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Distribution of Beneficial Bacteria in the Intestines after Enzamin Ingestion of Bacillus subtilis AK Strain Fermentation (Bacillus subtilis AK균 발효액(Enzamin)의 섭취 후 장내 유익세균의 분포조사)

  • Ryu, Seo Won;Lee, Hyung H.
    • Journal of Naturopathy
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    • v.7 no.2
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    • pp.27-38
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    • 2018
  • Purpose: The purpose of this study was to investigate whether intestinal proliferation is promoted in beneficial intestinal bacteria or decreased in harmful bacteria before and after ingesting Bacillus fermentation broth (ENM) for 8 weeks in the 16 subjects. Method: Intestinal bacteria were identified by PCR amplification using specific 16S rRNA primers. Results: The Bifidobacterium gene index(%)(gi%) increased to 58.92% in the control group and 69.53% in the test group after the ingestion of ENM, but there was no significant difference. Lactobacillus gi% increased significantly (49.37% in the control and 66.43% in the test) (p<.029). Clostridium gi% was significantly decreased after treatment (83.16% in the control and 67.76% in the test) (p<.077). Bacteroides gi% increased significantly (12.58% in the control and 20.87% in the test) after ingesting (p<.095). Prevotella gi% increased significantly (7.55% in the control and 17.28% in the test) after ingesting (p<.005). After ingesting, the median bacteria increased significantly in the control (20.06%) and the test (35.88%) (p<.001). Conclusions: After ingestion of the ENM, the number of beneficial bacteria increased and the number of harmful bacteria Clostridium tended to decrease. This suggests that ingestion of the Bacillus fermented beverage ENM has an effect on the proliferation of intestinal bacteria.

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Heavy Snow Vulnerability in South Korea Using PSR and DPSIR Methods (PSR과 DPSIR을 이용한 대한민국 대설 취약성 분석)

  • Keunwoo Lee;Hyeongjoo Lee;Gunhui Chung
    • Journal of Wetlands Research
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    • v.25 no.4
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    • pp.345-352
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    • 2023
  • Recently, the risk of snow disasters has been increasing South Korea. The damages of heavy snow were categorized into direct and indirect. Direct damage is usually the collapse of buildings as houses, greenhouse or barns. Indirect damage is various, for example, traffic congestion, traffic acident, drop damage, and so on. In South Korea, direct damage is severe in rural area, mosty collapse of greenhouse or barns. However, indirect damage such as traffic accident is mostly occurred in urban area. Therefore, the regional characteristics should be considered when vulnerability is evaluated. Therefore, in this study, the PSR and DPSIR method were applied by regional scale in South Korea. The PSR evaluation method is divided into pressure, state, and reaction index. however, the DPSIR evaluation method is divided into Driving force, Pressure, State, Impact, and Response index. the DPSIR evaluation method is divided into Driving force, Pressure, State, Impact, and Response index. Data corresponding to each indicator were collected, and the weight was calculated using the entropy method to calculate the snowfall vulnerability index by regional scale in South Korea. Calculated heavy snow damage vulnerabilities from the two methods were compared. The calculated vulnerabilities were validated using the recent snow damage in South Korea from 2018 to 2022. Snow vulnerability index calculated using the DPSIR method showed more reliable results. The results of this study could be utilized as an information to prepare the mitigation of heavy snow damage and to establish an efficient snow removal response system.

The Moderating Effect of Job Satisfaction on Social Exclusion and Quality of Life of the Disabled (장애인의 사회적 배제와 삶의 질에 대한 직무만족의 조절효과)

  • Aeran Kwon;Hyeongki Lee
    • Journal of Internet of Things and Convergence
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    • v.10 no.1
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    • pp.13-20
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    • 2024
  • The purpose of this study is to objectively quantify the degree of social exclusion of the disabled and verify the impact of the derived degree of social exclusion on the quality of life of the disabled. And the purpose is to verify whether job satisfaction moderates the impact of social exclusion and quality of life of disabled people. The subjects of the study were 1,280 people extracted through a panel survey on employment of the disabled. The independent variables of social exclusion are economic difficulties, employment status, mental health, and social activities. The dependent variable was quality of life, and the control variable was job satisfaction. The research results are as follows. First, the sub-factors of social exclusion that affect quality of life were economic difficulties, mental health, participation in social activities, and employment status. Second, job satisfaction showed a moderating effect in the relationship between social exclusion and quality of life. And the sub-factors of social exclusion that have a moderating effect on quality of life were identified as economic difficulties, employment status, and social activities. In follow-up research, it will be necessary to investigate employment programs for the disabled in developed countries and analyze the implementation background, implementation details, achievements, and limitations, thereby contributing to the establishment of employment policies for the disabled. It is hoped that through this research, the vicious cycle of social exclusion and discrimination of the disabled will be improved and an opportunity will be provided to improve the quality of life through the economic activities of the disabled.

