• Radiation Oncology Journal
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• v.15 no.3
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• pp.233-241
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• 1997

Purpose : This study was done to evaluate the survival rate and Prognostic factors of patients with inoperable non-small cell lung cancer(NSCLC) treated with radiation therapy. Materials and Methods A retrospective analysis was undertaken of 62 Patients who had inoperable NSCLC treated with radiation therapy from January 1991 through December 1993. According to AJCC slaging, stage IIIA was 14 patients and stage IIIB was 48 patients. Forty Gy to 70.2Gy to the primary tumor site was delivered with daily fractions of 1.8Gy or 2Gy, 5days per week. Thirty-seven patients received neoadjuvant chemotherapy. Results : Complete, partial and no response to radiation therapy were 3 patients, 34 Patients and 25 patients, respectively The median survival period of all patients was 11 month. One rear survival rate, 2 year survival rateand 5 rear survival rate for all patients were 45.0%, 14.3%, and 6.0% respectively The median survival period was 6.5 months in stage IIIA and 13 months in stage IIIB. One year survival rates were 28.6% in stage IIIA and 50.3% in stage IIIB In univariaite analysis, prognostic factors affecting survival were T-s1aging, AJCC staging, and response after radiation therapy (P<0.05) . Pretreatment peformance status affected survival but was not statistically significant (0.050.1). In multivariate analysis, Pathology and response to radiation therapy are independently significant prognostic factor. T stage was marginally significant (P=0.0809). During follow-up duration, distant metastasis developed in 20 patients-bone metastasis in 10 patients, brain metastasis in 3 patients, liver mentastasis in 3 patients, contralateral lung metastasis in 1 patients and multiple metastases in 3 patients. Conclusion :　Conventional radiotherapy alone or combined chemoradiotherapy are unlikely to achieve long term survival in patients with NSCLC.　Surgery after concurrent chemoradiotherapy is Ivied to improve the local　control in our hospital

• Childhood Kidney Diseases
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• v.5 no.2
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• pp.109-116
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• 2001

Purpose Long- term use of steroid, cyclophosphamide and cyclosporin, which are frequently used in the therapy of SDNS, might cause severe side effects. Recently, the immune-modulator levamisole has been tried as a substitute therapy and it has been reported as a method with less side effects and more effectiveness. We started this research in order to observe the effects of levamisole and compare it to other therapy results. Patients and Methods : We chose 16 steroid dependent nephrotic syndrome children, those who had shown frequent relapse during the immunocompromised therapy period. Mean age was $9.1{\pm}1.4$ years in children and the male to female ratio was 15:1. All of subjects were diagonized with MCNS and had received cyclophosphamide or cyclosporin before receiving levamisole. Levamisole at a dose of 2.5mg/kg was used every other day for 1 year and the relapse rate was observed. Results : On average of 14 days after treatment, complete remission was visible in all of the children, and the relapse percentage was $50\%$, which represents 8 children, while remaining 8 children representing $50\%$ of the cases showed no relapse during treatment. During the levamisole therapy period, tile average relapse rate was reduced significantly from $2.18{\pm}0.9/year\;to\;0.77{\pm}0.9/year$(P=0.027). Also the average relapse rate after the therapy was reduced to $1.34{\pm}1.1/year$, which was a significant level compared to the level before treatment(P=0.003). There was no significant difference in terms of duration of remission maintenance. Duration of remission maintenance showed an average of $12.2{\pm}9.1$ months before the use of levamisole, but it was also $10.1{\pm}6.9$ month after therapy. No other side effects such as leukopenia, skin disease and other clinically significant symptoms appeared at all during therapy. Conclusion : The long-term medication of levamisole for the therapy of SDNS children is thought to be able to maintain stable remission by reducing the relapse frequency without causing severe side effects. Further study with a broader range of subjects is required to eluccidate the long-term effects of this treatment. (J. Korean Soc Pediatr Nephrol 2001;5 : 109-16)

• Journal of Korean Library and Information Science Society
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• v.48 no.1
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• pp.291-318
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• 2017

In this study, We found out that bibliotherapy program for university student has its strong point and effectiveness. The result of this study are follows: 1) bibliotherapy program is a safe method which covers the advantage of group psychotherapy and make up for the disadvantages. 2) significant changes in imitational behavior, cohesion and acceptance of reality suggest the necessity of bibliotherapy program that focuses on university career. 3) In light of the gloomy reality of young people, the fact that university students discuss love and hope for romance was meaningful phenomenon. It is necessary to study the after reading activities that can enhance the effectiveness of the bibliotherapy program and the specific topics and media that is needed by universities. The study is an approach that is widely available in university and will be the first step to establish the professional direction for bibliotherapy program.

