• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.191-198
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• 2018

This study was conducted to evaluate the clinical effectiveness of proton therapy as an advanced convergent cancer therapy. Clinical data of proton therapy were analyzed. As proton enters patient's body, it releases low dose of energy and shows an increasing energy deposition as it reaches certain point unlike x-ray. It may therefore reduce the radiation dose to the normal tissues in front and beyond the lesion and minimize the radiation damage. Proton therapy is expected to improve clinical outcomes and reduce treatment related toxicities. It is used in various cancers. Further studies are necessary.

• Journal of Korean Orthopaedic Sports Medicine
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• v.9 no.2
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• pp.91-97
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• 2010

Purpose: The purpose of this study was to evaluate the results of treatment for longitudinal meniscal tear in ACL rupture patients by clinical evaluation and $2^{nd}$ look arthroscopy. Materials and Methods: Among the patients who underwent surgery due to ACL rupture and longitudinal meniscal tear between 2002~2009, 32 patients were selected for the study. The patients were devided into three groups; group 1 had repair, group 2 had partial menisectomy due to impossible to repair, group 3 had conservative treatment due to stable meniscus. Comparative retrospective analysis was applied with KT 1000 arthrometer, Lysolm' score, Tegner activity score, IKDC subjective score, and $2^{nd}$ look arthroscopy. Results: Lysolm' score, Tegner activity score, IKDC subjective score showed no statistical difference in all three groups. KT-1000 side to side difference improved from 6.2, 6.15, 6.38 before surgery to 2.56, 2.49, 2.58 after surgery in group 1, 2, and 3, respectively. In group 1, second-look arthroscopy revealed complete healing in 12 patients, incomplete healing without any clinical symptoms in 2, and healing failure in 1. In group 2, second-look arthroscopy showed partial regeneration on margin of meniscectomy. In group 3, second-look arthroscopy revealed complete healing in 2 patients, while 4 showed incomplete healing so that have repaired. Conclusion: In the study, the outcome was better when the stable longitudinal meniscal tear on posterior horn with ACL rupture had active treatment.

• 대한핵의학회:학술대회논문집
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• 1998.11a
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• pp.48.1-48.1
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• 1998

• Tuberculosis and Respiratory Diseases
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• v.46 no.5
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• pp.709-717
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• 1999

Background & Method : Bronchiolitis obliterans organizing pneumonia(BOOP) is a specific clinicopathologic condition characterized by chronic inflammatory interstitial infiltrates. Cryptogenic form of BOOP presents subacute clinical course of flu-like illness, such as cough, fever, dyspnea with exertion and other constitutional symptoms. Pathologically it shows the presence of granulation tissue filling the lumen of terminal and respiratory bronchioles, extending into distal airspaces. Recently, we reviewed 24 cases of idiopathic type of BOOP, 5 cases of our hospital and another 19 cases on Korean literatures, and compared with reviewed data from foreign literatures. Results : Mean age was 54 years old and there was female preponderance in domestic reports. Their common presenting symptoms were dyspnea and cough, and mean duration of illness was 41 days. On chest examination, inspiratory crackle was a common finding. The laboratory findings were nonspecific except hypoxemia. Lung function studies revealed restrictive defect or combined obstructive and restrictive pattern in most patients. Bilateral patchy and nonsegmental alveolar opacities constituted characterized radiographic finding, highlighted on high resolution computed tomogram. It showed a favorable prognosis with an excellent responsiveness to corticosteroid therapy. The clinical features and laboratory findings were similar between domestic and foreign cases except female preponderance in Korean cases. Conclusion : If the clinical course is atypical or pregressive under proper treatment, clinicians should reevaluate clinical features and radiographic findings under the consideration of BOOP. Tissue confirmation would be recommended for the definitive diagnosis of BOOP.

• Tuberculosis and Respiratory Diseases
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• v.50 no.3
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• pp.300-309
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• 2001

Background : Sepsis is a clinical syndrome characterized by a systemic inflammatory and hemodynamic response to severe bacterial infections that involve various mediators. Endothelin (ET)-1, a potent vasoconstrictor is associated with mu1tiple organ failure, and interleukin (IL)-8, a proinflammtory cytokine, plays a major role in neurophil activation. Both have been reported to be useful parameters in the clinical assessment of sepsis. The levels of ET-1 and IL-8 in the blood were measured in patients with sepsis, and the correlation of both parameters and their relationship with the clinical data was assessed. Methods : 19 sepsis patients and 17 controls were studied. Blood samples of the sepsis patients were drawn in day 1, 3, 7, and 14. The APACHE III scores were calculated in concurrent days. The ET-1 and IL-8 levels were measured using immunoassay methods. Results : The ET-1 levels of patients with sepsis were significantly higher than in the controls. In patients with sepsis, non-survivors had higher ET-1 levels than survivors on day 1 and 7, and patients with shock also had higher ET-1 levels than normotensive patients on admission. The ET-1 levels were significantly correlated with the creatinine levels on day 1, 7, and 14. The IL-8 levels showed a significant correlation with the ET-1 levels on day 14. Conclusion : ET-1 was found to be closely related with the clinical outcome, shock, and renal failure, and showed a correlation with IL-8. These mediators can be considered not only to play pathophysiologic roles but also as useful parameters in the clinical assessment of sepsis.

