• Journal of the Korean Orthopaedic Association
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• v.54 no.6
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• pp.509-518
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• 2019

Purpose: Lymph node metastasis is a very important prognostic factor for all skin cancers and some sarcomas. A sentinel lymph node (SLN) biopsy is the most useful technique for identifying SLNs. Recently, a new generation of diagnostic tools, such as single photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) enabled the detection of SLNs. This study compared the efficacy of PET/CT for detecting lymph node metastases with a SLN biopsy in a single medical center. Materials and Methods: From 2008 to 2018, 72 skin cancers of sarcoma patients diagnosed with some lymph node involvement in a whole body PET/CT reading were assessed. Patients suspected of lymph node metastasis were sent to biopsy and those suspected to be reactive lesions were observed. The analysis was performed retrospectively using the medical records, clinical information, PET/CT readings, and pathology results. Results: The age of patients ranged from 14 to 88 years and the mean follow-up period was 2.4 years. Twenty-two patients were suspected of a lymph node metastasis and confirmed. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT images in sarcoma and non-sarcoma tumors were increased significantly when the expert's findings were considered together. Conclusion: PET/CT is effective in detecting lymph node metastases.

• Korean Journal of Clinical Laboratory Science
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• v.56 no.3
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• pp.228-235
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• 2024

Using transcranial doppler ultrasonography (TCD) to measure the presence or absence of abnormalities in patent foramen ovale (PFO) is more effective than transesophageal echocardiography (TEE) because it is simple, inexpensive, and non-invasive. Thus, it can be a good alternative test in cases where it is difficult to perform TEE or in groups at a high risk of complications. Therefore, in this study, we sought to assist in arriving at a diagnosis by suggesting an appropriate method through the comparison of empirical results according to the presence or absence of blood use and varying patient posture. The results were compared depending on the patient's posture and whether blood was used. Patients in whom both middle cerebral arteries were observed were targeted. In cases where the temporal window was defective, it was replaced with basilar artery and compared. There were higher positivity rate and accuracy for sitting position using valsalva maneuver (VM) than for Resting and supine position using VM. Therefore, if it is possible to perform a sitting position using VM with a mixture of blood, it would be a good idea to perform it.

• Radiation Oncology Journal
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• v.26 no.3
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• pp.166-172
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• 2008

Purpose: The measurement of radiosensitivity of individuals is useful in radiation therapy. Unfortunately, the measurement of radiation survival using a clonogenic assay, which is the established standard, can be difficult and time consuming. The aim of this study is to compare radiosensitivity results obtained from the MTT and clonogenic assays, and to evaluate whether the MTT assay can be used on clinical specimens. Materials and Methods: HCT-8, LoVo, CT-26, and WiDr were the colon cancer cell lines used for this study. The clonogenic assay was performed to obtain the cell survival curves and surviving fractions at a dose of 2 Gy ($SF_2$) as the standard technique for radiosensitivity. Also, the MTT assay was performed for each of the cell lines (in vitro). To simulate clinical specimens, the cell lines were inoculated into nude mice, removed when the tumors reached 1 cm in diameter, and chopped. Next, the tumors were subjected to the same process involved with the MTT assay in vitro. The inhibition rates (IR) of 10 Gy or 20 Gy of irradiation for in vitro and ex vivo were calculated based on the optical density of the MTT assay, respectively. Results: According to $SF_2$ and the cell survival curve, the HCT-8 and WiDr cell lines were more resistant to radiation than LoVo and CT-26 (p<0.05). The IR was measured by in vitro. The MTT assay IR was 17.3%, 21%, 30% and 56.5% for the WiDr, HCT-8, LoVo and CT-26 cell lines, respectively. In addition, the IR measured ex vivo by the MTT assay was 23.5%, 26%, 38% and 53% in the HCT-8, WiDr, LoVo and CT-26 tumors, respectively. Conclusion: The radiosensitivity measured by the MTT assay was correlated with the measures obtained from the clonogenic assay. This result highlights the possibility that the MTT assay could be used in clinical specimens for individual radiosensitivity assays.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.3
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• pp.155-162
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• 2006

Purpose: Diabetes mellitus (DM) is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is glowing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. Subjects and Methods: 203 diabetic patients (64 male, mean age $64.1{\pm}9.0$ years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was $36{\pm}18$ months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Results: Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the ocurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. Conclusion: Patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events.

