• Proceedings of the Korean Information Science Society Conference
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• 1998.10c
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• pp.612-614
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• 1998

뇌정위 수술(Stereotactic Surgery)은 컴퓨터 단층영상과 자기공명 영상 같은 3차원 영상을 이용하여 뇌병변의 위치를 입체적으로 정확히 파악하여 정상 뇌에 대한 손상을 최소화하며 병변을 수술하는 기법이다. 본 논문에서는 수술 받을 환자의 컴퓨터 단층영상과 자기공명 영상 등 다양한 종류의 3차원 볼륨 데이터를 전처리한 다음 동일한 3차원 공간 내에서 정렬시켜 선택적 또는 동시적으로 3차원 영상을 가시화 하는 기법을 제안한다. 또한 3차원 영상에서 뇌정위 수술의 삽입점과 목표점을 지정할 수 있는 기능을 지원하며 수술 경로에 따른 가상 수술의 시뮬레이션을 통하여 수술 경로의 안전성을 검증할 수 있게 하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10d
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• pp.560-563
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• 2007

다시점 영상은 관찰자가 원하는 시점을 선택할 수 있고, 자연스러운 입체감을 제공한다. 하지만 카메라의 수가 증가함에 따라 데이터양이 늘어나는 단점이 있다. 본 논문은 시.공간적 상관성을 고려한 시점 간 움직임 벡터 예측 기법을 제안한다. 인접한 시점의 영상이 비슷한 움직임 정보를 가지는 특징을 이용해 현재 블록의 움직임 벡터의 예측간을 계산한다. 또한 시간적으로 연속한 프레임의 경우 비슷한 변이 벡터를 가지므로, 이전 프레임의 변이 벡터 정보를 현재 매크로블록의 변이벡터로 활용하는 방법을 제안한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.275-284
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• 2017

As the 3D Greenery system is known to improve the urban environment, it works as new alternative for eco-friendly building and warrants further study for application to the domestic field. This study aimed to apply the design components for eco-friendly composition by investigating the spatial characteristics of the 3D Greenery System reflected in interior and exterior of buildings and to analyze the organization and design elements of domestic and foreign cases. The results showed that instances of the Greenery System tended to be a large scale and high-density development in order to expand various exterior spaces. Although its early forms were often found in such public facilities as exhibition and education purpose, cases of multi-unit dwelling have been growing. Allowing apartment residents to prefer intimate space by providing various such spaces for residential units and offering independent green spaces would induce diverse residents' lifestyles rather than monotonous design. The analysis also indicated that community space composed of various outdoor spaces and atmosphere would change life patterns of multi-housing and establish a real neighborhood through social interaction. Moreover, further investigation of the design patterns of outdoor space arrangement is needed since the Greenery system actively reflects the environmental characteristics of building sites and clearly shows a tendency to utilize natural terrain and slope in building shapes.

• Journal of the Korean Society of Radiology
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• v.5 no.4
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• pp.161-169
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• 2011

This research experimented on the change of the multiple colleague scan angle facing one scan object facet to many directions of the form of 3D about the visual angle nervous system forming the cubic distribution with the gradient magnetic field of the mri system and considered the existing basic angle oblique direction test coverage and comparison. MR system can freely select various pulse sequence and image slice. To oblique imaging for optic nerve viewing, we have studied the variation of scan angle between typical oblique scan method (sagittal-coronal plane) and multi directional angles oblique scan method (sagittal-coronal-axial plane) using gradient of MR system. In this study, the subjects of the experiment were normal adults in our country. As a result, we confirmed that multi directional angles oblique scan method can display anatomical information of more wider area than typical oblique scan method. In addition, to clearly display optic nerve, we also confirmed that image slice thickness and pulse sequence have effect on it.

• KSBB Journal
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• v.19 no.1
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• pp.42-49
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• 2004

A gene coding for epoxide hydrolase (EH) of Aspergillus niger LK, a fungus possessing the enantioselective hydrolysis activity for racemic epoxides, was characterized by phylogenetic analysis. The deduced protein of A. niger LK epoxide hydrolase shares significant sequence similarity with several bacterial EHs and mammalian microsomal EHs (mEH) and belongs to the a/${\beta}$ hydrolase fold family. EH from A. niger LK had 90.6% identity with 3D crystal structure of lqo7 in Protein Data Bank. Sequence comparison with other source EHs suggested that Asp$\^$l92/, Asp$\^$374/ and His$\^$374/ constituted the catalytic triad. Based on the multiple sequence comparison of the functional and structural domain sequence, the phylogenetic tree between relevant epoxide hydrolases from various species were reconstructed by using Neighbor-Joining method. Genetic distances were so far as 1.841-2.682 but characteristic oxyanion hole and catalytic triad were highly conserved, which means they have diverged from a common ancestor.

