• Clinical and Experimental Reproductive Medicine
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• v.37 no.3
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• pp.253-259
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• 2010

Objective: To evaluate if there is any correlation between the growth rate of dominant follicles and clinical characteristics or outcome variables in women undergoing controlled ovarian hyperstimulation (COH). Methods: This study was performed in 313 in vitro fertilization (IVF) cycles. Follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) were measured on day 3 of menstrual cycle, and serial ultrasonographic measurement of the diameter of growing follicles was performed. The growth rates of dominant follicles calculated by diameter difference divided by days were correlated with clinical characteristics and outcome variables. Results: There was no significant difference in the growth rate of the dominant follicles between gonadotropin releasing hormone (GnRH) agonist and antagonist cycles. No significant correlation was found between the growth rates and evaluated factors such as age, body mass index, LH, FSH, $E_2$, retrieved oocytes and fertilization rate. Conclusion: The Growth rate of dominant follicles seems to show an independent feature of basal characteristics and ovarian response.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.399-405
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• 2018

The platelet count in clinical laboratories is essential for the diagnosis and treatment of hemostasis abnormalities, and accurate platelet counting in the low count range is of prime importance for deciding if a platelet transfusion is needed and for monitoring after chemotherapy. Quality control is designed to reduce and correct any deficiencies in the internal analytical process of a clinical laboratory prior to the release of patient results. Fragmented erythrocytes are the major confusing factors for platelet counting because of their similar size to platelets. The authors found that the low range QC values were out of 2SD with a Sysmex automatic analyzer in internal quality control process. Thus far, there has been little discussion on the relationship between hemolysis and the platelet parameters. Therefore, this study focused on the performance of automated platelet counts, including the PLT-F, the PLT-I, and PLT-O methods at the low platelet range using the low level QC materials and compared the 5 platelet parameters with the hemolyzed samples. The results showed that the CV was the smallest with PLT-F and P-LCR increased from 18.4 to 31.9% in the hemolysis samples. These results indicate that a more accurate estimation of the platelet counts can be achieved using the PLT-F method than the PLT-I method at the low platelet range. The use of the PLT-F system improves the confidence of results in low platelets samples in a routine hematology laboratory. The results suggest that P-LCR is a new parameter in assessing samples when the specimen is suspected of hemolysis and deterioration. Nevertheless, further studies will be needed to establish the relationship with P-LCR and hemolysis using human blood specimens.

• Journal of Korean Medicine for Obesity Research
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• v.15 no.2
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• pp.153-161
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• 2015

Gamrosu is a modified fasting therapy beverage (431 kcal/d). A retrospective observational study was conducted to investigate the detoxification feasibility of Gamrosu. Three cases were reviewed which participants have finished the fasting with Garmrosu for 10 consecutive days. Detoxification profiles of Gamrosu were reviewed at pre- and post-fasting sessions. Post-Gamrosu session, -6.3% of average weight, -6.5% of average body fat mass and -6.6% of average muscle mass were reduced with the nutrition indices being improved. The inflammation indices showed the significant diminished profiles. Liver/kidney functions and the standard of electrolytes were maintained within normal range in stable manners, however, marginal elevation of total bilirubin and mild ketoacidosis were observed. The indices of oxidative stress decreased and those of antioxidative activity increased. The fatigue scale scores indicated lower scores except insomnia symptom. Taken together, detoxification profiles of Gamrosu were sufficiently feasible and the observed findings should be considered for further clinical studies.

• Journal of agricultural medicine and community health
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• v.37 no.3
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• pp.167-180
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• 2012

Objective: This study was conducted to evaluate an education program for cardiocerebrovascular high-risk patients. Methods: This program was developed according to Tyler's model for curriculum development. To evaluate the effects of this program, we measured clinical outcome change (weight, waist circumference, systolic blood pressure, diastolic blood pressure) and behavior change stages (checking blood pressure, blood sugar levels, doing physical activity, consistent maintenance of food intake, eating low amounts of salt, abstention from tobacco and alcohol) before and 4 weeks after participation in the education program. The group of subjects consisted of High-risk group patients who attended basic program(32 patients), and staged program(37 patients) during KHyDDI meetings from Oct. 2009 to May 2010. Results: The staged educational program was developed three aspects(disease, nutrition and exercise)and three stages(basic, in-depth and individual education). In the staged education program, the evaluations were made by measuring clinical outcome and stage of behavior before and after education. Significant differences were found in waist circumference, systolic blood pressure, diastolic blood pressure, consistent maintenance of food intake(p<0.05), and eating low salt(p<0.001)and their self efficacy. Conclusion: In the practice-oriented staged education program, significant differences were found in the clinical outcomes and stage of behavior before and after education. Possible limitations of the study include the small number of participating subjects and the short follow-up management period, but the results indicate that continued application of this program could contribute to the prevention of cardiocerebrovascular diseases for the elderly patients with long periods of chronic diseases.