• Clinical and Experimental Pediatrics
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• v.49 no.3
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• pp.298-304
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• 2006

Purpose : We compared the asthma predictive index(API) and the modified asthma predictive index (mAPI) of the Tuscon Children's Respiratory Study Group in Korean children with recurrent wheezing. We investigated the atopic profiles and presence of allergen sensitization of each risk group, and ascertained the significant clinical risk factors. Methods : Two hundred and sixty two children, who visited for recurrent wheezing from 1998 to 2005, were enrolled and divided into groups by API and mAPI. We investigated the history of the patients and their families, atopic profiles, and sensitization to aeroallergen and food allergens. Twenty nine children were followed up to 6 years of age and we evaluated the sensitivity, specificity and positive and negative predictive value of both indices. Results : The high risk group of API were of older age, were more likely to be sensitized to aeroallergen(P=0.001) and food allergen(P=0.034) and had higher levels of total eosinophil count, eosinophil percent, serum ECP, total IgE, and D.p-, D.f-specific IgE. High risk group of mAPI showed higher levels of atopic markers such as egg-, milk-, D.p- and D.f-specific IgE. Even though API did not include allergen sensitization, the high risk group was more significantly sensitized to common allergens than the low risk group. Twenty nine children were followed up until 6 years of age; therefore 15 children were diagnosed as asthma, clinically. The sensitivity, specificity, positive and negative predictive values of mAPI were higher than API. Conclusion : Both high risk groups of API and mAPI had higher levels of atopic markers and were more sensitized to common allergens. These findings suggest that sensitization to aeroallergens and food allergens are more objective markers as asthma predictive indices. In addition, mAPI is a more reliable index in predicting asthma in Korean children with recurrent wheezing than is API. But only 29 patients were followed until the age of 6, so we need to include more children with long term follow up for future study.

• The Journal of the Korea Contents Association
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• v.20 no.7
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• pp.674-682
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• 2020

Recently, the problem of air pollution has become a global concern due to industrialization and overcrowding. Air pollution can cause various adverse effects on human health, among which respiratory diseases such as asthma, which have been of interest in this study, can be directly affected. Previous studies have used clinical data to identify how air pollutant affect diseases such as asthma based on relatively small samples. This is high likely to result in inconsistent results for each collection samples, and has significant limitations in that research is difficult for anyone other than the medical profession. In this study, the main focus was on predicting the actual asthmatic occurrence, based on data on the atmospheric environment data released by the government and the frequency of asthma outbreaks. First of all, this study verified the significant effects of each air pollutant with a time lag on the outbreak of asthma through the time-lag Pearson Correlation Coefficient. Second, train data built on the basis of verification results are utilized in Deep Learning algorithms, and models optimized for predicting the asthmatic occurrence are designed. The average error rate of the model was about 11.86%, indicating superior performance compared to other machine learning-based algorithms. The proposed model can be used for efficiency in the national insurance system and health budget management, and can also provide efficiency in the deployment and supply of medical personnel in hospitals. And it can also contribute to the promotion of national health through early warning of the risk of outbreak by atmospheric environment for chronic asthma patients.

• Therapeutic Science for Rehabilitation
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• v.9 no.2
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• pp.27-38
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• 2020

Introduction : This review aims to introduce an intention-to-treat analysis(ITT) method and demonstrate the importance of rigorous utilization of this method to researchers in Korea. Discussion : ITT analysis includes all data as results in randomized control trials (RCT). Thereby the result of RCT is high validated to adapt in the real-world so that the result should be expected at clinical practice. Therefore, many RCT quality assessment tools include the question of the utilization of ITT analysis in individual trials. However, many researchers omit to report ITT, not utilize ITT or use ITT incorrectly. Conclusion : Through this review, more Korean researchers may understand and utilize ITT which is expected to enhance the quality of RCT papers.

• Journal of Korea Multimedia Society
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• v.6 no.1
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• pp.148-160
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• 2003

TMA(Tissue Mineral Analysis) is very popular method in hair mineral analysis for health care professionals in over 48 countries medical center. Assesment of nutritional minerals and toxic elements in the hair is very important not only for determining adequacy, deficiencies and unbalance, but also for assessing their relative relationships in a body. In Korea, there are some problems in TMA method. Because of not haying a medical information database which is suitable for korean to do analyze, the requested TMA has to send to TEI-USA. However, as the TMA results from TEI-USA is composed of English documents and graphic files prohibited to open, its usability is very low and a lot of dollars has to be payed. Also, it can make some problems in the reliability of the TMA results, since the TMA results are based on the database of western health and mineral standards, To solve these problems, I developed the first Medical Information System of TMA in Korea here. The system can analyze the complex tissue mineral data with multiple stage decision tree classifier. It is also constructed with multiple fuzzy database and hence analyze the TMA data by fuzzy inference methods. The effectiveness test of this systems can be shown the increased business efficiency and satisfaction rate 86% and 92% respectively.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1817-1821
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• 2010