Geological Factor Analysis for Evaluating the Long-term Safety Performance of Natural Barriers in Deep Geological Repository System of High-level Radioactive Waste (지질학적 심지층 처분지 내 천연방벽의 고준위 방사성 폐기물 장기 처분 안전성 평가를 위한 지질학적 인자 분석)

  • Hyeongmok Lee;Jiho Jeong;Jaesung Park;Subi Lee;Suwan So;Jina Jeong
    • Economic and Environmental Geology
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    • v.56 no.5
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    • pp.533-545
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    • 2023
  • In this study, an investigation was conducted on the features, events, and processes (FEP) that could impact the long-term safety of the natural barriers constituting high-level radioactive waste geological repositories. The FEP list was developed utilizing the IFEP list 3.0 provided by the Nuclear Energy Agency (NEA) as foundational data, supplemented by geological investigations and research findings from leading countries in this field. A total of 49 FEPs related to the performance of the natural barrier were identified. For each FEP, detailed definitions, classifications, impacts on long-term safety, significance in domestic conditions, and feasibility of quantification were provided. Moreover, based on the compiled FEP list, three scenarios that could affect the long-term safety of the disposal facility were developed. Geological factors affecting the performance of the natural barrier in each scenario were selected and their relationships were visualized. The constructed FEP list and the visualization of interrelated factors in various scenarios are anticipated to provide essential information for selecting and organizing factors that must be considered in the development of mathematical models for quantitatively evaluating the long-term safety of deep geological repositories. In addition, these findings could be effectively utilized in establishing criteria related to the key performance of natural barriers for the confirmation of repository sites.

A Case of Cold Hypersensitivity of Hands and Feet Treated with Korean Medicine Including Gyejifabuja-tang-gmibang and Acupuncture in a Patient with Lumbar Spinal Herniated Intervertebral Disc - A Case Report (한방병원에 입원한 수족냉증을 동반한 추간판탈출증 환자에 대한 한방 치료 1례)

  • Sang-hun Yun;Sang-yoon Kim;Yen-min Wang;Gil-geun Baek;Yu-jin Lee;Hyung-chul Lee;Man-ho Kang;Sung-hwan Park
    • The Journal of Internal Korean Medicine
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    • v.44 no.5
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    • pp.1071-1082
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    • 2023
  • Objective: The purpose of this study is to report the efficacy of using Korean medicine treatment with cold hypersensitivity of the hands and feet with lumbar spinal herniated intervertebral disc. Case presentation: We used Korean medicine treatment (Gyejigabuja-tang, acupuncture) to treat a hospitalized patient with cold hypersensitivity of the hands and feet with lumbar spinal herniated intervertebral disc. To evaluate the treatment, we used the Numerical Rating Scale (NRS). The degree of cold hypersensitivity of the hands and feet was also evaluated using evaluation paper. The generic health status was measured using the European Quality of Life-5 Dimensions (EQ-5D) scale. The 31-year-old female underwent 13 days of inpatient treatment. Her pattern identification was that both hands and feet are cold (BiYangHeo) types. The treatments were herbal medicine and acupuncture. She took Gyejigabuja-tang for 13 days. She also received acupuncture for 20 minutes twice a day at LI11 (曲池), L14 (合谷), TE5 (外關) on her hands, LR3 (太衝), SP6 (三陰交), SP9 (陰陵泉) ST36 (足三里), GB41 (足臨泣) on Feet, GV4 (命門), GV3 (腰陽關), BL23 (腎兪), BL24 (氣海兪), BL25 (大腸兪), and BL26 (關元兪) on the low back. After 2 weeks of treatment, the NRS scale of her cold hypersensitivity of hands and feet symptoms dropped from NRS 7 to NRS 3, and her low back pain dropped from NRS 6 to NRS 3. Her cold hypersensitivity of hands and feet evaluation paper score decreased from 64 to 32, and her EQ-5D increased from 0.487 to 0.681. After the end of treatment, continued symptom improvements and no significant side effects were confirmed. Results: These findings suggest that Korean medical treatment (Gyejigabuja-tang, acupuncture) may be effective for treating cold hypersensitivity of hands and feet with lumbar spinal herniated intervertebral disc. The NRS, evaluation paper, and EQ-5D scores improved after treatment, with no side effects.