• Journal of Digital Convergence
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• v.21 no.1
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• pp.19-27
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• 2023

This is an implementation study towards the development of a strategy to improve the pneumonia adequacy evaluation index of regional public hospital and to confirm its effectiveness. One physician, eight nurses, one computer room staff, and one nursing professor working at a regional base public hospital located in N city participated in this study from March to October 2021. An implementation study was conducted based on the conceptual model of Zuber-Skerritt & Fletcher. The stages of planning, implementation, evaluation, and reflection were operated in two cycles, and the effectiveness was evaluated in the second and third quarters. Compared to the pneumonia adequacy evaluation index in 2019, all indicators reached 100% of the standard target in 2021. The results of this study therefore infer that to provide higher quality medical services in the future, it is necessary to apply medical quality improvement activities through practical research under multidisciplinary participation and cooperation and to review the applicability of clinical sites.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.2
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• pp.137-143
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• 2016

This study was conducted to investigate the electrolyte metabolic responses to a 100 km ultra-marathon in 22 male amateur runners. Their average age was $50.91{\pm}4.77$ years old and their $VO_2max$ value was $48.19{\pm}6.4 mL/kg/min$. The participants completed the race with a mean finishing time of $205.55{\pm}19.61$ minute. Electrolyte parameters based on blood tests including calcium, inorganic phosphorus, magnesium, sodium, potassium, chloride, total carbon dioxide, anion gap, plasma volume change and osmolality were measured pre-race, at 50 km, and at 100 km (post-race). Only slight changes in sodium level with no cases of hypernatremia or hyponatremia were observed. Additionally, all the electrolyte parameters changes were within the normal range and plasma volumes were unchanged. Overall, amateur marathon runners are not at risk to develop clinically significant electrolyte or osmolality changes during a 100 km ultra-marathon.

• Journal of Dental Rehabilitation and Applied Science
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• v.34 no.1
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• pp.39-45
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• 2018

Purpose: The purpose of this study was to evaluate the clinical effects of erythritol powder air polishing device (EPAP) in addition to scaling and root planing (SRP) in non-surgical periodontal treatment in moderate chronic periodontitis patients. Materials and Methods: Clinical evaluation was performed at 21 sites treated with SRP (control) and 21 sites treated with the addition of SRP+EPAP (test). All examinations were performed before treatment, 1 month after treatment, and 3 months after treatment. Depth of the periodontal pocket, gingival recession, clinical attachment level, plaque index, and bleeding of probing were measured as clinical parameters. Results: In both test and control groups, there was a significant decrease in the depth of the periodontal pocket, plaque index, bleeding of probing, increased gingival recession, and gain of clinical attachment level at 1 month and 3 months after treatment. However, there was no significant clinical difference between the test group and the control group. Clinical result was improved after 1 month compared to the baseline; in contrast, results at 3 months after treatment were worse than at 1 month after treatment. Conclusion: In this study, we cannot suggest that SRP + EPAP is clinically more effective than SRP alone as non-surgical periodontal treatments. Periodic periodontal therapy, at intervals of at least every three months, is important for sustaining effects of this treatment.

• Journal of Korean Medical classics
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• v.22 no.3
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• pp.299-320
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• 2009

