• The Korean Journal of Applied Statistics
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• v.22 no.3
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• pp.595-606
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• 2009

Two tests were introduced for comparing several survival functions with doubly interval-censored data and illustrated with data surveyed by Korean Cancer Prevention Study (Jee et al., 2005). The test which extended Kim et al. (2006)'s test to the doubly interval-censored data has an advantage over Sun (2006)'s test in terms of saving computation time because the proposed test only depends on the size of risk set, and also the proposed test is applicable to continuous failure time data as well as discrete failure time data unlike Sun's test. Comparing male with female groups on the incubation time of diabetes was highly different and the survival of female group was longer than that of male one. Regardless of gender, the difference in survival functions of four age groups was highly significant with p-value of less than 0.001. This trend was more remarkable for female group than for male one. Simulation results showed that the significance level of both tests was well controlled and the proposed test was better than Sun's test in terms of power.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.8 no.2
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• pp.95-99
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• 2014

Binaural interaction can recognize the same intensity sound by stimulating two ears alternatively, and it can be record auditory brainstem responses (ABR). However, We needs to be researched about binaural interaction in asymmetric binaural acoustic stimulation. 17 normal young hearing university students were participated. Clicks were presented at the intensity of 90 dB nHL to one ear and the click intensity was increased from 0 to 90 dB nHL with a separation of 10 dB to another ear, simultaneous. BI waveform was obtained by subtracting the sum of the asymmetrically evoked potentials from the binaurally evoked potentials; i.e. BI = B - (L + R). Latency and amplitude was measured 'peak to following trough' of IV-V complex of BI waveform. Threshold of BIC (t-BIC) was obtained using amplitude depend on stimulus intensities (paired sample t-test). Latency shifted in 4.65, 4.63, 4.57, 4.58, 4.62, 4.6, 4.48, 4.36, 4.23 ms for peak, 5.57, 5.51, 5.51, 5.59, 5.61, 5.55, 5.44, 5.28, 5.19 ms for trough, and amplitude shifted in .0.32, -0.3, -0.34, -0.32, -0.42, -0.53, -0.54, -0.61, $-0.67{\mu}V$ from 0 to 90 dB nHL in every 10 dB, respectively. t-BIC was observed 40 dB nHL(p=.001).

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.14-14
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• 1991

후두의 생리적 기능은 하기도를 보호하는 방어기능과 호흡기능 그리고 발성기능으로 대별할 수 있는데 이 가운데 계통발생적으로 가장 원시적이지만 중요한 기능은 하기도 방어기능으로 이는 다른 기능과 달리 전적으로 불수의적이고 반사적으로 이루어진다. 이 기능은 후두내 점막에 존재하는 촉각 수용체(tactile receptor)가 자극되면서 후두근육이 수축 반사를 일으켜 성문이 닫히는 성문폐쇄반사(glottic closure reflex)로서 다접합뇌간반사(polysynaptic brain stem response)이다. 현재까지 후두의 신경장애에서 그 부위나 정도 또는 신경재생 상태 등을 검사하는 방법으로 근전도검사가 주로 쓰여져 왔으나 그것이 주는 정보가 극히 제한되어 있다. 그러나 최근 청각뇌간유발반응과 같이 후두뇌간유발반응 이라 명명된 wave가 존재한다는 사실이 밝혀져 이에 대한 연구가 이루어지고 있어 이것이 임상에 쓰여질 수 있다면 현재 성문폐쇄반사의 소실이나 이상이 원인으로 사료되는 idiopathic laryngospasm, gastroesophageal reflux, spastic dysphonia, stuttering, sudden infant death syndrome과 같은 질환의 진단과 치료에 커다란 진전이 있을 것이다. 이에 저자들은 고양이 6마리를 이용하여 상후두신경을 전기적으로 자극하여 유발되는 반응을 far field recording을 이용 평균 가산법으로 그 wave를 측정하여 다음과 같은 결과를 얻었다. 1. 상후두신경자극(2㎃, stimuli frequency 3/s, Band filter 320-1000, 0.2 ㎳ duration)에 의한 반회신경에의 유발 반응을 기록하였고 그 잠복시간은 평균 8.2 ㎳ 였다. 2. 상후두신경을 자극하여 후두뇌간유발반응을 기록하였고 후두뇌간유발반응은 4개의 양 wave와 4개의 음 wave로 구성되었다. 3. 각 wave의 평균 잠복시간은 P1은 0.8㎳, P2는 2.3㎳, P3는 3.6㎳, P4는 4.3㎳였고 N1은 1.5㎳, N2 은 2.7㎳, N3는 3.9㎳, N4는 5.5㎳ 였다.

