• Clinical and Experimental Pediatrics
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• v.45 no.10
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• pp.1288-1291
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• 2002

Fetal valproate syndrome has been described as a distinctive pattern of minor anomalies of the face and digits. This pattern has not been delineated completely but appears to involve brachycephaly with a high forehead, shallow orbit, ocular hypertelorism, small nose, small mouth, low set posteriorly rotated ears, long overlapping fingers and toes, and hyperconvex fingernail. Cleft palate and congenital heart disease have occasionally been described in babies exposed to valproate during embryogenesis. We report a neonate born from an epileptic mother receiving sodium valproate during pregnancy. This neonate presented with characteristic facial abnormalities, both elbow contractures, and overlapping of right first and second toe, forth and fifth toe, and left first and second toe. This case raises the possibility that these abnormal appearances might be caused by intrauterine valproate exposure.

• 모자간호학회지
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• v.2 no.1
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• pp.34-44
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• 1992

지난 10년 동안 구미에서는 부모-아동 관계 영역에 혁신을 가져왔다. 특히 부모-아동 애착이론의 획기적인 변화로 가족 중심 출산 경험을 강조하고 있다. 과거에는 남편이 아내의 출산에 참여하던 것이 타부시되어 왔지만 애착의 개념이 대두되면서 남편도 출산에 함께 참여하도록 고려하여 임신에서부터 부부가 함께 이 과업을 완수하도록 모든 환경을 변화시키고 있다. 애착이론은 다양하여 정신분석이론, 학습이론, 인지발달이론과 동물 행동학적 측면에서 이해되고 있다. 다양한 이론적 배경과 개념들을 가지고 아버지-아동의 애착 및 유대관계에 대한 연구가 지난 10여년 이상 되어오고 있다. 가장 관심의 촛점이 되어 연구 되어온 것으로는 애착형성을 위해 중요하다고 하는 민감한 시기(Critical period)를 중심으로 애착의 특성인 시각, 청각, 촉각, 상호호혜적 관계, 긍정적 애정을 바탕으로 연구되어졌다. 이 연구는 부아 애착(Paternal Infant Attachment)의 연구를 연구방법, 측정도구 및 방법상문제와 변수들을 중심으로 재정리하여, 이 분야에 있어서 앞으로의 연구 방향을 살펴보았다. 17편의 연구들을 각각 년도, 표본수, 방법 및 측정, 결과 및 비고난을 비교 분석하여 도표를 작성하였다. 이론적 기틀과 문헌고찰에 근거하여 다음과 같은 적용과 제언을 한다. 1. 출산전 아버지의 특성에 대한 사정이 필요하다. 2. 연구자가 집단간 비교를 용이하게 하기 위해 연구전에 표본의 특성을 정확히 기술해야 한다. 3. 부모와 아버지의 과거력에 대한 상세한 정보수집이 강조되어야 한다. 4. 앞으로의 연구는 이론적 모델에 근거하여 이루어져, 대중교육 뿐 아니라 정책 결정에 기여해야 한다. 5. 연구결과 평가와 해석을 위해 정확한 이론적 근거가 필요로 된다. 6. 간호연구는 부적절한 부아 애착 형성에 있어서 아버지의 특성을 확인하고 부아유대와 애착 증진의 요소를 파악해야한다. 7. 부아 유대에 대한 위협요소 확인을 위한 도구개발과 그들에 대한 효과적인 간호전략이 필요 된다. 8. 가족에 있어서 모든 부모행위가 하나의 독립변수로서 연구되어야 하고 부아유대 증진에 관한 연구가 시도되어야겠다. 오늘날 부모들은 임신기간동안 많은 정보에 접하기를 원한다. 산전, 산후의 교육과 지식은 긍정적인 부아 관계를 증진시키고, 이것은 아동의 발달에 크게 기여할 수 있다. 긍정적으로 이러한 관계는 가족단위를 강하게 통합시키게 되므로 건강관리자(Health care workers)들은 애착에 대해 높은 관심을 갖어야 하겠다.

• Korean Journal of Child Studies
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• v.24 no.1
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• pp.99-108
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• 2003

This study was based on theories of the culture of poverty and the causes and consequences of poverty. The strong relationship of family income to mother's education presents the possibility of an intergenerational education cycle. Using a longitudinal approach, parental poverty status was measured by family income, welfare assistance, single parent, and occupation when children were 2 years of age; children's school performance was measured by teacher reports of their reading, mathematics, writing, and overall ability at grade 1. Data were analyzed by structure equation modeling. Results showed that mother's pre-childbearing level of education predicted child school performance in grade 1, confirming an intergenerational cycle. In addition, the results indicated that parental poverty acts as a mediator between the cycle.