Impact of customer experience characteristics on perceived value and revisit intention: Focusing on offline home appliance stores (고객체험특성이 지각된 가치와 재방문 의도에 미치는 영향: 가전 오프라인 매장을 중심으로)

  • Hosun Jeong;Jungmin Park;Hyoung-Yong Lee
    • Journal of Intelligence and Information Systems
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    • v.29 no.4
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    • pp.395-413
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    • 2023
  • This research studied the effect of customer experience characteristics in offline home appliance stores on perceived value and revisit intention. Among the offline distribution of home appliances with more than 100 stores nationwide, two home appliance retailers (HiMart, E-Land), three hypermarkets (E-Mart, Homeplus, Lotte Hi-Mart), and two home appliance stores (LG Best Shop, Samsung Digital Plaza) were selected, and a survey was conducted on men and women in their 20s or older in Seoul, Gyeonggi, and Incheon who had visited and purchased the home appliance store within the last 6 months. As a result of the survey, a statistical analysis was conducted on a total of 330 samples using the PLS (Partial Least Squares) structural equation model and SPSS statistical package. Through this study, the following research results can be obtained. First, educational experience, deviant experience, and aesthetic experience had a positive (+) effect on the functional value. However, entertainment experience did not affect functional value. Second, educational experience, deviant experience, and aesthetic experience all had a positive (+) effect on emotional value. Third, both functional and sensory values had a positive (+) effect on the revisit intention. Fourth, it was confirmed that brand loyalty had no moderating effect between functional value and sensory value revisit intention. The results of this study show the structural relationship between customer experience characteristics, perceived value (functional value, sensory value), and revisit intention. This result provides guidelines on what activities home appliance offline stores should do at a time when online channels threaten the survival of offline channels.

A Study on the Intention to Use ChatGPT Focusing on the Moderating Effect of the MZ Generation (MZ세대의 조절효과를 중심으로 한 ChatGPT의 사용의도에 관한 연구)

  • Yang-bum Jung;Jungmin Park;Hyoung-Yong Lee
    • Journal of Intelligence and Information Systems
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    • v.29 no.4
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    • pp.111-127
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    • 2023
  • This study is a study on user perception of ChatGPT use. The goal of this study is to analyze the relationship between user policy expectations and user innovativeness on ChatGPT technology acceptance and intention to use using variables of TRA (Theory of Reasoned Action). The impact of policy expectations and user innovativeness on the intention to use by mediating usefulness and hedonic motivation, and the impact of subjective norms on the usefulness and intention to use were analyzed by dividing them into the MZ generation and the non-MZ generation. It was verified whether there was a moderating effect on the effect of age differences on usefulness by interacting with policy expectations. An online survey was conducted on 300 ChatGPT users using PLS (Partial Least Square) structural equations and SPSS Package, and statistical analysis was performed using PLS and SPSS. According to the analysis results, it was confirmed that the higher the initial user's innovativeness, the higher the intention to use ChatGPT. In addition, the moderating effect analysis comparing the differences between the MZ generation and the non-MZ generation showed that policy expectations had a negative effect on the usefulness of ChatGPT use.

[Retracted]Gambigyeongsinhwan(4) Reduces Body Weight and Hepatic Lipid Accumulation in High Fat Diet-Fed Obese Male C57BL/6N Mice ([논문철회]고지방식이 마우스 비만모델에서 감비경신환(4)에 의한 체중감량과 간 지방축적의 변화)

