• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.3
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• pp.177-186
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• 2013

Skin dermal fibroblast is the major collagen-producing cell type in human skin. As aging process continues in human skin, collagen production is reduced and fragmentation is increased, which is initiated by matrix metalloproteinase-1 (MMP-1). This imbalance of collagen homeostasis impairs the structure and function of dermal collagenous extracellular matrix (ECM), thereby promoting skin aging. Cysteine-rich protein 61 (CCN1), a member of the CCN family, negatively regulates collagen homeostasis in primary human skin dermal fibroblast cells. It is known in aging fibroblast cells that elevated CCN1 expression substantially reduces type I procollagen and concurrently increases MMP-1, which initiates fibrillar collagen degradation. And proliferation rate of aging fibroblast cells is reduced compared to the pre-aging fibroblast cells. In this study, we confirmed that the replicative senescence dermal fibroblast cells increased the expression levels of MMP-1 and decreased the production of type I procollagen. Our results also showed that the replicative senescence dermal fibroblast cells increased in the expression of CCN1 and decreased in the proliferation rate. Hydrolyzed Ulva pertusa extracts are the materials to improve photo-aging by reducing the expression of MMP-1 that was increased by ultraviolet and by promoting the synthesis of new collagen from fibroblast cells. In this study, we also investigated the hydrolyzed U. pertusa extract to see whether it inhibits CCN1 protein expression in the senescence fibroblasts. Results showed that the hydrolyzed U. pertusa extract inhibited the expression of MMP-1 and increased the production of type I procollagen in the aging skin fibroblast cells cultured. In addition, the proteins that regulate collagen homeostasis CCN1 expression were greatly reduced. The hydrolyzed U. pertusa extract increased the proliferation rate of the aging fibroblast cells. These results suggest that replicative senescent fibroblast cells may be used in the study of cosmetic ingredients as a model of the natural aging. In conclusion, the hydrolyzed U. pertusa extract can be used in anti-wrinkle functional cosmetic material to improve the natural aging skin care as well as photo-aging.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.12-12
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• 2021

최근 길어진 여름 및 이상고온 현상이 지속됨에 따라 심화되는 광노화 피부의 특징으로는 건조, 굵고 깊은 주름, 탄력저하 및 불균일한 색소침착 등이 나타나게 됨. 화장품 소재는 기존 광노화 관련 화학물질인 Retinol 등을 대체하기 위해 자연 유래 성분을 적용한 신소재 연구를 진행하고 있음. 흰목이버섯(Tremella fuciformis)은 흰목이목에 속하는 버섯류로 자실체는 한천질로서, 주름이 되어 갈라져 있거나 또는 귓불 모양을 이루고 있으며, 크기는 10 cm 정도이다. 중국에서는 보양식의 주재료로 쓰일 만큼 탁월한 항노화 효능이 알려져 있다. 본 연구에서는 흰목이버섯의 자실체에서 추출하여 정제한 β-Glucan의 성분 확인, in vitro 수준의 피부 항노화 효과, 동물대체 독성 시험을 통한 피부독성 확인 및 인체 피부유효성 평가를 통한 항노화 효과를 확인하였다. 흰목이에서 추출, 정제 후 Bio-LC를 통한 유리당 분석 결과 Mannose, Fucose, Glucose를 확인하였으며, Human Keratinocyte에 UVB를 조사하여 광노화를 유발한 피부세포에 피부 자극 및 탄력저하 인자인 IL-6, TNFa 및 MMP-1을 평가한 결과 농도 의존적으로 현저히 개선됨을 확인하였다. 또한 보습 및 피부장벽 개선 인자인 Filaggrin과 Involucrin 생성효능을 평가한 결과 매우 높이 생성됨을 확인하였다. 본 연구결과를 토대로 광독성, 피부감작성 및 안점막 동물대체 독성시험을 실시한 결과 무독성임을 확인하여 피부에 안전하면서 효능이 우수한 것을 in vitro 수준에서 확인하였고, 피부 홍반완화, 주름개선, 탄력개선 및 보습증가 등 광노화 예방효과를 인체를 대상으로 평가한 결과 유의적인 홍반완화, 주름개선, 탄력 및 보습증가효과를 확인하였다. 본 연구결과를 종합하여 볼 때 흰목이버섯에서 추출, 정제한 β-Glucan은 in vitro 수준에서 자외선으로 인한 피부 트러블 완화, 탄력 및 보습개선을 확인하였고 독성시험을 통해 무자극임을 판정하였으며, 인체유효성 평가를 통해 광노화 예방효과를 확인하였으며 본 결과를 통해 아시아 및 글로벌 시장으로 천연유래 항노화 소재로 확장하고자 한다.

• Korean Journal of Community Nutrition
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• v.4 no.2
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• pp.254-259
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• 1999

노화는 모든 사람에게 공통적으로 일어나는 자연스러운 현상이다. 그러나 이에 따른 신체적인 변화는 각 개인에 따라, 그리고 한 개인 안에서조차 각종 장기별로 다양한 속도로 진행된다. 노년기의 생리적인 변화는 예비용량(reserve capacity)의 저하에 따라 외부의 스트레스에 대처하여 항상성을 유지하는 능력이 감소되어 나타나게 된다. 안정적 상태에서 기능수준에는 큰 변화가 없으나 활동상태의 기능 수준은 연령증가에 따라 상당히 저하되는 것을 보여준다. 노년기의 생리적 변화에 따라 직병에 대한 감수성은 증가하나 대다수의 만성퇴행성질환은 특정 병리현상에 의해 발생하며 노화가 직접적인 원인으로 작용하지는 않는 것으로 알려지고 있다.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.28-32
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• 1998