본 연구에서의 지리정보시스템(GIS)을 이용한 사방댐 입지선정모델 개발은 산사태 발생 예측을 위한 사면안정성 평가 기준을 개발하여 사방댐 지점을 선정하기 위하여 체계적으로 표준화된 시스템을 구축하는 것이 목표이며, 2002년 태풍 '루사'와 2003년 태풍 '매미'에 의하여 토석류와 산사태가 발생한 서부경남 지역의 38개 지점에 대하여 항공사진 수집 및 현장조사를 수행하고, 산사태 발생에 관계되는 강우, 지형, 지질 및 토양, 임상 등을 인자로서 규정하였다. 연구결과 서부경남지역에서 발생한 산사태는 지리산, 가야산, 좌굴산 등 EL. 500m 이상의 비교적 고도가 높은 산악지역에서 지형성 집중호우에 의하여 발생하는 것으로 분석되었으며, 강우량과 산사태의 상관분석결과 시강우량 70mm 이상 및 누가강우량 230mm 이상에서 산사태의 발생빈도가 높은 것으로 나타났다. 또한 산사태 발생지점에서의 고도(평균해수면 기준)와 능선의 고도와의 비를 백분율로 계산하여 빈도를 살펴보면 산사태 발생지점이 능선의 90% 이상의 고도에서 산사태의 발생빈도가 53%로 가장 높고, 80-90%는 21%, 70-80% 16%의 순으로 산사태 발생빈도가 감소하고 있으며, 고도가 더욱 낮아져 산사태 발생지점이 60% 이하로 내려가면 산사태 발생빈도는 급격히 감소한다. 예를 들어 능선의 고도가 1000m일 경우 900m 이상의 고도(90% 이상)에서 산사태 발생빈도가 가장 높고 600m 이하의 고도(70% 이하)에서는 발생빈도가 급격히 저하하는 것으로 나타났다. 산사태 발생지점의 표면 굴곡도에 따른 산사태의 발생빈도는 대부분의 평행사면에서 74%, 약간 오목사면에서 26%가 발생하는 것으로 나타났다. 각 지구의 지질 및 토양별 산사태 발생빈도는 화성암계열의 지질 및 자갈/암괴 섞인 토사의 토양에서 발생하는 것으로 분석되었고, $34-40^{\circ}$ 사면경사에서 40%, $26-34^{\circ}$ 사면경사에서 26%, $26^{\circ}$ 이하의 사면경사에서 22%가 주로 발생하였으며, $40^{\circ}$ 이상의 높은 사면경사에서는 극히 미미하였다. 또한 임상 기준으로는 침엽수림에서 주로 발생하는 것으로 나타났다. 본 연구에서는 이상의 결과를 기초로 매우 안정, 안정, 부분적 안정, 불안정, 매우 불안정, 위험 지역으로 구분하고, 평가한 결과는 불안정 33개소, 매우 불안정 5개소 등 38개소 지점 모두에 사방댐 설치가 필요한 것으로 분석되었다.

• Journal of Veterinary Clinics
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• v.31 no.6
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• pp.502-506
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• 2014

Recently nano particles have proven for wide array of bioactive properties. In the present study, antibacterial properties of chitosan silver nano composites (CAgNCs) were investigated against fish pathogenic Edwardsiella tarda. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of CAgNCs against E. tarda were $25{\mu}g/mL$ and $125{\mu}g/mL$, respectively. The field emission scanning electron microscope (FE-SEM) image of CAgNCs treated E. tarda showed the strongly damaged bacteria cells than non-treated bacteria. Furthermore, treatment of CAgNCs induced the level of intracellular reactive oxygen species (ROS) in E. tarda cells in concentration and time dependent manner suggesting that it may generate oxidative stress leading to bacterial cell death. In addition, MTT assay results showed that the lowest cell viability at $100{\mu}g/mL$ of CAgNCs treated E. tarda. Overall results of this study suggest that CAgNCs is a potential antibacterial agent to control pathogenic bacteria.