• Health and Mission
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• s.4
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• pp.26-38
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• 2005

최근 성체줄기세포도 배아줄기세포처럼 자신이 속한 조직이나 장기가 아닌 다른 배엽의 줄기세포로 부화할 수 있는 교차분화 능력이 알려지면서 여러 질환에서 이식치료가 활발하게 진행되고 있다. 특히 가톨릭대학교 외신경계 유전테연구센터에서는 난치성 혈관질환 중 놔경색, 버거씨병 등 환자 64명에게서 현저한 치료 효과를 보았다.

• Sim-seong Yeon-gu
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• v.35 no.1
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• pp.1-65
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• 2020

BMGIM is a method of individual psychotherapy which seeks to achieve self-knowledge via imagery experiences evoked by music. When dealing with imagery in BMGIM, emphasis is placed on the insight of the client, but there are occasions when clients sometimes are confused because they cannot understand their imagery experiences. Also therapists and clients tend to consider experiences of BMGIM from a causalistic-reductive perspective. In order to understand the meaning of BMGIM imagery experiences, in this thesis imagery experiences are interpreted from a Jungian perspective that understands imagery as a symbol and stresses the purposive meaning. At first the definition and procedures of BMGIM are dealt with, secondly music and imagery as components of BMGIM are examined, and lastly the symbolic meaning of two female clients' BMGIM imageries are discussed. Looking into deeply imagery experiences, both therapist and clients newly came to realize not only the symbolic meaning of imageries but also the purposive meaning of wounds and sufferings of clients, especially I was able to confirm the following three points. First, just like dreams or active imagination, BMGIM also deals with spontaneous contents of the psyche. Second, the autonomy of the objective psyche which orients the development of personality, healing and wholeness is also revealed in BMGIM. Lastly, Jungian perspective aids in understanding the meaning of the imagery experiences in a more deep and abundant way. From this point, BMGIM can also be seen as a useful therapeutic tool which deals with the unconscious such as dream analysis or active imagination.

• Clinical and Experimental Pediatrics
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• v.49 no.5
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• pp.552-557
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• 2006

Purpose : The recent results observed in precocious puberty and the hope that interrupting puberty might increase adult height have led to an attempt to use GnRH agonist(GnRHa) in children with premature puberty and a poor growth prognosis. We aimed to analyze the growth promoting effect of GnRHa in girls with early puberty and low predicted adult height(PAH). Methods : Thirty six girls were recruited. They were grouped according to the GnRHa treatment period(group 1>6 mo, n=18; group 2<6 mo, n=18). The following variables were analyzed before and after GnRHa treatment : chronological age(CA), bone age(BA), ${\Delta}age$(CA-BA), height, target height (TH), PAH, serum IGF-1, IGFBP-3. Results : Duration of the GnRHa treatment was $0.89{\pm}0.81yr$($1.37{\pm}0.92yr$ in group 1, and $0.41{\pm}0.08yr$ in group 2). Before treatment, none of the variables were different between the two groups. There were no differences in the following variables the between two groups at the end of treatment : CA, BA, ${\Delta}age$, PAH, serum IGF-1, IGFBP-3. But, growth velocity(GV) and PAH increment during treatment were significantly reduced in group 1. Compared with initial PAH, PAH at the end of treatment was significantly increased($3.7{\pm}3.2cm$). The last serum levels of IGF-1 and IGFBP-3 were lower than those before treatment. Conclusion : Even though last PAH didn't approach TH, short term GnRHa administration in early puberty with low predicted PAH was somewhat effective. But, GnRHa administration suppressed the growth hormone-IGF-1 axis. Therefore, it is recommended that growth hormone(GH) should be used in combination with GnRHa.

