• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.848-859
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• 2005

The following conclusions are drawn, through studying of referring literature, of contents of the prescription and of clinical applications in Hyungsang Medicine. Insamyangyung-tang(인삼양영탕) was appeared first in Taepunghyemin-whajegugbang(태평혜민화제국방) which was written by Jin and others at Song Dynasty. This prescription is applied to senility and long lasting weakness, little strength of spleen and lung(비폐기허), and insufficiency of blood. The Insamyangyung-tang is composed of medical stuffs which Rhizoma Cnidii is taken out from Sipjiendaebotang and Pericarpium Citri Nobilis, Fructus Schizandrae, Radix Polygalae are added to it. This prescription is used in China up to the present. In korea, according to Donguibogam, Rhizoma Cnidii and Poria are taken out from Sipjiendaebotang and Pericarpium Citri Nobilis, Fructus Schizandrae, Radix Polygalae are added to it, and Ramulus Cinnamomi is changed to Cortex Cinnamomi, and also Radix Ledebouriellae is newly added to it. This is reorganized to fit for Korean physical conditions and to be useful for deficiency of blood, and also to be efficacious for coming and going of chillness and fever and running with sweat due to weakness of Liver. In the point of view of Hyunsang medicine, Insamyangyung-tang is applied to shapes and symptoms as follows : This prescription becomes more efficacious to women than to men. At the age of fifties when liver grows weak it effects a cure. It takes effect to the shape of going easily into the deficiency of blood, that is, to the Hyul Kwa with an oval face. It effects a cure on the man who has wrinkles on the bridge of the nose, who has marks of being choked up on the central area between two brows, or who has distinctive size of eyes and nose. It is efficacious against symptoms which are to be exhausted, to be weak, to lose flesh, to be coming and going of chillness and fever and running with sweat.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.729-733
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• 2002

The purpose of this research was to investigate the effects of Insamyangyoung-tang water extract (IYT) on the specific immune response in BALB/c mice. When IYT (500mg/kg) was administerd p.o. once a day for 7 days to BALB/c mice, the cell viability of thymocytes and splenocytes was increased. Also, IYT increased the population of CD4/sup +/ cells in thymocytes and the population of Thy1/sup +/ cells and CD4/sup +/ cells in splenocytes. In addition, IYT increased the production of γ -interferon and interleukin-2 from thymocytes and the production of γ -interferon from splenocytes. These results suggest that IYT enhances the specific immune response via activation of Th1 cells in thymocytes and splenocytes.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.2
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• pp.145-157
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• 2015

Objective : This study aimed to analyze a comprehensive feature of experimental research on Insamyangyoungtang and develop a strategy that can be used for experimental studies on Insamyangyoung-tang in the future. Method : The journal search was performed using six databases : PubMed, Chinese database (China Network Knowledge Infrastructure, [CNKI]), Japan database (Japan Science and Technology Information Aggregator, Electronic, [J-STAGE]) and three Korean databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Service System [RISS], and Korean Studies Information Service System [KISS]). We used limited keywords and analyzed studies by publication year, experimental models, and the subjects of biological activities. The mechanism of pharmacological activity in accordance with the therapeutic effects of Insamyangyoung-tang was noted. Results and Conclusion : A total of 43 studies (6 domestic studies and 37 foreign ones) were examined according to the inclusion criteria of the experimental study. Research on the pharmacological activities of Insamyangyoung-tang showed its therapeutic effects on the nervous and immune systems, as well as its anti-aging, anti-fatigue, and hematopoietic effects. Additional efficacy and safety assessments and experimental and clinical studies should be performed to evaluate the mechanism of Insamyangyoung-tang. The present review has provided preliminary information for further studies on Insamyangyoung-tang.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.3
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• pp.257-266
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• 2006

Purpose : The purpose of this study is to evaluate the effects of Insamyang-yeongtang on menopausal disorder patients. Methods : We surveyed 15 menopausal disorder patients who had been administered Insamyang-yeongtang. The patients of menopausal disorder had been estimated twice with Kupperman's index. Results : When patients had been not administered Insamyang-yeongtang, the mean of Kupperman's index score are 42.73(SD ${\pm}$19.16). When administered Insamyang-yeongtang, the mean of kupperman's index score are 25.87(SD ${\pm}$19.16). The difference mean of first and last score are 16.87(p-value 0.001). Conclusion : This study suggests that Insamyang-yeongtang is significantly effective on menopausal disorder patients.

• Journal of Oriental Medical Thermology
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• v.5 no.1
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• pp.59-68
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• 2006

Objective: The purpose of this study is to evaluate the effects of Insamyang-yeongtang on menopausal disorder patients Methods : We surveyed 15 menopausal disorder patients who had been administered Insamyang-yeongtang. The patients of menopausal disorder had been estimated twice with Kupperman's index. Result : When patients had been not administered Insamyang-yeongtang. the mean of Kupperman's index score are $42.73(SD{\pm}19.16)$. When administered Insamyang-yeongtang, the mean of kupperman's index score are $25.87(SD{\pm}19.16)$. The difference mean of first and last score are 16.87(p-value 0.001). Conclusion : This study suggests that Insamyang-yeongtang is significantly effective on menopausal disorder patients.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.814-821
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• 2018