• The Journal of Natural Sciences
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• v.7
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• pp.47-51
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• 1995

In order to develope new asymmetric catalyst, we synthesized the following new sulfonamide derivatives start from S-Indoline-2-Carboxylic Acid via the following 5 steps. Hydroxy methyl derivative(1) was thus treated with methane sulfonyl chloride in the presence of triethylamine as base to give mesylated derivative(2) in 85% of isolated yield. The mesylate compound (2) was treated with excess sodium azide to give Azido derivative (4) in 95% isolated yield. Azido compound (3) was then reduced to the corresponding amino derivative in near quntitative yield by the hydrogenation under hydrogen atmospere in the presence of catalytic amount of Pd-C. The amino derivative (4) was converted to its sulfonamide derivatives by the treatment of compound(4) with triisopropyl benzene sulfonyl chloride in the presence of triethyl amine as base. Finally t-BOC group of the compound(5) was removed by the treatement of excess Trifluoro-acetic acid in near quantitative yield to give the target sulfonamide derivative (7) .in this paper we prepared compound(6) in 49% overall yield via the 5 steps of synthesis starting from t-Boc- 2-hydroxy methyl indoline(1) which cab be easily prepared from commercial available S-indoline-2-carboxylic acid by known methods. we plan to apply this new catalyst for the asymmetric reduction , diels-alder reaction, aldolcondensation reaction in due courses.

• Journal of the Korean Chemical Society
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• v.45 no.1
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• pp.51-60
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• 2001

One-pot Mannich reaction of substituted hydroxy aromatic compounds with secondary amines in an aprotic solvent has been studied. The results demonstrate that the relative reactivity and regioselectivity of the Mannich reaction depend on the steric hindrance of amines as well as the nucleophilicity of hydroxy aromatic rings.

• KSBB Journal
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• v.24 no.3
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• pp.239-245
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• 2009

Enantiopure styrene oxide derivatives are versatile building blocks for the synthesis of enantiopure pharmaceuticals. Styrene monooxygenase (SMO) catalyzes an asymmetric addition of an oxygen atom into a double bond of vinylaromatic compounds. SMO is a commercially potential biocatalyst to synthesize a variety of enantiopure epoxides with high enantiopurity and recovery yield. In this paper development of SMO biocatalyst and commercial feasibility of SMO-catalyzed asymmetric synthesis of enantiopure stylers oxide derivatives are reviewed.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10a
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• pp.615-618
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• 2001

본 논문은 기존의 3D 게임 엔진에 실시간으로 상호 작용이 가능하고 3D MMORPG(Massive Multi-play Online Role flaying Game) 게임에 적합한 가상 공간을 표현하기 위한 필요한 기술을 분석하고 이를 활용하려 한다. 기존의 머드 게임에 3 차원 기술을 적용하고, 3 차원 물체를 모델링 하는데 있어서 메쉬나 버텍스, 혹은 폴리곤으로 사실적인 지형 처리와 렌드링 속도 향상을 위하여 3 차원 개체의 폴리곤을 동적으로 생성시키고 가시성 판단이나 충돌 검출을 위한 방법으로 Height field 처리 기법과 거리에 변화에 따라 다르게 모델링 된 데이터를 선택적으로 사용하는 CLOD(Continuous Level of Detail) 처리 기법과 입체 컬링 방법으로 옥트리를 이용하여 가상공간을 분해하기 위한 자료 구조로 사용한다. 거리의 변화에 따라 지형을 표현하는 vertex 들을 병합 또는 삭제함으로써 그 표현의 정도를 동적으로 달리 할 수 있는 CLOD 를 이용하여 카메라의 위치와 방향에 따라 적절한 폴리곤을 생성해 낼 수 있다. 본 논문은 기존의 3 차원 공간을 표현하기 위하여 사용되고 있는 옥트리 구조를 이용하여 공간을 분할하고, 이를 세부 수준으로 나누어 처리하기 위한 LOD(Level of Detail)와 CLOD 개념을 이용하여 외부지형을 폴리곤으로 표현하는 방법에 대한 처리 기법과 가시성 판단이나 충돌 검출을 위한 방법을 제시하려 한다.

• Journal of the Korean Chemical Society
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• v.36 no.6
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• pp.879-888
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• 1992

Separation of the optical isomers of free amino acids by a reversed phase high performance liquid chromatography has been studied by adding a copper(II) complex of L-proline or L-proline derivatives (hydroxy-L-proline, N-benzyl-L-proline, p-xylenyl-L-proline, p-xylenyl-hydroxy-L-proline) in the mobile phase. An OPA postcolumn detection system was used for the detection of amino acids. The chromatographic properties for the free amino acids were discussed in terms of the pH, the kinds and concentration of chelate or organic modifier. The retention behaviors of the free amino acids were considerably different from, those of DNS-amino acids or DABS-amino acids. The enantioselectivity of the free amino acids was better than that of derivatized amino acids. The enantioselectivity between the optical isomers observed by use of the Cu(II)-p-xylenyl-L-proline chiral cheleate was the best among the several copper(II) chelate. A separation mechanism could be illustrated not only by the hydrophobic interaction of the diastereomer with stationary phase but also by the steric effect of the ligand exchange reaction between the free-amino acids and copper chelate.