• The Korean Journal of Applied Statistics
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• v.33 no.6
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• pp.777-789
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• 2020

COVID-19 has been rapidly spread world wide since late December 2019. In this paper, our interest is to estimate distribution of incubation time defined as period between infection of virus and the onset. Due to the limit of accessibility and asymptomatic feature of COVID-19 virus, the exact infection and onset time are not always observable. For estimation of incubation time, interval censoring technique is implemented. Furthermore, a competing risk model is applied to estimate the case fatality and cure fraction. Based on the result, the mean incubation time is about 5.4 days and the fatality rate is higher for older and male patient and the cure rate is higher at younger,female and asymptomatic patient.

• The Korean Journal of Pharmacology
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• v.20 no.2
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• pp.15-21
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• 1984

It was aimed to study the effects of ${\alpha}_2-adrenoceptor$ agonists on the sleeping time in $one{\sim}two-day-old$ chickens. Furthermore, it was also evaluated whether ${\alpha}_1-adrenoceptor$ agonist and antagonist might affect the sleeping in the chickens and discussed in relation with opiate receptor. 1) Guanabenz, clonidine, guanfacine and B-HT 933 decreased the latency of the loss of righting reflex in a dose-dependent manner, but B-HT 920 and oxymetazoline slightly prolonged it. 2) ${\alpha}_2-Adrenoceptor$ agonists produced dose·related increase in sleeping time. The potency was guanabenz>clonidine>oxymetazoline${\geq}$B-HT 933${\geq}$B-HT 920>guanfacine in this order. 3) ${\alpha}_2-Adrenoceptor$ antagonists decreased guanabenz-induced sleeping time in a dose ·dependent manner. The rank order of ${\alpha}_2-adrenoceptor$ antagonists was yohimbine>rauwolscine>piperoxan${\geq}$RX 781094. 4) Sleeping time caused by both ethanol and hexobarbital was not affected by yohimbine in chickens. 5) Methoxamine and phenylephrine showed little significant effect on the guanabenz-induced sleeping time. However, prazosin increased it. Paradoxically, corynanthine rather caused to decrease it. These results suggest that the stimulation of central ${\alpha}_2-adrenoceptor$ mediates sleeping, however it is remained uncertain in the role of central ${\alpha}_1-adrenoceptor$ in chickens. In addition, the one~two-day-old chickens may be considered as a useful, inexpensive and simple experimental model to evaluate the in vivo pharmacological action of the ${\alpha}_2-adrenoceptor$ agonist and antagonist related to sedation.

• The Korean Journal of Pharmacology
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• v.22 no.2
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• pp.123-127
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• 1986

n-Butyrate (n-BT A) increased the rate and number of infectious units produced in the in vitro reactivation of latent herpes simplex virus. While the mechanism of action of n-BT A is obscure, a continuous presence of n-BT A is necessary for its inductive effect.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.457-457
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• 2012