• Korean Journal of Animal Reproduction
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• v.27 no.2
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• pp.143-152
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• 2003

The objective of this study were to investigate the effects of Se and Vit. E administration on blood chemical values and Vit. E concentrations of serum in calves born from Hanwoo dams injected Se and Vit. E at late pregnancying periods. The effects of Se and Vit. E administration of blood chemical values in calves born from Hanwoo dams injected Se and Vit. E at the last month of pregnancying periods were examined. In albumin concentration of blood, the Vit. E 2000IU group were slightly higher than other groups and the cholesterol concentrations were also higher in Vit. E 15001u group than other groups. But, another components examined of blood chemical values were not significantly different in all experimental groups. The blood chemical values in calves born from Hanwoo dams administrated Se and Vit. E at two months before parturition were examined. However, there were not significantly different in all experimental groups in concentrations of albumin, cholesterol, BUN, creatinine, glucose, inorganic phosphorous, calcium, total protein and triglycerides. The concentrations of serum Vit. E in calves born from Hanwoo dams administrated Se and Vit. E at 30 and 15 days before parturition were examined. The concentrations of Vit. E in serum were higher in treatment groups than in control group(P>0.05). The concentrations of serum Vit. E in calves born from Hanwoo dams administrated Se and Vit. E at 60 days before parturition were examined, the concentrations of Vit. E in serum were slightly higher in groups administrated than in control group(P>0.05), but there were not significantly difference in all experimental groups.

• 한국벤처창업학회:학술대회논문집
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• 2019.04a
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• pp.75-78
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• 2019

통계청의 '2018년 경력단절여성 현황'을 보면, 지난해 4월 기준으로 15~54세 기혼여성 가운데 경력단절여성은 184만7000명으로 전년 대비 1만5000명(0.8％) 늘었다. 경력단절여성의 비중도 20.5％로 1년 전보다 0.5％포인트 상승했다. 2015년 21.7％, 2016년 20.5％, 2017년 20.0％로 점차 떨어지다가 다시 반등세로 돌아섰다. 경력단절여성의 경우 재취업 성공도 힘들었다. 지난해 경력단절 후 다시 취업한 기혼여성은 1년 전보다 50만7000명(19.6％) 줄어든 208만3000명으로 2014년 통계작성 이후 가장 적었다. 경력단절 후 다시 취업한 이들의 비중도 지난해 23.1％로 최저였다. 경제활동을 시작하는 20대부터 경력을 쌓아가는 30대, 40대는 노동자의 생산성이 증폭되는 시기인데, 정작 여성은 이 연령대에 결혼 임신 출산 육아로 인해 경력이 단절되는 현실이다. 본 연구는 우리나라 경력단절여성의 자기지각, 사회적지지 및 대처행동이 취창업의지와 삶의 질에 미치는 영향에 대한 연구로 최근의 정부정책에 있어서 이슈가 되고 있는 사항들을 연구할 예정이다.

• Journal of Life Science
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• v.20 no.6
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• pp.894-901
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• 2010

The purpose of this study was to examine obstetrical & gynecological health status and body composition for married female immigrants. The participants were 154 immigrant women living in Busan. Data were collected from July 2008 to July 2009 using a questionnaire and a bioelectrical impedance analysis tool (Inbody 720) for analysis of body composition. Most subjects were in the normal range for body composition, but some of those who answered the questionnaire had experienced some gynecological problems such as dysmenorrhea, or irregular menstruation. There was a significant difference in experiences with in vitro fertilization, pregnancy and abortion according to age and in premensturaion syndrome, as well as differences in regulation of menstruation during the past year, leukorrhea odor, experiences in in vitro fertilization, and delivery and breastfeeding according to nationality. There were significant differences in body mass index and waist-hip ratio according to age, as well as differences in percent body fat, body mass index and waist-hip ratio according to nationality. There were also significant differences in body mass index and waist-hip ratio according to period of stay in Korea. Procreative care protocols concerning married female immigrants' characteristics should be developed.

• Clinical and Experimental Reproductive Medicine
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• v.24 no.2
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• pp.225-232
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• 1997

폐색성 혹은 비폐색성 무정자증에서 부정소 정자채취법 등이 부적절하다고 여겨질때는 정소 조직을 일부 절제하여 그 조직으로부터 정자를 직접 채취하게 되는데 일반적으로 이렇게 정소로부터 추출한 정소정자는 운동성이 전혀 없거나 매우 약한 운동성을 보이는 경우가 많다. 본 연구의 목적은 이러한 정소정자를 Vero cell과 공배양을 시킴으로써 운동성을 획득시키거나 향상시키고 이를 수정시키는 시기까지 지속시킴으로써 정소정자추출술 (TESE)을 시행하는 환자나 의료진들에게 보다 편안하고 융통성있는 시간대를 부여하고, 아울러 정자직접주입술 (ICSI)을 보다 용이하게 하여 성공적인 수정률과 임신율을 얻음에 있다. 또한 ICSI를 시행한 후, 운동성이 향상된 잉여의 정소정자를 냉동보존함으로써 차후에 TESE을 다시 시행치않고도 시험관 아기 시술을 시도할 수 있는 부가적인 잇점도 있다고 할 수 있다. 대상환자군은 정관폐색증(n=11) 혹은 비정관폐색증(n=2)을 보이는 13명의 무정자증의 남성불임환자였으며 난자회수예정일 3일전에 TESE를 시행하여 정소정자를 얻은 후 이를 정자직접주입술이 시행되는 당일까지 Vero cell과 공배양을 실시하였다. Vero cell과의 공배양에 의하여 운동성이 있는 정소정자의 수는 공배양전과 비교하여 평균 3.3배가 증가하였으며, 특히 공배양전에 운동성이 있는 정소정자의 수가 50,000/ml이하의 미약한 운동성만을 보였던 경우 (n=5)에는 공배양 후에 운동성이 있는 정소정자 수의 평균증가율이 7.7배였다. 공배양전 정자운동성이 전혀 없었던 2례의 비정관폐색증환자중 3일간의 공배양을 통하여 1례에서 운동성을 획득한 정소정자를 얻을 수 있었으며 (14,300/ml), 정자직접주입술을 통하여 성공적인 수정 및 임신에 도달할 수 있었다. Vero cell과 공배양을 하고 ICSI했던 결과, 평균 수정률은 75.0% 이었으며 임신율은 61.5%였다.

