• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.253-260
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• 2020

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease that can be described by the occurrence of dementia due to a decline in cognitive function. The disease is characterized by the formation of extracellular and intracellular amyloid plaques. Amyloid beta (Aβ) is a hallmark of AD, and microglia can be activated in the presence of Aβ. Activated microglia secrete pro-inflammatory cytokines. Furthermore, S100A9 is an important innate immunity pro-inflammatory contributor in inflammation and a potential contributor to AD. This study examined the effects of metformin and α-LA on the inflammatory response and NLRP3 inflammasome activation in Aβ- and S100A9-induced BV-2 microglial cells. Metformin and α-LA attenuated inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). In addition, metformin and α-LA inhibited the phosphorylation of JNK, ERK, and p38. They activated the nuclear factor kappa B (NF-κB) pathway and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Moreover, metformin and α-LA reduced the marker levels of the M1 phenotype, ICAM1, whereas the M2 phenotype, ARG1, was increased. These findings suggest that metformin and α-LA are therapeutic agents against the Aβ- and S100A9-induced neuroinflammatory responses.

• 대한공업교육학회지
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• v.34 no.1
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• pp.19-43
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• 2009

An ideology what a modern society seeks is lifelong employment through lifelong learning. The single word which draws the attainment is lifelong vocational competency development. This study is designed for exploring its possibility and limit of a redesign of it, and tries to propose efficiently a redesign idea of a vocational educational path. To this end, it was analyzed by a subject for a national human resource foundation plan and a lifelong bocational competency development foundation plan. In addition to that, it was covered a structure and content analysis of main laws and regulations which are a base of policy making. An educational path could be divided into an area of formal education system, an area of workplace for labors, and an area of lifelong vocational competency development. And the insights were drawn by pulling apart an operational situation of main organizations and a recurrent process of the educational path. The redesign plan of a vocational education path we did analyze to activate lifelong vocational competency development system is deduced as following. Firstly, it should be re-organized with a direction towards an effective manpower training to be linked with skills and demands required by an industry. Secondly, it should be generalized for a model of recurrence between work and learning and its alternation for lifelong vocational competency development. Thirdly, it should create a cluster in the region for lifelong vocational competency development so that it is to form an efficient network to have a division of labor and its liaison with cooperative relationship.

• 대한공업교육학회지
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• v.38 no.2
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• pp.1-26
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• 2013

This study inquired following research questions by a narrative research method : What was the job of an engineer in mechanical design field? How did he fulfill his job-related learning in his workplace? What were the context and the characteristic of the job-related learning in the workplace? And some implications of the job-related learning on engineering education were discussed. We identified that the research participant's career as a mechanical engineer has developed through three stages. At first, he engaged on conceptual design of a semi-conductor test machine through self-initiated learning from basic to whole system of the machine. At second stage, he leaded a design group for the concrete design of a ball type semi-conductor test machine. In this stage he learned the meaning of cooperation and cooperative learning. At third stage, he initiated to found an entrepreneur company that was specified to design a semi-conductor test machine. He became CEO of the company. He learned the R & D policy making through contacts with global company, visiting exhibition in abroad. Eventually his main task as a mechanical engineer was the problem solving in the process of machine design. He had experienced and learned through his works : project management, independent fulfilling of tasks, functional analysis and reverse engineering, conceptualizing and test, cohesive cooperation, dialogue and discussion, mediation of conflict, human relationship, leadership. The implication of the narrative analysis on engineering education is, proposed, to give the students more chances to experience and to learn such activities.

• Journal of Korean Home Economics Education Association
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• v.15 no.2
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• pp.79-99
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• 2003

This study is designed to identify the goals of home economics education. starting from the needs for basic research to establish a theoretical framework in home economics and for the development of basic logics to strengthen the position of home economics education as a prerequisite course in a national curriculum. To this end. this article thoroughly studied curriculum documents prepared at the national level and curriculum papers reflecting research trends of home economics education. using the results as data to identify the theoretical goals of home economics education. The research results are as follows : First, home economics education should help students become independent members of society. on the basis of daily lives. Second, with respect to personal capability development. home economics education should help to identify and solve various life-related problems in a practical problem solving. Practical members of society should be able to maintain balance in family, job, and personal career, solving the aforementioned problems in a practical way. Third, home economics education should make contributions to promoting a creative family culture in which life styles tailored for personal needs are created (education for creative members of society). The theoretical results of the study should be verified in a critical manner, followed by quantitative research that will lead to agreement among experts as to the theoretical goals.