한중 맥진기 관련 학술 교류와 맥진기 수출을 위한 전략으로 중국의 광주중의약대학 중의사를 대상으로 맥진과 맥진기에 대한 인식을 조사하여 보고하는 바이다. 임상에서 가장 중요하게 생각하고 활용도가 높은 전통적인 병증으로 장부병증과 팔강병증으로 나타났으며, 한방 진단방법 중 가장 중요하게 생각하고 활용하는 방법으로 문진과 맥진으로서, 그 이유는 진단 효율성과 환자와의 상담으로 나타났다. 또한 임상에서 한방 진단기기의 중요한 이유로는 측정기술과 데이터의 신뢰를 들었으며, 중요하지 않다고 생각하는 이유로는 측정기술과 데이터의 신뢰성 부족과 전통적인 진단법을 보조하기엔 적합하지 못함을 들었다. 진단방법 중에서 맥진의 중요도와 활용도는 75%가 가장 높게 나타났고, 맥진법 중에서 가장 잘 활용하는 부위는 촌구맥진법으로 나타났다. 촌구 맥진시 가장 중요하게 생각하는 요소는 환자의 자세와 손목 높이와 촌관척 부위였으며, 단안(單按)과 총안(總按)의 순서는 총안(總按)후 단안(單按)이 단연 우수하였다. 임상의 중요 맥상으로는 부침(浮沈)을 들었으며, 맥상 형성 기전과 표준화 연구에 가장 적합한 연구 방법론은 위수형세론에 입각한 문헌 연구와 병증별 맥상에 대한 임상 데이터 구축으로 나타났다. 그리고 대표적인 노인 특유의 맥상은 미세약맥이었으며, 그 이유는 노화로 인한 체력저하와 기혈부족을 들었다. 그리고 맥진기와 연계하는 만성 생활습관병 병증지표 연구개발에 가장 적합하다고 판단되는 병증 체계는 장부병증이었으며, 질병은 고혈압과 동맥경화증으로 나타났다. 또한 임상에서의 활용도와 유의성이 높은 맥진기로써의 주된 기능으로는 오장육부 상태 진단을 들었으며, 맥진기의 임상적인 활용도를 높일 수 있는 현대적인 임상 분야는 심혈관 질환이 가장 높게 나타났다. 맥진기 개발에 선행되어야 할 기반연구로는 촌관척 부위 찾기의 기준 확립과 임상 변증과의 관계 확립으로 나타났으며, 제공 받고자 하는 맥상 정보구성은 환자의 맥상명과 맥상 정도와 환자의 맥상에 따른 병증명 제시로 나타났으며, 제공되는 병증 서비스로는 장부병증이 가장 높게 나타났다.

• Clinical and Experimental Pediatrics
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• v.51 no.7
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• pp.736-741
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• 2008

Purpose : The incidence of thromboembolic episodes in children with nephrotic syndrome (NS) is low; however, these episodes are often severe. Moreover, both pulmonary thromboembolism (PTE) and renal vein thrombosis (RVT) rarely show clinical symptoms. This study was performed to determine the benefits of routine screening in the detection of thrombosis in childhood NS. Methods : Among 62 children with nephrotic syndrome, a total of 54 children (43 males, 11 females) were included in this study. When the patients experienced their first NS episode, we performed renal Doppler ultrasonography in order to detect RVT. To rule out the possibility of PTE, a lung perfusion scan was performed. Computed tomographic (CT) pulmonary angiography was recommended to patients who showed possible signs of PTE. All patients were evaluated for clinical signs of thrombosis, biochemical indicators of renal disease, as well as clotting and thrombotic parameters. Results : RVT or related clinical symptoms were not observed in any children. Based on the findings of the lung perfusion scans, 15 patients (27.8%) were observed with as a high probability of PTE. We were able to perform a CT pulmonary angiography only on 12 patients, and 5 patients were diagnosed with PTE (prevalence 8.1%). The serum fibrinogen level in the group with PTE was significantly higher ($776.7{\pm}382.4mg/dL$, P<0.05) than that in the group without PTE, and other parameters were not significantly different between each group. Conclusion : Further studies are required for clarifying the role of renal Doppler ultrasonography for the detection of RVT in NS. Children with NS who developed non-specific respiratory symptoms should be evaluated for the diagnosis of PTE. In the management of NS, a lung perfusion scan should be performed at the time of the initial episode of NS regardless of the pulmonary symptoms, since patients having PTE are either often asymptomatic, or present with nonspecific symptoms.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.1
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• pp.44-53
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• 2018

The WHtR (waist to height ratio) and ABSI (a body shape index) are indicators that reflect abdominal obesity. This study examined the insulin resistance and metabolic syndrome prediction ability of ABSI and WHtR. In this study, 4,395 people aged 20 years or older, who underwent physical examinations at a General Hospital in Gyeonggi-do from January 2017 to September 2017 were assessed on a cross section survey. Metabolic syndrome was defined according to the criteria of the AHA/NHLBI. Insulin resistance was judged to be insulin resistance when the HOMA-IR value was 3.0 or more. Both men and women showed a stronger correlation between WHtR and the metabolic risk factors than ABSI. The AUC value of WHtR and ABSI was 0.849 and 0.676, respectively (p<0.001). The AUC value of WHtR and ABSI for predicting insulin resistance was 0.818 and 0.641, respectively (p<0.001). In conclusion, the ABSI has low predictive power of insulin resistance and metabolic syndrome whereas the WHtR has good predictive power for metabolic syndrome and insulin resistance.