• Journal of Nutrition and Health
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• v.55 no.3
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• pp.330-347
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• 2022

Folate, a water-soluble vitamin, acts as a coenzyme for one-carbon metabolism in nucleic acid synthesis and amino acid metabolism. Adequate folate nutritional status during the periconceptional period is known to prevent neural tube defects. In addition, insufficient folate intake is associated with various conditions, such as anemia, hyperhomocysteinemia, cardiovascular disease, cancer, cognitive impairment, and depression. This review discusses the rationale for the revision of the 2020 Korean dietary reference intakes for folate, and suggestions for future revisions. Based on the changes in the standard body weight in 2020, the adequate intake (AI) for infants (5-11 months) and the estimated average requirements (EARs) for 15-18 years of age were revised, but there were no changes in the recommended nutrient intakes (RNIs) and tolerable upper intake levels (ULs) for all age groups. Mean folate intake did not reach RNI in most age groups and was particularly low in women aged 15-29 years, according to the results of the 2016-2018 Korea National Health and Nutrition Examination Survey (KNHANES). The percentages of folate intake to RNI were lower than 60% in pregnant and lactating women, but serum folate concentrations were higher than those in other age groups, presumably due to the use of supplements. Therefore, total folate intake, from both food and supplements, should be evaluated. In addition, the database of folate in raw, cooked, and fortified foods should be further expanded to accurately assess the folate intake of Koreans. Determination of the concentrations of erythrocyte folate and plasma homocysteine as well as serum folate is recommended, and quality control of the analysis is critical.

• Clinical and Experimental Reproductive Medicine
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• v.37 no.3
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• pp.245-251
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• 2010

Objective: Human sperm nucleus DNA damage may negatively affect pregnancy outcome, and the spermatozoa of infertile men have more DNA damage than that of fertile men. The aim of this study was to evaluate the effect of microsurgical varicocelectomy on human sperm nucleus DNA integrity. Methods: We reviewed the medical records of 18 subfertile male patients who underwent microsurgical varicocelectomy at our hospital from April 2006 to April 2007. Varicocele was diagnosed by physical examination and Doppler ultrasound. Standard semen analysis was performed in 18 patients before and 4 months after microsurgical varicoceletcomy using a computer assisted semen analyzer. Sperm nucleus DNA integrity was assessed by a single-cell gel electrophoresis (comet assay). Results: No recurrence of varicocele was observed after 4 months later. The DNA fragmentation index improved after varicocelectomy compared with pre-operatively (19.3 versus 13.7%, respectively, p<0.05). Semen analysis parameters (total count, concentration, motile sperm, viability, strict morphology) increased after varicocelectomy, but the difference did not reach statistical significance. Conclusion: Our data suggest that microsurgical varicocelectomy can improve semen analysis parameters and human sperm nucleus DNA integrity in infertile men with varicocele.

• Women's Health Nursing
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• v.19 no.4
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• pp.219-229
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• 2013

Purpose: This study was conducted to identify awareness levels in regard to preconception care and gender differences targeting single undergraduate students in their 20s. Methods: The study participants were 867 single undergraduate students aged 20~29 (523 women, 344 men). This was a descriptive research, in which awareness levels of preconception care and pregnancy were identified the through questionnaire surveys. Results: Gender differences in the awareness of reproductive care before conception were found. Generally, women's awareness of issues related to preconception care and pregnancy was higher than that of men. Women recognized risk factors in pregnancy ($x^2$=22.85, p<.001) and positive behaviors ($x^2$=10.91, p=.012) better than men. Women's awareness of preconception care was significantly higher than that of men (t=8.37, p<.001). The awareness levels of the students who completed a reproduction related class (t=3.16, p=.002) and the students who knew about folic acid (t=-10.78, p<.001) in preconception care were statistically significantly higher. Conclusion: The results indicate that the ways to educate and alert students to major risk factors before pregnancy and other reproductive care content before conception is to provide education both single women and single men.