GB21 were significantly correlated with ENoG, Forehead abnormal site of NET. Conclusions : Severity of Bell's palsy can be evaluated through DITI.

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Effect of Scutellaria Baicalensis Georgi Extraction (SbGE) on H2O2-induced Inhibition of Phosphate Transport in Renal Epithelial Cells (황금약침액(黃芩藥鍼液)이 신장상피세포(腎臟上皮細胞)에서의 H2O2에 의한 인산염(燐酸鹽) 운반(運搬)의 억제(抑制)에 미치는 영향(影響))

  • Cho, Eun-jin;Youn, Hyoun-min;Jang, Kyung-jeon;Song, Choon-bo;Ahn, Chang-beobm
    • Journal of Acupuncture Research
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    • v.19 no.4
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    • pp.190-199
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    • 2002
  • Objective : This study was performed to determine if Scutellaria balicalensis Georgi extract (SbGE) prevents oxidant-induced membrane transport dysfunction in renal tubular cells. Methods : Membrane transport function was estimated by measuring $Na^+$-dependent inorganic phosphate transport in opossum kidney (OK) cells. $H_2O_2$ inhibited phosphate transport in a dose-dependent manner. Results : The inhibitory effect of $H_2O_2$ was significantly prevented SbGE over concentration range of 0.005-0.05%. $H_2O_2$ caused ATP depletion, which was prevented by SbGE. $H_2O_2$ induced the loss of mitochondrial function as evidenced by decreased MTT reduction and its effect was prevented by SbGE. The $H_2O_2$-induced inhibition of phosphate transport was not affected by a potent antioxidant DPPD, but the inhibition was prevented by an iron chelator deferoxamine, suggesting that $H_2O_2$ inhibits $Na^+$-dependent phosphate transport via an iron-dependent nonperoxidative mechanism in renal tubular cells. Conclusion : These data suggest that SbGE may exert the protective effect against oxidant-induced membrane transport dysfunction by a mechanism similar to iron chelators in renal epithelial cells. However, furher studies should be carried out to find the active ingredient(s) of SbGE that exerts the protective effect.

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The Effect of CF Herbal Acupuncture by Oswestry Disability Index (오스웨스트리 장애지수를 이용한 홍화약침(CF)의 효과)

  • Cho, Tae-Sung;Son, In-Suk;Kwon, Hae-Yon;Youn, Hyoun-Min;Jang, Kyung-Jeon;Song, Choon-Ho;Ahn, Chang-Beohm;Seo, Jung-Chul
    • Journal of Pharmacopuncture
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    • v.4 no.3
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    • pp.15-20
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    • 2001
  • Objective: The aim of this study was to assess the effect of CF herbal acupuncture for low back pain by Oswestry Disability Index Methods: Ten patients with back pain were selected and CF herbal acupuncture was administered one time per 5 days after admission. The degree of improvement was evaluated by Oswestry Disability Index and visual analogue scale(VAS). Oswestry Disability Index consisted of eleven items and they were scored as 5 or 6 points per one item. Results: All of the 10 patients, after CF herbal acupuncture, showed decreased score by Oswestry Disability Index and VAS. It means that the patient's satisfaction increased after treatment. Conclusion: These results suggest that the CF herbal acupuncture was effective for low back pain