• The Journal of the Korean bone and joint tumor society
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• v.9 no.2
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• pp.190-199
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• 2003

Purpose: The aim of this study was to find out a clinically appliable method to insert a biodegradable solid material containing holmium-166-chitosan complex into the surgical field, and to evaluate the histological changes in the normal tissues after ${\beta}$ -ray irradiation from holmium-166 according to the dose, period and type of tissues. Materials and Methods: 3.0 mCi, 50 ${\mu}l$ of the liquid state $^{166}$Ho-chitosan complex was attached to the absorbable gelatin sponge. The radiation activity measured by dose caliberator was 1.5 mCi. These $^{166}$Ho-chitosan complex containing absorbable gelatin sponges were inserted into the thigh muscles and over the femur bones of the Wistar rats. The cases were evaluated at 2 weeks after insertion, and 4, 6 weeks with respect to the histological changes of the soft tissues and bone, the depth of the tissue necrosis, and the changes of the $^{166}$Ho-chitosan complex containing absorbable gelatin sponges. Results: At 2 weeks, the muscles showed coagulation necrosis, degenerating myocytes, regenerating myocytes, intermuscular edema, and inflammatory cells. The necrosis depth was 3.3 mm. In the bones, there was no osteocyte in the lacuna of cortex (empty lacuna), marrow fibrosis, inflammation. The necrosis depth was 2.9 mm. At 4 weeks, in the muscle, calcification and increased fibrosis with necrosis depth by 3.3 mm were the additional findings. In the bone, marrow fibrosis with necrosis depth by 3.3 mm were detected. At 6 weeks, soft tissue shrinkage, increased fibrosis and granulation tissue formation, and nearly resolving inflammatory reaction were the findings. Conclusion: The local application of the $^{166}$Ho-chitosan complex attached to biodegradable gelatin material with surgery in the laboratory animals resulted in no mortality and morbidity, and satisfactory tissue necrosis. Holmium-166 can be applied to the treatment of the malignant tumor patients.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.33 no.5
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• pp.425-429
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• 2011

Bone grafts are becoming increasingly common in oral and maxillofacial surgery to improve bone healing procedures. Bovine bone as a xenograft is a representative osteoconductor and space filler; however, sometimes complications, such as infection and wound dehiscence are encountered with its use. We report the result of an eight-year follow-up of a xenograft case and processing methods of inorganic bovine bone along with a review of the literature. Xenograft ($LUBBOC^{(R)}$) was used in a cyst enucleation site of the maxilla, as a bone substitute and space filler. Inflammation and infection were defined several times as lack of osseous contact between the graft and host bone, caused by remodeling failure over an eight-year period. Pathologic findings of the xenograft revealed dead bony trabeculae with inflamed fibrous tissue and actinomycosis.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.8 no.1
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• pp.46-59
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• 1999

A fixed bridge is preferred as a prosthetic option supported by oral implants. However, it is very difficult to re tore edentulous maxilla with fixed prosthesis in cases with improper position and angulation of fixtures, abnormal jaw relation, and need for proper lip support. Six Br${\aa}$nemark implants were installed in edentulous maxilla opposing mandible with natural dentition. A removable hybrid prosthesis attached to a bar milled by 6 degrees was therefore designed to overcome such disadvantages of fixed prosthesis. Lateral stabilization of removable prosthesis was obtained by framework closely fitting the milled bar. Support for the prosthesis was ensured by three elevated areas on the bar. Two precision attachments(CEKA REVAX) provided appropriate direct and indirect retention without influencing support. A clinical and laboratory procedure was presented.

• KSBB Journal
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• v.25 no.3
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• pp.257-264
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• 2010

Bone morphogenetic protein-7 (BMP-7) is one of important growth factors for skeletal development and bone growth. In this work, BMP-7 was efficiently expressed in recombinant Bacillus subtilis. The mature BMP-7 protein indicated molecular weight of 15.4 kDa by Western blot assay and was secreted into culture medium with 0.35 ng/mL. The extracellular and intracellular rhBMP-7 proteins were purified by using a FPLC system with an ion exchange column and a gel filtration column. The extracellular and intracellular rhBMP-7 proteins had finally a 57.1% purity and a 36.2% purity, respectively. The purified rhBMP-7 proteins showed an intact biological activity which stimulated alkaline phophatase (ALP) activity in MC3T3-E1 cells.