• Korea journal of population studies
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• v.33 no.2
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• pp.1-31
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• 2010

As increasing numbers of married women enter the labor force, scholars pay attentions to work-to-family and family-to-work spillover. So accumulating empirical research has been done to examine negative and positive spillover between two life areas. But existing research focuses only on this negative or positive spillover and do not combine these two interdependent aspects of spillover. But individuals experience the negative and positive spillover everyday. Therefore scholars point out the need of research to represent this reality of married men and women. Using data from a sample of 721 male and 359 female married workers, this study try to examine the 'global' measures of spillover between work and family. In particular, this study focuses on gender differences in this global measures and some potential factors influencing levels of global spillover. I find that while women and men do not differ in global work-to-family spillover, they do differ in global family-to-work spillover. It is found that four out of ten wives belong to 'high' in negative family-to-work spillover and 'low' in positive family-to-work spillover and only one out of ten wives belong to 'low' in negative family-to-work spillover and 'high' in positive family-to-work spillover. It is well documented that women do the bulk of family responsibilities such as housework and childrearing and consider home as their second workplace. The findings in this paper may represent unequal gender realities.

• Korean Journal of Social Welfare Studies
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• v.47 no.4
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• pp.5-42
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• 2016

This study investigates why some female workers come to decide to leave work after their taking parental leave and subsequently classifies their resignation backgrounds into four ideal types. The current debates on parental leave have mostly focused on clarifying the factors that influence on workers' usage of parental leave. But given that the final goal of parental leave is to help workers return to work after temporary rest for parenting, it is very important to inquire why some workers fail in reverting to their companies after parental leave. Based on in-depth interviews with 8 female workers who leave work after parental leave, this study analyses and compares their previous work-family conditions, reasons for taking parental leave and withdrawing from work, and behavioral patterns after resignation. This article then typifies four ideal types of resignation backgrounds (i.e. penalty by company, evasion from work, decision by family, choice for family). At the conclusion, this paper suggests policy alternatives to diminish female workers' resignation after parental leave and to heighten their work-family balance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.565-572
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• 2019

As a public research institute, government-supported institutes have led the industrial development and the advancement of science and technology in Korea. Robert Levering has annually selected 'Fortune 100 GPTW(Great Place to Work)' by measuring the Trust Index which was originated by himself. The objectives of this study are to attempt newly to analyze the inter-relations among 5 elements of GPTW trust index such as credibility, respect, fairness, camaraderie, and pride perceived by the K institute's 262 employees; to verify that GPTW trust index is valid for the selection of the fortune 100 GPTW. Amart PLS 2.0 and SPSS 18 were utilized for the statistical analysis. The results of this study are as follows. Credibility has positive effect to pride; respect has positive effect to pride and camaraderie; fairness has positive effect to camaraderie; and camaraderie has positive to pride. Pride and camaraderie have positive effect to the perceived GPTW. Recent studies mainly focused on the relations between GPTW trust index as independent, mediating variables or parameters and organizational performances. It is meaningful that this study has firstly tried to analyze the inter-relations among 5 elements of the trust index for the employees of research institute. This study has implication that the in order to enhance the performance the institute has to manage GPTW trust index perceived by the employees.

• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.31-47
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• 2019

This study analyzes the emotional labor experiences of 8 social workers in social welfare facilities and public institutions by thematic analysis method with interveiws with them. Six categories and Twenty two themes concerning the emotional labor experience were derived from the analysis. Six categories are as follows: 'work life as a target for anger', 'unsafe workplace', 'emotional labor that ruins life', 'overcoming hurt emotion', and 'living with emotional labor'. Social workers are constantly required to perform emotional labor providing services to clients in the field of practice, and they also suffer verbal abuse from clients. Social workers feel the pressure of work in the environment that does not tolerate mistakes and they must keep their safety on their own. In these cases, emotional labor has effects on the physical and mental health of workers. The problem of emotional labor is difficult to solve and there might not be no choice but to endure. This study suggests practical and policy measures for social workers based on the results of the analysis. Policy suggestions are as follows: safety assurance for social workers, establishment of base facilities for employee support, human rights education for employees, preparation of super vision system, and the provision of a mental health care system.

• Management & Information Systems Review
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• v.38 no.2
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• pp.47-66
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• 2019

The purpose of this study is to investigate the mediating role of proactive behaviors in the mechanism which job crafting affects organizational effectiveness. Through this study, we tried to contribute to the following theoretical and practical aspects. First, we tried to extend the theoretical discussion by identifying the relationship between job crafting, proactive behavior, and organizational effectiveness. Second, we provide practical implications for Korean organizational members based on proven job crafting, proactive behavior, and organizational effectiveness, and contribute to creating a work environment that enhances job satisfaction and reduces turnover intention. The results of this study are as follows. First, increasing structural job resource, increasing social job resource and increasing challenging job demand, which are sub-factors of job crafting, had a positive effect on job satisfaction. Second, increasing structural job resource, increasing social job resource and increasing challenging job demand, which are sub-factors of job crafting, had a negative effect on turnover intention. Third, job crafting had a positive effect on proactive behavior. Fourth, proactive behavior mediated the relationship of increasing structural job resource, increasing social job resource, increasing challenging job demand, and job satisfaction. Fifth, proactive behavior mediated the relationship of increasing structural job resource, increasing social job resource and turnover intention. This study provides an understanding of the impact of job crafting on organizational effectiveness and is expected to contribute to future research on job crafting.

• The Journal of Korean Society for School & Community Health Education
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• v.22 no.4
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• pp.49-60
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• 2021

Objectives: Laboratories have various latent physical, chemical, biological, and ergonomical factors according to the diversification and fusion of research and development activities. This study aims to investigate the chemical exposure concentrations of college laboratories and evaluate their health risks, and use them as basic data to promote the health of college students. Methods: The sampling and analysis of harmful chemicals in the air in laboratories were performed using Method 1500 of the U.S. National Institute for Occupational Safety and Health (NIOSH)의 Method 1500. The harmful chemicals in the laboratories were divided into carcinogenic and non-carcinogenic chemicals. Risk assessment was performed using the cancer risk (CR) for carcinogenic chemicals and using the hazard index (HI) for non-carcinogenic chemicals. Results: The harmful chemicals in college laboratories consisted of acetone, diethyl ether, methylene chloride, n-hexane, ethyl acetate, chloroform, tetrahydrofuran, toluene, and xylenes. They showed the highest concentrations in laboratories A (acetone 0.001~2.34ppm), B (chloroform 0.95~6.35ppm), C (diethyl ether 0.08~8.68ppm), and D (acetone 0.07~14.96ppm). The risk assessment result for non-carcinogenic chemicals showed that the HI of methylene chloride was 2.052 for men and 2.333 for women, the HI of N-hexane was 4.442 for men and 5.05 for women. Thus, the HI values were higher than 1. The risk of carcinogenic chemicals is determined by an excess cancer risk (ECR) value of 1.0×10^-5, which means that one in 100,000 people has a cancer risk. The ECRs of chloroform exceeded 1.0×10^-5 for both men and women, indicating the possibility of cancer risk. Conclusion: College laboratories showed the possibility of non-carcinogenic health risks for methylene chloride, n-hexane, tetrahydrofuran (THF), toluene, and xylenes, and carcinogenic health risks for chloroform, methylene chloride. However, this study used the maximum values of measurements to determine the worst case, and assumed that the subjects were exposed to the corresponding concentrations continuously for 8 hours per day for 300 days per year. In consideration of the nature of laboratory environment in which people are intermittently exposed, rather than continuously, to the chemicals, the results of this study has an element of overestimation.