말라리아는 매개체에 의한 전염병으로써 국내에서는 이미 1970년대에 사라진 것으로 알려져 있다. 하지만 1990년대에 재발생하여 2000년대 초반까지 경기도와 강원도 북부지역에서 환자가 증가하는 양상을 보였다. 사람에게서 발병하는 말라리아는 4종으로 알려져 있으나 우리나라의 경우 이 중 오로지 삼일열 원충감염에 의한 것으로 밝혀졌다(질병관리 본부, 2010). 기후변화는 질병의 발생에 영향을 미칠 수 있는 중요한 요인 중 하나로써 매개체에 의한 질병의 경우 기후요소는 매개체의 번식과 활동에 적지않은 영향을 미친다. 특히 말라리아의 경우 병원균을 가진 개체수와 모기에 물리는 횟수, 감염된 모기의 수, 그 모기에 사람이 물리는 횟수와 관계가 있으나 기온과 강수량, 습도의 변화 등 기후 및 수문학적 요소와도 밀접한 관계를 가지는 것으로 밝혀졌다(Lindsay & Birley, 1996; 박윤형 외, 2006; 신호성, 2011 재인용). 본 연구의 목적은 한반도 기후-수문학적 환경특성 및 변화를 파악하고 지역적 말라리아 발생과의 상관관계를 도출하며 이를 기반으로 하여 말라리아 발생의 변동을 예측하는 것이다. 분석에 사용된 데이터는 말라리아 발생자료의 경우, 질병관리 본부에서 제공하는 2001년 1월~2011년 12월 까지의 약 16000건의 발병자료가 포함 되었고 분석의 시간 단위는 2WEEKS 이며 전국 251개의 시군구에서 발생한 전염병을 합산하였다. 기상자료의 경우 기상청 기후자료 관리 시스템에서 제공하는 동일 기간대의 평균기온, 최고(최저)기온, 강수량, 신적설, 평균 해면기압, 평균 이슬점 온도, 평균 상대습도, 평균풍속, 평균운량, 일조시간 자료를 활용하였다. 본 연구에 사용된 AWS(Automatic Weather Station)자료의 경우 기본적으로 point 형태의 관측자료이고, 분석기간 동안의 개수에서도 차이가 있기 때문에 공간 내삽기법인 kriging을 활용하여 행정구역과 zonal하는 방법으로 재가공 하였다. 지역의 수문학적 특성의 경우 10*10 DEM을 기반으로 ESRI ArcGIS 소프트웨어의 ArcHydro 기능을 이용 하여 유역을 생성하는 방법을 채택하였다. 본 연구에서는 통계적 모형을 기본으로 기후 및 수문 특성과 말라리아 발생간의 상관관계를 분석하였으며 시계열 자료의 특성상 포아송 분포의 Generalized Estimation Equation 과 Generalized Linear Model을 이용한다(Baccini 외, 2008; 신호성, 2011). 또한 말라리아 잠복시간의 지연효과 및 전염병의 계절 영향을 반영하기 위하여 Fourier transform 을 적용 하였다.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.6
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• pp.287-293
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• 2013

Cochlear implant (CI) is an auditory prosthesis that delivers electrical stimulation via inserted electrodes into a cochlea. To evaluate CI performance, it is important to understand how auditory nerves are responded to electrical stimulations. In clinic, electrically evoked compound action potential (ECAP) is measured. In this study, we developed 3D finite element (FE) cochlear model to simulate ECAP in response to electrical stimulation. The model prododuced ECAP similar to that measured in animal experiments and clinics. This 3D FE cochlear model could be used in electrical stimulus method study to improve CI by analyzing neural responses to electrical stimulations.

• Research in Plant Disease
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• v.7 no.3
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• pp.140-144
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• 2001

Occurrence of ripe rot in Vitis vinifera cv, Campbell Early was examined at Daegu, Yaungchon, and Kimchon in Kyungbuk province, Korea from 1997 through 1999. Its occurrence was related to rainfall days in July and Auguest. In cv, Campbell Early, the disease started in late July, and increased rapidly from mid August. Considering the incubation time, the pathogen infection might have increased from late July, which was confirmed by wrapping grape clusters in field and in vitro tests. By scanning electron microscopy, it took 24 h or longer for infection to occur in moisturized conditions. Chlrorothalonyl WP (500$\times$) sufficiently reduced ripe rot disease when the chemical was sprayed 3 or 4 times during the growing season.

• The Journal of the Korea Contents Association
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• v.18 no.5
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• pp.432-445
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• 2018

For health care professionals(HCPs) who have relatively higher possibility of exposing tuberculosis(Tb), it is important for them to equip with proper levels of knowledge and prevention activities. In terms of establishment of Tb education model for junior HCPs, therefore, literature review was done alongside 129 junior HCPs and 14 HCPs were asked to answer questionnaires and telephone survey. The results are follows.; Firstly, six educational themes such as epidermiology of Tb, Tb transmission and patho-physiology, test and diagnosis, latent Tb, Tb treatment, and Tb prevention were identified, based on the literature review. Secondly, the junior HCPs showed lower levels of knowledge regarding epidermiology, transmission and patho-physiology and latent Tb, compared to the other themes. When education courses are planned, longer period of time should be given to the lower level of knowledge areas. Thirdly, the HCPs emphasized that definition and type of Tb should be well integrated into the education in particular epidermiology education. They also responded that hospital infection and infection cycle of Tb need to be addressed during educational session about transmission and patho-physiology. in addition, they said that specific and detailed contents about diagnosis and group examination should be carefully delivered during the education, along with diagnosis, test and application of personal protective devices during education of latent Tb. They also answered that patient education and adverse effect of Tb medication should be taught during Tb treatment session, as well as self activities of health promotion for junior HCPs and systematic TB education as key way of Tb prevention. As the findings were from limited numbers of respondents and contained the sampling bias, the result has to be carefully interpretated prior to generalization. Therefore, further survey with larger study population is required in terms of development of Tb education model.