• Journal of Oral Medicine and Pain
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• v.20 no.2
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• pp.377-383
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• 1995

이 연구의 목적은 측두하악관절통에 있어서 인도메타신 포노포레시스의 동통완화효과를 평가하기 위한 것이다. 측두하악관절통을 가진 20명의 환자들이 이 연구에 참여했다. 10명은 인도메타신을 이용하여 초음파치료를 받았고 다른 10명은 순수 초음파 치료용 젤을 이용하여 초음파 치료를 받았다. 동통완화효과를 평가하기 위하여 치료전과 치료후에 유추지수와 압력통각역치를 이중맹검법으로 평가하였다. 실험결과는 다음과 같다. 인도메다신을 이용하여 초음파 치료를 받은 군은 유추지수와 압력통각역치에서 다 유의한 동통의 감소를 보였다. 반면에 대조군에서는 치료후에 유추지수와 압력통각역치에서 동통의 감소를 보였지만 통계적으로 유의하지 않았다. 이 결과는 측두하악관절통에 있어서 단순한 초음파 치료보다 포노포레시스가 더 효과적이라는 것을 의미한다.

• Tuberculosis and Respiratory Diseases
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• v.42 no.4
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• pp.502-512
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• 1995

Background: One quarter to one third of patients with NSCLC present with primary tumors that although confined to the thorax are too extensive for surgical resection. Until resently standard treatment for these patients had been thoracic radiation, which produces tumor regression in most patients but few cures and dismal 5-year survival rate. The fact that death for most patients with stage III tumors is caused by distant metastases has promped a reevaluation of combined modality treatment approaches that include systemic chemotherapy. Therefore, we report the results observed in a study to evaluate the effect of multimodality treatment in locally advanced non-small cell lung cancer from 1/91 to 8/93 in CNUH. Method: We grouped the patients according to the treatment modalities and evaluated response rate, median survival and the effect of prognostic variables. Among 67 patients evaluated, twenty seven patients classified with group A, received cisplatin and etoposide containing combination chemotherapy alone, eighteen patients, classified with group B, received chemotherapy and radiotherapy, fifteen patients, group C, received neoadjuvant or adjuvant chemotherapy and surgery with/without radiation therapy, seven patients, group D, received only supportive care. Result: The major response rate for group A and B was 37% and 61% respectively. There was no statistically significant difference in response rate between A and B groups(p=0.97). The analysis of prognostic factors showed that differences of age, sex, pathology, blood type, smoking year, stage and ECOG performance did not related to improvement in survival. Median survival time was 8.6 months for group A, 13.4 months for group B, 19.2 months for group C, and 5.4 months for group D, respectively and there was statistically significant difference(p=0.003), suggesting that multimodality therapy was associated with signigicant improvement in survival. Subset survival analysis showed a significant therapeutic effect for earlier stage and good performance state(p=0.007, 0.009, respectively). A possible survival advantages were observed for major response groups. Conclusion: It was suggested that multimodality therapy for the management of patients who had stage III disease, has yielded good median survival and long survival for seleted patients. But, it is necessory to validate above result with further investigation in large scale and in prospective randomized trials.

• 한국어정보학회:학술대회논문집
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• 2016.10a
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• pp.51-55
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• 2016

본 논문에서는 임상 의사 결정 지원을 위한 UMLS와 위키피디아를 이용하여 지식 정보를 추출하고 질병중심 문서 클러스터와 단어 의미 표현을 이용하여 질의 확장 및 문서를 재순위화하는 방법을 제안한다. 질의로는 해당 환자가 겪고 있는 증상들이 주어진다. UMLS와 위키피디아를 사용하여 병명과 병과 관련된 증상, 검사 방법, 치료 방법 정보를 추출하고 의학 인과 관계를 구축한다. 또한, 위키피디아에 나타나는 의학 용어들에 대하여 단어의 효율적인 의미 추정 기법을 이용하여 질병 어휘의 의미 표현 벡터를 구축하고 임상 인과 관계를 이용하여 질병 중심 문서 클러스터를 구축한다. 추출한 의학 정보를 이용하여 질의와 관련된 병명을 추출한다. 이후 질의와 관련된 병명과 단어 의미 표현을 이용하여 확장 질의를 선택한다. 또한, 질병 중심 문서 클러스터를 이용하여 문서 재순위화를 진행한다. 제안 방법의 유효성을 검증하기 위해 TREC Clinical Decision Support(CDS) 2014, 2015 테스트 컬렉션에 대해 비교 평가한다.

• 한국호스피스완화의료학회:학술대회논문집
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• 2005.12a
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• pp.320-324
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• 2005