• Journal of Veterinary Clinics
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• v.13 no.1
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• pp.96-101
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• 1996

면역성 용혈성 빈혈증 병견은 임상적으로 허약, 황달, 발열, 침울 및 점막창백을 나타낸다. 본 병의 진단은 구상적혈구증가증, 혈구응집반응 또는 직접적 Coomb시험 양성반응을 확인함과 동시에 용혈성 빈혈의 다른 원인을 배제함으로서 확정하여야 한다. 치료방법에는 적절한 보조적 요법과 함께 면역억압제가 포함된다. 일반적으로 치료에 있어서는 일차적으로 glucocorticoids가 선택되는데 흔히 cytoxan, aziothioprin, vincristine 또는 danazole과 같은 다른 약제와 병용된다. 치료는 그 반응에 근거하여 면역억압제의 용량을 2-4주 간격으로 점차 감량하면서 6개월 또는 그 이상까지 계속한다. 면역억압제에 대한 치료반응은 지연될 수 있고 또 적혈구 보유가 골수로부터 새로운 적혈구를 유리하게될 때까지 병축을 유지시키기에 부적당할 수 있기 때문에 병축의 예후판정은 경계하여야 한다. 심급성 내지 급성 예는 일반적으로 예후가 보다더 좋지 않다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.416-417
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• 2014

SNOMED CT is a standard clinical terminology to provide a standardized way for recording and managing of clinical records in EMR systems. However, because of its huge expressive power, it is very difficult to consistently record patients' status such as diagnosis and procedure. The reason is that one clinical meaning can be expressed in variety of ways using multiple terminologies and vice versa. This paper proposes a novel requirement of effective search browser for SNOMED CT terminologies by analyzing duplicated or similar terminologies.

• Proceedings of the Korean Information Science Society Conference
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• 2001.10b
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• pp.337-339
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• 2001

본 연구에서는 임상적으로 얻어진 95개의 영상 자료를 전산화하여 특정 간 영역의 명도분포를 분석하여 이와 간의 지방화 정도와의 상관성을 연구하였다. 지방화 정도를 판단하는 임상적 기준으로 보편적으로 인정되는 지방간지수와 계산된 평균 명도 수치와의 선형 상관 계수를 구하였다. 각각의 영상의 밝기 및 에코정도가 일반적으로 불균일하기 때문에 이를 보정하기 위해 밝은 명도와 어두운 명도의 기준영역을 선정하여 상대명도를 추출하였다. 두 가지 독립적인 방법으로 기준 영역을 선택하여 비교한 결과, 임상 지방간지수와 높은 상관성을 보임을 알 수 있었고, 지방간 진단의 보조자료로 유용함을 확인하였다. 계산된 지방간지수와 상대명도의 상관계수는 0.69 에서 0.79로 나타났다.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.23-30
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• 2023

This study was attempted to be used as basic data for efficient clinical practice education operation by identifying differences in program outcomes before and after integrated clinical practice of nursing students. Data collection was conducted before and after 6 weeks of integrated clinical practice for 38 nursing college students from July 19 to September 10, 2021 with a single group pre- and post-design. The collected data were analyzed by frequency, Wilcoxon sign rank, and Pearson correlation using SPSS/Win 23.0. After the integrated clinical practice, 1st program outcomes(Care integration)(Z=-4.63, p<.001), 2nd(Core practice)(Z=-3.99, p<.001), 6th(Critical thinking)(Z=-3.60, p<.001) and 11th(Research practice)(Z=-2.76, p=.005) increased significantly compared to before practice. Since integrated clinical practice was found to be an effective practice to improve program outcomes, it is suggested to actively utilize it as a strategy for improving program outcomes.

• Korean Journal of Psychosomatic Medicine
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• v.7 no.1
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• pp.134-141
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• 1999

Objects : Cancer patients receiving radiotherapy have many psychological problems. Those problems depend on clinical factors of cancer and the characteristics of patients. This study was designed to estimate the morbidity of psychiatric disorder and to investigate the relationship between psychiatric disorders and clinical variables. Methods : The subjects were 47 patients who had been treated by radiotherapy. Psychiatric disorder was diagnosed according to DSM-IV. The authors assessed the relation between psychiatric disorder and demographic features, clinical features of cancer such as site, duration, frequency of recurrence of cancer, and patients' awareness of disease and expectation of outcome of radiotherapy. Results : 21 patients(44.7%) had a psychiatric disorder. The most common psychiatric disorder were adjustment disorder(66.7%), and the next major depressive disorder(23.8%). There was a significant positive relationship between psychiatric disorder and recurrence of cancer, patients' expectation of poor outcome after radiotherapy. Psychiatric morbidity was significantly low in those who had no evidence of recurrence and who considered radiation treatment as curative. However, site and duration of cancer, patients' awareness about serious illness were not related with psychiatric disorder. Conclusion : Psychiatric disorders are common among cancer patients on radiotherapy. Further clinical attention and effective treatment of psychiatric complication in cancer patients are needed not only for reducing symptoms but for better adjustment.