Thyroid cancer is one of the most common cancers in Korea, and thyroidectomy is the first-line treatment. Hypoparathyroidism is a common complication of thyroidectomy and can cause symptoms such as numbness, spasm, and anxiety, but these issues have seldom been reported in the Korean medical literature. The present case was a 53-year-old thyroid cancer patient who complained of numbness caused by hypoparathyroidism, general weakness, fatigue, and postoperative pain after total thyroidectomy. The patient was treated with Korean medicine treatment, including herbal medicine, acupuncture, cupping, and moxibustion, and her changes in clinical symptoms were measured with a numeric rating scale (NRS), the Karnofsky performance status scale (KPS), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). After treatment, her clinical symptoms were improved, leading to an improvement in her quality of life. Therefore, Korean medicine may be effective in the treatment of thyroid cancer patients who experience numbness caused by hypoparathyroidism, general weakness and fatigue after total thyroidectomy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.63-77
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• 2013

The object of this study was to observe anticancer and related immunomodulatory and anticachexic effects of Insamyangyoung-tang aqueous extracts (ISYYTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Changes on the tumor volume and weights, lymphatic organ(spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes and peritoneal macrophage activities (NK cell activity), splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents, splenic T-lymphocyte subsets (CD3+, CD4+ and CD8+) and TNF-${\alpha}+$ cells were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. In addition, changes on the body weights, epididymal fat weights and serum IL-6 levels were also detected with the thicknesses of deposited cervical brown adipose tissue and their mean diameters to monitor the tumor-related anticachexic effects. The results obtained in this study suggest that over 50 mg/kg of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory and anticachexic effects. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.2
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• pp.55-75
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• 2015

Objectives : The object of this study was to evaluate the effect of Insamyangyoung-tang aqueous extracts (ISYYT) on the propylthiouracil (PTU) induced rat hypothyroidism. Methods : The rats were divided into 6 groups : intact control, PTU control, Levothyroxine (LT ₄ ), 500, 250 and 125 mg/kg ISYYT treated groups. In ISYYT treated groups, PTU and ISYYT were administered for 4 weeks after 500, 250 and 125 mg/kg ISYYT were administered for 2 weeks. In LT ₄ group, PTU and LT ₄ were administered for 4 weeks. The changes were observed : the weigh, serum thyroid hormone levels, serum sex hormone levels, serum lipid profiles, serum liver enzyme levels, liver and testis antioxidant defense system, histopathology of thyroid gland, liver, epididymis, prostate and testis. Results were compared with PTU control group in this experiment. Results : In comparison with PTU control group, 500 and 250 mg/kg ISYYT treated groups showed significant increase of body, thyroid, liver, testis, epididymis and prostate weights, decrease of serum TSH levels with increase of serum T3 and T4 level, increase of serum testosterone and DHT levels with decrease of serum FSH levels, decrease of serum HDL with increase of TG and increase of serum AST levels. Histopathological inspections of hepatic and male reproductive organ damage induced by PTU were improved. And the changes of antioxidant defense system of Liver and testis induced by PTU were improve. There was no significant difference between 125 mg/kg ISYYT treated group and PTU control group in this experiment. Conclusions : The results obtained in this study considered that Insamyangyoung-tang may be effective in hypothyroidism and related organ damages.

• Herbal Formula Science
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• v.21 no.1
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• pp.51-70
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• 2013

Objectives : The object of this study was to observe anticancer and related immunomodulatory effects of Insamyangyoung-tang extracts (ISYYTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of ISYYTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, which are intact control, tumor bearing control, 5-fluorouracil (FU) 30 mg/kg, ISYYTe 50 mg/kg, ISYYTe 100 mg/kg, ISYYTe 200 mg/kg, each of 8 mice per group were used in the present study. Changes on the body weight, tumor volume and weight, lymphatic organ (spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. Results : As results of ISYYTe 50, 100 and 200 mg/kg treatment, decreases in the tumor volumes and weights were detected. At histopathological observations, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of all three different dosages of ISYYTe. As results of tumor cell inoculation, marked decreases of spleen and popliteal lymph node weights, serum IFN-${\gamma}$, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents and splenocytes were observed with histopathological atrophic changes of spleen and popliteal lymph nodes. Conclusions : Over 50 mg/kg of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in ISYYTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, there are no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.

• Journal of Oriental Neuropsychiatry
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• v.21 no.1
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• pp.109-124
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• 2010

Objectives: This experiment was designed to investigate the effect of the InSamYangYoung-tang(Renshenyangrongtang) extract on $A{\beta}$-induced AD model. Methods: The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of cultured PC12 cells induced by $A{\beta}$ were investigated. The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of hippocampal and cortical neurons in the mouse induced by $\beta$-amyloid were investigated. Results: 1. $A{\beta}$ treatment into neuronal cells activated cell death pathway when analyzed by MTT assay and by histological analysis. Then InSamYangYoung-tang(Renshenyangrongtang) treatment improved cell survival to a similar level as in normal group. 2. $A{\beta}$ treatment increased caspase 3 protein levels but decreased phospho-Erk1/2 in neuronal cells. InSamYangYoung-tang(Renshenyangrongtang) treatment reversed the production levels of two proteins close to those in normal group. 3. $A{\beta}$ treatment induced the atrophy of neuronal cells in terms of neuronal processes and cell body shrinkage, but InSamYangYoung-tang(Renshenyangrongtang) greatly improved their morphology. 4. Neuroprotective activity, as observed in InSamYangYoung-tang(Renshenyangrongtang)-treated groups, was similarly observed in cells treated with galantamine which was used as a positive control. Moreover, overall recovery pattern by InSamYangYoung-tang(Renshenyangrongtang) was similar between cultured PC12 cells and in vivo hippocampal and cerebral cortical neurons in the mouse brain. Conclusions: This experiment shows that the InSamYangYoung-tang(Renshenyangrongtang) may play a protective role in neural tissues damaged by cytotoxic substances. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. InSamYangYoung-tang(Renshenyangrongtang) might be effective for the treatment of AD. Investigation into the clinical use of the InSamYangYoung-tang(Renshenyangrongtang) for AD is suggested for future research.