• Proceedings of the KSEEG Conference
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• 1999.04a
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• pp.36-38
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• 1999

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.595-601
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• 2020

During the safety inspection of nitrocellulose-made explosive containers stored for more than 10 years, cracks were found in the containers. Therefore, a failure cause analysis test was performed. First, the cause of failure through the failure tree analysis was conducted to select the factors that influenced failure. The changes in the properties of the container caused by the acceleration of the reaction were found to be the cause of the failure by confirming the influence on the environment and internal/external factors that may occur during storage. To confirm this, environmental tests, such as thermal shock test and vacuum thermal stability test, were performed using a naturally aged container to analyze the cause of failure, and an accelerated aging test was performed to reproduce the failure. Through this, the chemical reaction was accelerated by heat and charge, as in the result of the fault tree analysis, and it was confirmed that the physical properties of the container were changed. In addition, the service life of the container was estimated using the Arrhenius model for the storage life due to thermal aging.

• Journal of Digital Convergence
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• v.19 no.12
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• pp.513-521
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• 2021

The purpose of this study is to suggest an anti-aging health care plan through a literature analysis of the life activity system of Oriental Medicine. The source of normal maintenace, development, and change of the natural world and the human body's life activity process is the dynamical cooperative equilibrium of the internal Shen-Ji's discipline that creates, grows, changes, makes differences and stores(生长化收藏) and external Qi-Li's process of change from birth to growth, maturity to old age and ending of life(生長壯老已). Therefore, it was analyzed that the natural and human life activity processes are normally maintained, developed, and transformed. As a result, when the natural healing power of Genuine-Qi, the source of the human vitality, rises with the 'breathing massage' that combines a static breathing method which is anti-aging health care method applying the lifting entering movement of Qi and a dynamic abdominal massage, and it harmonizes the Shen-Ji which is the life process system and Qi-Li so that it is believed to be helpful in prolonging a healthy lifespan.

• 기계와재료
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• v.23 no.1
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• pp.14-22
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• 2011

노화가 시작되면 체력이 저하되어 면역기능이 떨어져 쉽게 병에 걸리고 환경에 대한 적응력이 떨어진다. 특히 60세 이상이 되면 근육 양과 근력이 급격히 가속화되어 신체적으로 약화되기 시작한다. 노화는 자연스럽게 진행되지만 꾸준한 운동을 통해 근력 저하 속도를 늦출 수 있다. 근력 증강을 위한 다양한 기기 개발에도 불구하고 노인들이 사용하는데 어려움이 있다. 특히 노인 신체적 특성에 맞는 운동기기 개발이 절실하며, 노인의 흥미를 유발시켜 자발적 참여를 유도하는 환경이 제공되어야 한다. 가상현실 기술은 실재하지 않거나 먼 거리에 있는 환경을 가상세계로 생성시켜서, 인간의 오감을 각종 인터페이스 장치를 통해 신호를 전달하여 가상의 현실 환경에 실재하고 있다고 느끼도록 만들어 주고, 가상세계와 상호작용을 통해 의료 진단, 치료, 재활 등에 유용한 도구 및 환경을 제공한다. 이러한 가상현실 기술의 특성 때문에 노인의 운동 참여와 운동 효과를 극대화 할 수 있다. 본 논문에서는 근력의 특성을 분석하고 노화와 근력과의 관계를 조사하고, 상지근력 증강 운동기와 해당 가상현실 컨텐츠 그리고 관련 컨텐츠 개발 동향에 대해 제시하고자 한다.

• International Journal of Highway Engineering
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• v.13 no.2
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• pp.1-8
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• 2011

The objective of this paper is to evaluate the performance of low $CO_2$ asphalt binder properties using LEADCAP$^{(R)}$(Low Energy and Carbon Asphalt Pavement) additive as function of various aging methods such as RTFO(Rolling thin film oven), Ultraviolet(UV) lay. In order to simulate the short-term aging of asphalt binder that occurs during the hot-mixing asphalt process, the Rolling Thin Film Oven(RTFO) was used. Asphalt binder using LEADCAP$^{(R)}$ is prepared by addition of a photoinitiator activated by ultraviolet lay. The mechanical and rheological properties of the asphalt binder were estimated using UTM(Universal Testing Machine) and DSR(Dynamic Shear Rheometer). The test results showed that the asphalt binder using LEADCAP$^{(R)}$ additive was improved the rutting resistance at testing temperature ($70^{\circ}C$) and increased tensile strength at low temperature. Also, Thermal analysis shows that the Melting Point(Tm) of asphalt binder using LEADCAP$^{(R)}$ additive was constant although the asphalt binder was aged by Ultraviolet.

• Journal of the Korean Data and Information Science Society
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• v.25 no.1
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• pp.77-85
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• 2014

The purpose of the current study was to identify expectations regarding aging and health-promoting behaviors and to examine whether expectation regarding aging was associated with health-promoting behaviors among community-residing Korean adults. Data were collected from 233 adults dwelling in the community of Daegu and Kyungpook province. The influence of expectations regarding on health-promoting behaviors was analyzed through hierarchical multiple regression controlling for sociodemographic variables. As a result, the mean score of expectations regarding aging was significantly lower in 40s and 50s than 20s and 30s. The participants had the lowest expectations regarding aging in terms of physical health domain and the highest expectations in terms of mental health domain. No significant differences were found in health-promoting behaviors among different age groups. After controlling for sociodemographic variables, expectations regarding aging were independently associated with health-promoting behaviors in adults in 20s~30s but not in those in 40s~50s. The findings suggest the need for encouraging Korean adults to strive for having positive and active perspective on aging and for getting higher expectations regarding aging, in particular, for 20s and 30s, as a health-promoting strategy.