  • Lee, Hye Rim;Ahn, Ye Ji;Lee, Hee Young;Lee, Hyung Hee;Kim, Dong Yeo;Yoon, Mi Chung;Lee, Yong Tae;Shin, Soon Shik
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.1
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    • pp.99-106
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    • 2013
  • We investigated the effects of gambigyeongsinhwan(GGH)(4) on body weight and non-alcoholic fatty liver disease(NAFLD) examined whether blood total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels and hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, GGH(4)-1, GGH(4)-2 and GGH(4)-3. After mice were treated with GGH(4) for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma ALT, leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Compared with controls, GGH(4)-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in GGH(4)-2. Compared with controls, GGH(4)-treated mice had lower feeding efficiency ratio and blood leptin level, the magnitudes of which was prominent in GGH(4)-2. Compared with controls, GGH(4)-treated mice had lower blood plasma total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels. Compared with controls, GGH(4)-2 treated mice had lower blood plasma ALT concentration. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by GGH(4), whereas the adipocyte number per unit area was significantly increased, suggesting that GGH(4) decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGH(4). In conclusion, these results suggest that GGH(4) exhibits anti-obesity effects through the modulation of feeding efficiency ratio and plasma obesity parameters. Moreover, it seems that GGH(4) also contributes to improve NAFLD through the regulation of plasma ALT and hepatic triglyceride accumulation.

Cox Model Improvement Using Residual Blocks in Neural Networks: A Study on the Predictive Model of Cervical Cancer Mortality (신경망 내 잔여 블록을 활용한 콕스 모델 개선: 자궁경부암 사망률 예측모형 연구)

  • Nang Kyeong Lee;Joo Young Kim;Ji Soo Tak;Hyeong Rok Lee;Hyun Ji Jeon;Jee Myung Yang;Seung Won Lee
    • The Transactions of the Korea Information Processing Society
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    • v.13 no.6
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    • pp.260-268
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    • 2024
  • Cervical cancer is the fourth most common cancer in women worldwide, and more than 604,000 new cases were reported in 2020 alone, resulting in approximately 341,831 deaths. The Cox regression model is a major model widely adopted in cancer research, but considering the existence of nonlinear associations, it faces limitations due to linear assumptions. To address this problem, this paper proposes ResSurvNet, a new model that improves the accuracy of cervical cancer mortality prediction using ResNet's residual learning framework. This model showed accuracy that outperforms the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study. As this model showed accuracy that outperformed the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study, this excellent predictive performance demonstrates great value in early diagnosis and treatment strategy establishment in the management of cervical cancer patients and represents significant progress in the field of survival analysis.

Effects of Relaxation Techniques on Flexibility and Balance of the Lower Limb in Adults with Hamstring Shortening (넙다리뒤근 단축이 있는 성인에게 이완 기법의 적용이 하지의 유연성과 균형에 미치는 영향)

  • Jung-Woo Lee;Seong-Min Jeon;Ha-Yeong Kim;Jong-Yeon Bae;Song-Chan Son;Eun-Jin Song;Sang-Eun Sim;Hyeong-Uk Lee;Hye-Kyeong Lee;Baek-Gwang Jo;Sung-Bin Jo;Jin-Hee Joo;Ha-Yeon Jin;Jeong-Hyeon Hwang;Min-Hee Kim
    • PNF and Movement
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    • v.22 no.1
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    • pp.55-70
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    • 2024
  • Purpose: The purpose of this study was to investigate the effects of three relaxation techniques, namely, Static Stretching Exercise (SSE), Eccentric Contraction Exercise (ECE), and Suboccipital Muscle Release (SMR) on the flexibility and balance of the lower limb in adults with hamstring shortening. Methods: The participants were 45 adults in their 20s with hamstring shortening. They performed three exercises (i.e., SSE, ECE, and SMR) for two weeks. We measured flexibility, muscle tone and stiffness, proprioception, and balance before and after the intervention, applying each relaxation technique. Data were analyzed using two-way repeated measures analysis of variance (ANOVA). The significance level was set at α=0.05. Results: Flexibility increased in the SSE, ECE, and SMR groups, with the SSE group showing the greatest improvement. Muscle tone and stiffness decreased in all groups, with the ECE group exhibiting the highest reduction. Proprioception increased in the SSE, ECE, and SMR groups, with SSE demonstrating the greatest enhancement. Balance also increased in all groups, with the ECE group showing the most pronounced improvement. Conclusion: Overall, all three relaxation techniques for hamstring shortening resulted in improved flexibility, muscle tone and stiffness, proprioception, and balance of the lower limb in adults with hamstring shortening. The findings of this study underscore the importance of selecting an appropriate technique according to the purpose of treatment and the condition of the patient.