• Korean Journal of Cleft Lip And Palate
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• v.5 no.2
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• pp.117-122
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• 2002

성장기 환자에서의 각 부위별 임플란트 식려 시기를 요약해보면 다음과 같다. 1) 상악전방부 : 외상이나 선천적 결손을 해결하는 방법으로 임플란트를 사용하는 술식이 권장하지만 성장이 완료되지 않았기 때문에 야기되는 문제를 해결하기 위해 성장이 완료될 때까지 연기하는 것이 좋다. 2)상악 후방부: 수직적인 성장량이 최고 1cm까지 일어날 수 있으면 상악동의 흡수로 조기에 임플란트 침강과 치근부의 노출을 야기할 수 있다. 그리고 동시에 보철에 의한 구개열의 횡적인 성장방해를 피해야한다. 3) 하악 전방부 : 무치증 아이에서 임플란트의 조기식립이 적응증이 되는 유일한 곳으로 치아가 없을 때는 치조골의 성장이 최소이며 초기에 횡적, 후방 성장이 대부분 완료된다. 그러나 단일 임플란트 식립은 권장되지 않는다. 4)하악후방부: 늦게까지 성장변화가 지속되기 때문에 전후방, 횡적, 수직적 성장의 많은 양이 일어난다. 하악의 회전성장의 영향을 많이 받아 하악 무치악에서 조기 임플란트 사용한 보고도 적고. 자연치아에 인접하여 임플란트를 식립한 기록은 있으나 골격성장이 완료될 때 까지는 식립하지 않는 것이 좋다.

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.416-417
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• 2006

• Maxillofacial Plastic and Reconstructive Surgery
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• v.14 no.4
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• pp.269-274
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• 1992

Osteopetrosis is a rare skeletal disease of unknown etiology. Osteomyelitic changes in the jaw bones are frequently seen in this disease, especially in the mandible and may follow upon tooth extraction. A case is reported of a 31-year-old male who was seen because of intraorally exposed bony spicule and chronic dull pain. Radiographic and haematological investigations led to the diagnosis of osteopeirosis with osteomyelitis. The striking radiologic findings were pathologic mandibular fracture and generalized skeletal thickening. The present case could be grouped under the benign form, type II osteopetrosis. With the conservative and minimally invasive modes of treatment including administration of penicillin G sodium, curettage and closed reduction, we could successfully manage the osteomyelitis and pathologic fracture associated osteopetrosis.

• Proceedings of The Korean Cleft Lip And Palate Association
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• 2002.05a
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• pp.35-35
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• 2002

• Proceedings of the IEEK Conference
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• 2007.07a
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• pp.395-396
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• 2007

Bone age assessment has been widely used to measure the ossification in pediatric radiology. For the assessment, first bone age of each epiphyseal plate is estimated using DCT/LDA, then the bone age of a patient is calculated by using the median of 9 estimations. For some patients, however, due to various reasons such as X-ray image quality or the pose of fingers, it is common to miss couple of plates in automated systems. In this paper, we investigate the relationship between the number of detected plates and the accuracy of bone age assessment. In the experimental results, we confirmed the similarity between bone age assessed using more than 7 epiphyseal plates and that assessed using 9 epiphyseal plates.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.4
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• pp.324-333
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• 2005

Distraction osteogenesis for the advancement of hypoplastic maxilla of cleft patients has shown successful results. In this report, rigid external distraction(RED) system and internal distraction device were used for maxillary advancement. Each system has its advantages and disadvantages. Larger amount of advancement can be achieved with RED system. But complex external device may give patients psychological stress. Internal device is invisible. However its distraction amount have limitation for the advancement (< 20mm) and the vector cannot be changed freely during distraction. The authors treated five cleft patients with maxillary hypoplasia(three with RED system and two with internal distractor). Their results were clinically satisfactory. We present the pros and cons of RED and internal system for maxillary distraction osteogenesis.